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Aliases for CTAG2 Gene

Aliases for CTAG2 Gene

  • Cancer/Testis Antigen 2 2 3 3 5
  • Autoimmunogenic Cancer/Testis Antigen NY-ESO-2 3 4
  • Cancer/Testis Antigen Family 6, Member 2a 2 3
  • Cancer/Testis Antigen Family 6, Member 2b 2 3
  • CTL-Recognized Antigen On Melanoma 2 3
  • Cancer/Testis Antigen 6.2 3 4
  • L Antigen Family Member 1 3 4
  • LAGE-1a Protein 2 3
  • LAGE-1 3 4
  • CT6.2 3 4
  • ESO2 3 4
  • CT2 3 4
  • CT6.2a 3
  • CT6.2b 3
  • LAGE2B 3
  • CAMEL 3
  • LAGE1 4

External Ids for CTAG2 Gene

Previous GeneCards Identifiers for CTAG2 Gene

  • GC0XM147943
  • GC0XM150260
  • GC0XM151465
  • GC0XM152347
  • GC0XM153443
  • GC0XM153533
  • GC0XM153880
  • GC0XM142426

Summaries for CTAG2 Gene

Entrez Gene Summary for CTAG2 Gene

  • This gene encodes an autoimmunogenic tumor antigen that belongs to the ESO/LAGE family of cancer-testis antigens. This protein is expressed in a wide array of cancers including melanoma, breast cancer, bladder cancer and prostate cancer. This protein is also expressed in normal testis tissue. An alternative open reading frame product of this gene has been described in PMID:10399963. This alternate protein, termed CAMEL, is a tumor antigen that is recognized by melanoma-specific cytotoxic T-lymphocytes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

CIViC summary for CTAG2 Gene

GeneCards Summary for CTAG2 Gene

CTAG2 (Cancer/Testis Antigen 2) is a Protein Coding gene. An important paralog of this gene is CTAG1A.

Additional gene information for CTAG2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTAG2 Gene

Genomics for CTAG2 Gene

GeneHancer (GH) Regulatory Elements for CTAG2 Gene

Promoters and enhancers for CTAG2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ154653 Promoter 0.5 EPDnew 650.7 0.0 -23 0.1 LOC105373387 CTAG2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CTAG2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CTAG2 gene promoter:

Genomic Locations for CTAG2 Gene

Genomic Locations for CTAG2 Gene
chrX:154,651,972-154,653,579
(GRCh38/hg38)
Size:
1,608 bases
Orientation:
Minus strand
chrX:153,880,246-153,881,853
(GRCh37/hg19)

Genomic View for CTAG2 Gene

Genes around CTAG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTAG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTAG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTAG2 Gene

Proteins for CTAG2 Gene

  • Protein details for CTAG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75638-CTAG2_HUMAN
    Recommended name:
    Cancer/testis antigen 2
    Protein Accession:
    O75638
    Secondary Accessions:
    • O75637
    • Q0VIL6
    • Q14CD6
    • Q2Z1N4
    • Q9BU80
    • Q9UJ89
    • Q9Y479

    Protein attributes for CTAG2 Gene

    Size:
    210 amino acids
    Molecular mass:
    21061 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CTAG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CTAG2 Gene

Post-translational modifications for CTAG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTAG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CTAG2 Gene

Domains & Families for CTAG2 Gene

Gene Families for CTAG2 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for CTAG2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CTAG2 Gene

Graphical View of Domain Structure for InterPro Entry

O75638

UniProtKB/Swiss-Prot:

CTAG2_HUMAN :
  • Belongs to the CTAG/PCC1 family.
Family:
  • Belongs to the CTAG/PCC1 family.
genes like me logo Genes that share domains with CTAG2: view

Function for CTAG2 Gene

Gene Ontology (GO) - Molecular Function for CTAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CTAG2: view
genes like me logo Genes that share phenotypes with CTAG2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTAG2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CTAG2 Gene

Localization for CTAG2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTAG2 gene
Compartment Confidence
cytoskeleton 4
extracellular 2
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for CTAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with CTAG2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CTAG2 Gene

Pathways & Interactions for CTAG2 Gene

SuperPathways for CTAG2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CTAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with CTAG2: view

