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Aliases for CSNK2A1 Gene

Aliases for CSNK2A1 Gene

  • Casein Kinase 2 Alpha 1 2 3 5
  • Casein Kinase 2, Alpha 1 Polypeptide 2 3
  • Casein Kinase II Subunit Alpha 2 3
  • CK2A1 3 4
  • Casein Kinase II Alpha 1 Polypeptide Pseudogene 3
  • Casein Kinase II Alpha 1 Subunit 3
  • CK2 Catalytic Subunit Alpha 3
  • Protein Kinase CK2 3
  • CK II Alpha 4
  • EC 2.7.11.1 4
  • OCNDS 3
  • CKII 3
  • Cka1 3
  • Cka2 3

External Ids for CSNK2A1 Gene

Previous GeneCards Identifiers for CSNK2A1 Gene

  • GC20M000451
  • GC20M000458
  • GC20M000414

Summaries for CSNK2A1 Gene

Entrez Gene Summary for CSNK2A1 Gene

  • Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. Multiple transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Apr 2018]

GeneCards Summary for CSNK2A1 Gene

CSNK2A1 (Casein Kinase 2 Alpha 1) is a Protein Coding gene. Diseases associated with CSNK2A1 include Okur-Chung Neurodevelopmental Syndrome and Cardiomyopathy, Dilated, 1P. Among its related pathways are Gene Expression and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK2A3.

UniProtKB/Swiss-Prot for CSNK2A1 Gene

  • Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating Ser-392 of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at Ser-565 and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at Ser-90 which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:19188443, PubMed:20625391, PubMed:22406621). Phosphorylates CCAR2 at Thr-454 in gastric carcinoma tissue (PubMed:24962073).

Tocris Summary for CSNK2A1 Gene

  • Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase thought to have a regulatory function in cell proliferation, differentiation and apoptosis. CK2 functions as a tetrameric complex with 2 regulatory and 2 catalytic subunits.

Gene Wiki entry for CSNK2A1 Gene

Additional gene information for CSNK2A1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK2A1 Gene

Genomics for CSNK2A1 Gene

GeneHancer (GH) Regulatory Elements for CSNK2A1 Gene

Promoters and enhancers for CSNK2A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J000541 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 657.3 +0.5 492 2.9 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B CSNK2A1 ACTG1P3 TBC1D20 RBCK1 GC20M000488 GC20M000487 PIR56447
GH20J000544 Enhancer 0.3 ENCODE 650.7 -1.1 -1054 0.2 BACH1 CSNK2A1 GC20M000594
GH20J000406 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13.9 +135.2 135249 3.8 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 RBCK1 TBC1D20 CSNK2A1 ACTG1P3 GC20P000435
GH20J000645 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 12.1 -102.4 -102384 2.3 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B ZNF207 ZNF143 SRXN1 TCF15 CSNK2A1 SCRT2 SLC52A3 GC20M000621 GC20M000631 ENSG00000270299
GH20J000368 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +171.3 171318 8 MLX ZFP64 DMAP1 YY1 SLC30A9 E2F8 ZNF548 SP3 PPARGC1A MEF2D TBC1D20 TRIB3 ACTG1P3 ENSG00000272874 DEFB129 DEFB126 DEFB125 RBCK1 SRXN1 ENSG00000206797
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CSNK2A1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CSNK2A1 gene promoter:
  • TBP
  • TFIID

Genomic Locations for CSNK2A1 Gene

Genomic Locations for CSNK2A1 Gene
chr20:472,498-543,838
(GRCh38/hg38)
Size:
71,341 bases
Orientation:
Minus strand
chr20:459,116-524,482
(GRCh37/hg19)
Size:
65,367 bases
Orientation:
Minus strand

Genomic View for CSNK2A1 Gene

Genes around CSNK2A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSNK2A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSNK2A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK2A1 Gene

Proteins for CSNK2A1 Gene

  • Protein details for CSNK2A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P68400-CSK21_HUMAN
    Recommended name:
    Casein kinase II subunit alpha
    Protein Accession:
    P68400
    Secondary Accessions:
    • B4DYS6
    • D3DVV8
    • P19138
    • P20426
    • Q14013
    • Q5U065

