This gene encodes a protein that is highly similar to the casein kinase II alpha protein. Casein kinase II is a serine/threonine protein kinase complex that phosphorylates numerous substrates including casein. The alpha subunit is the catalytic component of the complex. Mutations in this gene may be associated with a susceptibility to lung cancer. There are contradictory views ... See more...

Aliases for CSNK2A3 Gene

Aliases for CSNK2A3 Gene

  • Casein Kinase 2 Alpha 3 2 3 5
  • Casein Kinase 2, Alpha 1 Polypeptide Pseudogene 2 3
  • Casein Kinase 2, Alpha 3 Polypeptide 2 3
  • Casein Kinase II Subunit Alpha 3 3 4
  • CSNK2A1P 3 4
  • Casein Kinase II Alpha 1 Polypeptide Pseudogene 4
  • CK II Alpha 3 4
  • EC 2.7.11.1 4
  • CSNK2A3 5

External Ids for CSNK2A3 Gene

Previous HGNC Symbols for CSNK2A3 Gene

  • CSNK2A1P

Previous GeneCards Identifiers for CSNK2A3 Gene

  • GC11M011373

Summaries for CSNK2A3 Gene

Entrez Gene Summary for CSNK2A3 Gene

  • This gene encodes a protein that is highly similar to the casein kinase II alpha protein. Casein kinase II is a serine/threonine protein kinase complex that phosphorylates numerous substrates including casein. The alpha subunit is the catalytic component of the complex. Mutations in this gene may be associated with a susceptibility to lung cancer. There are contradictory views among published reports of this gene as to whether or not it is a protein-coding gene or a processed pseudogene (PMIDs: 20625391, 20625391 and 10094393). [provided by RefSeq, Feb 2012]

GeneCards Summary for CSNK2A3 Gene

CSNK2A3 (Casein Kinase 2 Alpha 3) is a Protein Coding gene. Diseases associated with CSNK2A3 include Invasive Bladder Transitional Cell Carcinoma and Renal Pelvis Carcinoma. Among its related pathways are Mitophagy - animal and Wnt signaling pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK2A1.

UniProtKB/Swiss-Prot Summary for CSNK2A3 Gene

  • Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-regulating expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer development and progression.

Additional gene information for CSNK2A3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CSNK2A3 Gene

Genomics for CSNK2A3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CSNK2A3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J011354 Enhancer 0.2 Ensembl 600.7 +0.1 149 0.2 CSNK2A3 ENSG00000255351 piR-54710 piR-61448-001 GALNT18 ZBED5
GH11J012122 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.9 -772.0 -771954 6 ARHGAP35 CTCF TEAD4 RFX1 LEF1 IKZF1 KDM1A JUND PKNOX1 ZNF24 MICAL2 MICALCL CSNK2A3 lnc-DKK3-10 piR-61101-082 MN309334 PARVA
GH11J010597 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 12.7 +755.4 755441 1.2 ATF7 IKZF1 JUND PRDM1 CEBPA CEBPB ATF3 CEBPG ZNF592 ZNF584 CSNK2A3 IRAG1 ZBED5 RNF141 IRAG1-AS1 lnc-RNF141-1 LYVE1
GH11J011415 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 -63.3 -63251 2.6 PRDM10 ZNF629 ZIC2 ZNF10 CEBPB RUNX3 ZBTB17 ATF2 ZFHX2 FOSL2 CSNK2A3 ENSG00000255351 USP47 IRAG1 RF00017-862 GALNT18
GH11J011460 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas 10.6 -109.3 -109251 4.2 PRDM10 ZNF629 ZNF692 ZIC2 ZSCAN4 PKNOX1 PATZ1 ZNF600 ZNF341 ZNF561 CSNK2A3 ENSG00000255351 LOC107983976 RF00017-862 GALNT18
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CSNK2A3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CSNK2A3

