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Aliases for CTDSP2 Gene

Aliases for CTDSP2 Gene

  • CTD Small Phosphatase 2 2 3 5
  • Nuclear LIM Interactor-Interacting Factor 2 2 3 4
  • NLI-Interacting Factor 2 2 3 4
  • Small CTD Phosphatase 2 2 3 4
  • CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 2 2 3
  • Carboxy-Terminal Domain RNA Polymerase II Polypeptide A Small Phosphatase 2 3 4
  • Conserved Gene Amplified In Osteosarcoma 2 3
  • Small C-Terminal Domain Phosphatase 2 3 4
  • Protein OS-4 3 4
  • EC 3.1.3.16 4 56
  • SCP2 3 4
  • OS4 3 4
  • PSR2 3
  • NIF2 4

External Ids for CTDSP2 Gene

Previous GeneCards Identifiers for CTDSP2 Gene

  • GC12M056499
  • GC12M058213
  • GC12M055250

Summaries for CTDSP2 Gene

GeneCards Summary for CTDSP2 Gene

CTDSP2 (CTD Small Phosphatase 2) is a Protein Coding gene. Among its related pathways are Signaling by BMP and Coregulation of Androgen receptor activity. Gene Ontology (GO) annotations related to this gene include phosphatase activity and RNA polymerase II CTD heptapeptide repeat phosphatase activity. An important paralog of this gene is CTDSPL.

UniProtKB/Swiss-Prot for CTDSP2 Gene

  • Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.

Gene Wiki entry for CTDSP2 Gene

Additional gene information for CTDSP2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTDSP2 Gene

Genomics for CTDSP2 Gene

GeneHancer (GH) Regulatory Elements for CTDSP2 Gene

Promoters and enhancers for CTDSP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J057830 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 608.2 +7.5 7474 17 MTA3 SP1 ZFX CC2D1A ELF3 CTCF ZNF148 NKRF POLR2A MLLT1 CTDSP2 EEF1AKMT3 TSFM ATP23 METTL1 TSPAN31 CDK4 AGAP2 ENSG00000245651 ENSG00000257953
GH12J057109 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 89.8 +735.9 735891 4.1 HDGF ZNF473 MTA3 ZNF652 ZFX ELF3 SP1 CC2D1A CTCF ZNF148 STAT6 NEMP1 EEF1AKMT3 ENSG00000257740 BAZ2A PAN2 SMARCC2 CDK4 ANKRD52 DTX3
GH12J057750 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 34.6 +93.0 93029 6.5 HDGF MTA3 ZFX SP1 ELF3 CTCF ZKSCAN8 MNT CBFA2T2 ZNF148 CDK4 MARCH9 NEMP1 TSFM EEF1AKMT3 CTDSP2 TSPAN31 ENSG00000224713 MBD6 ENSG00000245651
GH12J057516 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 25.2 +325.9 325875 8.8 SP1 CC2D1A ZFX ELF3 ZKSCAN8 MNT CBFA2T2 ZNF148 NKRF POLR2A MBD6 ENSG00000285133 MIR616 DDIT3 NEMP1 BAZ2A RN7SL809P EEF1AKMT3 DTX3 CDK4
GH12J057242 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 30 +603.8 603769 2 SP1 CC2D1A ZFX CTCF ZNF148 MLLT1 CDC5L ZBTB7A ZNF548 CREM GC12P057242 BAZ2A NEMP1 CTDSP2 RN7SL809P CDK4 RNU6-343P STAT2 EEF1AKMT3 ARHGAP9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CTDSP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CTDSP2 gene promoter:
  • IRF-7A

Genomic Locations for CTDSP2 Gene

Genomic Locations for CTDSP2 Gene
chr12:57,819,927-57,846,964
(GRCh38/hg38)
Size:
27,038 bases
Orientation:
Minus strand
chr12:58,213,710-58,240,747
(GRCh37/hg19)
Size:
27,038 bases
Orientation:
Minus strand

