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Aliases for CTAG1B Gene

Aliases for CTAG1B Gene

  • Cancer/Testis Antigen 1B 2 3 5
  • Autoimmunogenic Cancer/Testis Antigen NY-ESO-1 3 4
  • Cancer/Testis Antigen 6.1 3 4
  • L Antigen Family Member 2 3 4
  • Cancer/Testis Antigen 1 2 3
  • LAGE-2 3 4
  • LAGE2B 3 4
  • CTAG1 3 4
  • CT6.1 3 4
  • CTAG 3 4
  • ESO1 3 4
  • New York Esophageal Squamous Cell Carcinoma 1 3
  • Cancer Antigen 3 3
  • NY-ESO-1 3
  • LAGE2A 4
  • LAGE2 4

External Ids for CTAG1B Gene

Previous HGNC Symbols for CTAG1B Gene

  • CTAG
  • CTAG1

Previous GeneCards Identifiers for CTAG1B Gene

  • GC0XP152282
  • GC0XM153410
  • GC0XM153499
  • GC0XM153845
  • GC0XM142391

Summaries for CTAG1B Gene

Entrez Gene Summary for CTAG1B Gene

  • The protein encoded by this gene is an antigen that is overexpressed in many cancers but that is also expressed in normal testis. This gene is found in a duplicated region of the X-chromosome and therefore has a neighboring gene of identical sequence. [provided by RefSeq, Jan 2012]

CIViC summary for CTAG1B Gene

GeneCards Summary for CTAG1B Gene

CTAG1B (Cancer/Testis Antigen 1B) is a Protein Coding gene. Diseases associated with CTAG1B include Testicular Cancer and Sarcoma, Synovial. An important paralog of this gene is CTAG1A.

Gene Wiki entry for CTAG1B Gene

Additional gene information for CTAG1B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTAG1B Gene

Genomics for CTAG1B Gene

GeneHancer (GH) Regulatory Elements for CTAG1B Gene

Promoters and enhancers for CTAG1B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ154619 Promoter 0.5 EPDnew 650.7 0.0 -21 0.1 CTAG1B ENSG00000273773
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CTAG1B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CTAG1B gene promoter:
  • CUTL1
  • C/EBPalpha
  • ATF6
  • MIF-1
  • HSF2
  • RORalpha2
  • Bach1
  • Evi-1
  • FOXJ2

Genomic Locations for CTAG1B Gene

Genomic Locations for CTAG1B Gene
1,674 bases
Minus strand
1,669 bases
Minus strand

Genomic View for CTAG1B Gene

Genes around CTAG1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTAG1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTAG1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTAG1B Gene

Proteins for CTAG1B Gene

  • Protein details for CTAG1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cancer/testis antigen 1
    Protein Accession:
    Secondary Accessions:
    • A1L417
    • B7WNL9
    • Q7LBY4
    • Q9NY13
    • A1L417
    • B7WNL9
    • Q7LBY4
    • Q9NY13

    Protein attributes for CTAG1B Gene

    180 amino acids
    Molecular mass:
    17992 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CTAG1B Gene

    Alternative splice isoforms for CTAG1B Gene


neXtProt entry for CTAG1B Gene

Post-translational modifications for CTAG1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTAG1B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CTAG1B

No data available for DME Specific Peptides for CTAG1B Gene

Domains & Families for CTAG1B Gene

Gene Families for CTAG1B Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for CTAG1B Gene


Suggested Antigen Peptide Sequences for CTAG1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CTAG/PCC1 family.
  • Belongs to the CTAG/PCC1 family.
genes like me logo Genes that share domains with CTAG1B: view

Function for CTAG1B Gene

Gene Ontology (GO) - Molecular Function for CTAG1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17137291
genes like me logo Genes that share ontologies with CTAG1B: view
genes like me logo Genes that share phenotypes with CTAG1B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTAG1B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CTAG1B Gene

Localization for CTAG1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTAG1B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTAG1B gene
Compartment Confidence
nucleus 2
extracellular 1
cytosol 1
endosome 1

Gene Ontology (GO) - Cellular Components for CTAG1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with CTAG1B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CTAG1B Gene

Pathways & Interactions for CTAG1B Gene

SuperPathways for CTAG1B Gene

No Data Available

Gene Ontology (GO) - Biological Process for CTAG1B Gene


No data available for Pathways by source and SIGNOR curated interactions for CTAG1B Gene

Drugs & Compounds for CTAG1B Gene

(2) Additional Compounds for CTAG1B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CTAG1B: view

