Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CSNK1G2 Gene

Aliases for CSNK1G2 Gene

  • Casein Kinase 1 Gamma 2 2 3 5
  • Casein Kinase I Isoform Gamma-2 3 4
  • CKI-Gamma 2 3 4
  • EC 2.7.11.1 4 56
  • Casein Kinase 1 Isoform Gamma-2 3
  • Casein Kinase 1, Gamma 2 2
  • Casein Kinase I 3
  • EC 2.7.11 56
  • CK1g2 3
  • CK1G2 4

External Ids for CSNK1G2 Gene

Previous GeneCards Identifiers for CSNK1G2 Gene

  • GC19P002032
  • GC19P001881
  • GC19P001892
  • GC19P001920
  • GC19P001713

Summaries for CSNK1G2 Gene

GeneCards Summary for CSNK1G2 Gene

CSNK1G2 (Casein Kinase 1 Gamma 2) is a Protein Coding gene. Among its related pathways are Sphingolipid metabolism and Dopamine-DARPP32 Feedback onto cAMP Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1G3.

UniProtKB/Swiss-Prot for CSNK1G2 Gene

  • Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.

Tocris Summary for CSNK1G2 Gene

  • Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. CK1 is involved in many cellular processes including DNA repair, cell division, nuclear localization and membrane transport. Isoforms are also integral to development.

Additional gene information for CSNK1G2 Gene

No data available for Entrez Gene Summary , CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK1G2 Gene

Genomics for CSNK1G2 Gene

GeneHancer (GH) Regulatory Elements for CSNK1G2 Gene

Promoters and enhancers for CSNK1G2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J001939 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 614.4 +0.9 868 5.4 SP1 ZFX ELF3 MNT ZNF148 NKRF POLR2A ZNF121 CEBPG CSDE1 CSNK1G2 LOC105372238 SF3A2 ZNF555 GRIN3B CIRBP ENSG00000267283 TMEM259 DAZAP1 KLF16
GH19J001382 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 19.6 -557.0 -557048 3 ZNF473 ZFX SP1 ELF3 MNT SIX5 CBFA2T2 ZNF148 NKRF MLLT1 PIR43938 NDUFS7 PIR60228 TRF-GAA1-6 TRN-GTT2-6 CIRBP SF3A2 TMEM259 DAZAP1 LOC100288123
GH19J001647 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 19.7 -290.7 -290675 6.7 ZNF473 ZFX SP1 MNT ZNF148 NKRF MLLT1 ZNF121 CEBPG POLR2A TCF3 SF3A2 LOC100288123 DAZAP1 TMEM259 DOT1L PTBP1 MED16 GRIN3B STK11
GH19J001236 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.2 -684.3 -684346 41.2 HDGF MTA3 SP1 ZFX CC2D1A ZNF652 ELF3 CTCF MNT SIX5 CIRBP C19orf24 MIDN CBARP ATP5F1D SF3A2 TMEM259 TCF3 LOC100288123 DAZAP1
GH19J001406 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.2 -528.3 -528319 13.5 HDGF SP1 ZNF652 ZFX ELF3 CTCF ZKSCAN8 MNT SIX5 ZNF148 DAZAP1 TCF3 SF3A2 TMEM259 LOC100288123 PTBP1 RPS15 MED16 GRIN3B ENSG00000267317
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CSNK1G2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CSNK1G2 gene promoter:
  • c-Myb
  • GATA-1
  • Hlf
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for CSNK1G2 Gene

Genomic Locations for CSNK1G2 Gene
chr19:1,941,149-1,981,338
(GRCh38/hg38)
Size:
40,190 bases
Orientation:
Plus strand
chr19:1,941,161-1,981,337
(GRCh37/hg19)
Size:
40,177 bases
Orientation:
Plus strand

Genomic View for CSNK1G2 Gene

Genes around CSNK1G2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSNK1G2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSNK1G2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK1G2 Gene

Proteins for CSNK1G2 Gene

  • Protein details for CSNK1G2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78368-KC1G2_HUMAN
    Recommended name:
    Casein kinase I isoform gamma-2
    Protein Accession:
    P78368
    Secondary Accessions:
    • B5BU42
    • O00704
    • Q8WUB1

    Protein attributes for CSNK1G2 Gene

    Size:
    415 amino acids
    Molecular mass:
    47457 Da
    Quaternary structure:
    • Monomer (By similarity). Interacts with MTA1 (short isoform) in the cytoplasm. Interacts with SMAD3.