    Protein attributes for CSNK2A1 Gene

    Size:
    391 amino acids
    Molecular mass:
    45144 Da
    Quaternary structure:
    • Heterotetramer composed of two catalytic subunits (alpha chain and/or alpha chain) and two regulatory subunits (beta chains). The tetramer can exist as a combination of 2 alpha/2 beta, 2 alpha/2 beta or 1 alpha/1 alpha/2 beta subunits. Also part of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, which forms following UV irradiation. Interacts with RNPS1. Interacts with SNAI1. Interacts with PML (isoform PML-12). Interacts with CCAR2.
    Miscellaneous:
    • Can use both ATP and GTP as phosphoryl donors. Phosphorylation by casein kinase 2 has been estimated to represent up to one quarter of the eukaryotic phosphoproteome. Casein kinase 2 has been found to be increased at protein level and up-regulated at the level of enzyme activity in the majority of cancers. However, elevated levels of casein kinase 2 are present in certain normal organs such as brain and testes.

    Three dimensional structures from OCA and Proteopedia for CSNK2A1 Gene

    Alternative splice isoforms for CSNK2A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSNK2A1 Gene

Post-translational modifications for CSNK2A1 Gene

  • Phosphorylated at Thr-344, Thr-360, Ser-362 and Ser-370 by CDK1 in prophase and metaphase and dephosphorylated during anaphase. Phosphorylation does not directly affect casein kinase 2 activity, but may contribute to its regulation by forming binding sites for interacting proteins and/or targeting it to different compartments.
  • Ubiquitination at Lys229
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CSNK2A1 Gene

Domains & Families for CSNK2A1 Gene

Gene Families for CSNK2A1 Gene

IUPHAR :
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for CSNK2A1 Gene

Graphical View of Domain Structure for InterPro Entry

P68400

UniProtKB/Swiss-Prot:

CSK21_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
genes like me logo Genes that share domains with CSNK2A1: view

Function for CSNK2A1 Gene

Molecular function for CSNK2A1 Gene

UniProtKB/Swiss-Prot Function:
Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating Ser-392 of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at Ser-565 and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at Ser-90 which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:19188443, PubMed:20625391, PubMed:22406621). Phosphorylates CCAR2 at Thr-454 in gastric carcinoma tissue (PubMed:24962073).
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Constitutively active protein kinase whose activity is not directly affected by phosphorylation. Seems to be regulated by level of expression and localization.
GENATLAS Biochemistry:
casein kinase II,catalytic unit,alpha 1,ubiquitously expressed,likely involved in regulation of cell growth,also putative target and regulator of RaF/MAPK signaling,as a free CK2 beta (CSNK2B) form

Enzyme Numbers (IUBMB) for CSNK2A1 Gene

Phenotypes From GWAS Catalog for CSNK2A1 Gene

Gene Ontology (GO) - Molecular Function for CSNK2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS,IMP 2174700
GO:0005515 protein binding IPI 7809103
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IDA 18548200
genes like me logo Genes that share ontologies with CSNK2A1: view
genes like me logo Genes that share phenotypes with CSNK2A1: view

Human Phenotype Ontology for CSNK2A1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CSNK2A1 Gene

MGI Knock Outs for CSNK2A1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CSNK2A1

CRISPR Products

miRNA for CSNK2A1 Gene

miRTarBase miRNAs that target CSNK2A1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSNK2A1

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for CSNK2A1 Gene

Localization for CSNK2A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSNK2A1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSNK2A1 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
cytoskeleton 1
mitochondrion 1
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CSNK2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,TAS 21282530
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS 10799509
GO:0005956 protein kinase CK2 complex IDA 15723517
genes like me logo Genes that share ontologies with CSNK2A1: view

Pathways & Interactions for CSNK2A1 Gene

genes like me logo Genes that share pathways with CSNK2A1: view

Gene Ontology (GO) - Biological Process for CSNK2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006457 protein folding TAS --
GO:0006468 protein phosphorylation IEA,IDA 18548200
GO:0006656 phosphatidylcholine biosynthetic process TAS --
genes like me logo Genes that share ontologies with CSNK2A1: view

