Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CSRNP3 Gene

Aliases for CSRNP3 Gene

  • Cysteine And Serine Rich Nuclear Protein 3 2 3 5
  • Family With Sequence Similarity 130, Member A2 2 3
  • Protein Phosphatase 1, Regulatory Subunit 73 2 3
  • FAM130A2 3 4
  • TAIP-2 3 4
  • TAIP2 3 4
  • Cysteine-Serine-Rich Nuclear Protein 3 2
  • Cysteine/Serine-Rich Nuclear Protein 3 3
  • TGF-Beta Induced Apoptosis Protein 2 3
  • TGF-Beta-Induced Apoptosis Protein 2 4
  • TGF Beta Induced Apotosis Protein 2 2
  • Protein FAM130A2 4
  • PPP1R73 3
  • CSRNP-3 4

External Ids for CSRNP3 Gene

Previous HGNC Symbols for CSRNP3 Gene

  • FAM130A2

Previous GeneCards Identifiers for CSRNP3 Gene

  • GC02P166036
  • GC02P166138
  • GC02P166326
  • GC02P158208

Summaries for CSRNP3 Gene

GeneCards Summary for CSRNP3 Gene

CSRNP3 (Cysteine And Serine Rich Nuclear Protein 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is CSRNP2.

UniProtKB/Swiss-Prot for CSRNP3 Gene

  • Binds to the consensus sequence 5-AGAGTG-3 and has transcriptional activator activity. Plays a role in apoptosis (By similarity).

Additional gene information for CSRNP3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSRNP3 Gene

Genomics for CSRNP3 Gene

GeneHancer (GH) Regulatory Elements for CSRNP3 Gene

Promoters and enhancers for CSRNP3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I165469 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 555.8 +0.2 154 1.2 PKNOX1 TAF1 ZNF384 FEZF1 RAD21 YY1 ZNF335 ZNF213 ZNF366 POLR2A CSRNP3 SCN2A GC02P165687
GH02I165572 Promoter 0.9 EPDnew 550.1 +102.7 102676 0.1 MXI1 ZNF529 ZNF843 OSR2 ZSCAN21 POLR2A SCRT2 ZSCAN5C ZNF600 RCOR1 CSRNP3 GC02P165687
GH02I165697 Enhancer 0.9 FANTOM5 Ensembl ENCODE 4.4 +228.5 228520 1.6 CTCF ZNF654 TRIM22 ZNF143 SMC3 RAD21 GALNT3 CSRNP3 GC02P165687
GH02I165067 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 2.5 -401.3 -401276 0.9 MXI1 RFX1 BMI1 SP1 ZSCAN21 ZNF335 RFX3 POLR2A ZNF366 CTBP2 SCN3A CSRNP3 SCN2A GC02M165092 SLC38A11 ENSG00000236283
GH02I165606 Enhancer 0.2 FANTOM5 7.9 +136.9 136851 0.2 CSRNP3 SCN3A TTC21B SCN2A GC02P165687
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CSRNP3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CSRNP3 gene promoter:

Genomic Locations for CSRNP3 Gene

Genomic Locations for CSRNP3 Gene
chr2:165,469,647-165,689,407
(GRCh38/hg38)
Size:
219,761 bases
Orientation:
Plus strand
chr2:166,326,157-166,545,917
(GRCh37/hg19)

Genomic View for CSRNP3 Gene

Genes around CSRNP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSRNP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSRNP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSRNP3 Gene

Proteins for CSRNP3 Gene

  • Protein details for CSRNP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WYN3-CSRN3_HUMAN
    Recommended name:
    Cysteine/serine-rich nuclear protein 3
    Protein Accession:
    Q8WYN3
    Secondary Accessions:
    • B3KPR4
    • Q53SG0
    • Q6ZTX3
    • Q9HAF9

    Protein attributes for CSRNP3 Gene

    Size:
    585 amino acids
    Molecular mass:
    64900 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13890.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC86454.1; Type=Frameshift; Positions=180; Evidence={ECO:0000305}; Sequence=BAC86454.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305};

    Alternative splice isoforms for CSRNP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSRNP3 Gene

Post-translational modifications for CSRNP3 Gene

No Post-translational modifications

Other Protein References for CSRNP3 Gene

No data available for DME Specific Peptides for CSRNP3 Gene

Domains & Families for CSRNP3 Gene

Gene Families for CSRNP3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for CSRNP3 Gene

Suggested Antigen Peptide Sequences for CSRNP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WYN3

UniProtKB/Swiss-Prot:

CSRN3_HUMAN :
  • Belongs to the AXUD1 family.
Family:
  • Belongs to the AXUD1 family.
genes like me logo Genes that share domains with CSRNP3: view

Function for CSRNP3 Gene

Molecular function for CSRNP3 Gene

UniProtKB/Swiss-Prot Function:
Binds to the consensus sequence 5-AGAGTG-3 and has transcriptional activator activity. Plays a role in apoptosis (By similarity).

