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Aliases for CSNK1E Gene

Aliases for CSNK1E Gene

  • Casein Kinase 1 Epsilon 2 3 5
  • CKIe 3 4
  • Casein Kinase I Isoform Epsilon 3
  • Casein Kinase 1, Epsilon 2
  • CKI-Epsilon 4
  • EC 2.7.11.1 4
  • CKIepsilon 3
  • HCKIE 3

External Ids for CSNK1E Gene

Previous GeneCards Identifiers for CSNK1E Gene

  • GC22M035302
  • GC22M036929
  • GC22M036930
  • GC22M037011
  • GC22M038686
  • GC22M021653
  • GC22M038397
  • GC22M038521
  • GC22M038831
  • GC22M039969
  • GC22M040661
  • GC22M041110
  • GC22M041514
  • GC22M041931

Summaries for CSNK1E Gene

Entrez Gene Summary for CSNK1E Gene

  • The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]

GeneCards Summary for CSNK1E Gene

CSNK1E (Casein Kinase 1 Epsilon) is a Protein Coding gene. Diseases associated with CSNK1E include Advanced Sleep Phase Syndrome. Among its related pathways are Circadian rhythm pathway and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include protein kinase activity. An important paralog of this gene is TPTEP2-CSNK1E.

UniProtKB/Swiss-Prot for CSNK1E Gene

  • Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.

Gene Wiki entry for CSNK1E Gene

Additional gene information for CSNK1E Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK1E Gene

Genomics for CSNK1E Gene

GeneHancer (GH) Regulatory Elements for CSNK1E Gene

Promoters and enhancers for CSNK1E Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J038308 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 650.7 +3.8 3847 11.9 HDGF PKNOX1 SMAD1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 CSNK1E DDX17 JOSD1 TMEM184B PICK1 MAFF KCNJ4 KDELR3 SNORD83B PLA2G6
GH22J038392 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.2 -78.2 -78228 7 FEZF1 GLI4 ZNF2 ZNF48 TCF12 POLR2B GLIS2 ZNF143 KLF7 ATF7 CSNK1E GGA1 NPTXR ENSG00000228274 TPTEP2-CSNK1E TPTEP2 ENSG00000229955
GH22J038294 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 650.4 +17.1 17142 12.5 HDGF PKNOX1 ARID4B SIN3A IRF4 BRCA1 GLIS2 ZNF143 ATF7 FOS CSNK1E PLA2G6 GGA1 TMEM184B BAIAP2L2 PICK1 SOX10 POLR2F MAFF KCNJ4
GH22J038335 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 650.4 -18.1 -18118 2.3 KLF1 KLF14 ZEB1 ZNF316 GLIS2 POLR2A VEZF1 PRDM10 ZNF444 FOS CSNK1E DDX17 JOSD1 RPL3 TMEM184B KCNJ4 KDELR3 SNORD83B PLA2G6 PIR43912
GH22J038289 Promoter/Enhancer 1.5 EPDnew ENCODE dbSUPER 655.6 +26.5 26543 4.7 CTCF HDGF KLF1 ZSCAN4 KLF17 ZIC2 ZFHX2 POLR2A PATZ1 SCRT2 CSNK1E PLA2G6 BAIAP2L2 MAFF KDELR3 KCNJ4 PICK1 GALR3 ENSG00000277385 TPTEP2-CSNK1E
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CSNK1E on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CSNK1E gene promoter:

Genomic Locations for CSNK1E Gene

Genomic Locations for CSNK1E Gene
chr22:38,290,691-38,318,084
(GRCh38/hg38)
Size:
27,394 bases
Orientation:
Minus strand
chr22:38,686,697-38,794,527
(GRCh37/hg19)

Genomic View for CSNK1E Gene

Genes around CSNK1E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSNK1E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSNK1E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK1E Gene

Proteins for CSNK1E Gene

  • Protein details for CSNK1E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49674-KC1E_HUMAN
    Recommended name:
    Casein kinase I isoform epsilon
    Protein Accession:
    P49674

    Protein attributes for CSNK1E Gene

    Size:
    416 amino acids
    Molecular mass:
    47315 Da
    Quaternary structure:
    • Monomer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts with ANKRD6, DBNDD2, LRP5, LRP6 and SOCS3. Interacts with SNAI1 (via zinc fingers). Interacts with DDX3X; the interaction greatly improves CSNK1E affinity for ATP and enhances DVL2 phosphorylation (PubMed:23413191).

