The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This prote... See more...

Aliases for CSNK1E Gene

Aliases for CSNK1E Gene

  • Casein Kinase 1 Epsilon 2 3 5
  • Casein Kinase I Isoform Epsilon 3 4
  • EC 2.7.11.1 4 50
  • CKIepsilon 2 3
  • HCKIE 2 3
  • CKIe 3 4
  • Casein Kinase 1, Epsilon 2
  • CKI-Epsilon 4
  • EC 2.7.11 50
  • CSNK1E 5
  • CKIE 2

External Ids for CSNK1E Gene

Previous GeneCards Identifiers for CSNK1E Gene

  • GC22M035302
  • GC22M036929
  • GC22M036930
  • GC22M037011
  • GC22M038686
  • GC22M021653
  • GC22M038397
  • GC22M038521
  • GC22M042806
  • GC22M042921
  • GC22M042993
  • GC22M044617
  • GC22M038831
  • GC22M039969
  • GC22M040661
  • GC22M041110
  • GC22M041514
  • GC22M041931
  • GC22M042362
  • GC22M042693
  • GC22M045469
  • GC22M046343

Summaries for CSNK1E Gene

Entrez Gene Summary for CSNK1E Gene

  • The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]

GeneCards Summary for CSNK1E Gene

CSNK1E (Casein Kinase 1 Epsilon) is a Protein Coding gene. Diseases associated with CSNK1E include Developmental And Epileptic Encephalopathy 1 and West Syndrome. Among its related pathways are G-Beta Gamma Signaling and Pathways of neurodegeneration - multiple diseases. Gene Ontology (GO) annotations related to this gene include protein kinase activity. An important paralog of this gene is TPTEP2-CSNK1E.

UniProtKB/Swiss-Prot Summary for CSNK1E Gene

  • Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.

Gene Wiki entry for CSNK1E Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CSNK1E Gene

Genomics for CSNK1E Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CSNK1E Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CSNK1E on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CSNK1E

Top Transcription factor binding sites by QIAGEN in the CSNK1E gene promoter:
  • HNF-4alpha1
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for CSNK1E Gene

Latest Assembly
chr22:38,290,691-38,318,084
(GRCh38/hg38)
Size:
27,394 bases
Orientation:
Minus strand

Previous Assembly
chr22:38,686,697-38,714,089
(GRCh37/hg19 by Entrez Gene)
Size:
27,393 bases
Orientation:
Minus strand

chr22:38,686,697-38,794,527
(GRCh37/hg19 by Ensembl)
Size:
107,831 bases
Orientation:
Minus strand

Genomic View for CSNK1E Gene

Genes around CSNK1E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSNK1E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSNK1E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK1E Gene

Proteins for CSNK1E Gene

  • Protein details for CSNK1E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49674-KC1E_HUMAN
    Recommended name:
    Casein kinase I isoform epsilon
    Protein Accession:
    P49674

    Protein attributes for CSNK1E Gene

    Size:
    416 amino acids
    Molecular mass:
    47315 Da
    Quaternary structure:
    • Monomer (PubMed:23106386). Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins (By similarity). Interacts with PER1 (PubMed:10790862). Interacts with ANKRD6 (By similarity). Interacts with DBNDD2 (PubMed:16618118). Interacts with LRP5 and LRP6 (PubMed:16513652). Interacts with SOCS3 (PubMed:15070676). Interacts with SNAI1 (via zinc fingers) (PubMed:20305697). Interacts with DDX3X; this interaction greatly enhances CSNK1E affinity for ATP and DVL2 phosphorylation, but inhibits DDX3X ATPase/helicase activity. In the presence of RNA, the interaction is decreased (PubMed:23413191, PubMed:29222110).

