The protein encoded by this gene is a tumor cell antigen found in various types of cancers, which makes it a good candidate for a cancer vaccine. This gene is also highly expressed in normal ovary and testis tissues. An identical copy of this gene is found on the same chromosome. [provided by RefSeq, Dec 2015] See more...

Aliases for CTAG1A Gene

Aliases for CTAG1A Gene

  • Cancer/Testis Antigen 1A 2 3 5
  • LAGE2A 2 3 4
  • ESO1 2 3 4
  • Autoimmunogenic Cancer/Testis Antigen NY-ESO-1 3 4
  • Cancer/Testis Antigen 6.1 3 4
  • L Antigen Family Member 2 3 4
  • Cancer/Testis Antigen 1 3 4
  • LAGE-2 3 4
  • CT6.1 3 4
  • New York Esophageal Squamous Cell Carcinoma 1 3
  • Cancer/Testis Antigen 1-A 3
  • NY-ESO-1 3
  • CTAG1A 5
  • LAGE2B 4
  • CTAG1 4
  • LAGE2 4
  • CTAG 4

External Ids for CTAG1A Gene

Previous GeneCards Identifiers for CTAG1A Gene

  • GC0XP152283
  • GC0XM153409
  • GC0XM153500
  • GC0XP153467
  • GC0XP153813

Summaries for CTAG1A Gene

Entrez Gene Summary for CTAG1A Gene

  • The protein encoded by this gene is a tumor cell antigen found in various types of cancers, which makes it a good candidate for a cancer vaccine. This gene is also highly expressed in normal ovary and testis tissues. An identical copy of this gene is found on the same chromosome. [provided by RefSeq, Dec 2015]

GeneCards Summary for CTAG1A Gene

CTAG1A (Cancer/Testis Antigen 1A) is a Protein Coding gene. Diseases associated with CTAG1A include Synovium Cancer and Cellular Myxoid Liposarcoma. An important paralog of this gene is CTAG1B.

Additional gene information for CTAG1A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CTAG1A Gene

Genomics for CTAG1A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CTAG1A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ154585 Promoter 0.3 EPDnew 600.7 0.0 -10 0.1 CTAG1A ATF4P2 G6PD MN298114-331
GH0XJ154595 Enhancer 0.8 Ensembl ENCODE 0.4 +11.4 11367 1.8 TEAD4 CTCF CEBPB RCOR1 JUND MAX SALL2 EP300 RAD21 SMC3 ENSG00000260081 GDI1 GAB3 PDZD4 L1CAM FAM3A piR-55809-041 CTAG1A CTAG1B MN298114-331
GH0XJ154599 Enhancer 0.8 Ensembl ENCODE 0.4 +15.8 15768 2.2 JUND ZNF148 MNT SMARCC1 ZNF248 FOS JUN FOSL1 MXI1 EP300 FAM3A GAB3 MECP2 PLXNA3 ENSG00000232155 piR-55809-041 CTAG1A CTAG1B MN298114-331
GH0XJ154603 Enhancer 0.8 Ensembl ENCODE 0.4 +19.0 18968 1.8 PRDM1 SCRT2 JUND ZNF10 CEBPB FOS JUN RCOR1 MAX DEK ENSG00000232155 FAM3A piR-55809-041 CTAG1A CTAG1B MN298114-331
GH0XJ154580 Promoter 0.3 Ensembl 0.7 -4.1 -4132 0.4 ATF4P2 CTAG1A G6PD MN298114-331
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CTAG1A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CTAG1A

Top Transcription factor binding sites by QIAGEN in the CTAG1A gene promoter:
  • ATF6
  • Bach1
  • C/EBPalpha
  • CUTL1
  • Evi-1
  • HSF2
  • MIF-1
  • RORalpha2
  • TBP

Genomic Locations for CTAG1A Gene

Genomic Locations for CTAG1A Gene
chrX:154,585,133-154,586,821
(GRCh38/hg38)
Size:
1,689 bases
Orientation:
Plus strand
chrX:153,813,407-153,815,075
(GRCh37/hg19)
Size:
1,669 bases
Orientation:
Plus strand

Genomic View for CTAG1A Gene

Genes around CTAG1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTAG1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTAG1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTAG1A Gene

Proteins for CTAG1A Gene

  • Protein details for CTAG1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78358-CTG1B_HUMAN
    Recommended name:
    Cancer/testis antigen 1
    Protein Accession:
    P78358
    Secondary Accessions:
    • A1L417
    • B7WNL9
    • Q7LBY4
    • Q9NY13

    Protein attributes for CTAG1A Gene

    Size:
    180 amino acids
    Molecular mass:
    17992 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CTAG1A Gene

    Alternative splice isoforms for CTAG1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CTAG1A Gene

Post-translational modifications for CTAG1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTAG1A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CTAG1A Gene

Domains & Families for CTAG1A Gene

Gene Families for CTAG1A Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for CTAG1A Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P78358

UniProtKB/Swiss-Prot:

CTG1B_HUMAN :
  • Belongs to the CTAG/PCC1 family.
Family:
  • Belongs to the CTAG/PCC1 family.
genes like me logo Genes that share domains with CTAG1A: view