Transcripts for CTAG1B Gene

mRNA/cDNA for CTAG1B Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CTAG1B Gene

Cancer/testis antigen 1B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTAG1B

Alternative Splicing Database (ASD) splice patterns (SP) for CTAG1B Gene

No ASD Table

Relevant External Links for CTAG1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTAG1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CTAG1B Gene

Protein differential expression in normal tissues from HIPED for CTAG1B Gene

This gene is overexpressed in Bone (43.6), Liver, secretome (12.1), and Testis (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CTAG1B Gene

Protein tissue co-expression partners for CTAG1B Gene

NURSA nuclear receptor signaling pathways regulating expression of CTAG1B Gene:


SOURCE GeneReport for Unigene cluster for CTAG1B Gene:


mRNA Expression by UniProt/SwissProt for CTAG1B Gene:

Tissue specificity: Expressed in testis and ovary and in a wide variety of cancers. Detected in uterine myometrium. Expressed from 18 weeks until birth in human fetal testis. In the adult testis, is strongly expressed in spermatogonia and in primary spermatocytes, but not in post-meiotic cells or in testicular somatic cells (at protein level).

Evidence on tissue expression from TISSUES for CTAG1B Gene

  • Blood(2.3)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with CTAG1B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTAG1B Gene

Orthologs for CTAG1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CTAG1B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 91 (a)
-- 34
  • 91 (a)
(Canis familiaris)
Mammalia -- 34
  • 33 (a)
(Mus musculus)
Mammalia Gm6880 34
  • 21 (a)
(Danio rerio)
Actinopterygii CABZ01063556.1 34
  • 35 (a)
Species where no ortholog for CTAG1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTAG1B Gene

Gene Tree for CTAG1B (if available)
Gene Tree for CTAG1B (if available)

Paralogs for CTAG1B Gene

Paralogs for CTAG1B Gene

(2) SIMAP similar genes for CTAG1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CTAG1B: view

Variants for CTAG1B Gene

Structural Variations from Database of Genomic Variants (DGV) for CTAG1B Gene

Variant ID Type Subtype PubMed ID
esv27930 CNV gain 19812545
esv29893 CNV gain 19812545
esv33199 CNV gain+loss 17666407
esv3369299 OTHER inversion 20981092
esv33784 CNV gain+loss 17666407
esv3577563 CNV gain 25503493
nsv1075747 CNV deletion 25765185
nsv1075748 CNV deletion 25765185
nsv1144327 CNV deletion 24896259
nsv508816 CNV insertion 20534489
nsv518228 CNV gain 19592680
nsv519042 CNV gain 19592680
nsv7469 OTHER inversion 18451855

Additional Variant Information for CTAG1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for CTAG1B Gene

Disorders for CTAG1B Gene

MalaCards: The human disease database

(5) MalaCards diseases for CTAG1B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
testicular cancer
  • childhood neoplasm of the testis
sarcoma, synovial
  • synovial sarcoma
squamous cell carcinoma
  • epidermoid carcinoma
esophageal cancer
  • esophageal cancer, somatic
lung cancer
  • lung cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CTAG1B

genes like me logo Genes that share disorders with CTAG1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTAG1B Gene

Publications for CTAG1B Gene

  1. Multiple pathogenic and benign genomic rearrangements occur at a 35 kb duplication involving the NEMO and LAGE2 genes. (PMID: 11709543) Aradhya S … Nelson DL (Human molecular genetics 2001) 2 3 4 58
  2. Genomic cloning and localization of CTAG, a gene encoding an autoimmunogenic cancer-testis antigen NY-ESO-1, to human chromosome Xq28. (PMID: 9605863) Chen YT … Arden KC (Cytogenetics and cell genetics 1997) 2 3 22 58
  3. A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening. (PMID: 9050879) Chen YT … Old LJ (Proceedings of the National Academy of Sciences of the United States of America 1997) 3 4 22 58
  4. Tumor-reactive CD8+ T-cell responses after vaccination with NY-ESO-1 peptide, CpG 7909 and Montanide ISA-51: association with survival. (PMID: 19728336) Karbach J … Jäger E (International journal of cancer 2010) 3 22 58
  5. Synergistic induction of NY-ESO-1 antigen expression by a novel histone deacetylase inhibitor, valproic acid, with 5-aza-2'-deoxycytidine in glioma cells. (PMID: 19030781) Oi S … Wakabayashi T (Journal of neuro-oncology 2009) 3 22 58

Products for CTAG1B Gene

Sources for CTAG1B Gene

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