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Aliases for CTDSP2 Gene
Aliases for CTDSP2 Gene
External Ids for CTDSP2 Gene
- HGNC: 17077
- Entrez Gene: 10106
- Ensembl: ENSG00000175215
- OMIM: 608711
- UniProtKB: O14595
Previous GeneCards Identifiers for CTDSP2 Gene
- GC12M056499
- GC12M058213
- GC12M055250
Summaries for CTDSP2 Gene
GeneCards Summary for CTDSP2 Gene
CTDSP2 (CTD Small Phosphatase 2) is a Protein Coding gene. Diseases associated with CTDSP2 include Acute Tympanitis and Myasthenic Syndrome, Congenital, 16. Among its related pathways are Signaling by BMP and Coregulation of Androgen receptor activity. Gene Ontology (GO) annotations related to this gene include phosphatase activity and RNA polymerase II CTD heptapeptide repeat phosphatase activity. An important paralog of this gene is CTDSPL.
UniProtKB/Swiss-Prot Summary for CTDSP2 Gene
-
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.
Additional gene information for CTDSP2 Gene
- HGNC(17077)
- Entrez Gene(10106)
- Ensembl(ENSG00000175215)
- OMIM(608711)
- UniProtKB(O14595)
- Open Targets Platform(ENSG00000175215)
- Search for CTDSP2 at DataMed
- Search for CTDSP2 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CTDSP2 Gene
Genomics for CTDSP2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CTDSP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CTDSP2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CTDSP2
- Top Transcription factor binding sites by QIAGEN in the CTDSP2 gene promoter:
-
- IRF-7A
Genomic Locations for CTDSP2 Gene
Genomic Locations for CTDSP2 Gene
- chr12:57,816,702-57,846,729
- (GRCh38/hg38)
- Size:
- 30,028 bases
- Orientation:
- Minus strand
- chr12:58,213,710-58,240,747
- (GRCh37/hg19)
- Size:
- 27,038 bases
- Orientation:
- Minus strand
Genomic View for CTDSP2 Gene
Genes around CTDSP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q14.1 by HGNC
- 12q14.1 by Entrez Gene
- 12q14.1 by Ensembl
CTDSP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CTDSP2 Gene
Proteins for CTDSP2 Gene
-
Protein details for CTDSP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O14595-CTDS2_HUMAN
- Recommended name:
- Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
- Protein Accession:
- O14595
- A8K5H4
- Q53ZR2
- Q6NZY3
- Q9UEX1
Protein attributes for CTDSP2 Gene
- Size:
- 271 amino acids
- Molecular mass:
- 30664 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Monomer (By similarity). Interacts with REST.
- SequenceCaution:
-
- Sequence=AAB71816.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAP34399.1; Type=Frameshift; Evidence={ECO:0000305};
Protein Expression for CTDSP2 Gene
Selected DME Specific Peptides for CTDSP2 Gene
- O14595:
-
- HQVYVLKRP
- DNSPASY
- DLDETLVHSSFK
- FTASLAKYADPV
- NADFIVP
Post-translational modifications for CTDSP2 Gene
Other Protein References for CTDSP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences CTDSP2 Antibody
- NSJ Bioreagents CTDSP2 Antibody
- GeneTex Anti-CTDSP2 antibody
- Novus Biologicals Antibodies for CTDSP2
-
Abcam antibodies for CTDSP2
- Invitrogen Antibodies for CTDSP2 (AFLGC-CTDSP2)
- antibodies-online: Show 23 available CTDSP2 Antibodies ranked by validation data
- Compare Top CTDSP2 Antibodies
-
Recommended
- 58 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 1 DB Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 12 IF (p) Antibodies (anti-mouse)
- 12 WB Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 6 WB Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for CTDSP2
- Sino Biological Antibodies for CTDSP2
Protein Products
-
OriGene Purified Proteins for CTDSP2
- Search Origene for MassSpec and Protein Over-expression Lysates for CTDSP2
- Origene Custom Protein Services for CTDSP2
-
Abcam proteins for CTDSP2
Assay Products
- antibodies-online: Show 4 available CTDSP2 Elisa Kits ranked by validation data
- Compare Top CTDSP2 Elisa Kits
-
Quality Products:
Domains & Families for CTDSP2 Gene
Gene Families for CTDSP2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for CTDSP2 Gene
- InterPro:
- Blocks:
-
- NLI interacting factor
- ProtoNet:
Suggested Antigen Peptide Sequences for CTDSP2 Gene
- GenScript: Design optimal peptide antigens:
-
- Small CTD phosphatase 2 (CTDS2_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CTDSP2 Gene
Function for CTDSP2 Gene
Molecular function for CTDSP2 Gene
- UniProtKB/Swiss-Prot Function:
- Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16;.
