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Aliases for CSTF2 Gene

Aliases for CSTF2 Gene

  • Cleavage Stimulation Factor Subunit 2 2 3 3 5
  • Cleavage Stimulation Factor, 3 Pre-RNA, Subunit 2, 64kD 2 3
  • Cleavage Stimulation Factor 64 KDa Subunit 3 4
  • CF-1 64 KDa Subunit 3 4
  • CSTF 64 KDa Subunit 3 4
  • CstF-64 3 4
  • Cleavage Stimulation Factor, 3 Pre-RNA, Subunit 2, 64kDa 3
  • Cleavage Stimulation Factor, 3 Pre-RNA, Subunit 2 2
  • BetaCstF-64 Variant 2 3

External Ids for CSTF2 Gene

Previous GeneCards Identifiers for CSTF2 Gene

  • GC0XP095357
  • GC0XP097036
  • GC0XP098111
  • GC0XP098847
  • GC0XP099881
  • GC0XP100075
  • GC0XP089874

Summaries for CSTF2 Gene

Entrez Gene Summary for CSTF2 Gene

  • This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs. [provided by RefSeq, Jul 2008]

GeneCards Summary for CSTF2 Gene

CSTF2 (Cleavage Stimulation Factor Subunit 2) is a Protein Coding gene. Among its related pathways are Processing of Capped Intronless Pre-mRNA and Sertoli-Sertoli Cell Junction Dynamics. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is CSTF2T.

UniProtKB/Swiss-Prot for CSTF2 Gene

  • One of the multiple factors required for polyadenylation and 3-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity).

Gene Wiki entry for CSTF2 Gene

Additional gene information for CSTF2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSTF2 Gene

Genomics for CSTF2 Gene

GeneHancer (GH) Regulatory Elements for CSTF2 Gene

Promoters and enhancers for CSTF2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ100819 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 -0.1 -58 1.8 PKNOX1 SMAD1 ATF1 ARID4B SIN3A DMAP1 ZNF48 YY1 ETS1 ZNF121 CSTF2 SYTL4 ENSG00000275320
GH0XJ100642 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.9 -173.3 -173346 8.9 FOXA2 ARID4B DMAP1 YY1 FOS RXRA SP5 REST PPARG NFIL3 SRPX2 SYTL4 TSPAN6 ARMCX4 CSTF2 PPIAP90 PCDH19 GC0XP100679
GH0XJ100829 Enhancer 0.5 ENCODE 0.4 +9.5 9543 0.9 CTCF SRF PKNOX1 JUNB EBF1 ETV6 RELA SYTL4 NOX1 GC0XP100835 GC0XM100823 CSTF2 ENSG00000202231
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CSTF2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CSTF2 gene promoter:
  • PPAR-gamma2
  • PPAR-gamma1
  • Sox5
  • C/EBPalpha
  • POU2F1
  • POU2F1a
  • ZIC2
  • LCR-F1
  • AML1a
  • Cart-1

Genomic Locations for CSTF2 Gene

Genomic Locations for CSTF2 Gene
21,162 bases
Plus strand
20,577 bases
Plus strand

Genomic View for CSTF2 Gene

Genes around CSTF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSTF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSTF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSTF2 Gene

Proteins for CSTF2 Gene

  • Protein details for CSTF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cleavage stimulation factor subunit 2
    Protein Accession:
    Secondary Accessions:
    • Q5H951
    • Q6LA74
    • Q8N502

    Protein attributes for CSTF2 Gene

    577 amino acids
    Molecular mass:
    60959 Da
    Quaternary structure:
    • The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). CSTF2 directly interacts with CSTF3, SYMPK and RPO2TC1. Interacts with HSF1 in heat-stressed cells. Interacts with CPSF2, CPSF3 and FIP1L1. Interacts with DDX1.
    • Sequence=CAI42681.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CSTF2 Gene

    Alternative splice isoforms for CSTF2 Gene


neXtProt entry for CSTF2 Gene

Post-translational modifications for CSTF2 Gene

  • Ubiquitination at Lys572, posLast=189189, and Lys148
  • Modification sites at PhosphoSitePlus

Other Protein References for CSTF2 Gene

No data available for DME Specific Peptides for CSTF2 Gene

Domains & Families for CSTF2 Gene

Gene Families for CSTF2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CSTF2: view

No data available for UniProtKB/Swiss-Prot for CSTF2 Gene

Function for CSTF2 Gene

Molecular function for CSTF2 Gene

UniProtKB/Swiss-Prot Function:
One of the multiple factors required for polyadenylation and 3-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated during the G0 to S phase transition.
GENATLAS Biochemistry:
cleavage stimulation factor,subunit 2,component of the 3 pre RNA polyadenylation

Gene Ontology (GO) - Molecular Function for CSTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IDA 1741396
GO:0003729 mRNA binding IBA --
GO:0005515 protein binding IPI 10477523
genes like me logo Genes that share ontologies with CSTF2: view
genes like me logo Genes that share phenotypes with CSTF2: view

Animal Model Products

miRNA for CSTF2 Gene

miRTarBase miRNAs that target CSTF2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CSTF2 Gene

Localization for CSTF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSTF2 Gene