    Three dimensional structures from OCA and Proteopedia for CSNK1E Gene

neXtProt entry for CSNK1E Gene

Post-translational modifications for CSNK1E Gene

  • Autophosphorylated. Partially dephosphorylated by PPP5C. May be dephosphorylated by PP1.
  • Ubiquitination at posLast=294294
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CSNK1E Gene

Domains & Families for CSNK1E Gene

Gene Families for CSNK1E Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for CSNK1E Gene

Graphical View of Domain Structure for InterPro Entry

P49674

UniProtKB/Swiss-Prot:

KC1E_HUMAN :
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Family:
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
genes like me logo Genes that share domains with CSNK1E: view

Function for CSNK1E Gene

Molecular function for CSNK1E Gene

UniProtKB/Swiss-Prot Function:
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylation leads to a decrease of the catalytic activity.
UniProtKB/Swiss-Prot Induction:
Down-regulated during granulocytic differentiation.
GENATLAS Biochemistry:
casein kinase 1,catalytic unit,epsilon 1,involved in the transduction of WNT signal

Enzyme Numbers (IUBMB) for CSNK1E Gene

Phenotypes From GWAS Catalog for CSNK1E Gene

Gene Ontology (GO) - Molecular Function for CSNK1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding HDA 22681889
GO:0004672 protein kinase activity IDA,ISS --
GO:0004674 protein serine/threonine kinase activity TAS 7797465
GO:0005515 protein binding IPI 11425858
genes like me logo Genes that share ontologies with CSNK1E: view
genes like me logo Genes that share phenotypes with CSNK1E: view

Animal Models for CSNK1E Gene

MGI Knock Outs for CSNK1E:

Animal Model Products

miRNA for CSNK1E Gene

miRTarBase miRNAs that target CSNK1E

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSNK1E Gene

Localization for CSNK1E Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSNK1E Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSNK1E gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CSNK1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS,IBA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 17244647
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CSNK1E: view

Pathways & Interactions for CSNK1E Gene

genes like me logo Genes that share pathways with CSNK1E: view

SIGNOR curated interactions for CSNK1E Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for CSNK1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0006281 DNA repair TAS 7797465
GO:0006364 rRNA processing TAS --
GO:0006468 protein phosphorylation ISS --
GO:0006897 endocytosis IBA --
genes like me logo Genes that share ontologies with CSNK1E: view

Drugs & Compounds for CSNK1E Gene

(6) Drugs for CSNK1E Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
IC261 Experimental Pharma 0
seliciclib Investigational Pharma Target Kinase Inhibitors 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(2) Additional Compounds for CSNK1E Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with CSNK1E: view

Transcripts for CSNK1E Gene

mRNA/cDNA for CSNK1E Gene

Unigene Clusters for CSNK1E Gene

Casein kinase 1, epsilon:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1E Gene

No ASD Table

Relevant External Links for CSNK1E Gene

GeneLoc Exon Structure for
CSNK1E
ECgene alternative splicing isoforms for
CSNK1E

Expression for CSNK1E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CSNK1E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CSNK1E Gene

This gene is overexpressed in Breast (22.5), Fetal Brain (21.0), Frontal cortex (11.7), and Heart (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CSNK1E Gene



NURSA nuclear receptor signaling pathways regulating expression of CSNK1E Gene:

CSNK1E

SOURCE GeneReport for Unigene cluster for CSNK1E Gene:

Hs.474833

mRNA Expression by UniProt/SwissProt for CSNK1E Gene:

P49674-KC1E_HUMAN
Tissue specificity: Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes.

Evidence on tissue expression from TISSUES for CSNK1E Gene

  • Lung(4.6)
  • Nervous system(4.4)
  • Liver(4.3)
  • Skin(3.2)
  • Intestine(2)
genes like me logo Genes that share expression patterns with CSNK1E: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSNK1E Gene