- UniProtKB/Swiss-Prot Induction:
- In primary sarcomas.
Enzyme Numbers (IUBMB) for CTDSP2 Gene
Phenotypes From GWAS Catalog for CTDSP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004721 | phosphoprotein phosphatase activity | IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 16724108 |
| GO:0008420 | RNA polymerase II CTD heptapeptide repeat phosphatase activity | IBA,IDA | 12721286 |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0016791 | phosphatase activity | IEA | -- |
Phenotypes for CTDSP2 Gene
- MGI mutant phenotypes for CTDSP2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CTDSP2:
Animal Models for CTDSP2 Gene
- MGI Knock Outs for CTDSP2:
-
- Ctdsp2 Ctdsp2<tm1.1(KOMP)Vlcg>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CTDSP2 - Select products 50% OFF >
- * CTDSP2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CTDSP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CTDSP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CTDSP2
miRNA for CTDSP2 Gene
- miRTarBase miRNAs that target CTDSP2
-
- hsa-miR-124-3p (MIRT002613)
- mmu-miR-124-3p (MIRT003927)
- mmu-miR-758-3p (MIRT007625)
- mmu-miR-26a-5p (MIRT011461)
- mmu-miR-15a-5p (MIRT011938)
- mmu-miR-34b-5p (MIRT012902)
- mmu-miR-9-5p (MIRT015578)
- hsa-miR-193b-3p (MIRT016407)
- hsa-miR-335-5p (MIRT017775)
- hsa-miR-375 (MIRT019804)
- hsa-miR-24-3p (MIRT030513)
- hsa-miR-615-3p (MIRT039866)
- hsa-miR-106b-5p (MIRT044322)
- hsa-miR-191-5p (MIRT054163)
- hsa-miR-6883-5p (MIRT478591)
- hsa-miR-6785-5p (MIRT478592)
- hsa-miR-4728-5p (MIRT478593)
- hsa-miR-149-3p (MIRT478594)
- hsa-miR-7106-5p (MIRT478595)
- hsa-miR-6797-5p (MIRT478596)
- hsa-miR-1249-5p (MIRT478597)
- hsa-miR-765 (MIRT478598)
- hsa-miR-6133 (MIRT478599)
- hsa-miR-6130 (MIRT478600)
- hsa-miR-6129 (MIRT478601)
- hsa-miR-6127 (MIRT478602)
- hsa-miR-4419a (MIRT478603)
- hsa-miR-4510 (MIRT478604)
- hsa-miR-6840-3p (MIRT478605)
- hsa-miR-665 (MIRT478606)
- hsa-miR-4459 (MIRT478607)
- hsa-miR-4756-5p (MIRT478608)
- hsa-miR-4739 (MIRT478609)
- hsa-miR-1321 (MIRT478610)
- hsa-miR-4779 (MIRT478611)
- hsa-miR-1207-5p (MIRT761256)
- hsa-miR-152-5p (MIRT762895)
- hsa-miR-3192-3p (MIRT765404)
- hsa-miR-4502 (MIRT769811)
- hsa-miR-4514 (MIRT769900)
- hsa-miR-4692 (MIRT771106)
- hsa-miR-4762-3p (MIRT772004)
- hsa-miR-4763-3p (MIRT772012)
- hsa-miR-6721-5p (MIRT777822)
- hsa-miR-6808-5p (MIRT779657)
- hsa-miR-6823-5p (MIRT779877)
- hsa-miR-6871-5p (MIRT780700)
- hsa-miR-6893-5p (MIRT781190)
- hsa-miR-940 (MIRT782884)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CTDSP2
- Browse OriGene Inhibitory RNA Products For CTDSP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTDSP2
Clone Products
- Applied Biological Materials (abm): Clones for CTDSP2 - Select products 50% OFF >
- * CTDSP2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CTDSP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CTDSP2
Cell Line Products
-
Horizon Cell Lines for CTDSP2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CTDSP2 Gene
