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CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
CSRP2 (Cysteine And Glycine Rich Protein 2) is a Protein Coding gene. Among its related pathways are Mesodermal Commitment Pathway and Immune response IL-23 signaling pathway. An important paralog of this gene is CSRP1.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH12J076876 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE CraniofacialAtlas | 609.2 | +0.4 | 374 | 4.6 | CTCF PRDM10 ZNF629 IKZF1 TARDBP PRDM1 RBFOX2 POLR2A PATZ1 IKZF2 | CSRP2 ENSG00000257910 lnc-E2F7-6 lnc-CSRP2-1 ZDHHC17 | |
GH12J076907 | Enhancer | 0.8 | Ensembl ENCODE | 21.9 | -29.4 | -29378 | 3.6 | PRDM10 ZIC2 PATZ1 ZNF561 ZXDB OSR2 BCL11A USF1 ZBTB17 ZNF189 | CSRP2 lnc-CSRP2-1 piR-38051-072 E2F7 | |
GH12J076915 | Enhancer | 0.6 | Ensembl | 20.9 | -37.0 | -36978 | 1.2 | REST FOXA1 FOXA2 GATA3 JUND ZNF843 HNF4A YY1 SP1 ZEB2 | CSRP2 piR-38051-072 lnc-CSRP2-1 E2F7 | |
GH12J076920 | Enhancer | 0.8 | Ensembl ENCODE | 11.1 | -41.6 | -41577 | 2 | SP1 SCRT2 RELB RUNX3 FOXA2 MYNN SCRT1 RAD21 HNF4A TRIM28 | CSRP2 piR-38051-072 lnc-CSRP2-1 E2F7 | |
GH12J076883 | Enhancer | 0.7 | Ensembl ENCODE | 8 | -4.4 | -4378 | 1.6 | USF1 ATF2 ZNF623 NR2F2 KLF8 POLR2A BHLHE40 FEZF1 GLIS1 SMARCA4 | lnc-CSRP2-1 CSRP2 E2F7 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003674 | molecular_function | ND | -- |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0008307 | structural constituent of muscle | IBA | 21873635 |
GO:0042805 | actinin binding | IBA | 21873635 |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | NAS | 8626582 |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005925 | focal adhesion | HDA | 21423176 |
GO:0030018 | Z disc | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Immune response IL-23 signaling pathway |
Immune response IL-10 signaling pathway
.36
|
|
2 | ATF-2 transcription factor network | ||
3 | Mesodermal Commitment Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007275 | multicellular organism development | IEA | -- |
GO:0030036 | actin cytoskeleton organization | IBA | 21873635 |
GO:0030154 | cell differentiation | NAS | 8626582 |
GO:0045214 | sarcomere organization | IBA | 21873635 |
GO:0060537 | muscle tissue development | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||
SP3: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CSRP2 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | CSRP2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Csrp2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Csrp2 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CSRP2 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CSRP2 31 |
|
OneToOne | |
LOC475409 30 |
|
||||
Chicken (Gallus gallus) |
Aves | CSRP2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CSRP2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | csrp2 30 |
|
||
Str.6131 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.15138 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | csrp2 30 31 |
|
OneToOne | |
zgc77740 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8116 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Mlp84B 30 31 32 |
|
ManyToMany | |
Mlp60A 31 |
|
ManyToMany | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012305 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | mlp-1 30 31 |
|
OneToMany |
No disorders were found for CSRP2 Gene.