Aliases for CSH2 Gene
External Ids for CSH2 Gene
Previous GeneCards Identifiers for CSH2 Gene
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, while the ratio of 1 to 2 increases by term. Structural and expression differences provide avenues for developmental regulation and tissue specificity. [provided by RefSeq, Jul 2008]
GeneCards Summary for CSH2 Gene
CSH2 (Chorionic Somatomammotropin Hormone 2) is a Protein Coding gene. Diseases associated with CSH2 include Choriocarcinoma and Testicular Trophoblastic Tumor. Among its related pathways are Jak-STAT signaling pathway (KEGG) and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include hormone activity. An important paralog of this gene is CSH1.
UniProtKB/Swiss-Prot for CSH2 Gene
Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization.