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Aliases for CSTF3 Gene

Aliases for CSTF3 Gene

  • Cleavage Stimulation Factor Subunit 3 2 3 3 5
  • Cleavage Stimulation Factor, 3 Pre-RNA, Subunit 3, 77kD 2 3
  • Cleavage Stimulation Factor 77 KDa Subunit 3 4
  • CF-1 77 KDa Subunit 3 4
  • CSTF 77 KDa Subunit 3 4
  • Cleavage Stimulation Factor, 3 Pre-RNA, Subunit 3, 77kDa 3
  • Cleavage Stimulation Factor, 3 Pre-RNA, Subunit 3 2
  • CSTF-77 3
  • CstF-77 4

External Ids for CSTF3 Gene

Previous GeneCards Identifiers for CSTF3 Gene

  • GC11M034638
  • GC11M033249
  • GC11M033145
  • GC11M033070
  • GC11M033062
  • GC11M032800

Summaries for CSTF3 Gene

Entrez Gene Summary for CSTF3 Gene

  • The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for CSTF3 Gene

CSTF3 (Cleavage Stimulation Factor Subunit 3) is a Protein Coding gene. Among its related pathways are Processing of Capped Intronless Pre-mRNA and Sertoli-Sertoli Cell Junction Dynamics. Gene Ontology (GO) annotations related to this gene include mRNA binding.

UniProtKB/Swiss-Prot for CSTF3 Gene

  • One of the multiple factors required for polyadenylation and 3-end cleavage of mammalian pre-mRNAs.

Gene Wiki entry for CSTF3 Gene

Additional gene information for CSTF3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSTF3 Gene

Genomics for CSTF3 Gene

GeneHancer (GH) Regulatory Elements for CSTF3 Gene

Promoters and enhancers for CSTF3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J033159 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 657.5 +1.1 1055 3.4 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 HIPK3 CSTF3 CSTF3-DT NAT10 EIF3M QSER1 CAPRIN1 TCP11L1 PIGCP1 DEPDC7
GH11J034050 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 14.9 -890.1 -890054 4.7 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF207 ZNF143 SP3 ZHX2 CAPRIN1 LOC101929918 CSTF3 NAT10 RPS24P15 GC11P034049
GH11J032890 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.2 +268.9 268916 4.9 PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZBTB7B YY1 POLR2B QSER1 HNRNPA3P9 CSTF3 CCDC73 PIR46589
GH11J033890 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -730.9 -730929 5.8 HDGF PKNOX1 SMAD1 ARNT IRF4 POLR2B ZNF143 JUNB REST ZNF592 LMO2 LOC105376621 CSTF3
GH11J033187 Enhancer 1 FANTOM5 Ensembl ENCODE 17.1 -25.8 -25769 1.6 MITF USF1 PRDM6 BHLHE40 POU5F1 USF2 WT1 CSTF3 CSTF3-DT HIPK3 TCP11L1 DEPDC7 GC11M033190 GC11M033171 ENSG00000206808 GC11M032953
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CSTF3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CSTF3 gene promoter:

Genomic Locations for CSTF3 Gene

Genomic Locations for CSTF3 Gene
chr11:33,077,188-33,162,371
(GRCh38/hg38)
Size:
85,184 bases
Orientation:
Minus strand
chr11:33,098,734-33,183,917
(GRCh37/hg19)

Genomic View for CSTF3 Gene

Genes around CSTF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSTF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSTF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSTF3 Gene

Proteins for CSTF3 Gene

  • Protein details for CSTF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12996-CSTF3_HUMAN
    Recommended name:
    Cleavage stimulation factor subunit 3
    Protein Accession:
    Q12996
    Secondary Accessions:
    • A8K471
    • D3DR04
    • E9PB40
    • Q32P22
    • Q96FQ8
    • Q96QD6
    • Q96QK4

    Protein attributes for CSTF3 Gene

    Size:
    717 amino acids
    Molecular mass:
    82922 Da
    Quaternary structure:
    • Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). CSTF3 directly interacts with CSTF1 and CSTF2. Interacts with FIP1L1.

    Three dimensional structures from OCA and Proteopedia for CSTF3 Gene

    Alternative splice isoforms for CSTF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSTF3 Gene

Post-translational modifications for CSTF3 Gene

  • Ubiquitination at Lys192 and Lys94
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CSTF3 Gene

Domains & Families for CSTF3 Gene

Gene Families for CSTF3 Gene

Protein Domains for CSTF3 Gene

Suggested Antigen Peptide Sequences for CSTF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CSTF3: view

No data available for UniProtKB/Swiss-Prot for CSTF3 Gene

Function for CSTF3 Gene

Molecular function for CSTF3 Gene

UniProtKB/Swiss-Prot Function:
One of the multiple factors required for polyadenylation and 3-end cleavage of mammalian pre-mRNAs.
GENATLAS Biochemistry:
cleavage stimulation factor,subunit 3,homolog of the Drosophila supressor of forked protein SU(b),component of the 3 pre RNA polyadenylation complex

Phenotypes From GWAS Catalog for CSTF3 Gene

Gene Ontology (GO) - Molecular Function for CSTF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0003729 mRNA binding IBA --
GO:0005515 protein binding IEA,IPI 7590244
genes like me logo Genes that share ontologies with CSTF3: view
genes like me logo Genes that share phenotypes with CSTF3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSTF3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CSTF3 Gene