Localization for CTDSP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CTDSP2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Mitochondria (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
Pathways & Interactions for CTDSP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Unfolded Protein Response (UPR) | ||
| 2 | Metabolism of proteins | ||
| 3 | Signaling by BMP | ||
| 4 | Coregulation of Androgen receptor activity | ||
| 5 | Regulation of cytoplasmic and nuclear SMAD2/3 signaling | ||
Pathways by source for CTDSP2 Gene
3 BioSystems pathways for CTDSP2 Gene
4 Reactome pathways for CTDSP2 Gene
Interacting Proteins for CTDSP2 Gene
Selected Interacting proteins:
O14595-CTDS2_HUMAN
ENSP00000381148
for CTDSP2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CTDSP2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001933 | negative regulation of protein phosphorylation | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006470 | protein dephosphorylation | IDA | 12721286 |
| GO:0016311 | dephosphorylation | IEA | -- |
| GO:0036498 | IRE1-mediated unfolded protein response | TAS | -- |
Transcripts for CTDSP2 Gene
mRNA/cDNA for CTDSP2 Gene
- 1 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000398073 4785 nts (view in UCSC)
- ENST00000548823 1368 nts (view in UCSC)
- ENST00000547169 1340 nts (view in UCSC)
- ENST00000549039 797 nts (view in UCSC)
- ENST00000547701 988 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CTDSP2 - Select products 50% OFF >
- * CTDSP2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CTDSP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CTDSP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CTDSP2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CTDSP2
- Browse OriGene Inhibitory RNA Products For CTDSP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTDSP2
Clone Products
- Applied Biological Materials (abm): Clones for CTDSP2 - Select products 50% OFF >
- * CTDSP2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CTDSP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CTDSP2
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | · | 9c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||
| SP5: |
Relevant External Links for CTDSP2 Gene
- GeneLoc Exon Structure for
- CTDSP2
Expression for CTDSP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Limb (Muscoskeletal System)
- Limb Bud Mesenchyme Cells Limb Bud
-
Mesoderm (Gastrulation Derivatives)
- Limb Bud Mesenchyme Cells Limb Bud
This gene is overexpressed in CD8 Tcells (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CTDSP2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CTDSP2
SOURCE GeneReport for Unigene cluster for CTDSP2 Gene:
Hs.524530mRNA Expression by UniProt/SwissProt for CTDSP2 Gene:
O14595-CTDS2_HUMAN
Tissue specificity:
Expression is restricted to non-neuronal tissues. Highest expression in pancreas and lowest in liver.
