Aliases for CSNK1G2 Gene

Aliases for CSNK1G2 Gene

  • Casein Kinase 1 Gamma 2 2 3 5
  • Casein Kinase I Isoform Gamma-2 3 4
  • CKI-Gamma 2 3 4
  • EC 2.7.11.1 4 51
  • CK1g2 2 3
  • Casein Kinase 1 Isoform Gamma-2 3
  • Casein Kinase 1, Gamma 2 2
  • Casein Kinase I 3
  • EC 2.7.11 51
  • CSNK1G2 5
  • CK1G2 4

External Ids for CSNK1G2 Gene

Previous GeneCards Identifiers for CSNK1G2 Gene

  • GC19P002032
  • GC19P001881
  • GC19P001892
  • GC19P001920
  • GC19P001713

Summaries for CSNK1G2 Gene

GeneCards Summary for CSNK1G2 Gene

CSNK1G2 (Casein Kinase 1 Gamma 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Wnt. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1G3.

UniProtKB/Swiss-Prot Summary for CSNK1G2 Gene

  • Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.

Tocris Summary for CSNK1G2 Gene

  • Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. CK1 is involved in many cellular processes including DNA repair, cell division, nuclear localization and membrane transport. Isoforms are also integral to development.

Additional gene information for CSNK1G2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CSNK1G2 Gene

Genomics for CSNK1G2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CSNK1G2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CSNK1G2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CSNK1G2

Top Transcription factor binding sites by QIAGEN in the CSNK1G2 gene promoter:
  • c-Myb
  • GATA-1
  • Hlf
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for CSNK1G2 Gene

Genomic Locations for CSNK1G2 Gene
chr19:1,941,149-1,981,338
(GRCh38/hg38)
Size:
40,190 bases
Orientation:
Plus strand
chr19:1,941,161-1,981,337
(GRCh37/hg19)
Size:
40,177 bases
Orientation:
Plus strand

Genomic View for CSNK1G2 Gene

Genes around CSNK1G2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSNK1G2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSNK1G2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK1G2 Gene

Proteins for CSNK1G2 Gene

  • Protein details for CSNK1G2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78368-KC1G2_HUMAN
    Recommended name:
    Casein kinase I isoform gamma-2
    Protein Accession:
    P78368
    Secondary Accessions:
    • B5BU42
    • O00704
    • Q8WUB1

    Protein attributes for CSNK1G2 Gene

    Size:
    415 amino acids
    Molecular mass:
    47457 Da
    Quaternary structure:
    • Monomer (By similarity). Interacts with MTA1 (short isoform) in the cytoplasm. Interacts with SMAD3.

    Three dimensional structures from OCA and Proteopedia for CSNK1G2 Gene

neXtProt entry for CSNK1G2 Gene

Selected DME Specific Peptides for CSNK1G2 Gene

P78368:
  • SSGVLMVGPNFRVGKKIGCGNFGEL
  • LIYRDVKPENFL
  • LCENFPEEM
  • TYLRYVRRLDFFEKPDY
  • KSRAPQLHLEYRFYK
  • SNAPITA
  • FDYEYDW
  • LKTVLMIAIQL
  • EQSRRDDLE
  • LTGTARY
  • LPWQGLKA
  • LGKNLYTNEYVAIKLEP
  • GTARYMSINTH
  • TPIEVLC
  • CCCFFKR
  • LLGPSLEDLF
  • IIDFGLA

Post-translational modifications for CSNK1G2 Gene

Antibody Products

Protein Products

  • Signalway Proteins for CSNK1G2

Domains & Families for CSNK1G2 Gene

Gene Families for CSNK1G2 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CSNK1G2 Gene

GenScript: Design optimal peptide antigens:
  • Casein kinase I isoform gamma-2 (KC1G2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P78368

UniProtKB/Swiss-Prot:

KC1G2_HUMAN :
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Family:
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
genes like me logo Genes that share domains with CSNK1G2: view

Function for CSNK1G2 Gene

Molecular function for CSNK1G2 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Stimulated by estrogen. Repressed by 5-iodotubercidin (DB04604).
GENATLAS Biochemistry:
casein kinase 1 gamma 2,predominantly expressed in testis,may be involved in signaling pathways downstream of RTKS

Enzyme Numbers (IUBMB) for CSNK1G2 Gene

Phenotypes From GWAS Catalog for CSNK1G2 Gene

Gene Ontology (GO) - Molecular Function for CSNK1G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,TAS 9403068
GO:0005515 protein binding IPI 15917222
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CSNK1G2: view
genes like me logo Genes that share phenotypes with CSNK1G2: view

Animal Models for CSNK1G2 Gene

MGI Knock Outs for CSNK1G2:
  • Csnk1g2 Csnk1g2<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSNK1G2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSNK1G2 Gene

Localization for CSNK1G2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSNK1G2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSNK1G2 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 3
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CSNK1G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IBA 21873635
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with CSNK1G2: view

Pathways & Interactions for CSNK1G2 Gene

genes like me logo Genes that share pathways with CSNK1G2: view

Pathways by source for CSNK1G2 Gene

1 KEGG pathway for CSNK1G2 Gene
1 GeneGo (Thomson Reuters) pathway for CSNK1G2 Gene
  • Translation Regulation of EIF2 activity
5 Qiagen pathways for CSNK1G2 Gene
  • Dopamine-DARPP32 Feedback onto cAMP Pathway
  • GSK3 Signaling
  • NFAT in Immune Response
  • Signaling in Gap Junctions
  • WNT Signaling

