Aliases for CSGALNACT1 Gene
Aliases for CSGALNACT1 Gene
- Chondroitin Sulfate N-Acetylgalactosaminyltransferase 1 2 3 4 5
- Glucuronylgalactosylproteoglycan 4-Beta-N- Acetylgalactosaminyltransferase 2 3
- Chondroitin Beta-1,4-N-Acetylgalactosaminyltransferase 1 3 4
- Chondroitin Beta1,4 N-Acetylgalactosaminyltransferase 2 3
- Beta4GalNAcT-1 3 4
- Beta4GalNAcT 3
- EC 2.4.1.174 4
External Ids for CSGALNACT1 Gene
- HGNC: 24290
- Entrez Gene: 55790
- Ensembl: ENSG00000147408
- OMIM: 616615
- UniProtKB: Q8TDX6
Previous GeneCards Identifiers for CSGALNACT1 Gene
- GC08M019306
- GC08M017801
Summaries for CSGALNACT1 Gene
-
This gene encodes an enzyme that transfers N-acetylglucosamine (GalNAc) to the core tetrasaccharide linker and to elongating chondroitin sulfate chains in proteoglycans. Knockout of the orthologous mouse gene indicates that the protein is necessary for normal cartilage development and aggrecan metabolism. Mutations in this gene are associated with multiple sclerosis progression, and with mild skeletal dysplasia and joint laxity. [provided by RefSeq, Aug 2017]
GeneCards Summary for CSGALNACT1 Gene
CSGALNACT1 (Chondroitin Sulfate N-Acetylgalactosaminyltransferase 1) is a Protein Coding gene. Among its related pathways are Chondroitin sulfate/dermatan sulfate metabolism and Glycosaminoglycan metabolism. Gene Ontology (GO) annotations related to this gene include glucuronosyltransferase activity and glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. An important paralog of this gene is CSGALNACT2.
UniProtKB/Swiss-Prot for CSGALNACT1 Gene
-
Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage formation and subsequent endochondral ossification (PubMed:11788602, PubMed:12163485, PubMed:12446672, PubMed:17145758). Moreover, is involved in the metabolism of aggrecan (By similarity).
Additional gene information for CSGALNACT1 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSGALNACT1 Gene
Genomics for CSGALNACT1 Gene
GeneHancer (GH) Regulatory Elements for CSGALNACT1 Gene
Promoters and enhancers for CSGALNACT1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH08J019756 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE | 607.4 | +0.9 | 933 | 3 | ZNF652 CEBPG CTCF TFE3 SP7 ELF1 KLF14 PRDM1 RAD21 GLIS2 | CSGALNACT1 SH2D4A ENSG00000253270 | |
| GH08J019681 | Promoter/Enhancer | 1.7 | EPDnew Ensembl ENCODE dbSUPER | 629.6 | +75.8 | 75786 | 2.3 | PRDM10 PKNOX1 FOS SCRT1 WT1 | CSGALNACT1 ENSG00000253270 | |
| GH08J019602 | Promoter/Enhancer | 1.7 | EPDnew Ensembl ENCODE | 616.7 | +155.6 | 155629 | 1.2 | KLF14 GLIS2 ZNF600 ZIC2 ZSCAN4 ZEB2 PATZ1 ZXDB ZBTB26 ZBTB17 | CSGALNACT1 INTS10 SH2D4A GC08M019610 LOC105379308 | |
| GH08J019758 | Enhancer | 0.5 | ENCODE | 600.7 | -0.7 | -696 | 0.2 | ZNF652 CTCF ZNF644 RAD21 SMC3 ZNF654 | CSGALNACT1 INTS10 | |
| GH08J019695 | Enhancer | 1.3 | FANTOM5 ENCODE dbSUPER | 44.6 | +61.1 | 61098 | 2.4 | SP1 MAFK CREM MLLT1 ZBED1 IKZF1 IKZF2 RELA CBFB SCRT2 | CSGALNACT1 SH2D4A ENSG00000253270 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CSGALNACT1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CSGALNACT1 gene promoter:
-
- Evi-1
- FOXJ2
- FOXJ2 (long isoform)
- NF-1
- POU6F1 (c2)
- TBP
Genomic Locations for CSGALNACT1 Gene
Genomic Locations for CSGALNACT1 Gene
- chr8:19,404,161-19,758,029
- (GRCh38/hg38)
- Size:
- 353,869 bases
- Orientation:
- Minus strand
- chr8:19,261,672-19,615,540
- (GRCh37/hg19)
- Size:
- 353,869 bases
- Orientation:
- Minus strand
Genomic View for CSGALNACT1 Gene
Genes around CSGALNACT1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p21.3 by HGNC
- 8p21.3 by Entrez Gene
- 8p21.3 by Ensembl
CSGALNACT1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CSGALNACT1 Gene
Proteins for CSGALNACT1 Gene
-
Protein details for CSGALNACT1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TDX6-CGAT1_HUMAN
- Recommended name:
- Chondroitin sulfate N-acetylgalactosaminyltransferase 1
- Protein Accession:
- Q8TDX6
- B2RBE4
- Q6P9G6
- Q8IUF9
- Q9NSQ7
- Q9NUM9
Protein attributes for CSGALNACT1 Gene
- Size:
- 532 amino acids
- Molecular mass:
- 61294 Da
- Quaternary structure:
- No Data Available
Protein Expression for CSGALNACT1 Gene
Post-translational modifications for CSGALNACT1 Gene
- N-glycosylated.
