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Aliases for CT45A2 Gene

Aliases for CT45A2 Gene

  • Cancer/Testis Antigen Family 45 Member A2 2 3 3 5
  • Cancer/Testis Antigen 45-2 3 4
  • Cancer/Testis Antigen 45A2 3 4
  • CT45-2 3 4
  • Cancer/Testis Antigen CT45-2 2
  • Cancer/Testis Antigen CT45 3
  • CT45.2 3

External Ids for CT45A2 Gene

Previous GeneCards Identifiers for CT45A2 Gene

  • GC0XP134695
  • GC0XP134866

Summaries for CT45A2 Gene

Entrez Gene Summary for CT45A2 Gene

  • This gene represents one of a cluster of several similar genes located on the q arm of chromosome X. The genes in this cluster encode members of the cancer/testis (CT) family of antigens, and are distinct from other CT antigens. These antigens are thought to be novel therapeutic targets for human cancers. [provided by RefSeq, Apr 2014]

GeneCards Summary for CT45A2 Gene

CT45A2 (Cancer/Testis Antigen Family 45 Member A2) is a Protein Coding gene. An important paralog of this gene is CT45A8.

Additional gene information for CT45A2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CT45A2 Gene

Genomics for CT45A2 Gene

GeneHancer (GH) Regulatory Elements for CT45A2 Gene

Promoters and enhancers for CT45A2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ135837 Promoter 0.5 EPDnew 0.4 -8.0 -7952 0.1 CT45A7 CT45A2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CT45A2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CT45A2 gene promoter:
  • SRF (504 AA)
  • SRF
  • HNF-1
  • HNF-1A
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4

Genomic Locations for CT45A2 Gene

Genomic Locations for CT45A2 Gene
17,681 bases
Minus strand
8,401 bases
Plus strand

Genomic View for CT45A2 Gene

Genes around CT45A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CT45A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CT45A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CT45A2 Gene

Proteins for CT45A2 Gene

  • Protein details for CT45A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cancer/testis antigen family 45 member A2
    Protein Accession:
    Secondary Accessions:
    • Q5JRH3

    Protein attributes for CT45A2 Gene

    189 amino acids
    Molecular mass:
    21363 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CT45A2 Gene

Post-translational modifications for CT45A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CT45A2 Gene

No data available for DME Specific Peptides for CT45A2 Gene

Domains & Families for CT45A2 Gene

Gene Families for CT45A2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CT45A2 Gene


Suggested Antigen Peptide Sequences for CT45A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CT45 family.
  • Belongs to the CT45 family.
genes like me logo Genes that share domains with CT45A2: view

Function for CT45A2 Gene

Phenotypes for CT45A2 Gene

genes like me logo Genes that share phenotypes with CT45A2: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CT45A2 Gene

Localization for CT45A2 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CT45A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032039 integrator complex IBA --
genes like me logo Genes that share ontologies with CT45A2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for CT45A2 Gene

Pathways & Interactions for CT45A2 Gene

SuperPathways for CT45A2 Gene

No Data Available

Interacting Proteins for CT45A2 Gene

Selected Interacting proteins: Q5DJT8-CT452_HUMAN for CT45A2 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for CT45A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034472 snRNA 3-end processing IBA --
genes like me logo Genes that share ontologies with CT45A2: view

No data available for Pathways by source and SIGNOR curated interactions for CT45A2 Gene

Drugs & Compounds for CT45A2 Gene

No Compound Related Data Available

Transcripts for CT45A2 Gene

mRNA/cDNA for CT45A2 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CT45A2 Gene

Cancer/testis antigen family 45, member A2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CT45A2 Gene

No ASD Table

Relevant External Links for CT45A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CT45A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CT45A2 Gene

mRNA differential expression in normal tissues according to GTEx for CT45A2 Gene

This gene is overexpressed in Testis (x25.0).

Protein differential expression in normal tissues from HIPED for CT45A2 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CT45A2 Gene

Protein tissue co-expression partners for CT45A2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CT45A2 Gene:


SOURCE GeneReport for Unigene cluster for CT45A2 Gene:


mRNA Expression by UniProt/SwissProt for CT45A2 Gene:

Tissue specificity: Testis specific. Expressed in cancer cell lines.
genes like me logo Genes that share expression patterns with CT45A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CT45A2 Gene

Orthologs for CT45A2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for CT45A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100609226 33
  • 98.59 (n)
Species where no ortholog for CT45A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CT45A2 Gene

Gene Tree for CT45A2 (if available)
Gene Tree for CT45A2 (if available)

Paralogs for CT45A2 Gene

(7) SIMAP similar genes for CT45A2 Gene using alignment to 1 proteins:

  • CT452_HUMAN Pseudogenes for CT45A2 Gene

genes like me logo Genes that share paralogs with CT45A2: view

Variants for CT45A2 Gene

Sequence variations from dbSNP and Humsavar for CT45A2 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs6635146 -- 135,815,964(-) G/C intron_variant
rs6635147 -- 135,816,002(-) C/A intron_variant
rs879950433 -- 135,814,666(-) C/T intron_variant
rs879958447 -- 135,815,202(-) C/T intron_variant
rs879969316 -- 135,815,171(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CT45A2 Gene

Variant ID Type Subtype PubMed ID
dgv2451e212 CNV loss 25503493
dgv2452e212 CNV gain 25503493
dgv2455e212 CNV gain 25503493
dgv2457e212 CNV gain 25503493
dgv2458e212 CNV loss 25503493
dgv2459e212 CNV gain 25503493
dgv2460e212 CNV loss 25503493
dgv2461e212 CNV gain 25503493
dgv2463e212 CNV loss 25503493
dgv2465e212 CNV gain 25503493
dgv2466e212 CNV loss 25503493
dgv2467e212 CNV gain 25503493
dgv2468e212 CNV loss 25503493
dgv2469e212 CNV gain 25503493
dgv2470e212 CNV gain 25503493
dgv2471e212 CNV loss 25503493
dgv2472e212 CNV loss 25503493
dgv2473e212 CNV gain 25503493
dgv2474e212 CNV loss 25503493
dgv4619e59 CNV duplication 20981092
dgv4620e59 CNV duplication 20981092
esv1010013 CNV gain 20482838
esv1531072 CNV deletion 17803354
esv2740498 CNV deletion 23290073
esv2758895 CNV gain+loss 17122850
esv27752 CNV gain+loss 19812545
esv3364974 CNV duplication 20981092
esv3574649 CNV loss 25503493
esv3574659 CNV loss 25503493
esv3574688 CNV loss 25503493
esv3574689 CNV loss 25503493
esv3574707 CNV loss 25503493
esv3577356 CNV gain 25503493
esv3577382 CNV gain 25503493
esv3577384 CNV gain 25503493
nsv1078133 CNV duplication 25765185
nsv1078134 CNV duplication 25765185
nsv1115292 CNV deletion 24896259
nsv1150167 CNV duplication 26484159
nsv469568 CNV gain 16826518
nsv471605 CNV gain+loss 15918152
nsv499485 CNV loss 21111241
nsv527747 CNV gain 19592680
nsv7107 CNV deletion 18451855
nsv7460 OTHER inversion 18451855

Additional Variant Information for CT45A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CT45A2 Gene

Disorders for CT45A2 Gene

Additional Disease Information for CT45A2

No disorders were found for CT45A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CT45A2 Gene

Publications for CT45A2 Gene

  1. Identification of cancer/testis-antigen genes by massively parallel signature sequencing. (PMID: 15905330) Chen YT … Simpson AJ (Proceedings of the National Academy of Sciences of the United States of America 2005) 2 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. A novel spliced fusion of MLL with CT45A2 in a pediatric biphenotypic acute leukemia. (PMID: 20920256) Cerveira N … Teixeira MR (BMC cancer 2010) 3 58
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for CT45A2 Gene

Sources for CT45A2 Gene

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