Genomic View for CTDSP2 Gene

Genes around CTDSP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTDSP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTDSP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTDSP2 Gene

Proteins for CTDSP2 Gene

  • Protein details for CTDSP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14595-CTDS2_HUMAN
    Recommended name:
    Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
    Protein Accession:
    O14595
    Secondary Accessions:
    • A8K5H4
    • Q53ZR2
    • Q6NZY3
    • Q9UEX1

    Protein attributes for CTDSP2 Gene

    Size:
    271 amino acids
    Molecular mass:
    30664 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer (By similarity). Interacts with REST.
    SequenceCaution:
    • Sequence=AAB71816.1; Type=Frameshift; Positions=267; Evidence={ECO:0000305}; Sequence=AAP34399.1; Type=Frameshift; Positions=267; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CTDSP2 Gene

neXtProt entry for CTDSP2 Gene

Selected DME Specific Peptides for CTDSP2 Gene

O14595:
  • HQVYVLKRP
  • DNSPASY
  • DLDETLVHSSFK
  • FTASLAKYADPV
  • NADFIVP

Post-translational modifications for CTDSP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTDSP2 Gene

Domains & Families for CTDSP2 Gene

Gene Families for CTDSP2 Gene

Protein Domains for CTDSP2 Gene

Suggested Antigen Peptide Sequences for CTDSP2 Gene

GenScript: Design optimal peptide antigens:
  • Small CTD phosphatase 2 (CTDS2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CTDSP2: view

No data available for UniProtKB/Swiss-Prot for CTDSP2 Gene

Function for CTDSP2 Gene

Molecular function for CTDSP2 Gene

UniProtKB/Swiss-Prot Function:
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16;.
UniProtKB/Swiss-Prot Induction:
In primary sarcomas.

Enzyme Numbers (IUBMB) for CTDSP2 Gene

Phenotypes From GWAS Catalog for CTDSP2 Gene

Gene Ontology (GO) - Molecular Function for CTDSP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IBA 21873635
GO:0005515 protein binding IPI 16724108
GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity IDA,IBA 12721286
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with CTDSP2: view
genes like me logo Genes that share phenotypes with CTDSP2: view

Animal Models for CTDSP2 Gene

MGI Knock Outs for CTDSP2:
  • Ctdsp2 Ctdsp2<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for CTDSP2 - Now 50% OFF >
  • * CTDSP2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CTDSP2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CTDSP2 Gene

Localization for CTDSP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTDSP2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTDSP2 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CTDSP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CTDSP2: view

Pathways & Interactions for CTDSP2 Gene

genes like me logo Genes that share pathways with CTDSP2: view

SIGNOR curated interactions for CTDSP2 Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for CTDSP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0006470 protein dephosphorylation IDA 12721286
GO:0016311 dephosphorylation IEA --
GO:0036498 IRE1-mediated unfolded protein response TAS --
genes like me logo Genes that share ontologies with CTDSP2: view

Drugs & Compounds for CTDSP2 Gene

(2) Drugs for CTDSP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
genes like me logo Genes that share compounds with CTDSP2: view

Transcripts for CTDSP2 Gene

mRNA/cDNA for CTDSP2 Gene

Unigene Clusters for CTDSP2 Gene

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for CTDSP2 - Now 50% OFF >
  • * CTDSP2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CTDSP2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for CTDSP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
SP1: - - -
SP2: - -
SP3: - -
SP4: - -
SP5:

Relevant External Links for CTDSP2 Gene

GeneLoc Exon Structure for
CTDSP2
ECgene alternative splicing isoforms for
CTDSP2

Expression for CTDSP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CTDSP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CTDSP2 Gene

This gene is overexpressed in CD8 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CTDSP2 Gene



Protein tissue co-expression partners for CTDSP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CTDSP2 Gene:

CTDSP2

SOURCE GeneReport for Unigene cluster for CTDSP2 Gene:

Hs.524530

mRNA Expression by UniProt/SwissProt for CTDSP2 Gene:

O14595-CTDS2_HUMAN
Tissue specificity: Expression is restricted to non-neuronal tissues. Highest expression in pancreas and lowest in liver.