- Glycosylation at posLast=324324 and isoforms=2315
- Modification sites at PhosphoSitePlus
Other Protein References for CSGALNACT1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_024302961.1
- XP_016869127.1
- XP_016869117.1
- XP_024302962.1
- NP_001341409.1
- NP_001341419.1
- NP_001341424.1
- NP_001341404.1
- NP_001341414.1
- NP_001341421.1
- NP_001341412.1
- XP_011542881.1
- XP_006716423.1
- XP_024302959.1
- XP_024302960.1
- XP_016869116.1
- NP_001341428.1
- NP_001341418.1
- XP_011542887.1
- NP_060841.5
- XP_016869113.1
- NP_001341427.1
- NP_001341417.1
- NP_001341420.1
- NP_001341410.1
- XP_011542880.1
- XP_024302958.1
- XP_006716426.1
- XP_016869114.1
- NP_001123990.1
- XP_024302963.1
- XP_011542885.1
- XP_011542886.1
- XP_016869112.1
- NP_001341425.1
- NP_001341405.1
- XP_016869118.1
- NP_001341426.1
- NP_001341406.1
- NP_001341416.1
- NP_001341423.1
- NP_001341413.1
- XP_006716427.1
Antibody Products
- Atlas Antibodies Anti-CSGALNACT1 Antibody
- Novus Biologicals Antibodies for CSGALNACT1
-
Abcam antibodies for CSGALNACT1
- Invitrogen Antibodies for CSGALNACT1 (AFLGC-CSGALNACT1)
- antibodies-online: Search results for 67 available CSGALNACT1 Antibodies ranked by validation data
- Compare Top CSGALNACT1 Antibodies
-
Recommended
- 44 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 18 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 5 WB Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
Protein Products
- Atlas Antibodies PrEST Antigen CSGALNACT1
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CSGALNACT1
- Origene Custom Protein Services for CSGALNACT1
-
Abcam proteins for CSGALNACT1
No data available for DME Specific Peptides for CSGALNACT1 Gene
Domains & Families for CSGALNACT1 Gene
Gene Families for CSGALNACT1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for CSGALNACT1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CSGALNACT1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ30592 fis, clone BRAWH2008706, highly similar to Chondroitinbeta-1,4-N-acetylgalactosaminyltransferase 1 (EC 2.4.1.174) (B3KNW4_HUMAN)
- Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1 (CGAT1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8TDX6UniProtKB/Swiss-Prot:
CGAT1_HUMAN :- Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
- Family:
-
- Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
Function for CSGALNACT1 Gene
Molecular function for CSGALNACT1 Gene
- UniProtKB/Swiss-Prot Function:
- Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage formation and subsequent endochondral ossification (PubMed:11788602, PubMed:12163485, PubMed:12446672, PubMed:17145758). Moreover, is involved in the metabolism of aggrecan (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP; Xref=Rhea:RHEA:23464, Rhea:RHEA-COMP:12573, Rhea:RHEA-COMP:12575, ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:67138, ChEBI:CHEBI:132093, ChEBI:CHEBI:132105; EC=2.4.1.174; Evidence={ECO:0000269 PubMed:21160489, ECO:0000269 PubMed:27599773};.