No data available for Pathways by source and SIGNOR curated interactions for CTAG2 Gene

Drugs & Compounds for CTAG2 Gene

No Compound Related Data Available

Transcripts for CTAG2 Gene

mRNA/cDNA for CTAG2 Gene

(28) Selected AceView cDNA sequences:
(11) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CTAG2 Gene

Cancer/testis antigen 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTAG2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTAG2 Gene

ExUns: 1a · 1b ^ 2 ^ 3
SP1:
SP2:

Relevant External Links for CTAG2 Gene

GeneLoc Exon Structure for
CTAG2
ECgene alternative splicing isoforms for
CTAG2

Expression for CTAG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CTAG2 Gene

mRNA differential expression in normal tissues according to GTEx for CTAG2 Gene

This gene is overexpressed in Testis (x17.5).

Protein differential expression in normal tissues from HIPED for CTAG2 Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CTAG2 Gene



Protein tissue co-expression partners for CTAG2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CTAG2 Gene:

CTAG2

SOURCE GeneReport for Unigene cluster for CTAG2 Gene:

Hs.87225

mRNA Expression by UniProt/SwissProt for CTAG2 Gene:

O75638-CTAG2_HUMAN
Tissue specificity: Testis and very low level in placenta and in some uterus samples. Observed in 25-50% of tumor samples of melanomas, non-small-cell lung carcinomas, bladder, prostate and head and neck cancers.
genes like me logo Genes that share expression patterns with CTAG2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTAG2 Gene

Orthologs for CTAG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CTAG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC465964 33
  • 98.52 (n)
-- 34
  • 67 (a)
ManyToMany
-- 34
  • 67 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 24 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ctag2 34
  • 14 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CABZ01063556.1 34
  • 23 (a)
OneToMany
Species where no ortholog for CTAG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTAG2 Gene

ENSEMBL:
Gene Tree for CTAG2 (if available)
TreeFam:
Gene Tree for CTAG2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CTAG2: view image

Paralogs for CTAG2 Gene

Paralogs for CTAG2 Gene

(2) SIMAP similar genes for CTAG2 Gene using alignment to 2 proteins:

  • CTAG2_HUMAN
  • A4FUI5_HUMAN
genes like me logo Genes that share paralogs with CTAG2: view

Variants for CTAG2 Gene

Sequence variations from dbSNP and Humsavar for CTAG2 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1005459161 -- 154,654,621(-) A/G/T upstream_transcript_variant
rs1012920766 -- 154,655,407(-) G/C upstream_transcript_variant
rs1018563147 -- 154,654,640(-) G/A upstream_transcript_variant
rs1026507215 -- 154,655,534(-) G/A upstream_transcript_variant
rs1029418580 -- 154,655,082(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CTAG2 Gene

Variant ID Type Subtype PubMed ID
esv33784 CNV gain+loss 17666407
nsv518228 CNV gain 19592680

Variation tolerance for CTAG2 Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.17; 39.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CTAG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CTAG2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTAG2 Gene

Disorders for CTAG2 Gene

Additional Disease Information for CTAG2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CTAG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CTAG2 Gene

Publications for CTAG2 Gene

  1. Identification and expression analysis of novel LAGE-1 alleles with single nucleotide polymorphisms in cancer patients. (PMID: 17899192) Shao Y … Zhao HT (Journal of cancer research and clinical oncology 2008) 3 4 22 44 58
  2. Interleukin-2-induced, melanoma-specific T cells recognize CAMEL, an unexpected translation product of LAGE-1. (PMID: 10399963) Aarnoudse CA … Schrier PI (International journal of cancer 1999) 2 3 4 22 58
  3. LAGE-1, a new gene with tumor specificity. (PMID: 9626360) Lethé B … Boon T (International journal of cancer 1998) 2 3 4 58
  4. Comparisons for detecting NY-ESO-1 mRNA expression levels in hepatocellular carcinoma tissues. (PMID: 19212631) Wang XY … Cai J (Oncology reports 2009) 3 22 58
  5. Prognostic impact of cancer/testis antigen expression in advanced stage multiple myeloma patients. (PMID: 18237105) Andrade VC … Colleoni GW (Cancer immunity 2008) 3 22 58

Products for CTAG2 Gene

Sources for CTAG2 Gene

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