    Three dimensional structures from OCA and Proteopedia for CSNK1G2 Gene

neXtProt entry for CSNK1G2 Gene

Selected DME Specific Peptides for CSNK1G2 Gene

P78368:
  • SSGVLMVGPNFRVGKKIGCGNFGEL
  • LIYRDVKPENFL
  • LCENFPEEM
  • TYLRYVRRLDFFEKPDY
  • KSRAPQLHLEYRFYK
  • SNAPITA
  • FDYEYDW
  • LKTVLMIAIQL
  • EQSRRDDLE
  • LTGTARY
  • LPWQGLKA
  • LGKNLYTNEYVAIKLEP
  • GTARYMSINTH
  • TPIEVLC
  • CCCFFKR
  • LLGPSLEDLF
  • IIDFGLA

Post-translational modifications for CSNK1G2 Gene

Domains & Families for CSNK1G2 Gene

Gene Families for CSNK1G2 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CSNK1G2 Gene

GenScript: Design optimal peptide antigens:
  • Casein kinase I isoform gamma-2 (KC1G2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P78368

UniProtKB/Swiss-Prot:

KC1G2_HUMAN :
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Family:
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
genes like me logo Genes that share domains with CSNK1G2: view

Function for CSNK1G2 Gene

Molecular function for CSNK1G2 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Stimulated by estrogen. Repressed by 5-iodotubercidin (DB04604).
GENATLAS Biochemistry:
casein kinase 1 gamma 2,predominantly expressed in testis,may be involved in signaling pathways downstream of RTKS

Enzyme Numbers (IUBMB) for CSNK1G2 Gene

Phenotypes From GWAS Catalog for CSNK1G2 Gene

Gene Ontology (GO) - Molecular Function for CSNK1G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,TAS 9403068
GO:0005515 protein binding IPI 15917222
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with CSNK1G2: view
genes like me logo Genes that share phenotypes with CSNK1G2: view

Animal Models for CSNK1G2 Gene

MGI Knock Outs for CSNK1G2:
  • Csnk1g2 Csnk1g2<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for CSNK1G2 - Now 50% OFF >
  • * CSNK1G2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CSNK1G2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSNK1G2 Gene

Localization for CSNK1G2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSNK1G2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSNK1G2 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CSNK1G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IBA 21873635
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with CSNK1G2: view

Pathways & Interactions for CSNK1G2 Gene

genes like me logo Genes that share pathways with CSNK1G2: view

SIGNOR curated interactions for CSNK1G2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for CSNK1G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,TAS 9403068
GO:0006897 endocytosis IBA 21873635
GO:0007165 signal transduction TAS 9403068
GO:0016055 Wnt signaling pathway IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with CSNK1G2: view

Drugs & Compounds for CSNK1G2 Gene

(11) Drugs for CSNK1G2 Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
5-iodotubercidin Experimental Pharma Target Adenosine kinase inhibitor,potent, Potent adenosine kinase inhibitor; also inhibits nucleoside transporters and a range of other kinases 0
IC261 Experimental Pharma Target 0
N-(2-Aminoethyl)-5-Chloroisoquinoline-8-Sulfonamide Experimental Pharma Target 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0
CKI 7 dihydrochloride Pharma 0

(1) Additional Compounds for CSNK1G2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0

(5) Tocris Compounds for CSNK1G2 Gene

Compound Action Cas Number
(R)-DRF053 dihydrochloride Dual CK1/cdk inhibitor 1241675-76-2
D 4476 Selective CK1 inhibitor. Also inhibits TGF-betaRI 301836-43-1
LH 846 Selective casein kinase 1delta inhibitor 639052-78-1
PF 4800567 hydrochloride Selective casein kinase 1epsilon inhibitor 1391052-28-0
PF 670462 Potent and selective CK1epsilon and CK1delta inhibitor 950912-80-8

(1) ApexBio Compounds for CSNK1G2 Gene

Compound Action Cas Number
CKI 7 dihydrochloride 1177141-67-1
genes like me logo Genes that share compounds with CSNK1G2: view

Transcripts for CSNK1G2 Gene

mRNA/cDNA for CSNK1G2 Gene

Unigene Clusters for CSNK1G2 Gene

Casein kinase 1, gamma 2:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for CSNK1G2 - Now 50% OFF >
  • * CSNK1G2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * CSNK1G2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1G2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^
SP1: - - - - - - -
SP2: - -
SP3: - - -
SP4: - - - - - - - - -
SP5:
SP6: -
SP7: - - -
SP8:
SP9: -
SP10: -
SP11: -
SP12: - - - -

ExUns: 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for CSNK1G2 Gene

GeneLoc Exon Structure for
CSNK1G2
ECgene alternative splicing isoforms for
CSNK1G2

Expression for CSNK1G2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CSNK1G2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CSNK1G2 Gene

This gene is overexpressed in Placenta (23.5), Spleen (17.4), Spinal cord (11.9), and CD8 Tcells (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CSNK1G2 Gene



NURSA nuclear receptor signaling pathways regulating expression of CSNK1G2 Gene:

CSNK1G2

SOURCE GeneReport for Unigene cluster for CSNK1G2 Gene:

Hs.651905

mRNA Expression by UniProt/SwissProt for CSNK1G2 Gene:

P78368-KC1G2_HUMAN
Tissue specificity: Testis.

