This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. The encoded protei... See more...

Aliases for CSNK1D Gene

Aliases for CSNK1D Gene

  • Casein Kinase 1 Delta 2 3 5
  • Casein Kinase I Isoform Delta 3 4
  • Tau-Protein Kinase CSNK1D 3 4
  • EC 2.7.11.1 4 52
  • CKI-Delta 3 4
  • HCKID 3 4
  • CKId 3 4
  • Casein Kinase 1, Delta 2
  • Casein Kinase I 3
  • EC 2.7.11.26 4
  • EC 2.7.11 52
  • CKIdelta 3
  • FASPS2 3
  • ASPS 3

External Ids for CSNK1D Gene

Previous GeneCards Identifiers for CSNK1D Gene

  • GC17M079094
  • GC17M083015
  • GC17M080732
  • GC17M080881
  • GC17M080880
  • GC17M077795
  • GC17M080203
  • GC17M075601

Summaries for CSNK1D Gene

Entrez Gene Summary for CSNK1D Gene

  • This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

GeneCards Summary for CSNK1D Gene

CSNK1D (Casein Kinase 1 Delta) is a Protein Coding gene. Diseases associated with CSNK1D include Advanced Sleep Phase Syndrome, Familial, 2 and Advanced Sleep Phase Syndrome. Among its related pathways are Metabolism of proteins and FoxO family signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1E.

UniProtKB/Swiss-Prot Summary for CSNK1D Gene

  • Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.

Gene Wiki entry for CSNK1D Gene

Additional gene information for CSNK1D Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CSNK1D Gene

Genomics for CSNK1D Gene

GeneHancer (GH) Regulatory Elements for CSNK1D Gene

Promoters and enhancers for CSNK1D Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CSNK1D on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CSNK1D

Top Transcription factor binding sites by QIAGEN in the CSNK1D gene promoter:
  • AP-1
  • C/EBPalpha
  • FOXD3
  • GR
  • GR-alpha
  • NF-1
  • NF-1/L
  • NRF-2
  • Pax-5
  • SRY

Genomic Locations for CSNK1D Gene

Genomic Locations for CSNK1D Gene
chr17:82,239,023-82,273,742
(GRCh38/hg38)
Size:
34,720 bases
Orientation:
Minus strand
chr17:80,196,899-80,231,607
(GRCh37/hg19)
Size:
34,709 bases
Orientation:
Minus strand

Genomic View for CSNK1D Gene

Genes around CSNK1D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSNK1D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSNK1D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK1D Gene

Proteins for CSNK1D Gene

  • Protein details for CSNK1D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48730-KC1D_HUMAN
    Recommended name:
    Casein kinase I isoform delta
    Protein Accession:
    P48730
    Secondary Accessions:
    • A2I2P2
    • Q96KZ6
    • Q9BTN5

    Protein attributes for CSNK1D Gene

    Size:
    415 amino acids
    Molecular mass:
    47330 Da
    Quaternary structure:
    • Monomer (PubMed:22168824, PubMed:23106386). Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins (By similarity). Interacts with DNMT1 and MAP1A (By similarity). Interacts directly with PER1 and PER2 which may lead to their degradation (PubMed:11165242). Interacts with MAPT/TAU (PubMed:14761950). Interacts with SNAPIN (By similarity). Interacts with DBNDD2 (PubMed:16618118). Interacts with AIB1/NCOA3 and ESR1 (PubMed:19339517). Interacts with AKAP9/AKAP450; this interaction promotes centrosomal subcellular location (PubMed:12270714). Binds to tubulins in mitotic cells upon DNA damage (PubMed:10826492). Interacts with GJA1 (PubMed:12270943).
    Miscellaneous:
    • May be involved in Alzheimer disease by phosphorylating MAPT/TAU.

    Three dimensional structures from OCA and Proteopedia for CSNK1D Gene

    Alternative splice isoforms for CSNK1D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSNK1D Gene

Selected DME Specific Peptides for CSNK1D Gene

P48730:
  • GEEVAIK
  • GIPTIRW
  • QGGVGIP
  • LGKKGNL
  • TKRQKYE
  • RERKVSMRLHRGAP
  • RVASSGL
  • ESLGYVL
  • RGLPSTASGRLRGTQEV
  • RSLRFDDKPDY
  • RKIGSGSFG
  • LFRNLFHR
  • SSSDLTGRQ
  • EQSRRDDLE
  • DLESLGY
  • LTGTARY
  • LPWQGLKA
  • QKYERISEKK
  • IHRDVKPDN
  • TKHPQLHIESK
  • PDNFLMG
  • LADQMISRI
  • TPIEVLC
  • LKTVLLLADQ
  • YLRQLFR
  • LLGPSLEDLF
  • DFGLAKKYRD
  • IIDFGLA
  • RKFSLKT
  • GIEQSRRDD

Post-translational modifications for CSNK1D Gene

  • Autophosphorylated on serine and threonine residues; this autophosphorylation represses activity. Reactivated by phosphatase-mediated dephosphorylation. May be dephosphorylated by PP1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for CSNK1D Gene

Gene Families for CSNK1D Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for CSNK1D Gene

