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Aliases for CTAGE5 Gene

Aliases for CTAGE5 Gene

  • CTAGE Family Member 5, ER Export Factor 2 5
  • Meningioma Expressed Antigen 6 (Coiled-Coil Proline-Rich) 2
  • CTAGE Family Member 5 ER Export Factor 4
  • Meningioma-Expressed Antigen 6/11 4
  • CTAGE Family, Member 5 2
  • CTAGE Family Member 5 2
  • Protein CTAGE-5 4
  • MGEA11 4
  • MGEA6 4
  • MEA11 4
  • MEA6 4

External Ids for CTAGE5 Gene

Previous HGNC Symbols for CTAGE5 Gene

  • MGEA
  • MGEA6

Previous GeneCards Identifiers for CTAGE5 Gene

  • GC14P038804
  • GC14P039734
  • GC14P019849

Summaries for CTAGE5 Gene

GeneCards Summary for CTAGE5 Gene

CTAGE5 (CTAGE Family Member 5, ER Export Factor) is a Protein Coding gene. Diseases associated with CTAGE5 include Cutaneous T Cell Lymphoma. Gene Ontology (GO) annotations related to this gene include enzyme activator activity. An important paralog of this gene is CTAGE1.

UniProtKB/Swiss-Prot for CTAGE5 Gene

  • Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites.

Additional gene information for CTAGE5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTAGE5 Gene

Genomics for CTAGE5 Gene

GeneHancer (GH) Regulatory Elements for CTAGE5 Gene

Promoters and enhancers for CTAGE5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I039265 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 566 +36.9 36893 3.9 HDGF PKNOX1 FOXA2 ARNT MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 CTAGE5 LOC100288846 PNN RPL7AP2 ENSG00000259083 GC14M039196 MIA2 GC14M039248
GH14I039228 Enhancer 0.8 Ensembl ENCODE 560.7 -1.1 -1069 2.2 TEAD4 TAL1 JUNB CBFA2T3 EBF1 BATF ZNF48 NR2F2 IKZF1 CBFA2T2 CTAGE5 MIA2 YTHDF2P1 GC14M039196
GH14I039430 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 11.7 +202.0 202048 3.8 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B NEUROD1 FBXO33 LOC105370461 PNN RPL7AP2 CTAGE5 ENSG00000259083 GC14M039394 COILP1
GH14I039231 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 10.8 +2.9 2853 3.3 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 SLC30A9 TCF12 ZNF143 MIA2 CTAGE5 ENSG00000258526 FBXO33 LOC100288846 GC14M039196
GH14I039376 Enhancer 0.8 Ensembl ENCODE 21.6 +146.9 146924 1.9 SMARCE1 HDAC1 MAFG PLRG1 SP1 JUND GATA3 MTA1 HDAC2 NFE2 CTAGE5 FBXO33 MIA2 GEMIN2 SEC23A ENSG00000271424 COILP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CTAGE5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CTAGE5 gene promoter:

Genomic Locations for CTAGE5 Gene

Genomic Locations for CTAGE5 Gene
chr14:39,230,231-39,388,513
(GRCh38/hg38)
Size:
158,283 bases
Orientation:
Plus strand
chr14:39,734,476-39,856,156
(GRCh37/hg19)

Genomic View for CTAGE5 Gene

Genes around CTAGE5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTAGE5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTAGE5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for RefSeq DNA sequence for CTAGE5 Gene

Proteins for CTAGE5 Gene

  • Protein details for CTAGE5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15320-CTGE5_HUMAN
    Recommended name:
    Endoplasmic reticulum export factor CTAGE5
    Protein Accession:
    O15320
    Secondary Accessions:
    • B3KRA6
    • B4DQS6
    • D3DSA6
    • G3XAC5
    • O00169
    • Q6MZN2
    • Q6P2R8
    • Q86TF6
    • Q8IX92
    • Q8IX93

    Protein attributes for CTAGE5 Gene

    Size:
    804 amino acids
    Molecular mass:
    90996 Da
    Quaternary structure:
    • Interacts with MIA3 (PubMed:21525241, PubMed:25202031, PubMed:27170179). Interacts with the COPII coat subunits SEC23A, SEC23B and maybe SEC24C (PubMed:21525241, PubMed:27551091). Interacts with PREB; recruits PREB to endoplasmic reticulum exit sites (PubMed:25202031, PubMed:27170179). May interact with APOB (PubMed:27138255).
    SequenceCaution:
    • Sequence=AAB86589.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CTAGE5 Gene

neXtProt entry for CTAGE5 Gene

Post-translational modifications for CTAGE5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CTAGE5 Gene

Domains & Families for CTAGE5 Gene

Gene Families for CTAGE5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CTAGE5 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CTAGE5 Gene

Graphical View of Domain Structure for InterPro Entry

O15320

UniProtKB/Swiss-Prot:

CTGE5_HUMAN :
  • The proline-rich domain (PRD) contains repeated PPP motifs. A single PPP motif is necessary and sufficient to mediate interaction with the COPII coat subunits SEC23A and SEC23B.
  • Belongs to the cTAGE family.
Domain:
  • The proline-rich domain (PRD) contains repeated PPP motifs. A single PPP motif is necessary and sufficient to mediate interaction with the COPII coat subunits SEC23A and SEC23B.
  • The coiled coil domains mediate interaction with MIA3 (PubMed:21525241). The first coiled coil domain mediates interaction with PREB (PubMed:25202031).
Family:
  • Belongs to the cTAGE family.
genes like me logo Genes that share domains with CTAGE5: view

Function for CTAGE5 Gene

Molecular function for CTAGE5 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites.

