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Aliases for CSNK1A1L Gene

Aliases for CSNK1A1L Gene

  • Casein Kinase 1 Alpha 1 Like 2 3 5
  • CKI-Alpha-Like 3 4
  • CK1 3 4
  • Casein Kinase I Isoform Alpha-Like 3
  • Casein Kinase 1, Alpha 1-Like 2
  • Casein Kinase I Alpha S-Like 3
  • EC 4

External Ids for CSNK1A1L Gene

Previous GeneCards Identifiers for CSNK1A1L Gene

  • GC13M035476
  • GC13M036575
  • GC13M037677
  • GC13M018489

Summaries for CSNK1A1L Gene

GeneCards Summary for CSNK1A1L Gene

CSNK1A1L (Casein Kinase 1 Alpha 1 Like) is a Protein Coding gene. Among its related pathways are Gastric cancer and Regulation of lipid metabolism Insulin signaling-generic cascades. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1A1.

UniProtKB/Swiss-Prot for CSNK1A1L Gene

  • Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity).

Additional gene information for CSNK1A1L Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSNK1A1L Gene

Genomics for CSNK1A1L Gene

GeneHancer (GH) Regulatory Elements for CSNK1A1L Gene

Promoters and enhancers for CSNK1A1L Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J037107 Enhancer 0.6 ENCODE 47.5 -3.1 -3143 2.4 CTCF ZNF654 REST ATF2 RAD21 SMC3 ZNF143 FOS CSNK1A1L ENSG00000274549
GH13J036997 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 7 +105.6 105582 4.6 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 EXOSC8 ALG5 SUPT20H RFXAP SPART-AS1 SMAD9 CSNK1A1L
GH13J037100 Enhancer 0.3 ENCODE 23 +4.4 4423 1.8 CEBPA CSNK1A1L SUPT20H
GH13J037133 Enhancer 0.8 Ensembl ENCODE 5.4 -29.5 -29525 3 JUN FEZF1 ZNF843 ZBTB40 OSR2 PRDM6 JUND GLIS1 SCRT2 PRDM10 SUPT20H CSNK1A1L ENSG00000274549
GH13J037209 Enhancer 0.4 ENCODE 10.8 -105.7 -105715 3.8 KLF1 FOS CSNK1A1L RPS12P24 GC13M037167 RN7SKP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CSNK1A1L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CSNK1A1L gene promoter:
  • Nkx6-1
  • LCR-F1
  • S8
  • Hand1
  • E47
  • AP-4
  • CP2
  • CUTL1
  • Nkx3-1
  • Nkx3-1 v1

Genomic Locations for CSNK1A1L Gene

Genomic Locations for CSNK1A1L Gene
2,406 bases
Minus strand
2,407 bases
Minus strand

Genomic View for CSNK1A1L Gene

Genes around CSNK1A1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSNK1A1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSNK1A1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK1A1L Gene

Proteins for CSNK1A1L Gene

  • Protein details for CSNK1A1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Casein kinase I isoform alpha-like
    Protein Accession:
    Secondary Accessions:
    • Q5T2N2

    Protein attributes for CSNK1A1L Gene

    337 amino acids
    Molecular mass:
    39086 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CSNK1A1L Gene

Post-translational modifications for CSNK1A1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CSNK1A1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CSNK1A1L Gene

Domains & Families for CSNK1A1L Gene

Gene Families for CSNK1A1L Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for CSNK1A1L Gene

Suggested Antigen Peptide Sequences for CSNK1A1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
genes like me logo Genes that share domains with CSNK1A1L: view

Function for CSNK1A1L Gene

Molecular function for CSNK1A1L Gene

UniProtKB/Swiss-Prot Function:
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for CSNK1A1L Gene

Phenotypes From GWAS Catalog for CSNK1A1L Gene

Gene Ontology (GO) - Molecular Function for CSNK1A1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with CSNK1A1L: view
genes like me logo Genes that share phenotypes with CSNK1A1L: view

Animal Model Products

miRNA for CSNK1A1L Gene

miRTarBase miRNAs that target CSNK1A1L

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CSNK1A1L Gene

Localization for CSNK1A1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSNK1A1L Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSNK1A1L gene
Compartment Confidence
cytosol 5
nucleus 4
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CSNK1A1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with CSNK1A1L: view