Orthologs for CSNK1E Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSNK1E Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 34
  • 100 (a)
OneToMany
CSNK1E 34
  • 47 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CSNK1E 34 33
  • 99.44 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CSNK1E 34 33
  • 92.63 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CSNK1E 34
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Csnk1e 33
  • 90.95 (n)
mouse
(Mus musculus)
Mammalia Csnk1e 16 34 33
  • 90.71 (n)
oppossum
(Monodelphis domestica)
Mammalia CSNK1E 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves CSNK1E 34 33
  • 83.73 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CSNK1E 34
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia csnk1e 33
  • 78.45 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.553 33
zebrafish
(Danio rerio)
Actinopterygii csnk1e 34 33
  • 74.48 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta dco 34 35 33
  • 76.86 (n)
OneToMany
CkIalpha 35
  • 70 (a)
CG2577 35
  • 58 (a)
CG7094 35
  • 56 (a)
CG12147 35
  • 53 (a)
CG9962 35
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea kin-20 34
  • 48 (a)
OneToMany
C55B7.10 35
  • 32 (a)
spe-6 35
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRR25 36
thale cress
(Arabidopsis thaliana)
eudicotyledons ckl12 33
  • 68.81 (n)
rice
(Oryza sativa)
Liliopsida Os.11642 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9629 34
  • 79 (a)
OneToMany
Species where no ortholog for CSNK1E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CSNK1E Gene

ENSEMBL:
Gene Tree for CSNK1E (if available)
TreeFam:
Gene Tree for CSNK1E (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CSNK1E: view image

Paralogs for CSNK1E Gene

Paralogs for CSNK1E Gene

(9) SIMAP similar genes for CSNK1E Gene using alignment to 11 proteins:

  • KC1E_HUMAN
  • B0QY34_HUMAN
  • B0QY35_HUMAN
  • B0QY36_HUMAN
  • H0Y5S9_HUMAN
  • H0Y645_HUMAN
  • H0Y682_HUMAN
  • H7C0Y5_HUMAN
  • H7C3J2_HUMAN
  • L8EC90_HUMAN
  • Q5U045_HUMAN
genes like me logo Genes that share paralogs with CSNK1E: view

Variants for CSNK1E Gene

Sequence variations from dbSNP and Humsavar for CSNK1E Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
VAR_042082 A lung adenocarcinoma sample p.Arg256Leu
rs1000114570 -- 38,317,554(-) A/ genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000213875 -- 38,295,400(-) G/T intron_variant
rs1000260491 -- 38,295,486(-) C/T intron_variant
rs1000311407 -- 38,295,820(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CSNK1E Gene

Variant ID Type Subtype PubMed ID
dgv831e199 CNV deletion 23128226
esv2667907 CNV deletion 23128226
esv29271 CNV loss 19812545
esv3647726 CNV loss 21293372
esv3647727 CNV loss 21293372
nsv1072210 CNV deletion 25765185
nsv1072637 CNV deletion 25765185
nsv1072638 CNV deletion 25765185
nsv1126631 CNV deletion 24896259
nsv1143410 CNV deletion 24896259
nsv834195 CNV loss 17160897
nsv964629 CNV duplication 23825009
nsv979674 CNV duplication 23825009

Variation tolerance for CSNK1E Gene

Residual Variation Intolerance Score: 19.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 24.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CSNK1E Gene

Human Gene Mutation Database (HGMD)
CSNK1E
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSNK1E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK1E Gene

Disorders for CSNK1E Gene

MalaCards: The human disease database

(1) MalaCards diseases for CSNK1E Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
advanced sleep phase syndrome
  • familial advanced sleep-phase syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CSNK1E

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CSNK1E: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CSNK1E Gene

Publications for CSNK1E Gene

  1. Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family. (PMID: 7797465) Fish KJ … Virshup DM (The Journal of biological chemistry 1995) 2 3 4 22 58
  2. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. (PMID: 20072116) Soria V … Urretavizcaya M (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010) 3 22 44 58
  3. Testing the circadian gene hypothesis in prostate cancer: a population-based case-control study. (PMID: 19934327) Zhu Y … Stanford JL (Cancer research 2009) 3 22 44 58
  4. Casein kinase I epsilon (CKIvarepsilon) N408 allele is very rare in the Brazilian population and is not involved in susceptibility to circadian rhythm sleep disorders. (PMID: 18571740) Castro RM … Tufik S (Behavioural brain research 2008) 3 22 44 58
  5. Genetic susceptibility to heroin addiction: a candidate gene association study. (PMID: 18518925) Levran O … Kreek MJ (Genes, brain, and behavior 2008) 3 22 44 58

Products for CSNK1E Gene

Sources for CSNK1E Gene

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