Aliases for CSNK1E Gene
External Ids for CSNK1E Gene
Previous GeneCards Identifiers for CSNK1E Gene
The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]
GeneCards Summary for CSNK1E Gene
CSNK1E (Casein Kinase 1 Epsilon) is a Protein Coding gene. Diseases associated with CSNK1E include Developmental And Epileptic Encephalopathy 1 and West Syndrome. Among its related pathways are G-Beta Gamma Signaling and Pathways of neurodegeneration - multiple diseases. Gene Ontology (GO) annotations related to this gene include protein kinase activity. An important paralog of this gene is TPTEP2-CSNK1E.
UniProtKB/Swiss-Prot Summary for CSNK1E Gene
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.