Aliases for CSNK1G1 Gene
External Ids for CSNK1G1 Gene
Previous GeneCards Identifiers for CSNK1G1 Gene
This gene encodes a member of the casein kinase I gene family. This family is comprised of serine/threonine kinases that phosphorylate acidic proteins such as caseins. The encoded kinase plays a role in cell cycle checkpoint arrest in response to stalled replication forks by phosphorylating Claspin. A mutation in this gene may be associated with non-syndromic early-onset epilepsy (NSEOE). [provided by RefSeq, Jul 2016]
GeneCards Summary for CSNK1G1 Gene
CSNK1G1 (Casein Kinase 1 Gamma 1) is a Protein Coding gene. Diseases associated with CSNK1G1 include Aortic Valve Prolapse and Epilepsy With Generalized Tonic-Clonic Seizures. Among its related pathways are S45 mutants of beta-catenin arent phosphorylated and Hedgehog signaling events mediated by Gli proteins. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1G3.
UniProtKB/Swiss-Prot Summary for CSNK1G1 Gene
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN.
Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. CK1 is involved in many cellular processes including DNA repair, cell division, nuclear localization and membrane transport. Isoforms are also integral to development.