Evidence on tissue expression from TISSUES for CTDSP2 Gene
- Nervous system(4.6)
- Blood(4.5)
- Pancreas(4.3)
- Lung(3.9)
- Muscle(3.6)
- Intestine(3.6)
- Skin(3.5)
- Eye(2.9)
- Heart(2.4)
- Liver(2.3)
- Kidney(2.2)
- Lymph node(2.2)
- Bone marrow(2)
Primer Products
-
OriGene qPCR primer pairs for CTDSP2
-
OriGene qPCR primer pairs and template standards for CTDSP2
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTDSP2 Gene
Orthologs for CTDSP2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CTDSP2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CTDSP2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CTDSP2 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CTDSP2 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ctdsp2 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CTDSP2 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CTDSP2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ctdsp2 30 |
|
||
| Str.2966 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | ctdsp2 30 31 |
|
OneToOne | |
| wufb16c04 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG5830 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | scpl-1 31 |
|
OneToMany | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F15620g 30 |
|
||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AAL158W 30 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PSR1 30 31 |
|
ManyToMany | |
| PSR2 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for CTDSP2 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for CTDSP2 Gene
- ENSEMBL:
- Gene Tree for CTDSP2 (if available)
- TreeFam:
- Gene Tree for CTDSP2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CTDSP2: view image
Paralogs for CTDSP2 Gene
(4) SIMAP similar genes for CTDSP2 Gene using alignment to 6 proteins:
- CTDS2_HUMAN
- F8VYL0_HUMAN
- F8W184_HUMAN
- F8W1I1_HUMAN
- H0YI12_HUMAN
- H0YI29_HUMAN
Pseudogenes.org Pseudogenes for CTDSP2 Gene
Variants for CTDSP2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CTDSP2 Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 755992 | Likely Benign: not provided | 57,826,355(-) | G/A | SYNONYMOUS_VARIANT |
Residual Variation Intolerance Score:
29.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.49;
10.60% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CTDSP2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CTDSP2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTDSP2 Gene
Disorders for CTDSP2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| acute tympanitis |
|
|
| myasthenic syndrome, congenital, 16 |
|
|
| myasthenic syndrome, congenital, 11, associated with acetylcholine receptor deficiency |
|
|
| myringitis bullosa hemorrhagica |
|
|
| epithelioid cell synovial sarcoma |
|
|
Search CTDSP2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CTDSP2
No data available for UniProtKB/Swiss-Prot and Genatlas for CTDSP2 Gene
Publications for CTDSP2 Gene
- A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. (PMID: 12721286) Yeo M … Gill GN (The Journal of biological chemistry 2003) 2 3 4
- Characterization of a highly conserved gene (OS4) amplified with CDK4 in human sarcomas. (PMID: 9315096) Su YA … Meltzer PS (Oncogene 1997) 2 3 4
- Small carboxyl-terminal domain phosphatase 2 attenuates androgen-dependent transcription. (PMID: 16724108) Thompson J … Jänne OA (The EMBO journal 2006) 3 23
- Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling. (PMID: 16882717) Knockaert M … Brivanlou AH (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 23
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
ExternalLinks
Products for CTDSP2 Gene
- Custom Antibody ServicesOriGene Antibodies for CTDSP2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CTDSP2
- Search Origene for MassSpec and Protein Over-expression Lysates for CTDSP2
- Origene Custom Protein Services for CTDSP2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CTDSP2
- Browse OriGene Inhibitory RNA Products For CTDSP2
- OriGene qPCR primer pairs for CTDSP2
- OriGene qPCR primer pairs and template standards for CTDSP2
- OriGene CRISPR knockouts for CTDSP2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CTDSP2
- Sino Biological Human cDNA Clone for CTDSP2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for CTDSP2
- Browse Sino Biological Assays
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for CTDSP2
- Novus Biologicals proteins and lysates for CTDSP2
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- Invitrogen Antibodies for CTDSP2 (AFLGC-CTDSP2)
- VectorBuilder Custom and pre-made DNA vectors for CTDSP2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CTDSP2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CTDSP2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CTDSP2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CTDSP2
- antibodies-online: Show 23 available CTDSP2 Antibodies ranked by validation data
- Compare Top CTDSP2 Antibodies
- Recommended
- 58 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 1 DB Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 12 IF (p) Antibodies (anti-mouse)
- 12 WB Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 6 WB Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- antibodies-online: Show 4 available CTDSP2 Elisa Kits ranked by validation data
- Compare Top CTDSP2 Elisa Kits
- Quality Products:
- antibodies-online: Show 4 available CTDSP2 Proteins ranked by validation data
- Compare Top CTDSP2 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CTDSP2
- Search Santa Cruz Biotechnology (SCBT) for CTDSP2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CTDSP2
- Horizon Cell Lines for CTDSP2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CTDSP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CTDSP2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CTDSP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTDSP2
Sources for CTDSP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap