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Aliases for CSRP1 Gene

Aliases for CSRP1 Gene

  • Cysteine And Glycine Rich Protein 1 2 3 5
  • Epididymis Luminal Protein 141 3 4
  • Cysteine-Rich Protein 1 3 4
  • HEL-141 3 4
  • CYRP 3 4
  • CRP1 3 4
  • CSRP 3 4
  • CRP 3 4
  • Cysteine And Glycine-Rich Protein 1 3
  • Epididymis Secretory Protein Li 286 3
  • LIM-Domain Protein 3
  • HEL-S-286 3
  • D1S181E 3

External Ids for CSRP1 Gene

Previous HGNC Symbols for CSRP1 Gene

  • CYRP

Previous GeneCards Identifiers for CSRP1 Gene

  • GC01M199155
  • GC01M196889
  • GC01M197919
  • GC01M198740
  • GC01M198184
  • GC01M199719
  • GC01M172618

Summaries for CSRP1 Gene

Entrez Gene Summary for CSRP1 Gene

  • This gene encodes a member of the cysteine-rich protein (CSRP) family. This gene family includes a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this gene product occurs in proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]

GeneCards Summary for CSRP1 Gene

CSRP1 (Cysteine And Glycine Rich Protein 1) is a Protein Coding gene. Diseases associated with CSRP1 include Pontiac Fever and Endocardial Fibroelastosis. Among its related pathways are MECP2 and Associated Rett Syndrome. An important paralog of this gene is CSRP2.

UniProtKB/Swiss-Prot for CSRP1 Gene

  • Could play a role in neuronal development.

Gene Wiki entry for CSRP1 Gene

Additional gene information for CSRP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSRP1 Gene

Genomics for CSRP1 Gene

GeneHancer (GH) Regulatory Elements for CSRP1 Gene

Promoters and enhancers for CSRP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J201498 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 656.5 +6.3 6315 10.2 PKNOX1 FOXA2 ZFP64 NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 CSRP1 IPO9-AS1 ELF3-AS1 IPO9 RNPEP ENSG00000273478 DDX59 RPS10P7 NAV1 LMOD1
GH01J201508 Enhancer 0.6 ENCODE dbSUPER 650.7 +0.3 347 1.3 SMARCA5 FOS CSRP1 ENSG00000224536 RPS10P7
GH01J201645 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.8 -139.7 -139749 7.1 PKNOX1 ATF1 SIN3A GLIS2 SP3 REST MBD2 MEF2D ZNF184 SMARCA4 GC01P201650 NAV1 ENSG00000236390 RNU6-501P ENSG00000235121 IPO9 IPO9-AS1 CSRP1 ENSG00000224536 LMOD1
GH01J201530 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12.1 -22.0 -22012 2.8 HDAC1 PKNOX1 CLOCK ATF1 RB1 ZSCAN4 SIN3A ZNF2 RAD21 GLIS2 NAV1 ENSG00000224536 CSRP1 PHLDA3 ENSG00000224818 RNU6-501P ENSG00000235121 ENSG00000236390 RPS10P7 GC01P201537
GH01J201709 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -203.9 -203886 8.7 HDGF PKNOX1 NEUROD1 SIN3A ZNF2 ZBTB7B ZNF143 ZNF548 FOS KLF13 NAV1 MIR1231 RPS27P8 ENSG00000236390 CSRP1 ENSG00000224536 PHLDA3 ENSG00000224818 ARL8A MIR5191
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CSRP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CSRP1 gene promoter:
  • CHOP-10
  • C/EBPalpha
  • GATA-3
  • Olf-1
  • AP-4
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for CSRP1 Gene

Genomic Locations for CSRP1 Gene
chr1:201,483,530-201,509,456
(GRCh38/hg38)
Size:
25,927 bases
Orientation:
Minus strand
chr1:201,452,658-201,478,584
(GRCh37/hg19)
Size:
25,927 bases
Orientation:
Minus strand