Phenotypes From GWAS Catalog for CSRNP3 Gene

Gene Ontology (GO) - Molecular Function for CSRNP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA,ISS 17726538
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with CSRNP3: view
genes like me logo Genes that share phenotypes with CSRNP3: view

Animal Models for CSRNP3 Gene

MGI Knock Outs for CSRNP3:

miRNA for CSRNP3 Gene

miRTarBase miRNAs that target CSRNP3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSRNP3 Gene

Localization for CSRNP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSRNP3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSRNP3 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CSRNP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS 17726538
genes like me logo Genes that share ontologies with CSRNP3: view

Pathways & Interactions for CSRNP3 Gene

SuperPathways for CSRNP3 Gene

No Data Available

Interacting Proteins for CSRNP3 Gene

Selected Interacting proteins: Q8WYN3-CSRN3_HUMAN for CSRNP3 Gene via IID

Symbol External ID(s) Details
PPP1CA

Gene Ontology (GO) - Biological Process for CSRNP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II IEA --
GO:0006915 apoptotic process IEA --
GO:0010923 negative regulation of phosphatase activity IDA 19389623
genes like me logo Genes that share ontologies with CSRNP3: view

No data available for Pathways by source and SIGNOR curated interactions for CSRNP3 Gene

Drugs & Compounds for CSRNP3 Gene

(1) Drugs for CSRNP3 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bisphosphonates Pharma 0
genes like me logo Genes that share compounds with CSRNP3: view

Transcripts for CSRNP3 Gene

mRNA/cDNA for CSRNP3 Gene

Unigene Clusters for CSRNP3 Gene

Cysteine-serine-rich nuclear protein 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSRNP3 Gene

No ASD Table

Relevant External Links for CSRNP3 Gene

GeneLoc Exon Structure for
CSRNP3
ECgene alternative splicing isoforms for
CSRNP3

Expression for CSRNP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CSRNP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CSRNP3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.3), Brain - Anterior cingulate cortex (BA24) (x4.8), and Brain - Nucleus accumbens (basal ganglia) (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of CSRNP3 Gene:

CSRNP3

SOURCE GeneReport for Unigene cluster for CSRNP3 Gene:

Hs.470479

Evidence on tissue expression from TISSUES for CSRNP3 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with CSRNP3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSRNP3 Gene

Orthologs for CSRNP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CSRNP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSRNP3 33 34
  • 99.32 (n)
cow
(Bos Taurus)
Mammalia CSRNP3 33 34
  • 89.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CSRNP3 34
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Csrnp3 33 16 34
  • 86.51 (n)
rat
(Rattus norvegicus)
Mammalia Csrnp3 33
  • 86.22 (n)
oppossum
(Monodelphis domestica)
Mammalia CSRNP3 34
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CSRNP3 33 34
  • 81.01 (n)
chicken
(Gallus gallus)
Aves CSRNP3 33 34
  • 80.67 (n)
lizard
(Anolis carolinensis)
Reptilia CSRNP3 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia csrnp3 33
  • 72.38 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100332048 33
  • 64.83 (n)
CSRNP3 34
  • 58 (a)
OneToOne
-- 33
fruit fly
(Drosophila melanogaster)
Insecta Axud1 34
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C41D11.3 34
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7164 34
  • 25 (a)
OneToMany
Species where no ortholog for CSRNP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSRNP3 Gene

ENSEMBL:
Gene Tree for CSRNP3 (if available)
TreeFam:
Gene Tree for CSRNP3 (if available)

Paralogs for CSRNP3 Gene

Paralogs for CSRNP3 Gene

(2) SIMAP similar genes for CSRNP3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CSRNP3: view

Variants for CSRNP3 Gene

Sequence variations from dbSNP and Humsavar for CSRNP3 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs766623860 A colorectal cancer sample 165,679,416(+) C/T coding_sequence_variant, missense_variant
rs1000001242 -- 165,580,072(+) G/A intron_variant
rs1000024753 -- 165,594,957(+) G/T intron_variant
rs1000031155 -- 165,517,176(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000033356 -- 165,641,787(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CSRNP3 Gene

Variant ID Type Subtype PubMed ID
nsv3017 CNV deletion 18451855
nsv472476 CNV novel sequence insertion 20440878
nsv583583 CNV gain 21841781
nsv956684 CNV deletion 24416366
nsv956709 CNV deletion 24416366
nsv3016 CNV insertion 18451855
nsv1147849 CNV duplication 26484159
nsv1136432 CNV deletion 24896259
nsv1125706 CNV tandem duplication 24896259
nsv1115582 CNV duplication 24896259
nsv1109310 CNV deletion 24896259
nsv1109309 CNV deletion 24896259
nsv1015115 CNV loss 25217958
esv4871 CNV loss 18987735
esv3593239 CNV loss 21293372
esv3560476 CNV deletion 23714750
esv3338498 CNV insertion 20981092
esv3307854 CNV mobile element insertion 20981092
esv2721075 CNV deletion 23290073
esv2721074 CNV deletion 23290073
esv2721072 CNV deletion 23290073
esv2721071 CNV deletion 23290073
esv2721070 CNV deletion 23290073

Variation tolerance for CSRNP3 Gene

Residual Variation Intolerance Score: 21.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.70; 57.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CSRNP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSRNP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSRNP3 Gene

Disorders for CSRNP3 Gene

Additional Disease Information for CSRNP3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CSRNP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSRNP3 Gene

Publications for CSRNP3 Gene

  1. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PMID: 19401682) Maestrini E … IMGSAC (Molecular psychiatry 2010) 3 44 58
  2. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PMID: 20468071) Dick DM … Bierut L (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 44 58
  3. Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP). (PMID: 17726538) Gingras S … Ihle JN (PloS one 2007) 2 3 58
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for CSRNP3 Gene

Sources for CSRNP3 Gene

Content
Loading form....