No data available for Suggested Antigen Peptide Sequences for CTAG1A Gene

Function for CTAG1A Gene

Gene Ontology (GO) - Molecular Function for CTAG1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17137291
genes like me logo Genes that share ontologies with CTAG1A: view
genes like me logo Genes that share phenotypes with CTAG1A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTAG1A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CTAG1A Gene

Localization for CTAG1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTAG1A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTAG1A gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytoskeleton 2
nucleus 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CTAG1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with CTAG1A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CTAG1A Gene

Pathways & Interactions for CTAG1A Gene

PathCards logo

SuperPathways for CTAG1A Gene

No Data Available

Gene Ontology (GO) - Biological Process for CTAG1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045944 positive regulation of transcription by RNA polymerase II IBA 21873635
GO:0070525 tRNA threonylcarbamoyladenosine metabolic process IBA 21873635
genes like me logo Genes that share ontologies with CTAG1A: view

No data available for Pathways by source and SIGNOR curated interactions for CTAG1A Gene

Drugs & Compounds for CTAG1A Gene

No Compound Related Data Available

Transcripts for CTAG1A Gene

mRNA/cDNA for CTAG1A Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTAG1A

Alternative Splicing Database (ASD) splice patterns (SP) for CTAG1A Gene

No ASD Table

Relevant External Links for CTAG1A Gene

GeneLoc Exon Structure for
CTAG1A

Expression for CTAG1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CTAG1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CTAG1A Gene

This gene is overexpressed in Bone (43.6), Liver, secretome (12.1), and Testis (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CTAG1A Gene



Protein tissue co-expression partners for CTAG1A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CTAG1A

SOURCE GeneReport for Unigene cluster for CTAG1A Gene:

Hs.534310

mRNA Expression by UniProt/SwissProt for CTAG1A Gene:

P78358-CTG1B_HUMAN
Tissue specificity: Expressed in testis and ovary and in a wide variety of cancers. Detected in uterine myometrium. Expressed from 18 weeks until birth in human fetal testis. In the adult testis, is strongly expressed in spermatogonia and in primary spermatocytes, but not in post-meiotic cells or in testicular somatic cells (at protein level).

Evidence on tissue expression from TISSUES for CTAG1A Gene

  • Blood(2.9)
  • Lymph node(2.6)
  • Spleen(2.5)
  • Skin(2.1)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with CTAG1A: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTAG1A Gene

Orthologs for CTAG1A Gene

Evolution for CTAG1A Gene

ENSEMBL:
Gene Tree for CTAG1A (if available)
TreeFam:
Gene Tree for CTAG1A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CTAG1A: view image

No data available for Orthologs for CTAG1A Gene

Paralogs for CTAG1A Gene

Paralogs for CTAG1A Gene

(2) SIMAP similar genes for CTAG1A Gene using alignment to 1 proteins:

  • CTG1B_HUMAN
genes like me logo Genes that share paralogs with CTAG1A: view

Variants for CTAG1A Gene

Additional dbSNP identifiers (rs#s) for CTAG1A Gene

Structural Variations from Database of Genomic Variants (DGV) for CTAG1A Gene

Variant ID Type Subtype PubMed ID
esv27930 CNV gain 19812545
esv29893 CNV gain 19812545
esv33199 CNV gain+loss 17666407
esv3369299 OTHER inversion 20981092
esv33784 CNV gain+loss 17666407
esv3577563 CNV gain 25503493
nsv1075747 CNV deletion 25765185
nsv1075748 CNV deletion 25765185
nsv1144327 CNV deletion 24896259
nsv508816 CNV insertion 20534489
nsv518228 CNV gain 19592680
nsv519042 CNV gain 19592680
nsv7469 OTHER inversion 18451855

Additional Variant Information for CTAG1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CTAG1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for CTAG1A Gene

Disorders for CTAG1A Gene

MalaCards: The human disease database

(5) MalaCards diseases for CTAG1A Gene - From: DISEASES

Disorder Aliases PubMed IDs
synovium cancer
  • malignant tumor of synovium
cellular myxoid liposarcoma
  • round cell liposarcoma
sarcoma, synovial
  • synovial sarcoma
myxoid liposarcoma
  • liposarcoma
myeloma, multiple
  • multiple myeloma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with CTAG1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTAG1A Gene

Publications for CTAG1A Gene

  1. Multiple pathogenic and benign genomic rearrangements occur at a 35 kb duplication involving the NEMO and LAGE2 genes. (PMID: 11709543) Aradhya S … Nelson DL (Human molecular genetics 2001) 2 3 4
  2. DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter. (PMID: 10523621) De Smet C … Boon T (Molecular and cellular biology 1999) 2 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The cancer-testis gene, NY-ESO-1, is expressed in normal fetal and adult testes and in spermatocytic seminomas and testicular carcinoma in situ. (PMID: 12065688) Satie AP … Samson M (Laboratory investigation; a journal of technical methods and pathology 2002) 3 4

Products for CTAG1A Gene

Sources for CTAG1A Gene