The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including... See more...

Aliases for CSK Gene

Aliases for CSK Gene

  • C-Terminal Src Kinase 2 3 5
  • CSK, Non-Receptor Tyrosine Kinase 2 3
  • Tyrosine-Protein Kinase CSK 3 4
  • Protein-Tyrosine Kinase CYL 3 4
  • C-Src Tyrosine Kinase 2 3
  • C-Src Kinase 3 4
  • EC 2.7.10.2 4 51
  • EC 2.7.10 51
  • CSK 5

External Ids for CSK Gene

Previous GeneCards Identifiers for CSK Gene

  • GC15M070982
  • GC15M068251
  • GC15P072650
  • GC15P072790
  • GC15P072861
  • GC15P075075
  • GC15P051872

Summaries for CSK Gene

Entrez Gene Summary for CSK Gene

  • The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]

GeneCards Summary for CSK Gene

CSK (C-Terminal Src Kinase) is a Protein Coding gene. Diseases associated with CSK include Osteopetrosis and Lupus Erythematosus. Among its related pathways are RET signaling and B cell receptor signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is MATK.

UniProtKB/Swiss-Prot Summary for CSK Gene

  • Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.

Gene Wiki entry for CSK Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CSK Gene

Genomics for CSK Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CSK Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CSK on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CSK

Top Transcription factor binding sites by QIAGEN in the CSK gene promoter:
  • E2F
  • E2F-1
  • HEN1
  • LCR-F1
  • N-Myc
  • Nkx5-1
  • p53
  • POU2F1
  • POU2F1a
  • POU2F1b

Genomic Locations for CSK Gene

Genomic Locations for CSK Gene
chr15:74,782,057-74,803,198
(GRCh38/hg38)
Size:
21,142 bases
Orientation:
Plus strand
chr15:75,074,398-75,095,539
(GRCh37/hg19)
Size:
21,142 bases
Orientation:
Plus strand

Genomic View for CSK Gene

Genes around CSK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSK Gene

Proteins for CSK Gene

  • Protein details for CSK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41240-CSK_HUMAN
    Recommended name:
    Tyrosine-protein kinase CSK
    Protein Accession:
    P41240
    Secondary Accessions:
    • Q2M3N2
    • Q6FGZ6

    Protein attributes for CSK Gene

    Size:
    450 amino acids
    Molecular mass:
    50704 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Homodimer (via SH3-domain) (PubMed:19888460). Interacts with PTPN22 (PubMed:15208781). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1; these interactions serve to recruit CSK to the membrane where it can phosphorylate and inhibit Src-family kinases (PubMed:11433379, PubMed:10790433, PubMed:14610046, PubMed:10838081). Interacts with SRCIN1 (PubMed:17525734). Interacts with RHOH (PubMed:20851766). Interacts (via SH2 domain) with SCIMP; this interaction is dependent on phosphorylation of SCIMP 'Tyr-107' (PubMed:21930792). Interacts (via SH2 domain) with PRAG1 (when phosphorylated at 'Tyr-391'); this interaction prevents translocation of CSK from the cytoplasm to the membrane leading to increased activity of CSK (By similarity).

    Three dimensional structures from OCA and Proteopedia for CSK Gene

neXtProt entry for CSK Gene

Selected DME Specific Peptides for CSK Gene

P41240:
  • RDLAARN
  • PPETGLFLVRESTNYPGDYTLCVSC
  • WPSGTECIAKYNFHGTAEQDLPF
  • KWTAPEA
  • IGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM
  • EAMEYLE
  • KGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGV
  • AARNVLV
  • KLSLMPWFHGKI
  • KSDVWSFG
  • LKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFL
  • FVHRDLA
  • NFVHRDLAARNVL
  • RLIKPKVMEGTVAAQDEF
  • HGKITRE
  • RSGWALNMK

Post-translational modifications for CSK Gene

  • Phosphorylated at Ser-364 by PKA, leading to increased activity. Autophosphorylated.
  • Ubiquitination at Lys193, Lys196, Lys329, and Lys337
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for CSK

Domains & Families for CSK Gene

Gene Families for CSK Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CSK Gene

InterPro:
Blocks:
  • SH2 domain signature
  • Tyrosine protein kinase, active site
  • SH3 domain signature
ProtoNet:

Suggested Antigen Peptide Sequences for CSK Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ93062, Homo sapiens c-src tyrosine kinase (CSK), mRNA (B2R6Q4_HUMAN)
  • C-src tyrosine kinase (B5BU52_HUMAN)
  • Protein-tyrosine kinase CYL (CSK_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P41240

UniProtKB/Swiss-Prot:

