Aliases for CTDSP2 Gene
External Ids for CTDSP2 Gene
Previous GeneCards Identifiers for CTDSP2 Gene
GeneCards Summary for CTDSP2 Gene
CTDSP2 (CTD Small Phosphatase 2) is a Protein Coding gene. Diseases associated with CTDSP2 include Acute Tympanitis and Myringitis Bullosa Hemorrhagica. Among its related pathways are Regulation of cytoplasmic and nuclear SMAD2/3 signaling and Coregulation of Androgen receptor activity. Gene Ontology (GO) annotations related to this gene include phosphatase activity and RNA polymerase II CTD heptapeptide repeat phosphatase activity. An important paralog of this gene is CTDSPL.
UniProtKB/Swiss-Prot Summary for CTDSP2 Gene
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.