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Aliases for CTAGE4 Gene

Aliases for CTAGE4 Gene

  • CTAGE Family Member 4 2 3 3 5
  • Cutaneous T-Cell Lymphoma-Associated Antigen 4 2 3
  • Protein CTAGE-4 3 4
  • Cutaneous-T-Cell-Lymphoma-Specific Tumor Antigen 4 3
  • CTAGE Family, Member 4 2
  • CTAGE-4 3

External Ids for CTAGE4 Gene

Previous GeneCards Identifiers for CTAGE4 Gene

  • GC07M143275
  • GC07P143318
  • GC07U901590
  • GC07P143509
  • GC07P143880
  • GC07P143219

Summaries for CTAGE4 Gene

GeneCards Summary for CTAGE4 Gene

CTAGE4 (CTAGE Family Member 4) is a Protein Coding gene. Diseases associated with CTAGE4 include Cutaneous T Cell Lymphoma. Gene Ontology (GO) annotations related to this gene include nucleotide binding. An important paralog of this gene is CTAGE8.

UniProtKB/Swiss-Prot for CTAGE4 Gene

  • Tumor-associated antigen.

Additional gene information for CTAGE4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTAGE4 Gene

Genomics for CTAGE4 Gene

GeneHancer (GH) Regulatory Elements for CTAGE4 Gene

Top Transcription factor binding sites by QIAGEN in the CTAGE4 gene promoter:
  • c-Ets-1
  • XBP-1
  • NCX
  • POU6F1 (c2)
  • FOXJ2 (long isoform)
  • FOXJ2
  • HFH-1
  • FOXI1
  • HFH-3
  • c-Myb

Genomic Locations for CTAGE4 Gene

Genomic Locations for CTAGE4 Gene
2,626 bases
Plus strand
2,626 bases
Plus strand

Genomic View for CTAGE4 Gene

Genes around CTAGE4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTAGE4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTAGE4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTAGE4 Gene

Proteins for CTAGE4 Gene

  • Protein details for CTAGE4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    cTAGE family member 4
    Protein Accession:
    Secondary Accessions:
    • A8K871
    • O95046

    Protein attributes for CTAGE4 Gene

    777 amino acids
    Molecular mass:
    87989 Da
    Quaternary structure:
    No Data Available
    • Tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL). Also found in colorectal and breast carcinomas, head and neck squamous cell carcinomas and melanoma.
    • Sequence=AAN77609.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAN77609.1; Type=Frameshift; Positions=643, 646, 662; Evidence={ECO:0000305};

neXtProt entry for CTAGE4 Gene

Post-translational modifications for CTAGE4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTAGE4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CTAGE4 Gene

Domains & Families for CTAGE4 Gene

Gene Families for CTAGE4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CTAGE4 Gene


Suggested Antigen Peptide Sequences for CTAGE4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cTAGE family.
  • Belongs to the cTAGE family.
genes like me logo Genes that share domains with CTAGE4: view

Function for CTAGE4 Gene

Molecular function for CTAGE4 Gene

UniProtKB/Swiss-Prot Function:
Tumor-associated antigen.

Gene Ontology (GO) - Molecular Function for CTAGE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042954 lipoprotein transporter activity IBA --
genes like me logo Genes that share ontologies with CTAGE4: view

Phenotypes for CTAGE4 Gene

genes like me logo Genes that share phenotypes with CTAGE4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CTAGE4 Gene

Localization for CTAGE4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTAGE4 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTAGE4 gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CTAGE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005789 endoplasmic reticulum membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070971 endoplasmic reticulum exit site IBA --
genes like me logo Genes that share ontologies with CTAGE4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CTAGE4 Gene

Pathways & Interactions for CTAGE4 Gene

SuperPathways for CTAGE4 Gene

No Data Available

Interacting Proteins for CTAGE4 Gene

Gene Ontology (GO) - Biological Process for CTAGE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport IBA --
GO:0008150 biological_process ND --
GO:0009306 protein secretion IBA --
GO:0035459 cargo loading into vesicle IBA --
genes like me logo Genes that share ontologies with CTAGE4: view

No data available for Pathways by source and SIGNOR curated interactions for CTAGE4 Gene

Drugs & Compounds for CTAGE4 Gene

No Compound Related Data Available

Transcripts for CTAGE4 Gene

mRNA/cDNA for CTAGE4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CTAGE4 Gene

CTAGE family, member 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTAGE4 Gene

No ASD Table

Relevant External Links for CTAGE4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTAGE4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CTAGE4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTAGE4 Gene

This gene is overexpressed in Testis (x5.8), Thyroid (x4.2), and Skin - Not Sun Exposed (Suprapubic) (x4.0).

Protein differential expression in normal tissues from HIPED for CTAGE4 Gene

This gene is overexpressed in Neutrophil (38.3) and Peripheral blood mononuclear cells (30.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CTAGE4 Gene

Protein tissue co-expression partners for CTAGE4 Gene

NURSA nuclear receptor signaling pathways regulating expression of CTAGE4 Gene:


SOURCE GeneReport for Unigene cluster for CTAGE4 Gene:


mRNA Expression by UniProt/SwissProt for CTAGE4 Gene:

Tissue specificity: Expressed in testis, placenta and skin. Expressed at lower level in mammary gland and stomach.