    Three dimensional structures from OCA and Proteopedia for CSNK1E Gene

neXtProt entry for CSNK1E Gene

Selected DME Specific Peptides for CSNK1E Gene

P49674:
  • GEEVAIK
  • QGGVGIP
  • LGKKGNL
  • TKRQKYE
  • RERKVSMRLHRGAP
  • ESLGYVL
  • RSLRFDDKPDY
  • RKIGSGSFG
  • LFRNLFHR
  • SSSDLTGRQ
  • EQSRRDDLE
  • DLESLGY
  • LTGTARY
  • LPWQGLKA
  • QKYERISEKK
  • IHRDVKPDN
  • TKHPQLHIESK
  • PDNFLMG
  • LADQMISRI
  • TPIEVLC
  • LKTVLLLADQ
  • YLRQLFR
  • LLGPSLEDLF
  • DFGLAKKYRD
  • IIDFGLA
  • RKFSLKT
  • GIEQSRRDD

Post-translational modifications for CSNK1E Gene

  • Autophosphorylated. Partially dephosphorylated by PPP5C. May be dephosphorylated by PP1.
  • Ubiquitination at Lys294
  • Modification sites at PhosphoSitePlus

Domains & Families for CSNK1E Gene

Gene Families for CSNK1E Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CSNK1E Gene

GenScript: Design optimal peptide antigens:
  • Casein kinase 1, epsilon (B0QY31_HUMAN)
  • Casein kinase 1, epsilon (B0QY32_HUMAN)
  • Casein kinase 1, epsilon (B0QY33_HUMAN)
  • Casein kinase I isoform epsilon (KC1E_HUMAN)
  • HCG2014051, isoform CRA_a (Q5U045_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P49674

UniProtKB/Swiss-Prot:

KC1E_HUMAN :
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Family:
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
genes like me logo Genes that share domains with CSNK1E: view

Function for CSNK1E Gene

Molecular function for CSNK1E Gene

UniProtKB/Swiss-Prot Function:
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269|PubMed:29222110};.
UniProtKB/Swiss-Prot Induction:
Down-regulated during granulocytic differentiation.
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylation leads to a decrease of the catalytic activity.
GENATLAS Biochemistry:
casein kinase 1,catalytic unit,epsilon 1,involved in the transduction of WNT signal

Enzyme Numbers (IUBMB) for CSNK1E Gene

Phenotypes From GWAS Catalog for CSNK1E Gene

Gene Ontology (GO) - Molecular Function for CSNK1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding HDA 22681889
GO:0004672 protein kinase activity IEA,ISS --
GO:0004674 protein serine/threonine kinase activity IEA,TAS 7797465
GO:0005515 protein binding IPI 11425858
genes like me logo Genes that share ontologies with CSNK1E: view
genes like me logo Genes that share phenotypes with CSNK1E: view

Animal Models for CSNK1E Gene

MGI Knock Outs for CSNK1E:

miRNA for CSNK1E Gene

miRTarBase miRNAs that target CSNK1E

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSNK1E

Clone products for research

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSNK1E Gene

Localization for CSNK1E Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSNK1E Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSNK1E gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
mitochondrion 2
plasma membrane 1
extracellular 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CSNK1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 17244647
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CSNK1E: view

Pathways & Interactions for CSNK1E Gene

genes like me logo Genes that share pathways with CSNK1E: view

Pathways by source for CSNK1E Gene

1 Sino Biological pathway for CSNK1E Gene
2 GeneGo (Thomson Reuters) pathways for CSNK1E Gene
  • Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
  • Translation Regulation of EIF2 activity
1 R&D Systems pathway for CSNK1E Gene
1 Tocris pathway for CSNK1E Gene
6 Qiagen pathways for CSNK1E Gene
  • Circadian Clock in Mammals
  • Dopamine-DARPP32 Feedback onto cAMP Pathway
  • GSK3 Signaling
  • NFAT in Immune Response
  • Signaling in Gap Junctions
2 Cell Signaling Technology pathways for CSNK1E Gene

