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CSTF2T (Cleavage Stimulation Factor Subunit 2 Tau Variant) is a Protein Coding gene. Diseases associated with CSTF2T include Oligoasthenoteratozoospermia. Among its related pathways are Cleavage of Growing Transcript in the Termination Region and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is CSTF2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH10J051697 | Promoter/Enhancer | 1.7 | Ensembl ENCODE CraniofacialAtlas | 607.5 | +0.1 | 112 | 3 | SP1 CREB1 PRDM10 REST ZNF629 SIX5 LEF1 IKZF1 POLR2A ZNF692 | CSTF2T MN298114-022 PRKG1 | |
GH10J051918 | Enhancer | 0.6 | Ensembl ENCODE | 6.5 | -219.7 | -219706 | 1.8 | NR2F2 JUN TRIM28 MAX BCL6B | CSTF2T piR-32214-058 piR-39341-041 DKK1 PRKG1 | |
GH10J051832 | Enhancer | 0.7 | Ensembl ENCODE | 4.7 | -133.5 | -133518 | 1 | BACH1 PKNOX1 NFE2 MAFF FOS CREB1 MAFK MAFG ZNF530 NFE2L2 | CSTF2T piR-32214-058 DKK1 PRKG1 | |
GH10J051914 | Enhancer | 0.5 | Ensembl ENCODE | 5.3 | -215.9 | -215906 | 2.2 | ZNF140 PRDM6 | CSTF2T piR-32214-058 piR-39341-041 DKK1 PRKG1 | |
GH10J051267 | Enhancer | 0.4 | Ensembl ENCODE | 4.8 | +431.8 | 431752 | 4.5 | POU5F1 | piR-44110-007 ENSG00000231132 CSTF2T PRKG1 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003723 | RNA binding | IBA | 21873635 |
GO:0003729 | mRNA binding | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 16189514 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005622 | intracellular | IDA | -- |
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex | IBA | 21873635 |
GO:0043231 | intracellular membrane-bounded organelle | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | mRNA Splicing - Major Pathway |
.79
|
.41
|
2 | Cleavage of Growing Transcript in the Termination Region | ||
3 | Processing of Capped Intronless Pre-mRNA | ||
4 | mRNA surveillance pathway | ||
5 | Sertoli-Sertoli Cell Junction Dynamics |
Epithelial Tight Junctions
.36
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000398 | mRNA splicing, via spliceosome | TAS | -- |
GO:0006369 | termination of RNA polymerase II transcription | TAS | -- |
GO:0006397 | mRNA processing | IEA | -- |
GO:0031124 | mRNA 3'-end processing | TAS | -- |
GO:0098789 | pre-mRNA cleavage required for polyadenylation | IBA | 21873635 |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CSTF2T 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CSTF2T 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cstf2t 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cstf2t 30 |
|
||
Dog (Canis familiaris) |
Mammalia | CSTF2T 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | CSTF2 31 |
|
OneToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | cstf2 31 31 |
|
ManyToMany | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CstF-64 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | cpf-2 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | IST3 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
776511 | Likely Benign: not provided | 51,698,827(-) | ATGC/A | INFRAME_DELETION,INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1045692 | CNV | gain | 25217958 |
nsv831875 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
oligoasthenoteratozoospermia |
|
|