CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the f... See more...

Aliases for CSRP2 Gene

Aliases for CSRP2 Gene

  • Cysteine And Glycine Rich Protein 2 2 3 5
  • SmLIM 2 3 4
  • CRP2 2 3 4
  • LMO5 2 3 4
  • Cysteine And Glycine-Rich Protein 2 3 4
  • Smooth Muscle Cell LIM Protein 3 4
  • LIM Domain Only Protein 5 3 4
  • Cysteine-Rich Protein 2 3 4
  • LMO-5 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • LIM Domain Only 5, Smooth Muscle 3
  • CSRP2 5
  • SMLIM 4

External Ids for CSRP2 Gene

Previous GeneCards Identifiers for CSRP2 Gene

  • GC12M076841
  • GC12M077594
  • GC12M077185
  • GC12M075754
  • GC12M074305

Summaries for CSRP2 Gene

Entrez Gene Summary for CSRP2 Gene

  • CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for CSRP2 Gene

CSRP2 (Cysteine And Glycine Rich Protein 2) is a Protein Coding gene. Diseases associated with CSRP2 include Vertical Talus, Congenital. Among its related pathways are Immune response IL-23 signaling pathway and ATF-2 transcription factor network. An important paralog of this gene is CSRP1.

UniProtKB/Swiss-Prot Summary for CSRP2 Gene

  • Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system.

Gene Wiki entry for CSRP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CSRP2 Gene

Genomics for CSRP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CSRP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J076876 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 259.2 +0.4 374 4.6 ZNF600 IKZF1 ATF2 POLR2A ZBTB10 YY1 FEZF1 ZNF639 TBP ZNF341 CSRP2 ENSG00000257910 lnc-E2F7-6 lnc-CSRP2-1 ZDHHC17
GH12J076907 Enhancer 0.9 Ensembl ENCODE 21.9 -29.4 -29378 3.6 ZSCAN16 ZIC2 FEZF1 ZNF843 PRDM6 ZNF189 ATF2 GLIS1 SP7 PRDM4 CSRP2 HSALNG0092572 HSALNG0092571 E2F7
GH12J076915 Enhancer 0.5 Ensembl 20.9 -37.0 -36977 1.2 JUND FOXA2 ZNF843 HNF4A ZEB2 REST YY1 SP1 HSALNG0092572 CSRP2 HSALNG0092571 E2F7
GH12J076920 Enhancer 0.8 Ensembl ENCODE 11.1 -41.6 -41578 2 FOXA2 HNF4A SCRT1 RAD21 SP1 TRIM28 SPI1 MYNN YY1 RXRA CSRP2 HSALNG0092572 piR-38051-072 E2F7
GH12J076883 Enhancer 0.7 Ensembl ENCODE 8 -4.4 -4378 1.6 ATF2 FEZF1 ZNF623 RAD51 GLIS1 BHLHE40 ZEB2 KLF8 USF1 NR2F2 lnc-CSRP2-1 CSRP2 E2F7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CSRP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CSRP2

Top Transcription factor binding sites by QIAGEN in the CSRP2 gene promoter:
  • Elk-1
  • FOXO4
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • Meis-1b
  • TBP

Genomic Locations for CSRP2 Gene

Latest Assembly
chr12:76,858,709-76,879,023
(GRCh38/hg38)
Size:
20,315 bases
Orientation:
Minus strand

Previous Assembly
chr12:77,252,489-77,272,799
(GRCh37/hg19 by Entrez Gene)
Size:
20,311 bases
Orientation:
Minus strand

chr12:77,252,495-77,272,840
(GRCh37/hg19 by Ensembl)
Size:
20,346 bases
Orientation:
Minus strand

Genomic View for CSRP2 Gene

Genes around CSRP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSRP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSRP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSRP2 Gene

Proteins for CSRP2 Gene

  • Protein details for CSRP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16527-CSRP2_HUMAN
    Recommended name:
    Cysteine and glycine-rich protein 2
    Protein Accession:
    Q16527
    Secondary Accessions:
    • Q93030

    Protein attributes for CSRP2 Gene

    Size:
    193 amino acids
    Molecular mass:
    20954 Da
    Quaternary structure:
    • Interacts with KAT14. The LIM domain 1 is necessary and sufficient for this interaction. Interacts with GLRX3 (By similarity).

neXtProt entry for CSRP2 Gene

Post-translational modifications for CSRP2 Gene

  • Ubiquitination at Lys65 and Lys69
  • Modification sites at PhosphoSitePlus

Other Protein References for CSRP2 Gene

No data available for DME Specific Peptides for CSRP2 Gene

Domains & Families for CSRP2 Gene

Gene Families for CSRP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CSRP2 Gene

InterPro:
Blocks:
  • Zn-binding protein, LIM

Suggested Antigen Peptide Sequences for CSRP2 Gene

GenScript: Design optimal peptide antigens:
  • Smooth muscle cell LIM protein (CSRP2_HUMAN)
genes like me logo Genes that share domains with CSRP2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CSRP2 Gene

Function for CSRP2 Gene

Molecular function for CSRP2 Gene

UniProtKB/Swiss-Prot Function:
Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system.
GENATLAS Biochemistry:
cysteine and glycine rich protein 2,putatively involved in cellular growth control,likely involved in the determination of cell lineage and regulation of cell differentiation

Phenotypes From GWAS Catalog for CSRP2 Gene

Gene Ontology (GO) - Molecular Function for CSRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
GO:0008307 structural constituent of muscle IBA 21873635
GO:0042805 actinin binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CSRP2: view
genes like me logo Genes that share phenotypes with CSRP2: view

