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Aliases for CTDSPL2 Gene

Aliases for CTDSPL2 Gene

  • CTD Small Phosphatase Like 2 2 3 5
  • CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase Like 2 2 3
  • CTDSP-Like 2 3 4
  • CTD Small Phosphatase-Like Protein 2 3
  • EC 56
  • EC 3.1.3.- 4
  • EC 3.1.3 56
  • HSPC058 3
  • HSPC129 3

External Ids for CTDSPL2 Gene

Previous GeneCards Identifiers for CTDSPL2 Gene

  • GC15P042508
  • GC15P044719
  • GC15P021542

Summaries for CTDSPL2 Gene

GeneCards Summary for CTDSPL2 Gene

CTDSPL2 (CTD Small Phosphatase Like 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity.

UniProtKB/Swiss-Prot for CTDSPL2 Gene

  • Probable phosphatase.

Additional gene information for CTDSPL2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTDSPL2 Gene

Genomics for CTDSPL2 Gene

GeneHancer (GH) Regulatory Elements for CTDSPL2 Gene

Promoters and enhancers for CTDSPL2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I044425 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 572.9 +0.6 562 3.8 HDGF FOXA2 ARNT SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 POLR2B CTDSPL2 ENSG00000259595 SPG11 ENSG00000259563 SPATA5L1 WDR76 ENSG00000259659 CATSPER2P1 GC15P044434
GH15I045400 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 56.6 +975.5 975469 3.4 PKNOX1 SMAD1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 SPATA5L1 GATM CTDSPL2 SPG11 C15orf48 ENSG00000259563 RNU7-5P SQOR DUOX2
GH15I044286 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 54.5 -138.4 -138441 3.7 HDGF PKNOX1 SMAD1 NEUROD1 SIN3A FEZF1 DMAP1 IRF4 YY1 ZNF207 CASC4 GC15M044288 CTDSPL2 ENSG00000259563 ZSCAN29 LCMT2 SPG11 TUBGCP4 ENSG00000249839 ENSG00000259659
GH15I043791 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 37.9 -630.7 -630739 10.5 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 SP3 NFYC MEF2D GC15P043795 SERINC4 PIR54305 HYPK GC15M043788 SERF2 SPG11 CTDSPL2 ENSG00000259563 RPS3AP47
GH15I043823 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 37.7 -601.2 -601206 5.7 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC SSRP1 GLIS1 NBN WDR76 MFAP1 SPG11 CTDSPL2 ENSG00000249839 ZSCAN29 ENSG00000259563 ADAL CATSPER2 TUBGCP4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CTDSPL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CTDSPL2 gene promoter:

Genomic Locations for CTDSPL2 Gene

Genomic Locations for CTDSPL2 Gene
101,805 bases
Plus strand

Genomic View for CTDSPL2 Gene

Genes around CTDSPL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTDSPL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTDSPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTDSPL2 Gene

Proteins for CTDSPL2 Gene

  • Protein details for CTDSPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CTD small phosphatase-like protein 2
    Protein Accession:
    Secondary Accessions:
    • Q3ZTU1
    • Q6AI06
    • Q8IYI9
    • Q9NVT2
    • Q9NZX8
    • Q9P030

    Protein attributes for CTDSPL2 Gene

    466 amino acids
    Molecular mass:
    52999 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF29030.1; Type=Frameshift; Positions=84, 95; Evidence={ECO:0000305}; Sequence=AAH18623.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA91664.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CTDSPL2 Gene


neXtProt entry for CTDSPL2 Gene

Selected DME Specific Peptides for CTDSPL2 Gene


Post-translational modifications for CTDSPL2 Gene

  • Ubiquitination at posLast=358358
  • Modification sites at PhosphoSitePlus

Domains & Families for CTDSPL2 Gene

Gene Families for CTDSPL2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CTDSPL2 Gene

Suggested Antigen Peptide Sequences for CTDSPL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CTDSPL2 family.
  • Belongs to the CTDSPL2 family.
genes like me logo Genes that share domains with CTDSPL2: view

Function for CTDSPL2 Gene

Molecular function for CTDSPL2 Gene

UniProtKB/Swiss-Prot Function:
Probable phosphatase.