CSK_HUMAN :
  • The architecture of this protein is similar to that of Src-family kinases (SFKs) with one N-terminal SH3 domain, one SH2 domain, and a C-terminal kinase domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.
Domain:
  • The architecture of this protein is similar to that of Src-family kinases (SFKs) with one N-terminal SH3 domain, one SH2 domain, and a C-terminal kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.
genes like me logo Genes that share domains with CSK: view

Function for CSK Gene

Molecular function for CSK Gene

UniProtKB/Swiss-Prot Function:
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence={ECO:0000269|PubMed:1639064, ECO:0000269|PubMed:7683130, ECO:0000269|PubMed:9281320};.
GENATLAS Biochemistry:
tyrosine kinase,SRC downregulating (putative antioncogene)

Enzyme Numbers (IUBMB) for CSK Gene

Phenotypes From GWAS Catalog for CSK Gene

Gene Ontology (GO) - Molecular Function for CSK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity TAS --
GO:0004715 non-membrane spanning protein tyrosine kinase activity IEA --
GO:0005515 protein binding IEA,IPI 7507203
genes like me logo Genes that share ontologies with CSK: view

Phenotypes for CSK Gene

MGI mutant phenotypes for CSK:
inferred from 6 alleles
GenomeRNAi human phenotypes for CSK:
genes like me logo Genes that share phenotypes with CSK: view

Animal Models for CSK Gene

MGI Knock Outs for CSK:
  • Csk Csk<tm1Sia>
  • Csk Csk<tm1Sor>
  • Csk Csk<tm2b(EUCOMM)Hmgu>
  • Csk Csk<tm2Sia>
  • Csk Csk<tm2Tara>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSK

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSK Gene

Localization for CSK Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSK Gene

Cytoplasm. Cell membrane. Note=Mainly cytoplasmic, also present in lipid rafts. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSK gene
Compartment Confidence
plasma membrane 5
cytosol 5
extracellular 4
cytoskeleton 3
golgi apparatus 3
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CSK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 8890164
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CSK: view

Pathways & Interactions for CSK Gene

PathCards logo

SuperPathways for CSK Gene

SuperPathway Contained pathways
1 RET signaling
2 Paradoxical activation of RAF signaling by kinase inactive BRAF
3 VEGF Signaling
4 ICos-ICosL Pathway in T-Helper Cell
.66
.66
5 Developmental Biology
genes like me logo Genes that share pathways with CSK: view

Pathways by source for CSK Gene

7 Qiagen pathways for CSK Gene
  • CD28 Signaling in T-Helper Cell
  • EGF Pathway
  • FAK1 Signaling
  • G-AlphaQ Signaling
  • ICos-ICosL Pathway in T-Helper Cell
1 Cell Signaling Technology pathway for CSK Gene

SIGNOR curated interactions for CSK Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for CSK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006468 protein phosphorylation TAS 1945408
GO:0007420 brain development IEA --
GO:0008285 negative regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with CSK: view

Drugs & Compounds for CSK Gene

(43) Drugs for CSK Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dasatinib Approved, Investigational Pharma Target Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 324
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Hydrochlorothiazide Approved, Vet_approved Pharma Inhibitor, Inhibition 453
Staurosporine Experimental Pharma Allosteric regulator, Positive, Neutral, Target Protein kinase inhibitor,potent and cell permeable 9
TG 100801 Investigational Pharma Target Multi-kinase inhibitor 0

(24) Additional Compounds for CSK Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) ApexBio Compounds for CSK Gene

Compound Action Cas Number
Apatinib VEGFR2 inhibitor, orally bioavailable, selective 811803-05-1
PP 1 Src family tyrosine kinase inhibitor 172889-26-8
PP 2 (AG 1879) Src-family kinases inhibitor 172889-27-9
genes like me logo Genes that share compounds with CSK: view

Transcripts for CSK Gene

mRNA/cDNA for CSK Gene

3 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSK

Alternative Splicing Database (ASD) splice patterns (SP) for CSK Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b · 16c ·
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - -
SP5: -
SP6: -
SP7: -
SP8:
SP9:
SP10: - - -

ExUns: 16d ^ 17a · 17b ^ 18a · 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for CSK Gene

GeneLoc Exon Structure for
CSK

Expression for CSK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CSK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CSK Gene

This gene is overexpressed in Whole Blood (x10.8).

Protein differential expression in normal tissues from HIPED for CSK Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.8), Lymph node (8.4), and Tlymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CSK Gene



Protein tissue co-expression partners for CSK Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CSK

SOURCE GeneReport for Unigene cluster for CSK Gene:

Hs.77793

mRNA Expression by UniProt/SwissProt for CSK Gene:

P41240-CSK_HUMAN
Tissue specificity: Expressed in lung and macrophages.

