Aliases for CSNK1A1L Gene

Aliases for CSNK1A1L Gene

  • Casein Kinase 1 Alpha 1 Like 2 3 5
  • Casein Kinase I Isoform Alpha-Like 3 4
  • CKI-Alpha-Like 3 4
  • EC 2.7.11.1 4 50
  • CK1 3 4
  • Casein Kinase 1, Alpha 1-Like 2
  • Casein Kinase I Alpha S-Like 3
  • EC 2.7.11 50
  • CSNK1A1L 5
  • MGC33182 2

External Ids for CSNK1A1L Gene

Previous GeneCards Identifiers for CSNK1A1L Gene

  • GC13M035476
  • GC13M036575
  • GC13M037677
  • GC13M018489

Summaries for CSNK1A1L Gene

GeneCards Summary for CSNK1A1L Gene

CSNK1A1L (Casein Kinase 1 Alpha 1 Like) is a Protein Coding gene. Diseases associated with CSNK1A1L include Alzheimer Disease. Among its related pathways are Pathways of neurodegeneration - multiple diseases and Gastric cancer. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1A1.

UniProtKB/Swiss-Prot Summary for CSNK1A1L Gene

  • Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CSNK1A1L Gene

Genomics for CSNK1A1L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CSNK1A1L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J037106 Enhancer 0.3 Ensembl 297.4 -1.2 -1237 1 USF1 CSNK1A1L lnc-EXOSC8-1 HSALNG0096414 POSTN
GH13J037107 Enhancer 0.7 Ensembl ENCODE 47.4 -3.1 -3143 2.4 ZNF654 CTCF REST RAD21 SMC3 ATF2 ZNF660 FOS TRIM22 CSNK1A1L lnc-EXOSC8-1 HSALNG0096414 lnc-CSNK1A1L-1 POSTN
GH13J036997 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 7 +105.3 105264 5.6 BCLAF1 SP1 ZNF207 MYC ZNF600 ZNF580 ATF2 CEBPA POLR2A ZNF10 EXOSC8 ALG5 lnc-ALG5-1 RFXAP SUPT20H SMAD9 SPART-AS1 CSNK1A1L lnc-ALG5-2
GH13J037085 Enhancer 0.7 FANTOM5 Ensembl ENCODE 14.7 +16.4 16419 7.9 ZNF10 MNT lnc-EXOSC8-1 SUPT20H CSNK1A1L piR-31292-042
GH13J036973 Enhancer 0.6 Ensembl 15.8 +131.9 131863 1.2 JUND MAFF ZNF316 NFE2 SPI1 MAFG IKZF1 BMI1 MAFK ATF3 CSNK1A1L lnc-SMAD9-3 piR-57209 EXOSC8 ALG5 SMAD9 lnc-ALG5-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CSNK1A1L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CSNK1A1L

Top Transcription factor binding sites by QIAGEN in the CSNK1A1L gene promoter:
  • AP-4
  • CP2
  • CUTL1
  • E47
  • Hand1
  • LCR-F1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx6-1
  • S8

Genomic Locations for CSNK1A1L Gene

Latest Assembly
chr13:37,103,259-37,105,664
(GRCh38/hg38)
Size:
2,406 bases
Orientation:
Minus strand

Previous Assembly
chr13:37,677,396-37,679,801
(GRCh37/hg19 by Entrez Gene)
Size:
2,406 bases
Orientation:
Minus strand

chr13:37,677,398-37,679,803
(GRCh37/hg19 by Ensembl)
Size:
2,406 bases
Orientation:
Minus strand

Genomic View for CSNK1A1L Gene

Genes around CSNK1A1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSNK1A1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSNK1A1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK1A1L Gene

Proteins for CSNK1A1L Gene

  • Protein details for CSNK1A1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N752-KC1AL_HUMAN
    Recommended name:
    Casein kinase I isoform alpha-like
    Protein Accession:
    Q8N752
    Secondary Accessions:
    • Q5T2N2

    Protein attributes for CSNK1A1L Gene

    Size:
    337 amino acids
    Molecular mass:
    39086 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CSNK1A1L Gene

Selected DME Specific Peptides for CSNK1A1L Gene

Q8N752:
  • QGGVGIP
  • HRDIKPDN
  • KYEKISEKK
  • DWTMLKQK
  • RKIGSGSFG
  • FLHRDIK
  • WYGQEKD
  • HPQLLYESKLY
  • RDIKPDNFL
  • PDNFLMG
  • LADQMISRI
  • YLRQLFR
  • LLGPSLEDLF
  • MYFNRTSLPWQGL
  • DFGLAKKYRD
  • GIEQSRRDD
  • VAVKLESQK

Post-translational modifications for CSNK1A1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CSNK1A1L Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

Domains & Families for CSNK1A1L Gene

Gene Families for CSNK1A1L Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for CSNK1A1L Gene

Suggested Antigen Peptide Sequences for CSNK1A1L Gene

GenScript: Design optimal peptide antigens:
  • CK1 (KC1AL_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N752

UniProtKB/Swiss-Prot:

KC1AL_HUMAN :
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Family:
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
genes like me logo Genes that share domains with CSNK1A1L: view

Function for CSNK1A1L Gene

Molecular function for CSNK1A1L Gene

UniProtKB/Swiss-Prot Function:
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.