Genomic View for CSRP1 Gene

Genes around CSRP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSRP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSRP1 Gene

Proteins for CSRP1 Gene

  • Protein details for CSRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21291-CSRP1_HUMAN
    Recommended name:
    Cysteine and glycine-rich protein 1
    Protein Accession:
    P21291
    Secondary Accessions:
    • A8K268
    • Q5U0J2

    Protein attributes for CSRP1 Gene

    Size:
    193 amino acids
    Molecular mass:
    20567 Da
    Quaternary structure:
    • Interacts with ASCC1; ASCC2 AND TRIP4.

neXtProt entry for CSRP1 Gene

Post-translational modifications for CSRP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for CSRP1
  • Boster Bio Antibodies for CSRP1

No data available for DME Specific Peptides for CSRP1 Gene

Domains & Families for CSRP1 Gene

Gene Families for CSRP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CSRP1 Gene

Blocks:
InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CSRP1: view

No data available for UniProtKB/Swiss-Prot for CSRP1 Gene

Function for CSRP1 Gene

Molecular function for CSRP1 Gene

UniProtKB/Swiss-Prot Function:
Could play a role in neuronal development.
GENATLAS Biochemistry:
cysteine and glycine rich protein,20.5kDa,expressed by a serum-inducible immediate response gene,likely involved in the determination of cell lineage and regulation of cell differentiation

Phenotypes From GWAS Catalog for CSRP1 Gene

Gene Ontology (GO) - Molecular Function for CSRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0008270 zinc ion binding TAS 1374386
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CSRP1: view
genes like me logo Genes that share phenotypes with CSRP1: view

Animal Models for CSRP1 Gene

MGI Knock Outs for CSRP1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSRP1 Gene

Localization for CSRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSRP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSRP1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CSRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 26924529
GO:0005925 focal adhesion HDA 21423176
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with CSRP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CSRP1 Gene

Pathways & Interactions for CSRP1 Gene

genes like me logo Genes that share pathways with CSRP1: view

Pathways by source for CSRP1 Gene

1 BioSystems pathway for CSRP1 Gene

Gene Ontology (GO) - Biological Process for CSRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070527 platelet aggregation HMP 23382103
genes like me logo Genes that share ontologies with CSRP1: view

No data available for SIGNOR curated interactions for CSRP1 Gene

Drugs & Compounds for CSRP1 Gene

(3) Drugs for CSRP1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dihydroartemisinin Approved, Investigational Pharma Target, ligand 100
genes like me logo Genes that share compounds with CSRP1: view

Transcripts for CSRP1 Gene

Unigene Clusters for CSRP1 Gene

Cysteine and glycine-rich protein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSRP1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - - -
SP9: - -
SP10: - - - - - - - - - - - -
SP11: -
SP12: - - - - - - - - - - - -
SP13: - - - - -
SP14:

ExUns: 8f ^ 9a · 9b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for CSRP1 Gene

GeneLoc Exon Structure for
CSRP1
ECgene alternative splicing isoforms for
CSRP1

Expression for CSRP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CSRP1 Gene

mRNA differential expression in normal tissues according to GTEx for CSRP1 Gene

This gene is overexpressed in Colon - Sigmoid (x4.8), Artery - Tibial (x4.5), and Esophagus - Muscularis (x4.0).

