Aliases for CSNK1A1 Gene

Aliases for CSNK1A1 Gene

  • Casein Kinase 1 Alpha 1 2 3 5
  • Casein Kinase I Isoform Alpha 3 4
  • Clock Regulator Kinase 2 3
  • EC 2.7.11.1 4 52
  • CKI-Alpha 3 4
  • CK1 3 4
  • Epididymis Secretory Sperm Binding Protein Li 77p 3
  • Down-Regulated In Lung Cancer 3
  • Casein Kinase 1, Alpha 1 2
  • HSALNG0045763 167
  • NONHSAG041905 92
  • Lnc-IL17B-2 168
  • HEL-S-77p 3
  • HLCDGP1 3
  • PRO2975 3
  • CK1a 3
  • CKIa 3

External Ids for CSNK1A1 Gene

Previous GeneCards Identifiers for CSNK1A1 Gene

  • GC05M148919
  • GC05M149467
  • GC05M148904
  • GC05M148902
  • GC05M148854
  • GC05M144021

Summaries for CSNK1A1 Gene

GeneCards Summary for CSNK1A1 Gene

CSNK1A1 (Casein Kinase 1 Alpha 1) is a Protein Coding gene. Diseases associated with CSNK1A1 include Chromosome 22Q11.2 Duplication Syndrome and Autosomal Recessive Non-Syndromic Intellectual Disability. Among its related pathways are FoxO family signaling and Signaling by Wnt. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1A1L.

UniProtKB/Swiss-Prot Summary for CSNK1A1 Gene

  • Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).

Tocris Summary for CSNK1A1 Gene

  • Casein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. CK1 is involved in many cellular processes including DNA repair, cell division, nuclear localization and membrane transport. Isoforms are also integral to development.

Gene Wiki entry for CSNK1A1 Gene

Additional gene information for CSNK1A1 Gene

No data available for Entrez Gene Summary , CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CSNK1A1 Gene

Genomics for CSNK1A1 Gene

GeneHancer (GH) Regulatory Elements for CSNK1A1 Gene

Promoters and enhancers for CSNK1A1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CSNK1A1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CSNK1A1

Top Transcription factor binding sites by QIAGEN in the CSNK1A1 gene promoter:
  • AML1a
  • CREB
  • Egr-2
  • Evi-1
  • FAC1
  • Lmo2
  • LUN-1
  • p300
  • Sox9
  • STAT1

Genomic Locations for CSNK1A1 Gene

Genomic Locations for CSNK1A1 Gene
chr5:149,492,982-149,551,552
(GRCh38/hg38)
Size:
58,571 bases
Orientation:
Minus strand
chr5:148,871,760-148,931,007
(GRCh37/hg19)
Size:
59,248 bases
Orientation:
Minus strand

Genomic View for CSNK1A1 Gene

Genes around CSNK1A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSNK1A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSNK1A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSNK1A1 Gene

Proteins for CSNK1A1 Gene

  • Protein details for CSNK1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48729-KC1A_HUMAN
    Recommended name:
    Casein kinase I isoform alpha
    Protein Accession:
    P48729
    Secondary Accessions:
    • D3DQG0
    • D3DQG1
    • Q4JJA0
    • Q5U046
    • Q5U047
    • Q6FGA2
    • Q71TU5
    • Q96HD2
    • Q9UDK3

    Protein attributes for CSNK1A1 Gene

    Size:
    337 amino acids
    Molecular mass:
    38915 Da
    Quaternary structure:
    • Monomer. Interacts with the Axin complex. Interacts with TUT1, leading to TUT1 phosphorylation. Interacts with FAM83H; recruits CSNK1A1 to keratin filaments (PubMed:23902688).