Phenotypes From GWAS Catalog for CTAGE5 Gene

Gene Ontology (GO) - Molecular Function for CTAGE5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008047 enzyme activator activity TAS --
genes like me logo Genes that share ontologies with CTAGE5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CTAGE5 Gene

Localization for CTAGE5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTAGE5 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Endoplasmic reticulum exit sites. {ECO:0000269 PubMed:21525241, ECO:0000269 PubMed:25202031}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTAGE5 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 2
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CTAGE5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070971 endoplasmic reticulum exit site IDA --
genes like me logo Genes that share ontologies with CTAGE5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CTAGE5 Gene

Pathways & Interactions for CTAGE5 Gene

SuperPathways for CTAGE5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CTAGE5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0032527 protein exit from endoplasmic reticulum IMP --
GO:0035459 cargo loading into vesicle IMP --
GO:0043085 positive regulation of catalytic activity IEA --
GO:0070973 protein localization to endoplasmic reticulum exit site IMP --
genes like me logo Genes that share ontologies with CTAGE5: view

No data available for Pathways by source and SIGNOR curated interactions for CTAGE5 Gene

Drugs & Compounds for CTAGE5 Gene

No Compound Related Data Available

Transcripts for CTAGE5 Gene

mRNA/cDNA for CTAGE5 Gene

(19) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTAGE5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b
SP1: -
SP2:
SP3: - -
SP4: - - -
SP5:

Relevant External Links for CTAGE5 Gene

GeneLoc Exon Structure for
CTAGE5
ECgene alternative splicing isoforms for
CTAGE5

Expression for CTAGE5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CTAGE5 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CTAGE5 Gene



Protein tissue co-expression partners for CTAGE5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CTAGE5 Gene:

CTAGE5

mRNA Expression by UniProt/SwissProt for CTAGE5 Gene:

O15320-CTGE5_HUMAN
Tissue specificity: Isoform 5A is expressed only in testis (at the protein level). Other isoforms are expressed in several other normal tissues, including brain, muscle and cranial skin. Isoform 5A (at protein level) and isoform 5B are expressed in cutaneous T-cell lymphoma (CTCL) cell lines, colorectal carcinomas, breast carcinomas and melanoma. Isoform 5B, but not isoform 5A, is expressed in head and neck squamous cell carcinoma.

Evidence on tissue expression from TISSUES for CTAGE5 Gene

  • Skin(4.1)
  • Liver(2.4)
genes like me logo Genes that share expression patterns with CTAGE5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTAGE5 Gene

Orthologs for CTAGE5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CTAGE5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTAGE5 34
  • 99 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 84 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ctage5 34
  • 77 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 52 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 40 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 37 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 36 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 36 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ctage5 34
  • 41 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tango1 34
  • 10 (a)
OneToMany
Species where no ortholog for CTAGE5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTAGE5 Gene

ENSEMBL:
Gene Tree for CTAGE5 (if available)
TreeFam:
Gene Tree for CTAGE5 (if available)

Paralogs for CTAGE5 Gene

Variants for CTAGE5 Gene

Sequence variations from dbSNP and Humsavar for CTAGE5 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs10162564 -- p.Lys250Glu
rs1060878 -- p.Gly738Arg
rs1140952 -- p.Ile699Val
rs17109109 -- p.Asn375Ser
rs17855895 -- p.Tyr11Asp

Structural Variations from Database of Genomic Variants (DGV) for CTAGE5 Gene

Variant ID Type Subtype PubMed ID
esv1110364 CNV deletion 17803354
esv2748622 CNV deletion 23290073
esv3584293 CNV gain 25503493
esv3634143 CNV loss 21293372
nsv1053133 CNV gain 25217958
nsv1138292 CNV deletion 24896259
nsv476312 CNV novel sequence insertion 20440878
nsv84573 CNV deletion 16902084
nsv976333 CNV duplication 23825009
nsv977461 CNV duplication 23825009
nsv977462 CNV duplication 23825009

Variation tolerance for CTAGE5 Gene

Residual Variation Intolerance Score: 69.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.01; 0.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CTAGE5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CTAGE5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTAGE5 Gene

Disorders for CTAGE5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CTAGE5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cutaneous t cell lymphoma
  • cutaneous t-cell lymphoma
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

CTGE5_HUMAN
  • Note=Autoantibodies against CTAGE5 are present in several cancer types, including benign meningioma and cutaneous T-cell lymphoma (CTCL).

Additional Disease Information for CTAGE5

genes like me logo Genes that share disorders with CTAGE5: view

No data available for Genatlas for CTAGE5 Gene

Publications for CTAGE5 Gene

  1. cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites. (PMID: 21525241) Saito K … Katada T (Molecular biology of the cell 2011) 2 4 58
  2. cDNA cloning and chromosomal mapping of a predicted coiled-coil proline-rich protein immunogenic in meningioma patients. (PMID: 9356211) Heckel D … Meese E (Human molecular genetics 1997) 2 4 58
  3. TANGO1 and Mia2/cTAGE5 (TALI) cooperate to export bulky pre-chylomicrons/VLDLs from the endoplasmic reticulum. (PMID: 27138255) Santos AJ … Malhotra V (The Journal of cell biology 2016) 4 58
  4. Dual function of cTAGE5 in collagen export from the endoplasmic reticulum. (PMID: 27170179) Tanabe T … Katada T (Molecular biology of the cell 2016) 4 58
  5. TANGO1/cTAGE5 receptor as a polyvalent template for assembly of large COPII coats. (PMID: 27551091) Ma W … Goldberg J (Proceedings of the National Academy of Sciences of the United States of America 2016) 4 58

Products for CTAGE5 Gene

Sources for CTAGE5 Gene

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