Suggested Antigen Peptide Sequences for CSNK1D Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55976, highly similar to Casein kinase I isoform delta (EC 2.7.11.1) (B4DIJ9_HUMAN)
  • cDNA FLJ50568, highly similar to Casein kinase I isoform delta (EC 2.7.11.1) (B4DLF1_HUMAN)
  • Casein kinase I isoform delta (KC1D_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P48730

UniProtKB/Swiss-Prot:

KC1D_HUMAN :
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Family:
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
genes like me logo Genes that share domains with CSNK1D: view

Function for CSNK1D Gene

Molecular function for CSNK1D Gene

UniProtKB/Swiss-Prot Function:
Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[tau protein]-L-serine + ATP = [tau protein]-O-phospho-L-serine + ADP + H(+); Xref=Rhea:RHEA:12801, Rhea:RHEA-COMP:13701, Rhea:RHEA-COMP:13702, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.26;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[tau protein]-L-threonine + ATP = [tau protein]-O-phospho-L-threonine + ADP + H(+); Xref=Rhea:RHEA:53904, Rhea:RHEA-COMP:13703, Rhea:RHEA-COMP:13704, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.26;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Exhibits substrate-dependent heparin activation. Drug-mediated inhibition leads to a delay of the oscillations with the magnitude of this effect dependent upon the timing of drug administration. Inhibited by phosphorylation. Repressed by 3-[(2,4,6-trimethoxyphenyl)methylidenyl]-indolin-2-one (IC261), N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide (CKI-7), 4-[4-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide (D4476), 3,4-diaryl-isoxazoles and -imidazoles, and 4-(3-cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl) pyrimidin-2-ylamine (PF670462, PF670).
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=36.5 uM for alpha-casein {ECO:0000269 PubMed:23636092}; KM=635.8 uM for PER2 peptide {ECO:0000269 PubMed:23636092}; KM=180.6 uM for ATP {ECO:0000269 PubMed:23636092}; Note=Maximal velocity nearly identical for the reactions with alpha-casein and PER2 peptide.;
GENATLAS Biochemistry:
casein kinase 1,catalytic unit,delta 1,involved in the transduction of WNT signal

Enzyme Numbers (IUBMB) for CSNK1D Gene

Phenotypes From GWAS Catalog for CSNK1D Gene

Gene Ontology (GO) - Molecular Function for CSNK1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity TAS,IEA 8786104
GO:0004674 protein serine/threonine kinase activity TAS,IDA --
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CSNK1D: view
genes like me logo Genes that share phenotypes with CSNK1D: view

Human Phenotype Ontology for CSNK1D Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CSNK1D Gene

MGI Knock Outs for CSNK1D:

Animal Model Products

  • Taconic Biosciences Mouse Models for CSNK1D

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for CSNK1D Gene

Localization for CSNK1D Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSNK1D Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Note=Localized at mitotic spindle microtubules, and at the centrosomes and interphase in interphase cells. Recruited to the spindle apparatus and the centrosomes in response to DNA-damage. Correct subcellular localization requires kinase activity.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSNK1D gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
cytosol 5
golgi apparatus 5
mitochondrion 2
extracellular 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CSNK1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus ISS,IBA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0005794 Golgi apparatus IEA,IDA 10826492
genes like me logo Genes that share ontologies with CSNK1D: view

Pathways & Interactions for CSNK1D Gene

genes like me logo Genes that share pathways with CSNK1D: view

Pathways by source for CSNK1D Gene

6 Qiagen pathways for CSNK1D Gene
  • Dopamine-DARPP32 Feedback onto cAMP Pathway
  • GSK3 Signaling
  • NFAT in Immune Response
  • p53 Signaling
  • Signaling in Gap Junctions
2 Cell Signaling Technology pathways for CSNK1D Gene

SIGNOR curated interactions for CSNK1D Gene

Activates:
Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for CSNK1D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0001934 positive regulation of protein phosphorylation IMP 20412773
GO:0006468 protein phosphorylation ISS,IEA --
GO:0007020 microtubule nucleation IMP 24648492
GO:0007030 Golgi organization IMP 24648492
genes like me logo Genes that share ontologies with CSNK1D: view

Drugs & Compounds for CSNK1D Gene

(6) Drugs for CSNK1D Gene - From: ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
IC261 Experimental Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0
D4476 Pharma CK1/ALK5 inhibitor,specific and cell permeable, Selective CK1 inhibitor. Also inhibits TGF-betaRI 0
LH846 Pharma Casein kinases inhibitor, Selective casein kinase 1delta inhibitor 0
CASEIN KINASE I INHIBITOR Pharma 0

(1) Additional Compounds for CSNK1D Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0

(2) ApexBio Compounds for CSNK1D Gene

Compound Action Cas Number
D4476 CK1/ALK5 inhibitor,specific and cell permeable 301836-43-1
LH846 Casein kinases inhibitor 639052-78-1
genes like me logo Genes that share compounds with CSNK1D: view

Drug Products

Transcripts for CSNK1D Gene

mRNA/cDNA for CSNK1D Gene

3 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
26 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1D Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8a · 8b ·
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4:
SP5: - - -
SP6: - - - -
SP7: - - - - - - - - - - - -
SP8:
SP9:
SP10:
SP11: - - - - - - - - - - - - -
SP12: - - - - - -
SP13: - - -
SP14: - - - -
SP15: -
SP16: -
SP17: - - - - -

ExUns: 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d · 15e
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8: -
SP9: -