    Three dimensional structures from OCA and Proteopedia for CSNK1A1 Gene

    Alternative splice isoforms for CSNK1A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSNK1A1 Gene

Selected DME Specific Peptides for CSNK1A1 Gene

P48729:
  • QGGVGIP
  • ESKLYKI
  • HRDIKPDN
  • KYEKISEKK
  • ESLGYVL
  • DWTMLKQK
  • RKIGSGSFG
  • WYGQEKD
  • LTGTARY
  • LPWQGLKA
  • HPQLLYESKLY
  • RDIKPDNFL
  • PDNFLMG
  • LADQMISRI
  • GQQAQTPTG
  • YLRQLFR
  • LLGPSLEDLF
  • MYFNRTSLPWQGL
  • DFGLAKKYRD
  • GIEQSRRDD
  • VAVKLESQK

Post-translational modifications for CSNK1A1 Gene

  • Ubiquitination at Lys8, Lys62, Lys65, Lys138, Lys225, and Lys304
  • Modification sites at PhosphoSitePlus

Protein Products

  • Signalway Proteins for CSNK1A1

Domains & Families for CSNK1A1 Gene

Gene Families for CSNK1A1 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CSNK1A1 Gene

Suggested Antigen Peptide Sequences for CSNK1A1 Gene

GenScript: Design optimal peptide antigens:
  • CK1 (KC1A_HUMAN)
  • CSNK1A1 protein (Q05DL3_HUMAN)
  • CSNK1A1 protein (Q6PJ06_HUMAN)
  • cDNA FLJ56335, highly similar to Casein kinase I isoform alpha (EC 2.7.11.1) (Q71TU5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P48729

UniProtKB/Swiss-Prot:

KC1A_HUMAN :
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Family:
  • Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
genes like me logo Genes that share domains with CSNK1A1: view

Function for CSNK1A1 Gene

Molecular function for CSNK1A1 Gene

UniProtKB/Swiss-Prot Function:
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
GENATLAS Biochemistry:
casein kinase I,catalytic unit,alpha 1,involved in the transduction of WNT signal

Enzyme Numbers (IUBMB) for CSNK1A1 Gene

Phenotypes From GWAS Catalog for CSNK1A1 Gene

Gene Ontology (GO) - Molecular Function for CSNK1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA,TAS 10777483
GO:0004674 protein serine/threonine kinase activity TAS,IMP --
GO:0005515 protein binding IPI 16511560
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity TAS --
genes like me logo Genes that share ontologies with CSNK1A1: view

Phenotypes for CSNK1A1 Gene

MGI mutant phenotypes for CSNK1A1:
inferred from 3 alleles
GenomeRNAi human phenotypes for CSNK1A1:
genes like me logo Genes that share phenotypes with CSNK1A1: view

Animal Models for CSNK1A1 Gene

MGI Knock Outs for CSNK1A1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CSNK1A1

CRISPR Products

miRNA for CSNK1A1 Gene

miRTarBase miRNAs that target CSNK1A1

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSNK1A1 Gene

Localization for CSNK1A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSNK1A1 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus speckle. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton (PubMed:23902688). {ECO:0000269 PubMed:1409656, ECO:0000269 PubMed:23902688}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSNK1A1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CSNK1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IBA 21873635
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with CSNK1A1: view

Pathways & Interactions for CSNK1A1 Gene

PathCards logo

SuperPathways for CSNK1A1 Gene

SuperPathway Contained pathways
1 S45 mutants of beta-catenin arent phosphorylated
2 CDK-mediated phosphorylation and removal of Cdc6
3 Signaling by Hedgehog
4 Gastric cancer
5 Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling
genes like me logo Genes that share pathways with CSNK1A1: view

Pathways by source for CSNK1A1 Gene

1 Tocris pathway for CSNK1A1 Gene
6 Qiagen pathways for CSNK1A1 Gene
  • Dopamine-DARPP32 Feedback onto cAMP Pathway
  • GSK3 Signaling
  • NFAT and Cardiac Hypertrophy
  • NFAT in Immune Response
  • Signaling in Gap Junctions
2 Cell Signaling Technology pathways for CSNK1A1 Gene
1 GeneTex pathway for CSNK1A1 Gene

SIGNOR curated interactions for CSNK1A1 Gene

Gene Ontology (GO) - Biological Process for CSNK1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IEA --
GO:0006468 protein phosphorylation IDA,IEA 18305108
GO:0007030 Golgi organization IMP 25500533
GO:0007049 cell cycle IEA --
GO:0007165 signal transduction NAS 10777483
genes like me logo Genes that share ontologies with CSNK1A1: view