Localization for CSTF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSTF3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSTF3 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CSTF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 7984242
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CSTF3: view

Pathways & Interactions for CSTF3 Gene

genes like me logo Genes that share pathways with CSTF3: view

Pathways by source for CSTF3 Gene

1 KEGG pathway for CSTF3 Gene
1 Qiagen pathway for CSTF3 Gene

Gene Ontology (GO) - Biological Process for CSTF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006378 mRNA polyadenylation TAS 7984242
GO:0006379 mRNA cleavage TAS 7984242
GO:0006396 RNA processing IEA --
genes like me logo Genes that share ontologies with CSTF3: view

No data available for SIGNOR curated interactions for CSTF3 Gene

Drugs & Compounds for CSTF3 Gene

(1) Additional Compounds for CSTF3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CSTF3: view

Transcripts for CSTF3 Gene

mRNA/cDNA for CSTF3 Gene

Unigene Clusters for CSTF3 Gene

Cleavage stimulation factor, 3 pre-RNA, subunit 3, 77kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSTF3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSTF3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP1: -
SP2: - -
SP3:
SP4: -

Relevant External Links for CSTF3 Gene

GeneLoc Exon Structure for
CSTF3
ECgene alternative splicing isoforms for
CSTF3

Expression for CSTF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CSTF3 Gene

Protein differential expression in normal tissues from HIPED for CSTF3 Gene

This gene is overexpressed in Lymph node (20.4) and Fetal ovary (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CSTF3 Gene



Protein tissue co-expression partners for CSTF3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CSTF3 Gene:

CSTF3

SOURCE GeneReport for Unigene cluster for CSTF3 Gene:

Hs.44402

Evidence on tissue expression from TISSUES for CSTF3 Gene

  • Nervous system(4.7)
  • Liver(4.2)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with CSTF3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSTF3 Gene

Orthologs for CSTF3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSTF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSTF3 34 33
  • 99.91 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 99 (a)
OneToMany
-- 34
  • 84 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CSTF3 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CSTF3 34 33
  • 95.49 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CSTF3 34 33
  • 95.03 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Cstf3 16 34 33
  • 93.44 (n)
rat
(Rattus norvegicus)
Mammalia Cstf3 33
  • 91.16 (n)
chicken
(Gallus gallus)
Aves CSTF3 34 33
  • 84.52 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSTF3 34
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cstf3 33
  • 79.66 (n)
MGC76035 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.16844 33
zebrafish
(Danio rerio)
Actinopterygii cstf3 34 33
  • 76.58 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8931 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003019 33
  • 57.4 (n)
fruit fly
(Drosophila melanogaster)
Insecta su(f) 34 35 33
  • 56.8 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea suf-1 34 35 33
  • 56.4 (n)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F26290g 33
  • 45.8 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RNA14 36 34 33
  • 45.56 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR137W 33
  • 42.5 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons CSTF77 33
  • 48.79 (n)
rice
(Oryza sativa)
Liliopsida Os12g0571900 33
  • 47.85 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 58 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rna14 33
  • 46.76 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09435 33
  • 44.4 (n)
Species where no ortholog for CSTF3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSTF3 Gene

ENSEMBL:
Gene Tree for CSTF3 (if available)
TreeFam:
Gene Tree for CSTF3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CSTF3: view image

Paralogs for CSTF3 Gene

(1) SIMAP similar genes for CSTF3 Gene using alignment to 5 proteins:

  • CSTF3_HUMAN
  • E9PJ06_HUMAN
  • E9PLP8_HUMAN
  • E9PNK2_HUMAN
  • H0YE74_HUMAN
genes like me logo Genes that share paralogs with CSTF3: view

No data available for Paralogs for CSTF3 Gene

Variants for CSTF3 Gene

Sequence variations from dbSNP and Humsavar for CSTF3 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000034650 -- 33,116,607(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000108214 -- 33,109,379(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000115825 -- 33,129,754(-) T/G genic_downstream_transcript_variant, intron_variant
rs1000206325 -- 33,124,145(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000237741 -- 33,136,056(-) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CSTF3 Gene

Variant ID Type Subtype PubMed ID
dgv1093n100 CNV gain 25217958
dgv1742n54 CNV gain 21841781
esv2761660 CNV gain 21179565
esv2762904 CNV gain 21179565
esv3334264 CNV insertion 20981092
esv3579468 CNV loss 25503493
nsv467786 CNV gain 19166990
nsv521130 CNV gain 19592680
nsv975378 CNV duplication 23825009

Variation tolerance for CSTF3 Gene

Residual Variation Intolerance Score: 17.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CSTF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSTF3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSTF3 Gene

Disorders for CSTF3 Gene

Additional Disease Information for CSTF3

No disorders were found for CSTF3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSTF3 Gene

Publications for CSTF3 Gene

  1. Complex protein interactions within the human polyadenylation machinery identify a novel component. (PMID: 10669729) Takagaki Y … Manley JL (Molecular and cellular biology 2000) 3 4 22 58
  2. A polyadenylation factor subunit is the human homologue of the Drosophila suppressor of forked protein. (PMID: 7984242) Takagaki Y … Manley JL (Nature 1994) 2 3 4 58
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4 58
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for CSTF3 Gene

Sources for CSTF3 Gene

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