Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CT83 Gene

Aliases for CT83 Gene

  • Cancer/Testis Antigen 83 2 3 4 5
  • Kita-Kyushu Lung Cancer Antigen 1 2 3
  • CXorf61 3 4
  • KK-LC-1 3 4
  • KKLC1 3 4
  • Chromosome X Open Reading Frame 61 2

External Ids for CT83 Gene

Previous HGNC Symbols for CT83 Gene

  • CXorf61

Previous GeneCards Identifiers for CT83 Gene

  • GC0XM115593

Summaries for CT83 Gene

GeneCards Summary for CT83 Gene

CT83 (Cancer/Testis Antigen 83) is a Protein Coding gene. Diseases associated with CT83 include Lung Cancer.

Additional gene information for CT83 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CT83 Gene

Genomics for CT83 Gene

GeneHancer (GH) Regulatory Elements for CT83 Gene

Promoters and enhancers for CT83 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ116462 Promoter 0.9 EPDnew 650.7 +0.0 37 0.1 STAT1 MAX CEBPB RFX5 POLR2A STAT3 SMC3 CHD2 TCF7L2 CT83 SLC6A14
GH0XJ116436 Promoter/Enhancer 1.1 EPDnew ENCODE 0.3 +26.4 26447 1.2 GTF2F1 DRAP1 SOX13 PKNOX1 MAZ FOXA3 CHD1 ELF1 CTBP1 POLR2A SLC6A14 CT83
GH0XJ116493 Enhancer 0.2 ENCODE 0.3 -30.4 -30381 0.2 CT83 LOC100422432
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CT83 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CT83 Gene

Genomic Locations for CT83 Gene
1,352 bases
Minus strand
1,316 bases
Minus strand

Genomic View for CT83 Gene

Genes around CT83 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CT83 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CT83 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CT83 Gene

Proteins for CT83 Gene

  • Protein details for CT83 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kita-kyushu lung cancer antigen 1
    Protein Accession:

    Protein attributes for CT83 Gene

    113 amino acids
    Molecular mass:
    12784 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CT83 Gene

Post-translational modifications for CT83 Gene

  • Glycosylation at Asn83
  • Modification sites at PhosphoSitePlus

Other Protein References for CT83 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CT83 Gene

Domains & Families for CT83 Gene

Gene Families for CT83 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CT83 Gene


Suggested Antigen Peptide Sequences for CT83 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CT83: view

No data available for UniProtKB/Swiss-Prot for CT83 Gene

Function for CT83 Gene

genes like me logo Genes that share phenotypes with CT83: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CT83 Gene

Localization for CT83 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CT83 Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CT83 gene
Compartment Confidence
nucleus 5
plasma membrane 4
extracellular 3
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CT83 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CT83: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CT83 Gene

Pathways & Interactions for CT83 Gene

No Data Available

Interacting Proteins for CT83 Gene

Selected Interacting proteins: Q5H943-KKLC1_HUMAN for CT83 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for CT83 Gene


No data available for Pathways by source and SIGNOR curated interactions for CT83 Gene

Drugs & Compounds for CT83 Gene

No Compound Related Data Available

Transcripts for CT83 Gene

mRNA/cDNA for CT83 Gene

(1) REFSEQ mRNAs :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CT83 Gene

No ASD Table

Relevant External Links for CT83 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CT83 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CT83 Gene

mRNA differential expression in normal tissues according to GTEx for CT83 Gene

This gene is overexpressed in Testis (x52.2).

Protein differential expression in normal tissues from HIPED for CT83 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CT83 Gene

Protein tissue co-expression partners for CT83 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CT83 Gene:


mRNA Expression by UniProt/SwissProt for CT83 Gene:

Tissue specificity: Specifically expressed in testis. Expressed by cancer cell lines.
genes like me logo Genes that share expression patterns with CT83: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CT83 Gene

Orthologs for CT83 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CT83 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CT83 34
  • 100 (a)
LOC742693 33
  • 99.71 (n)
(Canis familiaris)
Mammalia CXHXorf61 33
  • 81.73 (n)
CT83 34
  • 60 (a)
(Bos Taurus)
Mammalia LOC100138847 33
  • 78.87 (n)
Species where no ortholog for CT83 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CT83 Gene

Gene Tree for CT83 (if available)
Gene Tree for CT83 (if available)
Evolutionary constrained regions (ECRs) for CT83: view image

Paralogs for CT83 Gene Pseudogenes for CT83 Gene

genes like me logo Genes that share paralogs with CT83: view

No data available for Paralogs for CT83 Gene

Variants for CT83 Gene

Sequence variations from dbSNP and Humsavar for CT83 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1002063927 -- 116,464,693(-) A/G upstream_transcript_variant
rs1003601097 -- 116,462,998(-) C/T 5_prime_UTR_variant
rs1006735587 -- 116,461,563(-) G/A downstream_transcript_variant
rs1009327141 -- 116,464,634(-) T/C upstream_transcript_variant
rs1011416035 -- 116,462,614(-) C/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CT83 Gene

Variant ID Type Subtype PubMed ID
dgv2383e212 CNV gain 25503493
dgv2386e212 CNV gain 25503493
dgv526n21 CNV gain 19592680
nsv523582 CNV gain 19592680
nsv526428 CNV gain 19592680
nsv527804 CNV gain 19592680

Variation tolerance for CT83 Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CT83 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CT83 Gene

Disorders for CT83 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CT83 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search CT83 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CT83

genes like me logo Genes that share disorders with CT83: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CT83 Gene

Publications for CT83 Gene

  1. Identification of a new cancer/germline gene, KK-LC-1, encoding an antigen recognized by autologous CTL induced on human lung adenocarcinoma. (PMID: 16651449) Fukuyama T … Yasumoto K (Cancer research 2006) 2 3 4 58
  2. Correlation Between Expression of the Cancer/Testis Antigen KK-LC-1 and Helicobacter pylori Infection in Gastric Cancer. (PMID: 28438869) Fukuyama T … Kobayashi N (In vivo (Athens, Greece) 2017) 3 58
  3. Frequent High Expression of Kita-Kyushu Lung Cancer Antigen-1 (KK-LC-1) in Gastric Cancer. (PMID: 26026129) Shida A … Watanabe M (Anticancer research 2015) 3 58
  4. CXorf61 is a target for T cell based immunotherapy of triple-negative breast cancer. (PMID: 26327325) Paret C … Sahin U (Oncotarget 2015) 3 58
  5. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S … Oliva R (Proteomics 2011) 3 58

Products for CT83 Gene

Sources for CT83 Gene

Loading form....