Drugs & Compounds for CSNK1A1 Gene

(13) Drugs for CSNK1A1 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
IC261 Experimental Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0
PF 670462 Pharma CK1 ε/δ inhibitor, Potent and selective CK1epsilon and CK1delta inhibitor 0
CKI 7 dihydrochloride Pharma 0

(2) Additional Compounds for CSNK1A1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0

(5) Tocris Compounds for CSNK1A1 Gene

Compound Action Cas Number
(R)-DRF053 dihydrochloride Dual CK1/cdk inhibitor 1241675-76-2
D 4476 Selective CK1 inhibitor. Also inhibits TGF-betaRI 301836-43-1
LH 846 Selective casein kinase 1delta inhibitor 639052-78-1
PF 4800567 hydrochloride Selective casein kinase 1epsilon inhibitor 1391052-28-0
PF 670462 Potent and selective CK1epsilon and CK1delta inhibitor 950912-80-8

(2) ApexBio Compounds for CSNK1A1 Gene

Compound Action Cas Number
CKI 7 dihydrochloride 1177141-67-1
PF-670462 CK1 ε/δ inhibitor 950912-80-8
genes like me logo Genes that share compounds with CSNK1A1: view

Drug Products

Transcripts for CSNK1A1 Gene

mRNA/cDNA for CSNK1A1 Gene

4 REFSEQ mRNAs :
30 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
5 RNACentral transcripts :
3 NONCODE transcripts :
2 LncBook transcripts :
2 LNCipedia transcripts :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSNK1A1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5: - - -
SP6: - - -
SP7: - -
SP8:

Relevant External Links for CSNK1A1 Gene

GeneLoc Exon Structure for
CSNK1A1

Expression for CSNK1A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CSNK1A1 Gene

Protein differential expression in normal tissues from HIPED for CSNK1A1 Gene

This gene is overexpressed in Cervix (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CSNK1A1 Gene



Protein tissue co-expression partners for CSNK1A1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CSNK1A1

SOURCE GeneReport for Unigene cluster for CSNK1A1 Gene:

Hs.529862

Evidence on tissue expression from TISSUES for CSNK1A1 Gene

  • Nervous system(5)
  • Lung(4.8)
  • Skin(3.7)
  • Kidney(3.3)
  • Liver(3.2)
  • Intestine(2.8)
  • Pancreas(2.6)
  • Blood(2.2)
  • Heart(2.2)
  • Eye(2.1)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with CSNK1A1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSNK1A1 Gene

Orthologs for CSNK1A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CSNK1A1 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 100 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 31
  • 100 (a)
ManyToMany
CSNK1A1 30
  • 98.08 (n)
chimpanzee
(Pan troglodytes)
Mammalia CSNK1A1 31 30
  • 99.91 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 99 (a)
ManyToMany
-- 31
  • 79 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia CSNK1A1 30
  • 96.4 (n)
-- 31
  • 83 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Csnk1a1 30
  • 94.96 (n)
mouse
(Mus musculus)
Mammalia Csnk1a1 17 31 30
  • 94.65 (n)
chicken
(Gallus gallus)
Aves CSNK1A1 31 30
  • 90.5 (n)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 100 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia csnk1a1 30
  • 84.77 (n)
Str.3026 30
African clawed frog
(Xenopus laevis)
Amphibia MGC68433 30
zebrafish
(Danio rerio)
Actinopterygii csnk1a1 31 31 30
  • 99 (a)
ManyToMany
LOC100334765 30
  • 83.56 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.744 30
fruit fly
(Drosophila melanogaster)
Insecta dco 32
  • 70 (a)
CkIalpha 31 32 30
  • 67.81 (n)
OneToMany
CG7094 32
  • 64 (a)
CG2577 32
  • 58 (a)
CG12147 32
  • 55 (a)
CG9962 32
  • 49 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000627 30
  • 67.49 (n)
worm
(Caenorhabditis elegans)
Secernentea kin-19 31
  • 82 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ckl8 30
  • 61.43 (n)
rice
(Oryza sativa)