Enzyme Numbers (IUBMB) for CTDSPL2 Gene

Phenotypes From GWAS Catalog for CTDSPL2 Gene

Gene Ontology (GO) - Molecular Function for CTDSPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IBA --
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with CTDSPL2: view
genes like me logo Genes that share phenotypes with CTDSPL2: view

Animal Models for CTDSPL2 Gene

MGI Knock Outs for CTDSPL2:

Animal Model Products

  • Taconic Biosciences Mouse Models for CTDSPL2

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CTDSPL2 Gene

Localization for CTDSPL2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTDSPL2 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CTDSPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with CTDSPL2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CTDSPL2 Gene

Pathways & Interactions for CTDSPL2 Gene

SuperPathways for CTDSPL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CTDSPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0030514 negative regulation of BMP signaling pathway IEA --
GO:0046827 positive regulation of protein export from nucleus IEA --
genes like me logo Genes that share ontologies with CTDSPL2: view

No data available for Pathways by source and SIGNOR curated interactions for CTDSPL2 Gene

Drugs & Compounds for CTDSPL2 Gene

No Compound Related Data Available

Transcripts for CTDSPL2 Gene

Unigene Clusters for CTDSPL2 Gene

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTDSPL2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b · 13c
SP1: - - -
SP3: -

Relevant External Links for CTDSPL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTDSPL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CTDSPL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CTDSPL2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.7), CD8 Tcells (16.0), Blymphocyte (6.7), and Ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CTDSPL2 Gene

Protein tissue co-expression partners for CTDSPL2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CTDSPL2 Gene:


SOURCE GeneReport for Unigene cluster for CTDSPL2 Gene:


Evidence on tissue expression from TISSUES for CTDSPL2 Gene

  • Nervous system(4.5)
  • Blood(4.2)
  • Bone marrow(4.2)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with CTDSPL2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTDSPL2 Gene

Orthologs for CTDSPL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CTDSPL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Ornithorhynchus anatinus)
Mammalia CTDSPL2 34
  • 100 (a)
(Pan troglodytes)
Mammalia CTDSPL2 33 34
  • 99.86 (n)
(Canis familiaris)
Mammalia CTDSPL2 33 34
  • 96.42 (n)
(Bos Taurus)
Mammalia CTDSPL2 33 34
  • 95.64 (n)
(Monodelphis domestica)
Mammalia CTDSPL2 34
  • 95 (a)
(Mus musculus)
Mammalia Ctdspl2 33 16 34
  • 93.62 (n)
(Rattus norvegicus)
Mammalia Ctdspl2 33
  • 93.48 (n)
(Gallus gallus)
Aves CTDSPL2 33 34
  • 86.27 (n)
(Anolis carolinensis)
Reptilia CTDSPL2 34
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ctdspl2 33
  • 73.07 (n)
Str.516 33
African clawed frog
(Xenopus laevis)
Amphibia hspc129-prov 33
(Danio rerio)
Actinopterygii ctdspl2b 34
  • 71 (a)
ctdspl2a 33 34
  • 67.61 (n)
BX323045.3 34
  • 40 (a)
wufb81c12 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004967 33
  • 63.18 (n)
(Caenorhabditis elegans)
Secernentea scpl-3 34
  • 46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PSR2 34
  • 26 (a)
PSR1 34
  • 23 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8447 33
Species where no ortholog for CTDSPL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTDSPL2 Gene

Gene Tree for CTDSPL2 (if available)
Gene Tree for CTDSPL2 (if available)

Paralogs for CTDSPL2 Gene

(1) SIMAP similar genes for CTDSPL2 Gene using alignment to 6 proteins: Pseudogenes for CTDSPL2 Gene

genes like me logo Genes that share paralogs with CTDSPL2: view

No data available for Paralogs for CTDSPL2 Gene

Variants for CTDSPL2 Gene

Sequence variations from dbSNP and Humsavar for CTDSPL2 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000004969 -- 44,462,483(+) C/A intron_variant
rs1000058535 -- 44,436,004(+) A/G intron_variant
rs1000065786 -- 44,500,045(+) C/T intron_variant
rs1000088559 -- 44,504,145(+) C/T downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000101225 -- 44,456,261(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CTDSPL2 Gene

Variant ID Type Subtype PubMed ID
dgv4510n54 CNV loss 21841781
esv2449630 CNV deletion 19546169
esv2657720 CNV deletion 23128226
esv3636308 CNV loss 21293372
esv3636309 CNV loss 21293372
nsv1122958 CNV deletion 24896259
nsv1127429 CNV deletion 24896259
nsv569301 CNV loss 21841781

Variation tolerance for CTDSPL2 Gene

Residual Variation Intolerance Score: 22.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CTDSPL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTDSPL2 Gene

Disorders for CTDSPL2 Gene

Additional Disease Information for CTDSPL2

No disorders were found for CTDSPL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CTDSPL2 Gene

Publications for CTDSPL2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. (PMID: 27880917) St-Denis N … Gingras AC (Cell reports 2016) 3 58
  5. Human SCP4 is a chromatin-associated CTD phosphatase and exhibits the dynamic translocation during erythroid differentiation. (PMID: 26920047) Wani S … Hirose Y (Journal of biochemistry 2016) 3 58

Products for CTDSPL2 Gene

Sources for CTDSPL2 Gene

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