Aliases for CTDSPL2 Gene

Aliases for CTDSPL2 Gene

  • CTD Small Phosphatase Like 2 2 3 5
  • CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase Like 2 2 3
  • CTD Small Phosphatase-Like Protein 2 3 4
  • CTDSP-Like 2 3 4
  • HSPC129 2 3
  • EC 51
  • EC 3.1.3.- 4
  • FLJ10523 2
  • EC 3.1.3 51
  • HSPC058 3
  • CTDSPL2 5
  • SCP4 3

External Ids for CTDSPL2 Gene

Previous GeneCards Identifiers for CTDSPL2 Gene

  • GC15P042508
  • GC15P044719
  • GC15P021542

Summaries for CTDSPL2 Gene

GeneCards Summary for CTDSPL2 Gene

CTDSPL2 (CTD Small Phosphatase Like 2) is a Protein Coding gene. Diseases associated with CTDSPL2 include Nemaline Myopathy 1. Gene Ontology (GO) annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is CTDSPL.

UniProtKB/Swiss-Prot Summary for CTDSPL2 Gene

Additional gene information for CTDSPL2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CTDSPL2 Gene

Genomics for CTDSPL2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CTDSPL2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CTDSPL2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CTDSPL2

Top Transcription factor binding sites by QIAGEN in the CTDSPL2 gene promoter:
  • Egr-4
  • FOXJ2
  • FOXJ2 (long isoform)
  • GATA-1
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • Spz1
  • YY1

Genomic Locations for CTDSPL2 Gene

Genomic Locations for CTDSPL2 Gene
101,710 bases
Plus strand
101,805 bases
Plus strand

Genomic View for CTDSPL2 Gene

Genes around CTDSPL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTDSPL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTDSPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTDSPL2 Gene

Proteins for CTDSPL2 Gene

  • Protein details for CTDSPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CTD small phosphatase-like protein 2
    Protein Accession:
    Secondary Accessions:
    • Q3ZTU1
    • Q6AI06
    • Q8IYI9
    • Q9NVT2
    • Q9NZX8
    • Q9P030

    Protein attributes for CTDSPL2 Gene

    466 amino acids
    Molecular mass:
    52999 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF29030.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH18623.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA91664.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CTDSPL2 Gene


neXtProt entry for CTDSPL2 Gene

Selected DME Specific Peptides for CTDSPL2 Gene


Post-translational modifications for CTDSPL2 Gene

  • Ubiquitination at Lys358
  • Modification sites at PhosphoSitePlus

Domains & Families for CTDSPL2 Gene

Gene Families for CTDSPL2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CTDSPL2 Gene

Suggested Antigen Peptide Sequences for CTDSPL2 Gene

GenScript: Design optimal peptide antigens:
  • CTD small phosphatase-like protein 2 (CTSL2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CTDSPL2 family.
  • Belongs to the CTDSPL2 family.
genes like me logo Genes that share domains with CTDSPL2: view

Function for CTDSPL2 Gene

Molecular function for CTDSPL2 Gene

UniProtKB/Swiss-Prot Function:
Probable phosphatase.

Enzyme Numbers (IUBMB) for CTDSPL2 Gene

Phenotypes From GWAS Catalog for CTDSPL2 Gene

Gene Ontology (GO) - Molecular Function for CTDSPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IBA 21873635
GO:0005515 protein binding IPI 28514442
GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity IDA 26920047
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with CTDSPL2: view
genes like me logo Genes that share phenotypes with CTDSPL2: view

Animal Models for CTDSPL2 Gene

MGI Knock Outs for CTDSPL2:

Animal Model Products

  • Taconic Biosciences Mouse Models for CTDSPL2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTDSPL2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CTDSPL2 Gene

Localization for CTDSPL2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTDSPL2 gene
Compartment Confidence
nucleus 5
endosome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CTDSPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 26920047
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with CTDSPL2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CTDSPL2 Gene

Pathways & Interactions for CTDSPL2 Gene

PathCards logo

SuperPathways for CTDSPL2 Gene

No Data Available

SIGNOR curated interactions for CTDSPL2 Gene


Gene Ontology (GO) - Biological Process for CTDSPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0030514 negative regulation of BMP signaling pathway IEA --
GO:0046827 positive regulation of protein export from nucleus IEA --
genes like me logo Genes that share ontologies with CTDSPL2: view