SIGNOR curated interactions for CSNK1G2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for CSNK1G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,TAS 9403068
GO:0006897 endocytosis IBA 21873635
GO:0007165 signal transduction TAS 9403068
GO:0016055 Wnt signaling pathway IBA 21873635
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with CSNK1G2: view

Drugs & Compounds for CSNK1G2 Gene

(11) Drugs for CSNK1G2 Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
5-iodotubercidin Experimental Pharma Target Adenosine kinase inhibitor,potent, Potent adenosine kinase inhibitor; also inhibits nucleoside transporters and a range of other kinases 0
IC261 Experimental Pharma Target 0
N-(2-Aminoethyl)-5-Chloroisoquinoline-8-Sulfonamide Experimental Pharma Target 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0
CKI 7 dihydrochloride Pharma 0

(1) Additional Compounds for CSNK1G2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0

(5) Tocris Compounds for CSNK1G2 Gene

Compound Action Cas Number
(R)-DRF053 dihydrochloride Dual CK1/cdk inhibitor 1241675-76-2
D 4476 Selective CK1 inhibitor. Also inhibits TGF-betaRI 301836-43-1
LH 846 Selective casein kinase 1delta inhibitor 639052-78-1
PF 4800567 hydrochloride Selective casein kinase 1epsilon inhibitor 1391052-28-0
PF 670462 Potent and selective CK1epsilon and CK1delta inhibitor 950912-80-8

(1) ApexBio Compounds for CSNK1G2 Gene

Compound Action Cas Number
CKI 7 dihydrochloride 1177141-67-1
genes like me logo Genes that share compounds with CSNK1G2: view

Transcripts for CSNK1G2 Gene

mRNA/cDNA for CSNK1G2 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSNK1G2

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1G2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^
SP1: - - - - - - -
SP2: - -
SP3: - - -
SP4: - - - - - - - - -
SP5:
SP6: -
SP7: - - -
SP8:
SP9: -
SP10: -
SP11: -
SP12: - - - -

ExUns: 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for CSNK1G2 Gene

GeneLoc Exon Structure for
CSNK1G2

Expression for CSNK1G2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CSNK1G2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CSNK1G2 Gene

This gene is overexpressed in Placenta (23.5), Spleen (17.4), Spinal cord (11.9), and CD8 Tcells (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CSNK1G2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CSNK1G2

SOURCE GeneReport for Unigene cluster for CSNK1G2 Gene:

Hs.651905

mRNA Expression by UniProt/SwissProt for CSNK1G2 Gene:

P78368-KC1G2_HUMAN
Tissue specificity: Testis.

Evidence on tissue expression from TISSUES for CSNK1G2 Gene

  • Intestine(4.4)
  • Muscle(4.3)
  • Nervous system(3)
  • Skin(2.6)
genes like me logo Genes that share expression patterns with CSNK1G2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSNK1G2 Gene

Orthologs for CSNK1G2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CSNK1G2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CSNK1G2 30 31
  • 95.49 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CSNK1G2 30 31
  • 93.32 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CSNK1G2 30 31
  • 91.87 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Csnk1g2 30
  • 90.12 (n)
Mouse
(Mus musculus)
Mammalia Csnk1g2 30 17 31
  • 89.64 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CSNK1G2 31
  • 83 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CSNK1G2 31
  • 82 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LOC100857862 30
  • 82.85 (n)
CSNK1G2 31
  • 81 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CSNK1G2 31
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25786 30
Zebrafish
(Danio rerio)
Actinopterygii csnk1g2b 31
  • 83 (a)
OneToMany
csnk1g2a 30 31
  • 78.26 (n)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta gish 31 32
  • 56 (a)
OneToMany
CG9962 32
  • 42 (a)
Worm
(Caenorhabditis elegans)
Secernentea Y106G6E.6 32
  • 67 (a)
csnk-1 30 31
  • 57.75 (n)
OneToMany
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AFR040W 30
  • 62.75 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YCK1 30
  • 53.47 (n)
HRR25 31
  • 34 (a)
OneToMany
YCK2 33
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D11044g 30
  • 50.05 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2609 31
  • 71 (a)
OneToMany
Bread mold
(Neurospora crassa)
Ascomycetes NCU04005 30
  • 61.82 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cki1 30
  • 55.02 (n)
Species where no ortholog for CSNK1G2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for CSNK1G2 Gene

ENSEMBL:
Gene Tree for CSNK1G2 (if available)
TreeFam:
Gene Tree for CSNK1G2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CSNK1G2: view image

Paralogs for CSNK1G2 Gene

(8) SIMAP similar genes for CSNK1G2 Gene using alignment to 4 proteins:

  • KC1G2_HUMAN
  • K7EJC0_HUMAN
  • K7EP38_HUMAN
  • K7ESB6_HUMAN

Pseudogenes.org Pseudogenes for CSNK1G2 Gene

genes like me logo Genes that share paralogs with CSNK1G2: view

Variants for CSNK1G2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CSNK1G2 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs55702630 - p.Phe189Leu
rs55754218 - p.Arg217Cys
rs55780547 - p.Glu194Gly
rs55818316 - p.Glu208Gln
rs55923222 - p.Ile196Thr

Additional dbSNP identifiers (rs#s) for CSNK1G2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CSNK1G2 Gene

Variant ID Type Subtype PubMed ID
dgv488e201 CNV deletion 23290073
dgv568n67 CNV gain 20364138
dgv6212n54 CNV loss 21841781
dgv6213n54