Protein differential expression in normal tissues from HIPED for CSRP1 Gene

This gene is overexpressed in Prostate (8.9), Cardia (8.4), Urinary Bladder (7.9), and Colon muscle (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CSRP1 Gene



Protein tissue co-expression partners for CSRP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CSRP1 Gene:

CSRP1

SOURCE GeneReport for Unigene cluster for CSRP1 Gene:

Hs.108080

Evidence on tissue expression from TISSUES for CSRP1 Gene

  • Nervous system(5)
  • Intestine(4.6)
  • Liver(4.3)
  • Lung(3.8)
  • Stomach(3.8)
  • Kidney(3.7)
  • Skin(3.5)
  • Muscle(2.5)
  • Eye(2.2)
  • Gall bladder(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with CSRP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSRP1 Gene

Orthologs for CSRP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CSRP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSRP1 34 33
  • 99.31 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CSRP1 34
  • 97 (a)
OneToOne
LOC607054 33
  • 91.36 (n)
mouse
(Mus musculus)
Mammalia Csrp1 16 34 33
  • 90.85 (n)
cow
(Bos Taurus)
Mammalia CSRP1 34 33
  • 90.33 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csrp1 33
  • 89.29 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CSRP1 34
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CSRP1 34
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves CSRP1 34 33
  • 81.94 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSRP1 34
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia csrp1 33
  • 72.54 (n)
zebrafish
(Danio rerio)
Actinopterygii csrp1b 34
  • 82 (a)
OneToMany
csrp1a 34 33
  • 74.13 (n)
OneToMany
csrp1 33
fruit fly
(Drosophila melanogaster)
Insecta Mlp60A 34
  • 20 (a)
ManyToMany
Mlp84B 34 35
  • 20 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea mlp-1 34
  • 48 (a)
OneToMany
Species where no ortholog for CSRP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSRP1 Gene

ENSEMBL:
Gene Tree for CSRP1 (if available)
TreeFam:
Gene Tree for CSRP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CSRP1: view image

Paralogs for CSRP1 Gene

Paralogs for CSRP1 Gene

(10) SIMAP similar genes for CSRP1 Gene using alignment to 4 proteins:

  • CSRP1_HUMAN
  • E9PND2_HUMAN
  • E9PP21_HUMAN
  • E9PS42_HUMAN
genes like me logo Genes that share paralogs with CSRP1: view

Variants for CSRP1 Gene

Sequence variations from dbSNP and Humsavar for CSRP1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000037925 -- 201,492,219(-) T/C intron_variant
rs1000091437 -- 201,500,439(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000106423 -- 201,486,128(-) G/T intron_variant
rs1000191763 -- 201,494,026(-) G/A intron_variant
rs1000388937 -- 201,491,948(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CSRP1 Gene

Variant ID Type Subtype PubMed ID
esv3578371 CNV loss 25503493
nsv1009060 CNV gain 25217958
nsv1145393 CNV deletion 24896259
nsv467961 CNV gain 19166990
nsv470776 CNV gain 18288195
nsv548997 CNV gain 21841781
nsv832315 CNV loss 17160897
nsv947466 CNV duplication 23825009

Variation tolerance for CSRP1 Gene

Residual Variation Intolerance Score: 43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CSRP1 Gene

Human Gene Mutation Database (HGMD)
CSRP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSRP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSRP1 Gene

Disorders for CSRP1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CSRP1 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pontiac fever
endocardial fibroelastosis
  • efe
bruxism
  • bruxism - teeth grinding
- elite association - COSMIC cancer census association via MalaCards
Search CSRP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CSRP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CSRP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CSRP1 Gene

Publications for CSRP1 Gene

  1. Characterization of a human cDNA encoding a widely expressed and highly conserved cysteine-rich protein with an unusual zinc-finger motif. (PMID: 2115670) Liebhaber SA … Cooke NE (Nucleic acids research 1990) 2 3 4 58
  2. Mutations in Subunits of the Activating Signal Cointegrator 1 Complex Are Associated with Prenatal Spinal Muscular Atrophy and Congenital Bone Fractures. (PMID: 26924529) Knierim E … Schuelke M (American journal of human genetics 2016) 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Ultraviolet B radiation regulates cysteine-rich protein 1 in human keratinocytes. (PMID: 20415737) Latonen L … Laiho M (Photodermatology, photoimmunology & photomedicine 2010) 3 22 58
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58

Products for CSRP1 Gene

Sources for CSRP1 Gene

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