No data available for Pathways by source for CTDSPL2 Gene

Drugs & Compounds for CTDSPL2 Gene

No Compound Related Data Available

Transcripts for CTDSPL2 Gene

mRNA/cDNA for CTDSPL2 Gene

12 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTDSPL2

Alternative Splicing Database (ASD) splice patterns (SP) for CTDSPL2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b · 13c
SP1: - - -
SP3: -

Relevant External Links for CTDSPL2 Gene

GeneLoc Exon Structure for

Expression for CTDSPL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CTDSPL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CTDSPL2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.7), CD8 Tcells (16.0), Blymphocyte (6.7), and Ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CTDSPL2 Gene

Protein tissue co-expression partners for CTDSPL2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CTDSPL2

SOURCE GeneReport for Unigene cluster for CTDSPL2 Gene:


Evidence on tissue expression from TISSUES for CTDSPL2 Gene

  • Nervous system(4.5)
  • Liver(4.3)
  • Blood(4.3)
  • Bone marrow(4.2)
genes like me logo Genes that share expression patterns with CTDSPL2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTDSPL2 Gene

Orthologs for CTDSPL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CTDSPL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Ornithorhynchus anatinus)
Mammalia CTDSPL2 31
  • 100 (a)
(Pan troglodytes)
Mammalia CTDSPL2 30 31
  • 99.86 (n)
(Canis familiaris)
Mammalia CTDSPL2 30 31
  • 96.42 (n)
(Bos Taurus)
Mammalia CTDSPL2 30 31
  • 95.64 (n)
(Monodelphis domestica)
Mammalia CTDSPL2 31
  • 95 (a)
(Mus musculus)
Mammalia Ctdspl2 30 17 31
  • 93.62 (n)
(Rattus norvegicus)
Mammalia Ctdspl2 30
  • 93.48 (n)
(Gallus gallus)
Aves CTDSPL2 30 31
  • 86.27 (n)
(Anolis carolinensis)
Reptilia CTDSPL2 31
  • 89 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ctdspl2 30
  • 73.07 (n)
Str.516 30
African clawed frog
(Xenopus laevis)
Amphibia hspc129-prov 30
(Danio rerio)
Actinopterygii ctdspl2b 31
  • 71 (a)
ctdspl2a 30 31
  • 67.61 (n)
BX323045.3 31
  • 40 (a)
wufb81c12 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004967 30
  • 63.18 (n)
(Caenorhabditis elegans)
Secernentea scpl-3 31
  • 46 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PSR2 31
  • 26 (a)
PSR1 31
  • 23 (a)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.8447 30
Species where no ortholog for CTDSPL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CTDSPL2 Gene

Gene Tree for CTDSPL2 (if available)
Gene Tree for CTDSPL2 (if available)
Evolutionary constrained regions (ECRs) for CTDSPL2: view image

Paralogs for CTDSPL2 Gene

Paralogs for CTDSPL2 Gene

(1) SIMAP similar genes for CTDSPL2 Gene using alignment to 6 proteins:

  • L8E9X2_HUMAN Pseudogenes for CTDSPL2 Gene

genes like me logo Genes that share paralogs with CTDSPL2: view

Variants for CTDSPL2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CTDSPL2 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
714596 Benign: not provided 44,496,419(+) C/T MISSENSE_VARIANT
784321 Benign: not provided 44,490,806(+) A/G SYNONYMOUS_VARIANT
rs871923 - p.Ala244Val

Additional dbSNP identifiers (rs#s) for CTDSPL2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CTDSPL2 Gene

Variant ID Type Subtype PubMed ID
dgv4510n54 CNV loss 21841781
esv2449630 CNV deletion 19546169
esv2657720 CNV deletion 23128226
esv3636308 CNV loss 21293372
esv3636309 CNV loss 21293372
nsv1122958 CNV deletion 24896259
nsv1127429 CNV deletion 24896259
nsv569301 CNV loss 21841781

Variation tolerance for CTDSPL2 Gene

Residual Variation Intolerance Score: 22.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CTDSPL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTDSPL2 Gene

Disorders for CTDSPL2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CTDSPL2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
nemaline myopathy 1
  • nem1
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with CTDSPL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTDSPL2 Gene

Publications for CTDSPL2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids. (PMID: 30804502) Nakamura K … Groth A (Nature cell biology 2019) 3
  5. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. (PMID: 31091453) Shami Shah A … Baskin JM (Cell reports 2019) 3

Products for CTDSPL2 Gene

  • Biorbyt antibodies for CTDSPL2

Sources for CTDSPL2 Gene