Evidence on tissue expression from TISSUES for CSNK1G2 Gene

  • Intestine(4.3)
  • Muscle(4.2)
  • Nervous system(2.6)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with CSNK1G2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSNK1G2 Gene

Orthologs for CSNK1G2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CSNK1G2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CSNK1G2 35 34
  • 95.49 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CSNK1G2 35 34
  • 93.32 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CSNK1G2 35 34
  • 91.87 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csnk1g2 34
  • 90.12 (n)
mouse
(Mus musculus)
Mammalia Csnk1g2 17 35 34
  • 89.64 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CSNK1G2 35
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CSNK1G2 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857862 34
  • 82.85 (n)
CSNK1G2 35
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSNK1G2 35
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25786 34
zebrafish
(Danio rerio)
Actinopterygii csnk1g2b 35
  • 83 (a)
OneToMany
csnk1g2a 35 34
  • 78.26 (n)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta gish 35 36
  • 56 (a)
OneToMany
CG9962 36
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea Y106G6E.6 36
  • 67 (a)
csnk-1 35 34
  • 57.75 (n)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR040W 34
  • 62.75 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YCK1 34
  • 53.47 (n)
HRR25 35
  • 34 (a)
OneToMany
YCK2 37
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D11044g 34
  • 50.05 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2609 35
  • 71 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU04005 34
  • 61.82 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cki1 34
  • 55.02 (n)
Species where no ortholog for CSNK1G2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CSNK1G2 Gene

ENSEMBL:
Gene Tree for CSNK1G2 (if available)
TreeFam:
Gene Tree for CSNK1G2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CSNK1G2: view image

Paralogs for CSNK1G2 Gene

(8) SIMAP similar genes for CSNK1G2 Gene using alignment to 4 proteins:

  • KC1G2_HUMAN
  • K7EJC0_HUMAN
  • K7EP38_HUMAN
  • K7ESB6_HUMAN

Pseudogenes.org Pseudogenes for CSNK1G2 Gene

genes like me logo Genes that share paralogs with CSNK1G2: view

Variants for CSNK1G2 Gene

Sequence variations from dbSNP and Humsavar for CSNK1G2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000019331 -- 1,953,753(+) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000085525 -- 1,980,937(+) C/A/T 3_prime_UTR_variant, non_coding_transcript_variant
rs1000107196 -- 1,953,597(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000117357 -- 1,975,069(+) G/A intron_variant
rs1000145273 -- 1,957,052(+) C/A/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CSNK1G2 Gene

Variant ID Type Subtype PubMed ID
dgv488e201 CNV deletion 23290073
dgv568n67 CNV gain 20364138
dgv6212n54 CNV loss 21841781
dgv6213n54 CNV loss 21841781
dgv6214n54 CNV loss 21841781
esv1623717 CNV deletion 17803354
esv1678175 CNV deletion 17803354
esv2657128 CNV deletion 23128226
esv2661504 CNV deletion 23128226
esv2669669 CNV deletion 23128226
esv2674106 CNV deletion 23128226
esv26747 CNV gain+loss 19812545
esv2717856 CNV deletion 23290073
esv2717857 CNV deletion 23290073
esv2717858 CNV deletion 23290073
esv2717859 CNV deletion 23290073
esv2717860 CNV deletion 23290073
esv2717863 CNV deletion 23290073
esv2717864 CNV deletion 23290073
esv2717866 CNV deletion 23290073
esv2717867 CNV deletion 23290073
esv32942 CNV gain+loss 17666407
esv3555852 CNV deletion 23714750
esv3643414 CNV gain 21293372
esv3643415 CNV loss 21293372
esv3893156 CNV loss 25118596
esv989730 CNV deletion 20482838
nsv1070627 CNV deletion 25765185
nsv1071888 CNV deletion 25765185
nsv1072838 CNV deletion 25765185
nsv1118800 CNV deletion 24896259
nsv1123207 CNV deletion 24896259
nsv1126503 CNV deletion 24896259
nsv1160561 CNV deletion 26073780
nsv138132 CNV insertion 16902084
nsv470107 CNV loss 18288195
nsv472610 CNV novel sequence insertion 20440878
nsv578363 CNV loss 21841781
nsv578366 CNV loss 21841781
nsv820901 CNV deletion 20802225
nsv828388 CNV gain 20364138
nsv953942 CNV deletion 24416366

Variation tolerance for CSNK1G2 Gene

Residual Variation Intolerance Score: 26.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CSNK1G2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSNK1G2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK1G2 Gene

Disorders for CSNK1G2 Gene

Additional Disease Information for CSNK1G2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CSNK1G2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSNK1G2 Gene

Publications for CSNK1G2 Gene

  1. Polymorphisms of casein kinase I gamma 2 gene associated with simple febrile seizures in Chinese Han population. (PMID: 15342122) Yinan M … Xiru W (Neuroscience letters 2004) 3 4 23 45 58
  2. Cloning and chromosomal mapping of human casein kinase I gamma 2 (CSNK1G2). (PMID: 9403068) Kitabayashi AN … Hashimoto K (Genomics 1997) 2 3 4 23 58
  3. Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling. (PMID: 18794808) Guo X … Wang XF (Oncogene 2008) 3 4 23 58
  4. Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase. (PMID: 15077195) Mishra SK … Kumar R (Oncogene 2004) 3 4 23 58
  5. [Five single nucleotide polymorphisms of casein kinase I gamma 2 gene in children with familial febrile convulsions]. (PMID: 15300631) Ma YN … Qi Y (Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics 2004) 3 23 45 58

Products for CSNK1G2 Gene