Nucleus. Note=Localized with DDX1 in cleavage bodies.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSTF2 gene
Compartment Confidence
nucleus 5
extracellular 1
mitochondrion 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CSTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS,IDA --
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex IDA,IEA 18305108
GO:0016604 nuclear body IDA --
GO:0071920 cleavage body IDA 11598190
genes like me logo Genes that share ontologies with CSTF2: view

Pathways & Interactions for CSTF2 Gene

genes like me logo Genes that share pathways with CSTF2: view

Pathways by source for CSTF2 Gene

1 KEGG pathway for CSTF2 Gene
1 Qiagen pathway for CSTF2 Gene

Gene Ontology (GO) - Biological Process for CSTF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006378 mRNA polyadenylation IEA --
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation TAS --
GO:0006397 mRNA processing IEA --
genes like me logo Genes that share ontologies with CSTF2: view

No data available for SIGNOR curated interactions for CSTF2 Gene

Drugs & Compounds for CSTF2 Gene

No Compound Related Data Available

Transcripts for CSTF2 Gene

mRNA/cDNA for CSTF2 Gene

Unigene Clusters for CSTF2 Gene

Cleavage stimulation factor, 3 pre-RNA, subunit 2, 64kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSTF2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: -
SP6: - - - - - - - -
SP7: -

Relevant External Links for CSTF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CSTF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CSTF2 Gene

Protein differential expression in normal tissues from HIPED for CSTF2 Gene

This gene is overexpressed in Liver (48.3) and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CSTF2 Gene

Protein tissue co-expression partners for CSTF2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CSTF2 Gene:


SOURCE GeneReport for Unigene cluster for CSTF2 Gene:


Evidence on tissue expression from TISSUES for CSTF2 Gene

  • Kidney(4.2)
genes like me logo Genes that share expression patterns with CSTF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSTF2 Gene

Orthologs for CSTF2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSTF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CSTF2 34 33
  • 99.94 (n)
(Canis familiaris)
Mammalia CSTF2 34 33
  • 92.72 (n)
(Bos Taurus)
Mammalia CSTF2 34 33
  • 92.25 (n)
(Rattus norvegicus)
Mammalia Cstf2 33
  • 90.44 (n)
(Mus musculus)
Mammalia Cstf2 16 34 33
  • 89.49 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 73 (a)
(Gallus gallus)
Aves CSTF2 34 33
  • 74.46 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia cstf2 33
  • 71.84 (n)
Str.5893 33
(Danio rerio)
Actinopterygii LOC100534697 33
  • 70.76 (n)
cstf2 34 34
  • 69 (a)
wufb11e07 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7345 33
fruit fly
(Drosophila melanogaster)
Insecta CstF-64 34 35
  • 53 (a)
(Caenorhabditis elegans)
Secernentea cpf-2 34
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IST3 34
  • 22 (a)
RIE1 36
(Oryza sativa)
Liliopsida Os.21809 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
Species where no ortholog for CSTF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSTF2 Gene

Gene Tree for CSTF2 (if available)
Gene Tree for CSTF2 (if available)
Evolutionary constrained regions (ECRs) for CSTF2: view image

Paralogs for CSTF2 Gene

Paralogs for CSTF2 Gene

(8) SIMAP similar genes for CSTF2 Gene using alignment to 4 proteins:

  • B3V096_HUMAN
genes like me logo Genes that share paralogs with CSTF2: view

Variants for CSTF2 Gene

Sequence variations from dbSNP and Humsavar for CSTF2 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000118488 -- 100,828,410(+) G/T intron_variant
rs1000459783 -- 100,838,449(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000469182 -- 100,820,010(+) T/C upstream_transcript_variant
rs1000568269 -- 100,830,714(+) A/G intron_variant
rs1000633162 -- 100,820,245(+) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CSTF2 Gene

Variant ID Type Subtype PubMed ID
nsv510850 CNV deletion 20534489

Variation tolerance for CSTF2 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CSTF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSTF2 Gene

Disorders for CSTF2 Gene

Additional Disease Information for CSTF2

No disorders were found for CSTF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSTF2 Gene

Publications for CSTF2 Gene

  1. Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination. (PMID: 11389848) Calvo O … Manley JL (Molecular cell 2001) 3 4 22 58
  2. Association of human DEAD box protein DDX1 with a cleavage stimulation factor involved in 3'-end processing of pre-MRNA. (PMID: 11598190) Bléoo S … Godbout R (Molecular biology of the cell 2001) 3 4 22 58
  3. Complex protein interactions within the human polyadenylation machinery identify a novel component. (PMID: 10669729) Takagaki Y … Manley JL (Molecular and cellular biology 2000) 3 4 22 58
  4. Increase in the 64-kDa subunit of the polyadenylation/cleavage stimulatory factor during the G0 to S phase transition. (PMID: 9736695) Martincic K … Milcarek C (Proceedings of the National Academy of Sciences of the United States of America 1998) 3 4 22 58
  5. RNA recognition by the human polyadenylation factor CstF. (PMID: 9199325) Takagaki Y … Manley JL (Molecular and cellular biology 1997) 3 4 22 58

Products for CSTF2 Gene

Sources for CSTF2 Gene

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