Evidence on tissue expression from TISSUES for CTAGE4 Gene

  • Lung(3.6)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with CTAGE4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CTAGE4 Gene

Orthologs for CTAGE4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CTAGE4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC470576 33
  • 94.7 (n)
(Bos Taurus)
Mammalia -- 34
  • 71 (a)
(Mus musculus)
Mammalia Ctage5 34
  • 66 (a)
(Canis familiaris)
Mammalia -- 34
  • 45 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 34 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 33 (a)
(Gallus gallus)
Aves -- 34
  • 30 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 31 (a)
(Danio rerio)
Actinopterygii ctage5 34
  • 35 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tango1 34
  • 9 (a)
Species where no ortholog for CTAGE4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTAGE4 Gene

Gene Tree for CTAGE4 (if available)
Gene Tree for CTAGE4 (if available)

Paralogs for CTAGE4 Gene

Paralogs for CTAGE4 Gene

(7) SIMAP similar genes for CTAGE4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CTAGE4: view

Variants for CTAGE4 Gene

Sequence variations from dbSNP and Humsavar for CTAGE4 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1012661822 -- 144,182,954(+) G/ upstream_transcript_variant
rs1020283919 -- 144,184,253(+) C/T coding_sequence_variant, synonymous_variant
rs1023598923 -- 144,182,962(+) C/G upstream_transcript_variant
rs1025836438 -- 144,183,448(+) C/T upstream_transcript_variant
rs1045104352 -- 144,186,477(+) T/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CTAGE4 Gene

Variant ID Type Subtype PubMed ID
dgv11668n54 CNV gain 21841781
dgv11669n54 CNV loss 21841781
dgv152e203 CNV gain+loss 21179565
dgv24n31 CNV gain 19718026
dgv253n111 CNV duplication 26073780
dgv254n111 CNV duplication 26073780
dgv255n111 CNV deletion 26073780
dgv3965e59 CNV duplication 20981092
dgv3972e59 CNV duplication 20981092
dgv6725n100 CNV gain 25217958
dgv6726n100 CNV gain 25217958
dgv6727n100 CNV loss 25217958
dgv6728n100 CNV gain+loss 25217958
dgv6729n100 CNV gain 25217958
dgv6730n100 CNV loss 25217958
dgv6731n100 CNV gain+loss 25217958
dgv6732n100 CNV gain+loss 25217958
dgv6733n100 CNV gain+loss 25217958
dgv6734n100 CNV gain+loss 25217958
dgv6735n100 CNV gain 25217958
dgv6736n100 CNV gain 25217958
dgv6737n100 CNV gain 25217958
dgv6738n100 CNV gain+loss 25217958
dgv6739n100 CNV gain+loss 25217958
dgv6740n100 CNV loss 25217958
dgv6741n100 CNV loss 25217958
dgv6742n100 CNV loss 25217958
dgv6743n100 CNV gain+loss 25217958
dgv6744n100 CNV loss 25217958
esv1003295 OTHER inversion 20482838
esv1682998 OTHER inversion 17803354
esv24292 CNV gain+loss 19812545
esv2759570 CNV gain+loss 17122850
esv3369041 CNV duplication 20981092
esv3379639 CNV duplication 20981092
esv3380478 CNV duplication 20981092
esv3432947 CNV duplication 20981092
esv3584873 CNV loss 24956385
esv3891225 CNV gain 25118596
esv8347 OTHER inversion 19470904
nsv1016831 CNV gain 25217958
nsv1032320 CNV gain 25217958
nsv1119234 CNV duplication 24896259
nsv1119235 CNV duplication 24896259
nsv1133019 OTHER inversion 24896259
nsv1141559 CNV duplication 24896259
nsv1148453 CNV duplication 26484159
nsv1153905 CNV duplication 26484159
nsv428188 CNV gain+loss 18775914
nsv433394 CNV gain 18776910
nsv469769 CNV gain+loss 16826518
nsv471646 CNV gain+loss 15918152
nsv508489 CNV deletion 20534489
nsv510970 OTHER inversion 20534489
nsv515041 CNV gain 21397061
nsv608699 CNV gain 21841781
nsv608829 CNV loss 21841781
nsv608831 CNV loss 21841781
nsv608840 CNV loss 21841781
nsv608845 CNV loss 21841781
nsv7411 OTHER inversion 18451855
nsv819701 CNV insertion 19587683
nsv821609 CNV duplication 20802225
nsv8227 CNV gain+loss 18304495
nsv824360 CNV gain 20364138
nsv831174 CNV loss 17160897
nsv831175 CNV loss 17160897
nsv831176 CNV loss 17160897
nsv970955 CNV duplication 23825009
nsv970956 CNV duplication 23825009
nsv981601 CNV duplication 23825009

Variation tolerance for CTAGE4 Gene

Gene Damage Index Score: 1.16; 23.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CTAGE4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTAGE4 Gene

Disorders for CTAGE4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CTAGE4 Gene - From: GeneCards

Disorder Aliases PubMed IDs
cutaneous t cell lymphoma
  • cutaneous t-cell lymphoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CTAGE4

genes like me logo Genes that share disorders with CTAGE4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTAGE4 Gene

Publications for CTAGE4 Gene

  1. cTAGE: a cutaneous T cell lymphoma associated antigen family with tumor-specific splicing. (PMID: 12839582) Usener D … Eichmüller S (The Journal of investigative dermatology 2003) 2 3 4 58
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  3. Serological detection of cutaneous T-cell lymphoma-associated antigens. (PMID: 11149944) Eichmuller S … Schadendorf D (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 58
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58

Products for CTAGE4 Gene

Sources for CTAGE4 Gene

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