Drugs & Compounds for CSNK2A1 Gene

(66) Drugs for CSNK2A1 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Resveratrol Approved, Experimental, Investigational Pharma Target Cyclooxygenase inhibitor 126
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Quercetin Experimental, Investigational Nutra Target Antitumor agent, Non-selective PI 3-kinase inhibitor 42
(5-Oxo-5,6-Dihydro-Indolo[1,2-a]Quinazolin-7-Yl)-Acetic Acid Experimental Pharma Target 0
1,2,5,8-tetrahydroxyanthracene-9,10-dione Experimental Pharma Target 0

(30) Additional Compounds for CSNK2A1 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
TBCA
934358-00-6

(4) Tocris Compounds for CSNK2A1 Gene

Compound Action Cas Number
Ellagic acid Selective inhibitor of CK2. Also inhibits glutathione S-transferase 476-66-4
TBB Selective cell-permeable CK2 inhibitor 17374-26-4
TBCA Selective CK2 inhibitor 934358-00-6
TMCB Dual-kinase inhibitor; inhibits CK2 and ERK8 905105-89-7
genes like me logo Genes that share compounds with CSNK2A1: view

Transcripts for CSNK2A1 Gene

mRNA/cDNA for CSNK2A1 Gene

Unigene Clusters for CSNK2A1 Gene

Casein kinase 2, alpha 1 polypeptide:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSNK2A1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK2A1 Gene

No ASD Table

Relevant External Links for CSNK2A1 Gene

GeneLoc Exon Structure for
CSNK2A1
ECgene alternative splicing isoforms for
CSNK2A1

Expression for CSNK2A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CSNK2A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CSNK2A1 Gene

This gene is overexpressed in Fetal Brain (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CSNK2A1 Gene



Protein tissue co-expression partners for CSNK2A1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CSNK2A1 Gene:

CSNK2A1

SOURCE GeneReport for Unigene cluster for CSNK2A1 Gene:

Hs.644056

mRNA Expression by UniProt/SwissProt for CSNK2A1 Gene:

P68400-CSK21_HUMAN
Tissue specificity: Expressed in gastric carcinoma tissue and the expression gradually increases with the progression of the carcinoma (at protein level).

Evidence on tissue expression from TISSUES for CSNK2A1 Gene

  • Nervous system(4.7)
  • Lung(4.6)
  • Muscle(4.4)
  • Kidney(2.7)
  • Intestine(2.3)
  • Liver(2.2)
genes like me logo Genes that share expression patterns with CSNK2A1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSNK2A1 Gene

Orthologs for CSNK2A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSNK2A1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 34
  • 100 (a)
OneToMany
CSNK2A1 33
  • 96.76 (n)
cow
(Bos Taurus)
Mammalia CSNK2A1 34 33
  • 96.5 (n)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 96 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Csnk2a1 16 34 33
  • 94.54 (n)
rat
(Rattus norvegicus)
Mammalia Csnk2a1 33
  • 93.86 (n)
chimpanzee
(Pan troglodytes)
Mammalia CSNK2A1 33
  • 93.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 64 (a)
OneToMany
chicken
(Gallus gallus)
Aves CSNK2A1 34 33
  • 86.87 (n)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 95 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498392 33
  • 79.26 (n)
Str.714 33
zebrafish
(Danio rerio)
Actinopterygii ck2a1 34 33
  • 87 (a)
ManyToMany
LOC100535532 33
  • 73.2 (n)
fruit fly
(Drosophila melanogaster)
Insecta CkIIalpha 34 35 33
  • 73.39 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005569 33
  • 69.31 (n)
worm
(Caenorhabditis elegans)
Secernentea B0205.7 35
  • 83 (a)
kin-3 34 33
  • 69.11 (n)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F16467g 33
  • 59.52 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR204W 33
  • 59.01 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CKA2 34 33
  • 57.41 (n)
OneToMany
CKA1 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G23070 33
  • 69.35 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11074 34
  • 86 (a)
OneToMany
Cin.14189 33
bread mold
(Neurospora crassa)
Ascomycetes NCU03124 33
  • 66.14 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cka1 33
  • 62.95 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14189 33
Species where no ortholog for CSNK2A1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSNK2A1 Gene