Animal Models for CSRP2 Gene

MGI Knock Outs for CSRP2:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSRP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSRP2 Gene

Localization for CSRP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSRP2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSRP2 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CSRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,NAS 8626582
GO:0005737 cytoplasm IBA 21873635
GO:0005925 focal adhesion HDA 21423176
GO:0030018 Z disc IBA 21873635
genes like me logo Genes that share ontologies with CSRP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CSRP2 Gene

Pathways & Interactions for CSRP2 Gene

PathCards logo

SuperPathways for CSRP2 Gene

genes like me logo Genes that share pathways with CSRP2: view

Pathways by source for CSRP2 Gene

1 GeneGo (Thomson Reuters) pathway for CSRP2 Gene
  • Immune response IL-10 signaling pathway

Gene Ontology (GO) - Biological Process for CSRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0030036 actin cytoskeleton organization IBA 21873635
GO:0030154 cell differentiation NAS 8626582
GO:0045214 sarcomere organization IBA 21873635
GO:0060537 muscle tissue development IBA 21873635
genes like me logo Genes that share ontologies with CSRP2: view

No data available for SIGNOR curated interactions for CSRP2 Gene

Drugs & Compounds for CSRP2 Gene

(1) Drugs for CSRP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CSRP2: view

Transcripts for CSRP2 Gene

mRNA/cDNA for CSRP2 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSRP2

Alternative Splicing Database (ASD) splice patterns (SP) for CSRP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: - -
SP3:

Relevant External Links for CSRP2 Gene

GeneLoc Exon Structure for
CSRP2

Expression for CSRP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CSRP2 Gene

mRNA differential expression in normal tissues according to GTEx for CSRP2 Gene

This gene is overexpressed in Artery - Tibial (x6.3) and Artery - Coronary (x4.3).

Protein differential expression in normal tissues from HIPED for CSRP2 Gene

This gene is overexpressed in Amniocyte (20.8), Placenta (11.2), and Uterus (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CSRP2 Gene



Protein tissue co-expression partners for CSRP2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CSRP2

SOURCE GeneReport for Unigene cluster for CSRP2 Gene:

Hs.530904

mRNA Expression by UniProt/SwissProt for CSRP2 Gene:

Q16527-CSRP2_HUMAN
Tissue specificity: Highly expressed in the aorta, but not in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for CSRP2 Gene

  • Nervous system(3.5)
  • Heart(2.7)
  • Muscle(2.6)
  • Kidney(2.4)
  • Liver(2.3)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with CSRP2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CSRP2 Gene

Orthologs for CSRP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CSRP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CSRP2 29 30
  • 99.65 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 97 (a)
OneToMany
-- 30
  • 96 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia CSRP2 29 30
  • 93.78 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Csrp2 29
  • 93.61 (n)
Mouse
(Mus musculus)
Mammalia Csrp2 29 16 30
  • 91.88 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CSRP2 30
  • 91 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia CSRP2 30
  • 90 (a)
OneToOne
LOC475409 29
  • 85.26 (n)
Chicken
(Gallus gallus)
Aves CSRP2 29 30
  • 82.21 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CSRP2 30
  • 89 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia csrp2 29
  • 78.82 (n)
Str.6131 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.15138 29
Zebrafish
(Danio rerio)
Actinopterygii csrp2 29 30
  • 75.99 (n)
OneToOne
zgc77740 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8116 29
Fruit Fly
(Drosophila melanogaster)
Insecta Mlp84B 29 30 31
  • 55.56 (n)
ManyToMany
Mlp60A 30
  • 20 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012305 29
  • 55.43 (n)
Worm
(Caenorhabditis elegans)
Secernentea mlp-1 29 30
  • 50.83 (n)
OneToMany
Species where no ortholog for CSRP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CSRP2 Gene

ENSEMBL:
Gene Tree for CSRP2 (if available)
TreeFam:
Gene Tree for CSRP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CSRP2: view image
Alliance of Genome Resources:
Additional Orthologs for CSRP2

Paralogs for CSRP2 Gene

Paralogs for CSRP2 Gene

(5) SIMAP similar genes for CSRP2 Gene using alignment to 3 proteins:

  • CSRP2_HUMAN
  • F8VQR7_HUMAN
  • F8VW96_HUMAN

Pseudogenes.org Pseudogenes for CSRP2 Gene

genes like me logo Genes that share paralogs with CSRP2: view

Variants for CSRP2 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CSRP2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for CSRP2 Gene

Residual Variation Intolerance Score: 36.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CSRP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSRP2
Leiden Open Variation Database (LOVD)
CSRP2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for CSRP2 Gene

Disorders for CSRP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CSRP2 Gene - From: COP

Disorder Aliases PubMed IDs
vertical talus, congenital
  • cvt
- elite association - COSMIC cancer census association via MalaCards
Search CSRP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CSRP2

genes like me logo Genes that share disorders with CSRP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CSRP2 Gene

Publications for CSRP2 Gene

  1. Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2. (PMID: 9286703) Weiskirchen R … Bister K (Genomics 1997) 2 3 4 22
  2. The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein (CRP2BP). (PMID: 10924333) Weiskirchen R … Gressner AM (Biochemical and biophysical research communications 2000) 3 4 22
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1. (PMID: 11672422) Weiskirchen R … Gressner AM (The Biochemical journal 2001) 3 22
  5. Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells. (PMID: 8626582) Jain MK … Lee ME (The Journal of biological chemistry 1996) 3 4

Products for CSRP2 Gene

Sources for CSRP2 Gene