Enzyme Numbers (IUBMB) for CSGALNACT1 Gene
Phenotypes From GWAS Catalog for CSGALNACT1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008376 | acetylgalactosaminyltransferase activity | ISS | 11788602 |
| GO:0008955 | peptidoglycan glycosyltransferase activity | IDA | 11514575 |
| GO:0015020 | glucuronosyltransferase activity | IDA | 11514575 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0046872 | metal ion binding | NAS | 12163485 |
Phenotypes for CSGALNACT1 Gene
- MGI mutant phenotypes for CSGALNACT1:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for CSGALNACT1:
-
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased viability in esophageal squamous lineage
- Decreased IL-13 protein expression
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased hepcidin::fluc mRNA expression
- Decreased NF-kappaB reporter expression
- Increased transferrin (TF) endocytosis
Animal Models for CSGALNACT1 Gene
- MGI Knock Outs for CSGALNACT1:
-
- Csgalnact1 Csgalnact1<tm1.1Nari>
- Csgalnact1 Csgalnact1<tm1.1Migar>
- Csgalnact1 Csgalnact1<tm1Lex>
Animal Model Products
-
Taconic Biosciences Mouse Models for CSGALNACT1
- Cyagen custom Knockout/knockin (KOKI) mouse models for CSGALNACT1
-
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CSGALNACT1 - Now 50% OFF >
- * CSGALNACT1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * CSGALNACT1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for CSGALNACT1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CSGALNACT1
- genomics-online: gRNA clones - Search results for 98 available CSGALNACT1 gene related products
- Overview of 98 available CSGALNACT1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for CSGALNACT1
miRNA for CSGALNACT1 Gene
- miRTarBase miRNAs that target CSGALNACT1
-
- hsa-mir-335-5p (MIRT017694)
- hsa-mir-124-3p (MIRT022557)
- hsa-mir-126-5p (MIRT045696)
- hsa-mir-16-5p (MIRT051118)
- hsa-mir-1238-3p (MIRT538321)
- hsa-mir-670-3p (MIRT538322)
- hsa-mir-6749-3p (MIRT538323)
- hsa-mir-6792-3p (MIRT538324)
- hsa-mir-4691-5p (MIRT538325)
- hsa-mir-124-5p (MIRT538326)
- hsa-mir-616-3p (MIRT538327)
- hsa-mir-627-3p (MIRT538328)
- hsa-mir-3925-3p (MIRT538329)
- hsa-mir-1825 (MIRT538330)
- hsa-mir-153-5p (MIRT538331)
- hsa-mir-1250-3p (MIRT538332)
- hsa-mir-4255 (MIRT538333)
- hsa-mir-199a-5p (MIRT538334)
- hsa-mir-199b-5p (MIRT538335)
- hsa-mir-765 (MIRT720886)
- hsa-mir-3663-3p (MIRT720887)
- hsa-mir-4786-3p (MIRT720888)
- hsa-mir-665 (MIRT720889)
- hsa-mir-4459 (MIRT720890)
- hsa-mir-3620-3p (MIRT720891)
- hsa-mir-6871-3p (MIRT720892)
- hsa-mir-10b-5p (MIRT720893)
- hsa-mir-10a-5p (MIRT720894)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CSGALNACT1
- Browse OriGene Inhibitory RNA Products For CSGALNACT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSGALNACT1
- genomics-online: shRNA clones - Search results for 98 available CSGALNACT1 gene related products
- Overview of 98 available CSGALNACT1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for CSGALNACT1 - Now 50% OFF >
- * CSGALNACT1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * CSGALNACT1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG208499
- MR208499
- MR208499L1
- MR208499L1V
- MR208499L2
- MR208499L2V
- MR208499L3
- MR208499L3V
- MR208499L4
- MR208499L4V
- MR230401
- RC219296
- RC219296L1
- RC219296L1V
- RC219296L2
- RC219296L2V
- RC219296L3
- RC219296L3V
- RC219296L4
- RC219296L4V
- RC225915
- RC225915L1
- RC225915L1V
- RC225915L2
- RC225915L2V
- RC225915L3
- RC225915L3V
- RC225915L4
- RC225915L4V
- RG219296
- RG225915
- RR205692
- RR205692L1
- RR205692L1V
- RR205692L2
- RR205692L2V
- RR205692L3
- RR205692L3V
- RR205692L4
- RR205692L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CSGALNACT1
- Addgene plasmids for CSGALNACT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CSGALNACT1
Cell Line Products
-
Horizon Cell Lines for CSGALNACT1
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSGALNACT1 Gene
Localization for CSGALNACT1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CSGALNACT1 Gene
- Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 5 |
| extracellular | 2 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 2 |
| plasma membrane | 0 |
- Actin filaments (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0030173 | integral component of Golgi membrane | NAS | 11514575 |
Pathways & Interactions for CSGALNACT1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Chondroitin sulfate/dermatan sulfate metabolism | ||
| 2 | Glycosaminoglycan metabolism | ||
| 3 | Metabolism |
.40
|
|
Pathways by source for CSGALNACT1 Gene
3 BioSystems pathways for CSGALNACT1 Gene
5 Reactome pathways for CSGALNACT1 Gene
2 KEGG pathways for CSGALNACT1 Gene
Interacting Proteins for CSGALNACT1 Gene
Selected Interacting proteins:
ENSP00000411816
Q8TDX6-CGAT1_HUMAN
for CSGALNACT1 Gene via
STRING
IID
GPS-Prot Interaction Network for CSGALNACT1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001958 | endochondral ossification | IEA | -- |
