This gene encodes a member of a family of serine/threonine protein kinases that phosphorylate caseins and other acidic proteins. A related protein in the African clawed frog participates in the transmission of Wnt/beta-catenin signaling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] See more...

Aliases for CSNK1G3 Gene

Aliases for CSNK1G3 Gene

  • Casein Kinase 1 Gamma 3 2 3 5
  • Casein Kinase I Isoform Gamma-3 3 4
  • CKI-Gamma 3 3 4
  • EC 2.7.11.1 4 50
  • Casein Kinase 1, Gamma 3 2
  • Casein Kinase I 3
  • EC 2.7.11 50
  • CSNK1G3L 3
  • CSNK1G3 5

External Ids for CSNK1G3 Gene

Previous GeneCards Identifiers for CSNK1G3 Gene

  • GC05P122511
  • GC05P123217
  • GC05P122878
  • GC05P122957
  • GC05P122909
  • GC05P118036
  • GC05P122848

Summaries for CSNK1G3 Gene

Entrez Gene Summary for CSNK1G3 Gene

  • This gene encodes a member of a family of serine/threonine protein kinases that phosphorylate caseins and other acidic proteins. A related protein in the African clawed frog participates in the transmission of Wnt/beta-catenin signaling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for CSNK1G3 Gene

CSNK1G3 (Casein Kinase 1 Gamma 3) is a Protein Coding gene. Among its related pathways are G-Beta Gamma Signaling and p53 pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1G1.

UniProtKB/Swiss-Prot Summary for CSNK1G3 Gene

  • Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity).

Tocris Summary for CSNK1G3 Gene

  • Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. CK1 is involved in many cellular processes including DNA repair, cell division, nuclear localization and membrane transport. Isoforms are also integral to development.

No data available for CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CSNK1G3 Gene

Genomics for CSNK1G3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CSNK1G3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CSNK1G3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CSNK1G3

Top Transcription factor binding sites by QIAGEN in the CSNK1G3 gene promoter:
  • c-Myb
  • E47
  • FOXD3
  • FOXL1
  • GATA-3
  • Hand1
  • p300
  • Pax-4a
  • POU2F1
  • POU2F1a

Genomic Locations for CSNK1G3 Gene

Latest Assembly
chr5:123,512,099-123,617,049
(GRCh38/hg38)
Size:
104,951 bases
Orientation:
Plus strand

Previous Assembly
chr5:122,847,871-122,952,743
(GRCh37/hg19 by Entrez Gene)
Size:
104,873 bases
Orientation:
Plus strand

chr5:122,847,793-122,952,739
(GRCh37/hg19 by Ensembl)
Size:
104,947 bases
Orientation:
Plus strand

Genomic View for CSNK1G3 Gene

Genes around CSNK1G3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSNK1G3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSNK1G3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK1G3 Gene

Proteins for CSNK1G3 Gene

  • Protein details for CSNK1G3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6M4-KC1G3_HUMAN
    Recommended name:
    Casein kinase I isoform gamma-3
    Protein Accession:
    Q9Y6M4
    Secondary Accessions:
    • A8K040
    • B4DSH2
    • B7Z9Q4
    • E7EVD0
    • Q86WZ7
    • Q9Y6M3

    Protein attributes for CSNK1G3 Gene

    Size:
    447 amino acids
    Molecular mass:
    51389 Da
    Quaternary structure:
    • Monomer.
    Miscellaneous:
    • Triazolodiamine 1 is a commercial name for 5-amino-3-([4-(aminosulfonyl)phenyl]amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide.

    Three dimensional structures from OCA and Proteopedia for CSNK1G3 Gene

    Alternative splice isoforms for CSNK1G3 Gene

neXtProt entry for CSNK1G3 Gene

Selected DME Specific Peptides for CSNK1G3 Gene

Q9Y6M4:
  • SSGVLMVGPNFRVGKKIGCGNFGEL
  • LIYRDVKPENFL
  • TYLRYVRRLDFFEKPDY
  • KSRAPQLHLEYRFYK
  • SNAPITA
  • FDYEYDW
  • LKTVLMIAIQL
  • DRHGGSVQV
  • EQSRRDDLE
  • LTGTARY
  • LPWQGLKA
  • LGKNLYTNEYVAIKLEP
  • GTARYMSINTH
  • QVVSSTNGELN
  • TPIEVLC
  • CCCFFKR
  • LLGPSLEDLF
  • STNGELNTDDPTAG
  • IIDFGLA