Pathways & Interactions for CSNK1A1L Gene

genes like me logo Genes that share pathways with CSNK1A1L: view

Pathways by source for CSNK1A1L Gene

SIGNOR curated interactions for CSNK1A1L Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CSNK1A1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0006909 phagocytosis IBA --
GO:0008360 regulation of cell shape IBA --
GO:0016055 Wnt signaling pathway IBA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with CSNK1A1L: view

Drugs & Compounds for CSNK1A1L Gene

(7) Drugs for CSNK1A1L Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for CSNK1A1L Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CSNK1A1L: view

Transcripts for CSNK1A1L Gene

mRNA/cDNA for CSNK1A1L Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CSNK1A1L Gene

Casein kinase 1, alpha 1-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1A1L Gene

No ASD Table

Relevant External Links for CSNK1A1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CSNK1A1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CSNK1A1L Gene

mRNA differential expression in normal tissues according to GTEx for CSNK1A1L Gene

This gene is overexpressed in Testis (x25.1) and Whole Blood (x17.1).

Protein differential expression in normal tissues from HIPED for CSNK1A1L Gene

This gene is overexpressed in Cervix (44.2) and Heart (24.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CSNK1A1L Gene

Protein tissue co-expression partners for CSNK1A1L Gene

NURSA nuclear receptor signaling pathways regulating expression of CSNK1A1L Gene:


SOURCE GeneReport for Unigene cluster for CSNK1A1L Gene:

genes like me logo Genes that share expression patterns with CSNK1A1L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSNK1A1L Gene

Orthologs for CSNK1A1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSNK1A1L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CSNK1A1L 34 33
  • 99.6 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 95 (a)
(Mus musculus)
Mammalia Csnk1a1 34
  • 92 (a)
(Bos Taurus)
Mammalia CSNK1A1 34
  • 90 (a)
  • 72 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 90 (a)
-- 34
  • 89 (a)
-- 34
  • 83 (a)
-- 34
  • 75 (a)
-- 34
  • 75 (a)
-- 34
  • 71 (a)
(Canis familiaris)
Mammalia -- 34
  • 86 (a)
(Gallus gallus)
Aves CSNK1A1 34
  • 84 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 84 (a)
(Danio rerio)
Actinopterygii csnk1a1 34 34 33
  • 80.13 (n)
fruit fly
(Drosophila melanogaster)
Insecta CkIalpha 34
  • 71 (a)
(Caenorhabditis elegans)
Secernentea kin-19 34 33
  • 68.85 (n)
(Oryza sativa)
Liliopsida Os10g0476300 33
  • 64.16 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 85 (a)
  • 82 (a)
Species where no ortholog for CSNK1A1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CSNK1A1L Gene

Gene Tree for CSNK1A1L (if available)
Gene Tree for CSNK1A1L (if available)
Evolutionary constrained regions (ECRs) for CSNK1A1L: view image

Paralogs for CSNK1A1L Gene

Paralogs for CSNK1A1L Gene

(6) SIMAP similar genes for CSNK1A1L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CSNK1A1L: view

Variants for CSNK1A1L Gene

Sequence variations from dbSNP and Humsavar for CSNK1A1L Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs56158728 A colorectal cancer sample 37,105,196(-) G/A coding_sequence_variant, missense_variant
rs1000227474 -- 37,105,554(-) G/A 5_prime_UTR_variant
rs1000326070 -- 37,102,964(-) A/G downstream_transcript_variant
rs1000378569 -- 37,102,807(-) A/C downstream_transcript_variant
rs1001649216 -- 37,105,064(-) T/C coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for CSNK1A1L Gene

Variant ID Type Subtype PubMed ID
esv3892330 CNV gain 25118596
nsv826612 CNV loss 20364138

Variation tolerance for CSNK1A1L Gene

Residual Variation Intolerance Score: 89.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.76; 73.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CSNK1A1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK1A1L Gene

Disorders for CSNK1A1L Gene

Additional Disease Information for CSNK1A1L

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CSNK1A1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSNK1A1L Gene

Publications for CSNK1A1L Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells. (PMID: 27637333) Gabriel CH … Baumgrass R (The Journal of biological chemistry 2016) 3 58
  4. FBXW7 modulates cellular stress response and metastatic potential through ​HSF1 post-translational modification. (PMID: 25720964) Kourtis N … Aifantis I (Nature cell biology 2015) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for CSNK1A1L Gene

Sources for CSNK1A1L Gene

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