Enzyme Numbers (IUBMB) for CSNK1A1L Gene

Phenotypes From GWAS Catalog for CSNK1A1L Gene

Gene Ontology (GO) - Molecular Function for CSNK1A1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA 21873635
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with CSNK1A1L: view
genes like me logo Genes that share phenotypes with CSNK1A1L: view

miRNA for CSNK1A1L Gene

miRTarBase miRNAs that target CSNK1A1L

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSNK1A1L

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CSNK1A1L Gene

Localization for CSNK1A1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSNK1A1L Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSNK1A1L gene
Compartment Confidence
nucleus 4
cytosol 4
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CSNK1A1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with CSNK1A1L: view

Pathways & Interactions for CSNK1A1L Gene

genes like me logo Genes that share pathways with CSNK1A1L: view

Pathways by source for CSNK1A1L Gene

1 Sino Biological pathway for CSNK1A1L Gene
1 GeneGo (Thomson Reuters) pathway for CSNK1A1L Gene
  • Translation Regulation of EIF2 activity

SIGNOR curated interactions for CSNK1A1L Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for CSNK1A1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA 21873635
GO:0090090 negative regulation of canonical Wnt signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with CSNK1A1L: view

Drugs & Compounds for CSNK1A1L Gene

(7) Drugs for CSNK1A1L Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for CSNK1A1L Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CSNK1A1L: view

Transcripts for CSNK1A1L Gene

mRNA/cDNA for CSNK1A1L Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSNK1A1L

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1A1L Gene

No ASD Table

Relevant External Links for CSNK1A1L Gene

GeneLoc Exon Structure for
CSNK1A1L

Expression for CSNK1A1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CSNK1A1L Gene

mRNA differential expression in normal tissues according to GTEx for CSNK1A1L Gene

This gene is overexpressed in Testis (x25.1) and Whole Blood (x17.1).

Protein differential expression in normal tissues from HIPED for CSNK1A1L Gene

This gene is overexpressed in Cervix (44.2) and Heart (24.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CSNK1A1L Gene



Protein tissue co-expression partners for CSNK1A1L Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CSNK1A1L

SOURCE GeneReport for Unigene cluster for CSNK1A1L Gene:

Hs.512897
genes like me logo Genes that share expression patterns with CSNK1A1L: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSNK1A1L Gene

Orthologs for CSNK1A1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSNK1A1L Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CSNK1A1L 29 30
  • 99.6 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 95 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Csnk1a1 30
  • 92 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 90 (a)
ManyToMany
-- 30
  • 89 (a)
ManyToMany
-- 30
  • 83 (a)
ManyToMany
-- 30
  • 75 (a)
ManyToMany
-- 30
  • 75 (a)
ManyToMany
-- 30
  • 71 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia CSNK1A1 30
  • 90 (a)
ManyToMany
CSNK1B 30
  • 72 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 30
  • 86 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves CSNK1A1 30
  • 84 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 84 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii csnk1a1 29 30 30
  • 80.13 (n)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CkIalpha 30
  • 71 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea kin-19 29 30
  • 68.85 (n)
OneToMany
Rice
(Oryza sativa)
Liliopsida Os10g0476300 29
  • 64.16 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 85 (a)
ManyToMany
CS-CKI 30
  • 82 (a)
ManyToMany
Species where no ortholog for CSNK1A1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for CSNK1A1L Gene

ENSEMBL:
Gene Tree for CSNK1A1L (if available)
TreeFam:
Gene Tree for CSNK1A1L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CSNK1A1L: view image
Alliance of Genome Resources:
Additional Orthologs for CSNK1A1L

Paralogs for CSNK1A1L Gene

(6) SIMAP similar genes for CSNK1A1L Gene using alignment to 1 proteins:

  • KC1AL_HUMAN
genes like me logo Genes that share paralogs with CSNK1A1L: view

Variants for CSNK1A1L Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CSNK1A1L Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
rs373362769 A colorectal cancer sample p.Arg21Gln
rs17054882 -- p.Glu177Lys
rs17773251 -- p.Arg170Ser
rs55895045 -- p.Ala257Thr
rs56158728 -- p.Arg21Trp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CSNK1A1L Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CSNK1A1L Gene

Variant ID Type Subtype PubMed ID
esv3892330 CNV gain 25118596
nsv826612 CNV loss 20364138

Variation tolerance for CSNK1A1L Gene

Residual Variation Intolerance Score: 89.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.76; 73.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CSNK1A1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSNK1A1L
Leiden Open Variation Database (LOVD)
CSNK1A1L

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSNK1A1L Gene

Disorders for CSNK1A1L Gene

MalaCards: The human disease database

(1) MalaCards diseases for CSNK1A1L Gene - From: GCD

Disorder Aliases PubMed IDs
alzheimer disease
  • ad
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CSNK1A1L

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CSNK1A1L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CSNK1A1L Gene

Publications for CSNK1A1L Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D. (PMID: 31980649) Kennedy SA … Kolch W (Nature communications 2020) 3
  3. The RNF20/40 complex regulates p53-dependent gene transcription and mRNA splicing. (PMID: 31152661) Wu C … Yu X (Journal of molecular cell biology 2020) 3
  4. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. (PMID: 31586073) Capalbo L … D'Avino PP (Nature communications 2019) 3
  5. Peli1 Modulates the Subcellular Localization and Activity of Mdmx. (PMID: 29523541) Li D … Gu W (Cancer research 2018) 3

Products for CSNK1A1L Gene

Sources for CSNK1A1L Gene