Post-translational modifications for CSNK1G3 Gene

Domains & Families for CSNK1G3 Gene

Gene Families for CSNK1G3 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CSNK1G3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ76641, highly similar to Homo sapiens casein kinase 1, gamma 3 (CSNK1G3), transcript variant 2, mRNA (A8K040_HUMAN)
  • cDNA FLJ50193, highly similar to Homo sapiens casein kinase 1, gamma 3 (CSNK1G3), transcript variant 2, mRNA (B4DSH2_HUMAN)
  • Casein kinase I isoform gamma-3 (KC1G3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y6M4

UniProtKB/Swiss-Prot:

KC1G3_HUMAN :
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Family:
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
genes like me logo Genes that share domains with CSNK1G3: view

Function for CSNK1G3 Gene

Molecular function for CSNK1G3 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by triazolodiamine 1, 5-amino-3-{[4-(aminosulfonyl)phenyl]amino}-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide, (S)-propane-1,2-diol, 2-({6-[(3-chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methylbutan-1-ol, N2-[(1R,2S)-2-aminocyclohexyl]-N6-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine and [4-amino-2-(3-chloroanilino)-1,3-thiazol-5-yl](4-fluorophenyl)methanone.
GENATLAS Biochemistry:
casein kinase 1 gamma 3,predominantly expressed in testis,localized close to D5S622

Enzyme Numbers (IUBMB) for CSNK1G3 Gene

Phenotypes From GWAS Catalog for CSNK1G3 Gene

Gene Ontology (GO) - Molecular Function for CSNK1G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity TAS 9925945
GO:0004674 protein serine/threonine kinase activity IDA 25500533
GO:0005515 protein binding IPI --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CSNK1G3: view
genes like me logo Genes that share phenotypes with CSNK1G3: view

Animal Models for CSNK1G3 Gene

MGI Knock Outs for CSNK1G3:
  • Csnk1g3 Csnk1g3<tm1a(EUCOMM)Wtsi>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSNK1G3

Clone products for research

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSNK1G3 Gene

Localization for CSNK1G3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSNK1G3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSNK1G3 gene
Compartment Confidence
nucleus 4
plasma membrane 3
cytosol 3
extracellular 1
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CSNK1G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005886 plasma membrane IBA 21873635
genes like me logo Genes that share ontologies with CSNK1G3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CSNK1G3 Gene

Pathways & Interactions for CSNK1G3 Gene

PathCards logo

SuperPathways for CSNK1G3 Gene

SuperPathway Contained pathways
1 Hedgehog signaling pathway (KEGG)
2 p53 Signaling
3 Dopamine-DARPP32 Feedback onto cAMP Pathway
-
4 Nanog in Mammalian ESC Pluripotency
.61
5 GPCR Pathway
.58
genes like me logo Genes that share pathways with CSNK1G3: view

Pathways by source for CSNK1G3 Gene

1 Sino Biological pathway for CSNK1G3 Gene
1 KEGG pathway for CSNK1G3 Gene
1 GeneGo (Thomson Reuters) pathway for CSNK1G3 Gene
  • Translation Regulation of EIF2 activity
5 Qiagen pathways for CSNK1G3 Gene
  • Dopamine-DARPP32 Feedback onto cAMP Pathway
  • GSK3 Signaling
  • NFAT in Immune Response
  • Signaling in Gap Junctions
  • WNT Signaling

Gene Ontology (GO) - Biological Process for CSNK1G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 9925945
GO:0006468 protein phosphorylation IEA --
GO:0006897 endocytosis IBA 21873635
GO:0007165 signal transduction TAS 9925945
GO:0016055 Wnt signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with CSNK1G3: view

No data available for SIGNOR curated interactions for CSNK1G3 Gene

Drugs & Compounds for CSNK1G3 Gene

(10) Drugs for CSNK1G3 Gene - From: DrugBank, ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
{4-Amino-2-[(4-methoxyphenyl)amino]-1,3-thiazol-5-yl}(4-methoxyphenyl)methanone Experimental Pharma Target 0
4-Amino-2-[(3-chlorophenyl)amino]-5-(4-fluorobenzoyl)-1,3-thiazol-3-ium Experimental Pharma Target 0
K-00546 Experimental Pharma Target 0
Purvalanol A Experimental Pharma Target 0
ATP Investigational Nutra 0

(1) Additional Compounds for CSNK1G3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0