Genomic Locations for CSNK2A3 Gene

Genomic Locations for CSNK2A3 Gene
chr11:11,351,942-11,353,250
(GRCh38/hg38)
Size:
1,309 bases
Orientation:
Minus strand
chr11:11,373,321-11,374,904
(GRCh37/hg19)
Size:
1,584 bases
Orientation:
Minus strand

Genomic View for CSNK2A3 Gene

Genes around CSNK2A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSNK2A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSNK2A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK2A3 Gene

Proteins for CSNK2A3 Gene

  • Protein details for CSNK2A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEV1-CSK23_HUMAN
    Recommended name:
    Casein kinase II subunit alpha 3
    Protein Accession:
    Q8NEV1

    Protein attributes for CSNK2A3 Gene

    Size:
    391 amino acids
    Molecular mass:
    45220 Da
    Quaternary structure:
    • Heterotetramer composed of two catalytic subunits (alpha chain and/or alpha' chain) and two regulatory subunits (beta chains) (By similarity). Interacts with PML.

neXtProt entry for CSNK2A3 Gene

Post-translational modifications for CSNK2A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CSNK2A3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CSNK2A3 Gene

Domains & Families for CSNK2A3 Gene

Gene Families for CSNK2A3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for CSNK2A3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NEV1

UniProtKB/Swiss-Prot:

CSK23_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
genes like me logo Genes that share domains with CSNK2A3: view

No data available for Suggested Antigen Peptide Sequences for CSNK2A3 Gene

Function for CSNK2A3 Gene

Molecular function for CSNK2A3 Gene

UniProtKB/Swiss-Prot Function:
Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-regulating expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer development and progression.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:20625391};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:20625391};.

Enzyme Numbers (IUBMB) for CSNK2A3 Gene

Phenotypes From GWAS Catalog for CSNK2A3 Gene

Gene Ontology (GO) - Molecular Function for CSNK2A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005515 protein binding IPI --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CSNK2A3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSNK2A3

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CSNK2A3 Gene

Localization for CSNK2A3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSNK2A3 gene
Compartment Confidence
nucleus 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CSNK2A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IBA --
GO:0005956 protein kinase CK2 complex IBA --
genes like me logo Genes that share ontologies with CSNK2A3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CSNK2A3 Gene

Pathways & Interactions for CSNK2A3 Gene

genes like me logo Genes that share pathways with CSNK2A3: view

Pathways by source for CSNK2A3 Gene

Gene Ontology (GO) - Biological Process for CSNK2A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA --
GO:0008284 positive regulation of cell proliferation IDA --
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA --
GO:0018107 peptidyl-threonine phosphorylation IBA --
genes like me logo Genes that share ontologies with CSNK2A3: view

No data available for SIGNOR curated interactions for CSNK2A3 Gene

Drugs & Compounds for CSNK2A3 Gene

(4) Drugs for CSNK2A3 Gene - From: PharmGKB and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum 3412
Ellagic acid Investigational Pharma Casein kinase 2 (CK2) inhibitor, Selective inhibitor of CK2. Also inhibits glutathione S-transferase 0
CX-4945 (Silmitasertib) Pharma CK2 inhibitor 0
TTP 22 Pharma CK2 inhibitor 0

(3) ApexBio Compounds for CSNK2A3 Gene

Compound Action Cas Number
CX-4945 (Silmitasertib) CK2 inhibitor 1009820-21-6
Ellagic acid Casein kinase 2 (CK2) inhibitor 476-66-4
TTP 22 CK2 inhibitor 329907-28-0
genes like me logo Genes that share compounds with CSNK2A3: view

Drug Products

Transcripts for CSNK2A3 Gene

mRNA/cDNA for CSNK2A3 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSNK2A3

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK2A3 Gene

No ASD Table

Relevant External Links for CSNK2A3 Gene

GeneLoc Exon Structure for
CSNK2A3

Expression for CSNK2A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CSNK2A3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CSNK2A3

SOURCE GeneReport for Unigene cluster for CSNK2A3 Gene:

Hs.654675

mRNA Expression by UniProt/SwissProt for CSNK2A3 Gene:

Q8NEV1-CSK23_HUMAN
Tissue specificity: Detected in blood platelets and megakaryocyte cell lines. Poorly expressed in lung. Highly expressed in lung tumor tissues.

Evidence on tissue expression from TISSUES for CSNK2A3 Gene

  • Blood(4)
genes like me logo Genes that share expression patterns with CSNK2A3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSNK2A3 Gene

Orthologs for CSNK2A3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSNK2A3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CSNK2A3 31
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 97 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Csnk2a1 31
  • 97 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 96 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia CSNK2A1 31
  • 91 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 64 (a)
OneToMany
Chicken
(Gallus gallus)
Aves CSNK2A1 31
  • 96 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 95 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii CU928126.3 31
  • 80 (a)
ManyToMany
zgc:86598 30 31
  • 76.84 (n)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CkIIalpha 31
  • 85 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea kin-3 31
  • 77 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CKA2 31
  • 57 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons CKA1 30
  • 65.76 (n)
Rice
(Oryza sativa)
Liliopsida Os07g0114400 30
  • 67.07 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.11074 31
  • 85 (a)
OneToMany
Species where no ortholog for CSNK2A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for CSNK2A3 Gene

ENSEMBL:
Gene Tree for CSNK2A3 (if available)
TreeFam:
Gene Tree for CSNK2A3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CSNK2A3: view image

Paralogs for CSNK2A3 Gene

Paralogs for CSNK2A3 Gene

(32) SIMAP similar genes for CSNK2A3 Gene using alignment to 1 proteins:

  • CSK23_HUMAN
genes like me logo Genes that share paralogs with CSNK2A3: view

Variants for CSNK2A3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CSNK2A3 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs2071460 A lung carcinoma sample p.Ile133Thr

Additional dbSNP identifiers (rs#s) for CSNK2A3 Gene

Structural Variations from Database of Genomic Variants (DGV) for CSNK2A3 Gene

Variant ID Type Subtype PubMed ID
esv32920 CNV gain+loss 17666407
esv34098 CNV loss 18971310
nsv483000 CNV loss 15286789
nsv553480 CNV loss 21841781
nsv832065 CNV gain 17160897
nsv975884 CNV duplication 23825009

Variation tolerance for CSNK2A3 Gene

Residual Variation Intolerance Score: 97.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.78; 93.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CSNK2A3 Gene

Human Gene Mutation Database (HGMD)
CSNK2A3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSNK2A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK2A3 Gene

Disorders for CSNK2A3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CSNK2A3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
invasive bladder transitional cell carcinoma
  • invasive bladder urothelial carcinoma
renal pelvis carcinoma
  • carcinoma of kidney pelvis
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with CSNK2A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CSNK2A3 Gene

Publications for CSNK2A3 Gene

  1. Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer. (PMID: 20625391) Hung MS … You L (PloS one 2010) 2 3 4
  2. Sequencing of full-length cDNA encoding the alpha and beta subunits of human casein kinase II from human platelets and megakaryocytic cells. Expression of the casein kinase IIalpha intronless gene in a megakaryocytic cell line. (PMID: 12102635) Singh LS … Kalafatis M (Biochemistry 2002) 2 3 4
  3. Human casein kinase II subunit alpha: sequence of a processed (pseudo)gene and its localization on chromosome 11. (PMID: 1610905) Wirkner U … Pyerin W (Biochimica et biophysica acta 1992) 2 3 4
  4. Structure and sequence of an intronless gene for human casein kinase II-alpha subunit. (PMID: 8420794) Devilat I … Carvallo P (FEBS letters 1993) 3 4
  5. ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair. (PMID: 28242625) Leung JW … Miller KM (Genes & development 2017) 3

Products for CSNK2A3 Gene

Sources for CSNK2A3 Gene