Evidence on tissue expression from TISSUES for CTDSP2 Gene

  • Nervous system(4.5)
  • Blood(4.4)
  • Pancreas(4.3)
  • Lung(3.6)
  • Intestine(3.2)
  • Muscle(3.1)
  • Skin(2.8)
  • Eye(2.4)
genes like me logo Genes that share expression patterns with CTDSP2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTDSP2 Gene

Orthologs for CTDSP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CTDSP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTDSP2 35 34
  • 99.51 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CTDSP2 35 34
  • 93.6 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CTDSP2 35 34
  • 93.6 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CTDSP2 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ctdsp2 17 35 34
  • 90.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CTDSP2 35
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CTDSP2 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ctdsp2 34
  • 75.68 (n)
Str.2966 34
zebrafish
(Danio rerio)
Actinopterygii ctdsp2 35 34
  • 71.35 (n)
OneToOne
wufb16c04 34
fruit fly
(Drosophila melanogaster)
Insecta CG5830 35
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea scpl-1 35
  • 30 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F15620g 34
  • 54.97 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL158W 34
  • 52.93 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PSR1 35 34
  • 52.58 (n)
ManyToMany
PSR2 35
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 69 (a)
OneToMany
Species where no ortholog for CTDSP2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTDSP2 Gene

ENSEMBL:
Gene Tree for CTDSP2 (if available)
TreeFam:
Gene Tree for CTDSP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CTDSP2: view image

Paralogs for CTDSP2 Gene

Paralogs for CTDSP2 Gene

(4) SIMAP similar genes for CTDSP2 Gene using alignment to 6 proteins:

  • CTDS2_HUMAN
  • F8VYL0_HUMAN
  • F8W184_HUMAN
  • F8W1I1_HUMAN
  • H0YI12_HUMAN
  • H0YI29_HUMAN
genes like me logo Genes that share paralogs with CTDSP2: view

Variants for CTDSP2 Gene

Sequence variations from dbSNP and Humsavar for CTDSP2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000144335 -- 57,837,080(-) G/A intron_variant
rs1000210181 -- 57,827,083(-) G/A coding_sequence_variant, synonymous_variant
rs1000324911 -- 57,830,658(-) T/G intron_variant
rs1000396709 -- 57,818,421(-) C/G/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000466102 -- 57,845,806(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CTDSP2 Gene

Variant ID Type Subtype PubMed ID
nsv559046 CNV gain 21841781
nsv726 CNV insertion 18451855
nsv826388 CNV gain 20364138
nsv983335 CNV duplication 23825009

Variation tolerance for CTDSP2 Gene

Residual Variation Intolerance Score: 29.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CTDSP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CTDSP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTDSP2 Gene

Disorders for CTDSP2 Gene

Additional Disease Information for CTDSP2

No disorders were found for CTDSP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CTDSP2 Gene

Publications for CTDSP2 Gene

  1. A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. (PMID: 12721286) Yeo M … Gill GN (The Journal of biological chemistry 2003) 2 3 4 58
  2. Characterization of a highly conserved gene (OS4) amplified with CDK4 in human sarcomas. (PMID: 9315096) Su YA … Meltzer PS (Oncogene 1997) 2 3 4 58
  3. Small carboxyl-terminal domain phosphatase 2 attenuates androgen-dependent transcription. (PMID: 16724108) Thompson J … Jänne OA (The EMBO journal 2006) 3 23 58
  4. Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling. (PMID: 16882717) Knockaert M … Brivanlou AH (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 23 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for CTDSP2 Gene

Sources for CTDSP2 Gene

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