(5) Tocris Compounds for CSNK1G3 Gene

Compound Action Cas Number
(R)-DRF053 dihydrochloride Dual CK1/cdk inhibitor 1241675-76-2
D 4476 Selective CK1 inhibitor. Also inhibits TGF-betaRI 301836-43-1
LH 846 Selective casein kinase 1delta inhibitor 639052-78-1
PF 4800567 hydrochloride Selective casein kinase 1epsilon inhibitor 1391052-28-0
PF 670462 Potent and selective CK1epsilon and CK1delta inhibitor 950912-80-8

(1) ApexBio Compounds for CSNK1G3 Gene

Compound Action Cas Number
PF-670462 CK1 ε/δ inhibitor 950912-80-8
genes like me logo Genes that share compounds with CSNK1G3: view

Drug products for research

Transcripts for CSNK1G3 Gene

mRNA/cDNA for CSNK1G3 Gene

17 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSNK1G3

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1G3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: - -
SP3: -
SP4: -

Relevant External Links for CSNK1G3 Gene

GeneLoc Exon Structure for
CSNK1G3

Expression for CSNK1G3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CSNK1G3 Gene

Protein differential expression in normal tissues from HIPED for CSNK1G3 Gene

This gene is overexpressed in Plasma (58.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CSNK1G3 Gene



Protein tissue co-expression partners for CSNK1G3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CSNK1G3

SOURCE GeneReport for Unigene cluster for CSNK1G3 Gene:

Hs.129206

Evidence on tissue expression from TISSUES for CSNK1G3 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with CSNK1G3: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSNK1G3 Gene

Orthologs for CSNK1G3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CSNK1G3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CSNK1G3 29 30
  • 99.93 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CSNK1G3 29 30
  • 96.7 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CSNK1G3 29 30
  • 96.29 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Csnk1g3 29
  • 93.44 (n)
Mouse
(Mus musculus)
Mammalia Csnk1g3 29 16 30
  • 92.67 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CSNK1G3 30
  • 83 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CSNK1G3 30
  • 96 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia csnk1g3 29
  • 85.99 (n)
Str.7252 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.33424 29
Zebrafish
(Danio rerio)
Actinopterygii csnk1g2b 29
  • 70.83 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003997 29
  • 64.12 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta gish 29 30 31
  • 62.68 (n)
OneToMany
CG9962 31
  • 42 (a)
Worm
(Caenorhabditis elegans)
Secernentea csnk-1 30
  • 66 (a)
OneToMany
Y106G6E.6 31
  • 65 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRR25 30
  • 34 (a)
OneToMany
YCK3 32
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2609 30
  • 72 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.3005 29
Species where no ortholog for CSNK1G3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CSNK1G3 Gene

ENSEMBL:
Gene Tree for CSNK1G3 (if available)
TreeFam:
Gene Tree for CSNK1G3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CSNK1G3: view image
Alliance of Genome Resources:
Additional Orthologs for CSNK1G3

Paralogs for CSNK1G3 Gene

(6) SIMAP similar genes for CSNK1G3 Gene using alignment to 2 proteins:

  • KC1G3_HUMAN
  • H0YBN6_HUMAN
genes like me logo Genes that share paralogs with CSNK1G3: view

Variants for CSNK1G3 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CSNK1G3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CSNK1G3 Gene

Variant ID Type Subtype PubMed ID
esv2730717 CNV deletion 23290073
esv3606611 CNV loss 21293372
esv3606612 CNV loss 21293372
nsv507289 OTHER sequence alteration 20534489
nsv527734 CNV loss 19592680
nsv968239 CNV duplication 23825009

Variation tolerance for CSNK1G3 Gene

Residual Variation Intolerance Score: 13.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CSNK1G3 Gene

Human Gene Mutation Database (HGMD)
CSNK1G3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSNK1G3
Leiden Open Variation Database (LOVD)
CSNK1G3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CSNK1G3 Gene

Disorders for CSNK1G3 Gene

Additional Disease Information for CSNK1G3

No disorders were found for CSNK1G3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSNK1G3 Gene

Publications for CSNK1G3 Gene

  1. Cloning and chromosome mapping of the human casein kinase I gamma3 gene (CSNK1G3). (PMID: 9925945) Kusuda J … Hashimoto K (Cytogenetics and cell genetics 1998) 2 3 4 22
  2. Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. (PMID: 19451621) Landers JE … Brown RH (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 40
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents. (PMID: 32780723) Lan W … Iovanna J (JCI insight 2020) 3

Products for CSNK1G3 Gene

Sources for CSNK1G3 Gene