Evidence on tissue expression from TISSUES for CSK Gene

  • Nervous system(4.8)
  • Lung(4.6)
  • Blood(4.1)
  • Skin(3.7)
  • Intestine(3.1)
  • Lymph node(3.1)
  • Spleen(3)
  • Heart(2.8)
  • Muscle(2.7)
  • Kidney(2.7)
  • Bone marrow(2.7)
  • Stomach(2.6)
  • Liver(2.5)
  • Thyroid gland(2.2)
  • Pancreas(2.2)
  • Adrenal gland(2.2)
genes like me logo Genes that share expression patterns with CSK: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CSK Gene

Orthologs for CSK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CSK Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CSK 30 31
  • 98.3 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CSK 31
  • 96 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia CSK 30 31
  • 93.41 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CSK 30 31
  • 93.04 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Csk 30
  • 90.22 (n)
Mouse
(Mus musculus)
Mammalia Csk 30 17 31
  • 90.07 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 20 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves CSK 30 31
  • 84.59 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CSK 31
  • 93 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia csk 30
  • 74.63 (n)
African clawed frog
(Xenopus laevis)
Amphibia csk-A 30
Zebrafish
(Danio rerio)
Actinopterygii CSK (1 of 2) 31
  • 84 (a)
OneToMany
csk 30 31
  • 77.88 (n)
OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9844 30
Fruit Fly
(Drosophila melanogaster)
Insecta Csk 30 31 32
  • 64.74 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea csk-1 30 31
  • 53.38 (n)
OneToMany
Y38H6C.20 32
  • 31 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC15 31
  • 8 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.5205 31
  • 50 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.9183 30
Species where no ortholog for CSK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CSK Gene

ENSEMBL:
Gene Tree for CSK (if available)
TreeFam:
Gene Tree for CSK (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CSK: view image

Paralogs for CSK Gene

(58) SIMAP similar genes for CSK Gene using alignment to 6 proteins:

  • CSK_HUMAN
  • B2R6Q4_HUMAN
  • B5BU52_HUMAN
  • H3BN15_HUMAN
  • H3BU69_HUMAN
  • H3BUM9_HUMAN
genes like me logo Genes that share paralogs with CSK: view

Variants for CSK Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CSK Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
713186 Benign: not provided 74,801,568(+) G/A MISSENSE_VARIANT
rs34616395 - p.Arg398Gln
rs34866753 - p.Gly287Asp
rs35556162 - p.His442Arg
VAR_041678 - p.Pro45Leu

Additional dbSNP identifiers (rs#s) for CSK Gene

Structural Variations from Database of Genomic Variants (DGV) for CSK Gene

Variant ID Type Subtype PubMed ID
dgv307e201 CNV deletion 23290073
esv2749883 CNV deletion 23290073
esv2749886 CNV deletion 23290073
esv3636909 CNV loss 21293372
nsv1069866 CNV deletion 25765185
nsv1118322 CNV deletion 24896259
nsv1121512 CNV deletion 24896259
nsv833055 CNV loss 17160897

Variation tolerance for CSK Gene

Residual Variation Intolerance Score: 22.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CSK Gene

Human Gene Mutation Database (HGMD)
CSK
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSK

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSK Gene

Disorders for CSK Gene

MalaCards: The human disease database

(8) MalaCards diseases for CSK Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
osteopetrosis
  • albers-schonberg osteopetrosis
lupus erythematosus
  • systemic lupus erythematosus
cd45 deficiency
systemic lupus erythematosus
  • sle
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards
Search CSK in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CSK

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CSK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CSK Gene

Publications for CSK Gene

  1. p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity. (PMID: 17525734) Di Stefano P … Defilippi P (The EMBO journal 2007) 3 4 23
  2. Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor. (PMID: 11181701) Vang T … Taskén K (The Journal of experimental medicine 2001) 3 4 23
  3. Identification of csk tyrosine phosphorylation sites and a tyrosine residue important for kinase domain structure. (PMID: 9148770) Joukov V … Bergman M (The Biochemical journal 1997) 3 4 23
  4. The c-src tyrosine kinase (CSK) gene, a potential antioncogene, localizes to human chromosome region 15q23----q25. (PMID: 1377109) Armstrong E … Alitalo K (Cytogenetics and cell genetics 1992) 2 3 23
  5. SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling. (PMID: 21930792) Draber P … Brdicka T (Molecular and cellular biology 2011) 3 4

Products for CSK Gene