ENSEMBL:
Gene Tree for CSNK2A1 (if available)
TreeFam:
Gene Tree for CSNK2A1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CSNK2A1: view image

Paralogs for CSNK2A1 Gene

Paralogs for CSNK2A1 Gene

(21) SIMAP similar genes for CSNK2A1 Gene using alignment to 7 proteins:

  • CSK21_HUMAN
  • B5BUH5_HUMAN
  • E7EU96_HUMAN
  • Q5U5J2_HUMAN
  • V9GY80_HUMAN
  • V9GYA2_HUMAN
  • V9GYW6_HUMAN
genes like me logo Genes that share paralogs with CSNK2A1: view

Variants for CSNK2A1 Gene

Sequence variations from dbSNP and Humsavar for CSNK2A1 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs869312840 pathogenic, not provided, Okur-chung neurodevelopmental syndrome, Okur-Chung neurodevelopmental syndrome (OCNDS) [MIM:617062] 492,282(-) T/C coding_sequence_variant, missense_variant
rs869312845 pathogenic, Okur-chung neurodevelopmental syndrome, Okur-Chung neurodevelopmental syndrome (OCNDS) [MIM:617062] 505,191(-) C/T 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs869312846 pathogenic, Okur-chung neurodevelopmental syndrome 488,676(-) A/G splice_donor_variant
rs869312848 pathogenic, Okur-chung neurodevelopmental syndrome, Okur-Chung neurodevelopmental syndrome (OCNDS) [MIM:617062] 492,351(-) T/C coding_sequence_variant, missense_variant
rs869312849 pathogenic, not provided, Okur-chung neurodevelopmental syndrome, Okur-Chung neurodevelopmental syndrome (OCNDS) [MIM:617062] 505,182(-) T/C/G 5_prime_UTR_variant, coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for CSNK2A1 Gene

Variant ID Type Subtype PubMed ID
dgv4221n100 CNV gain 25217958
dgv4222n100 CNV gain 25217958
esv2673541 CNV deletion 23128226
esv2674635 CNV deletion 23128226
esv3644952 CNV gain 21293372
esv3644953 CNV gain 21293372
nsv1056266 CNV gain 25217958
nsv1066598 CNV gain 25217958
nsv469833 CNV gain 16826518
nsv833891 CNV gain+loss 17160897

Variation tolerance for CSNK2A1 Gene

Residual Variation Intolerance Score: 26.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CSNK2A1 Gene

Human Gene Mutation Database (HGMD)
CSNK2A1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSNK2A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK2A1 Gene

Disorders for CSNK2A1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CSNK2A1 Gene - From: HGMD, OMIM, ClinVar, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

CSK21_HUMAN
  • Okur-Chung neurodevelopmental syndrome (OCNDS) [MIM:617062]: An autosomal dominant neurodevelopmental disorder characterized by developmental delay, intellectual disability, behavioral problems, hypotonia, speech problems, microcephaly, pachygyria and variable dysmorphic features. {ECO:0000269 PubMed:27048600}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for CSNK2A1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CSNK2A1: view

No data available for Genatlas for CSNK2A1 Gene

Publications for CSNK2A1 Gene

  1. Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit. (PMID: 1766873) Yang-Feng TL … Canaani D (Nucleic acids research 1991) 2 3 22 58
  2. Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II. (PMID: 2174700) Lozeman FJ … Krebs EG (Biochemistry 1990) 2 3 4 58
  3. De novo mutations in CSNK2A1 are associated with neurodevelopmental abnormalities and dysmorphic features. (PMID: 27048600) Okur V … Chung WK (Human genetics 2016) 3 4 58
  4. CK2α phosphorylates DBC1 and is involved in the progression of gastric carcinoma and predicts poor survival of gastric carcinoma patients. (PMID: 24962073) Bae JS … Jang KY (International journal of cancer 2015) 3 4 58
  5. The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA. (PMID: 22406621) Rabellino A … Scaglioni PP (Cancer research 2012) 3 4 58

Products for CSNK2A1 Gene

Sources for CSNK2A1 Gene