Aliases for CSNK2A3 Gene
External Ids for CSNK2A3 Gene
Previous HGNC Symbols for CSNK2A3 Gene
Previous GeneCards Identifiers for CSNK2A3 Gene
This gene encodes a protein that is highly similar to the casein kinase II alpha protein. Casein kinase II is a serine/threonine protein kinase complex that phosphorylates numerous substrates including casein. The alpha subunit is the catalytic component of the complex. Mutations in this gene may be associated with a susceptibility to lung cancer. There are contradictory views among published reports of this gene as to whether or not it is a protein-coding gene or a processed pseudogene (PMIDs: 20625391, 20625391 and 10094393). [provided by RefSeq, Feb 2012]
GeneCards Summary for CSNK2A3 Gene
CSNK2A3 (Casein Kinase 2 Alpha 3) is a Protein Coding gene. Diseases associated with CSNK2A3 include Renal Pelvis Carcinoma. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling and T cell receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK2A1.
UniProtKB/Swiss-Prot Summary for CSNK2A3 Gene
Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-regulating expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer development and progression.