SIGNOR curated interactions for CSNK1E Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CSNK1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0006281 DNA repair TAS 7797465
GO:0006468 protein phosphorylation IEA,ISS --
GO:0006897 endocytosis IBA 21873635
GO:0007165 signal transduction TAS 7797465
genes like me logo Genes that share ontologies with CSNK1E: view

Drugs & Compounds for CSNK1E Gene

(8) Drugs for CSNK1E Gene - From: DrugBank, PharmGKB, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Umbralisib Approved, Investigational Pharma Target, Enzyme, inhibitor 0
IC261 Experimental Pharma 0
seliciclib Investigational Pharma Target Kinase Inhibitors 0
ATP Investigational Nutra 0
Heroin Pharma 140

(2) Additional Compounds for CSNK1E Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
genes like me logo Genes that share compounds with CSNK1E: view

Transcripts for CSNK1E Gene

mRNA/cDNA for CSNK1E Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSNK1E

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1E Gene

No ASD Table

Relevant External Links for CSNK1E Gene

GeneLoc Exon Structure for
CSNK1E

Expression for CSNK1E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CSNK1E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CSNK1E Gene

This gene is overexpressed in Breast (22.5), Fetal Brain (21.0), Frontal cortex (11.7), and Heart (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CSNK1E Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CSNK1E

SOURCE GeneReport for Unigene cluster for CSNK1E Gene:

Hs.474833

mRNA Expression by UniProt/SwissProt for CSNK1E Gene:

P49674-KC1E_HUMAN
Tissue specificity: Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes.

Evidence on tissue expression from TISSUES for CSNK1E Gene

  • Lung(4.7)
  • Nervous system(4.6)
  • Liver(4.4)
  • Blood(4.4)
  • Skin(3.7)
  • Muscle(2.6)
  • Heart(2.4)
  • Pancreas(2.4)
  • Intestine(2.4)
  • Eye(2.3)
  • Kidney(2.3)
  • Adrenal gland(2.3)
  • Stomach(2.1)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with CSNK1E: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSNK1E Gene

Orthologs for CSNK1E Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSNK1E Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia -- 30
  • 100 (a)
OneToMany
CSNK1E 30
  • 47 (a)
OneToMany
Chimpanzee
(Pan troglodytes)
Mammalia CSNK1E 29 30
  • 99.44 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CSNK1E 29 30
  • 92.63 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CSNK1E 30
  • 92 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Csnk1e 29
  • 90.95 (n)
Mouse
(Mus musculus)
Mammalia Csnk1e 29 16 30
  • 90.71 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CSNK1E 30
  • 85 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CSNK1E 29 30
  • 83.73 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CSNK1E 30
  • 97 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia csnk1e 29
  • 78.45 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.553 29
Zebrafish
(Danio rerio)
Actinopterygii csnk1e 29 30
  • 74.48 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta dco 29 30 31
  • 76.86 (n)
OneToMany
CkIalpha 31
  • 70 (a)
CG2577 31
  • 58 (a)
CG7094 31
  • 56 (a)
CG12147 31
  • 53 (a)
CG9962 31
  • 47 (a)
Worm
(Caenorhabditis elegans)
Secernentea kin-20 30
  • 48 (a)
OneToMany
C55B7.10 31
  • 32 (a)
spe-6 31
  • 31 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRR25 32
Thale Cress
(Arabidopsis thaliana)
eudicotyledons ckl12 29
  • 68.81 (n)
Rice
(Oryza sativa)
Liliopsida Os.11642 29
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.9629 30
  • 79 (a)
OneToMany
Species where no ortholog for CSNK1E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CSNK1E Gene

ENSEMBL:
Gene Tree for CSNK1E (if available)
TreeFam:
Gene Tree for CSNK1E (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CSNK1E: view image
Alliance of Genome Resources:
Additional Orthologs for CSNK1E

Paralogs for CSNK1E Gene

(9) SIMAP similar genes for CSNK1E Gene using alignment to 11 proteins:

  • KC1E_HUMAN
  • B0QY34_HUMAN
  • B0QY35_HUMAN
  • B0QY36_HUMAN
  • H0Y5S9_HUMAN
  • H0Y645_HUMAN
  • H0Y682_HUMAN
  • H7C0Y5_HUMAN
  • H7C3J2_HUMAN
  • L8EC90_HUMAN
  • Q5U045_HUMAN
genes like me logo Genes that share paralogs with CSNK1E: view

Variants for CSNK1E Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CSNK1E Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
929456 Uncertain Significance: not provided 38,302,910(-) C/A
NM_152221.3(CSNK1E):c.287G>T (p.Cys96Phe)
MISSENSE
rs1569077009 Pathogenic: Epileptic encephalopathy, early infantile, 1 38,298,785(-) C/T
NM_152221.3(CSNK1E):c.885+1G>A
SPLICE_DONOR
rs1803340 Benign: not provided 38,300,896(-) G/A
NM_152221.3(CSNK1E):c.393C>T (p.Pro131=)
SYNONYMOUS
rs186918102 Benign: not provided 38,302,851(-) G/A
NM_152221.3(CSNK1E):c.336+10C>T
INTRON
rs368463837 Benign: not provided 38,294,256(-) G/T
NM_152221.3(CSNK1E):c.1079-8C>A
INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CSNK1E Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CSNK1E Gene

Variant ID Type Subtype PubMed ID
dgv831e199 CNV deletion 23128226
esv2667907 CNV deletion 23128226
esv29271 CNV loss 19812545
esv3647726 CNV loss 21293372
esv3647727 CNV loss 21293372
nsv1072210 CNV deletion 25765185
nsv1072637 CNV deletion 25765185
nsv1072638 CNV deletion 25765185
nsv1126631 CNV deletion 24896259
nsv1143410 CNV deletion 24896259
nsv834195 CNV loss 17160897
nsv964629 CNV duplication 23825009
nsv979674 CNV duplication 23825009

Variation tolerance for CSNK1E Gene

Residual Variation Intolerance Score: 19.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 24.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CSNK1E Gene

Human Gene Mutation Database (HGMD)
CSNK1E
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSNK1E
Leiden Open Variation Database (LOVD)
CSNK1E

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK1E Gene

Disorders for CSNK1E Gene

MalaCards: The human disease database

(8) MalaCards diseases for CSNK1E Gene - From: CVR, COP, and GCD

Disorder Aliases PubMed IDs
developmental and epileptic encephalopathy 1
  • dee1
west syndrome
  • epileptic encephalopathy, early infantile, 1
advanced sleep phase syndrome
  • familial advanced sleep-phase syndrome
gum cancer
  • malignant gingival tumor
delayed sleep phase disorder
  • delayed sleep phase disorder, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CSNK1E

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CSNK1E: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CSNK1E Gene

Publications for CSNK1E Gene

  1. Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family. (PMID: 7797465) Fish KJ … Virshup DM (The Journal of biological chemistry 1995) 2 3 4 22
  2. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. (PMID: 20072116) Soria V … Urretavizcaya M (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010) 3 22 40
  3. Testing the circadian gene hypothesis in prostate cancer: a population-based case-control study. (PMID: 19934327) Zhu Y … Stanford JL (Cancer research 2009) 3 22 40
  4. Casein kinase I epsilon (CKIvarepsilon) N408 allele is very rare in the Brazilian population and is not involved in susceptibility to circadian rhythm sleep disorders. (PMID: 18571740) Castro RM … Tufik S (Behavioural brain research 2008) 3 22 40
  5. Genetic susceptibility to heroin addiction: a candidate gene association study. (PMID: 18518925) Levran O … Kreek MJ (Genes, brain, and behavior 2008) 3 22 40

Products for CSNK1E Gene

  • Boster Bio Antibodies for CSNK1E
  • Boster Bio ELISA Kits for CSNK1E

Sources for CSNK1E Gene