| GO:0007399 | nervous system development | NAS | 11514575 |
| GO:0008037 | cell recognition | NAS | 11514575 |
| GO:0008283 | cell proliferation | NAS | 11514575 |
| GO:0009653 | anatomical structure morphogenesis | NAS | 11514575 |
No data available for SIGNOR curated interactions for CSGALNACT1 Gene
Drugs & Compounds for CSGALNACT1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Uridine 5'-diphosphate | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Uridine diphosphate-N-acetylgalactosamine |
|
7277-98-7 |
|
Drug Products
- Atlas Antibodies PrEST Antigen CSGALNACT1
Transcripts for CSGALNACT1 Gene
mRNA/cDNA for CSGALNACT1 Gene
- (22) REFSEQ mRNAs :
- (21) Additional mRNA sequences :
- (102) Selected AceView cDNA sequences:
- (16) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000454498 4232 bps (ENST00000454498.6)
- ENST00000332246 3872 bps (ENST00000332246.10)
- ENST00000397998 3962 bps (ENST00000397998.7)
- ENST00000522854 1990 bps (ENST00000522854.5)
- ENST00000518542 895 bps (ENST00000518542.1)
Unigene Clusters for CSGALNACT1 Gene
- Chondroitin sulfate N-acetylgalactosaminyltransferase 1:
- Representative Sequences:
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CSGALNACT1 - Now 50% OFF >
- * CSGALNACT1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * CSGALNACT1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for CSGALNACT1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CSGALNACT1
- genomics-online: gRNA clones - Search results for 98 available CSGALNACT1 gene related products
- Overview of 98 available CSGALNACT1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for CSGALNACT1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CSGALNACT1
- Browse OriGene Inhibitory RNA Products For CSGALNACT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSGALNACT1
- genomics-online: shRNA clones - Search results for 98 available CSGALNACT1 gene related products
- Overview of 98 available CSGALNACT1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for CSGALNACT1 - Now 50% OFF >
- * CSGALNACT1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * CSGALNACT1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG208499
- MR208499
- MR208499L1
- MR208499L1V
- MR208499L2
- MR208499L2V
- MR208499L3
- MR208499L3V
- MR208499L4
- MR208499L4V
- MR230401
- RC219296
- RC219296L1
- RC219296L1V
- RC219296L2
- RC219296L2V
- RC219296L3
- RC219296L3V
- RC219296L4
- RC219296L4V
- RC225915
- RC225915L1
- RC225915L1V
- RC225915L2
- RC225915L2V
- RC225915L3
- RC225915L3V
- RC225915L4
- RC225915L4V
- RG219296
- RG225915
- RR205692
- RR205692L1
- RR205692L1V
- RR205692L2
- RR205692L2V
- RR205692L3
- RR205692L3V
- RR205692L4
- RR205692L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CSGALNACT1
- Addgene plasmids for CSGALNACT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CSGALNACT1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | · | 11d | · | 11e | · | 11f | · | 11g | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP10: |
Relevant External Links for CSGALNACT1 Gene
- GeneLoc Exon Structure for
- CSGALNACT1
- ECgene alternative splicing isoforms for
- CSGALNACT1
Expression for CSGALNACT1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Oligodendrocyte Precursor Cells Forebrain White Matter
- Striatum
- Cerebral Cortex
-
Eye (Sensory Organs)
- GABAergic Amacrine Cells Inner Nuclear Layer
- Lens
-
Ovary (Reproductive System)
- Pre-Granulosa Cells Primordial Follicle
-
Neurons
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Neural Tube (Nervous System)
- Dermis (Integumentary System)
- Fibroblasts
- Lateral Plate Mesoderm (Gastrulation Derivatives)
- Neural Crest (Gastrulation Derivatives)
-
Thyroid (Endocrine System)
This gene is overexpressed in Placenta (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CSGALNACT1 Gene
NURSA nuclear receptor signaling pathways regulating expression of CSGALNACT1 Gene:
CSGALNACT1SOURCE GeneReport for Unigene cluster for CSGALNACT1 Gene:
Hs.613729mRNA Expression by UniProt/SwissProt for CSGALNACT1 Gene:
Q8TDX6-CGAT1_HUMAN
Tissue specificity:
Ubiquitous, with the highest levels in placenta, thyroid, bladder, prostate and adrenal gland. Detected at low levels in the other tissues examined.
Evidence on tissue expression from TISSUES for CSGALNACT1 Gene
- Nervous system(4.8)
Primer Products
-
OriGene qPCR primer pairs for CSGALNACT1
- genomics-online: primer clones - Search results for 98 available CSGALNACT1 gene related products
- Overview of 98 available CSGALNACT1 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSGALNACT1 Gene
Orthologs for CSGALNACT1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CSGALNACT1 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CSGALNACT1 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CSGALNACT1 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CSGALNACT1 35 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Csgalnact1 17 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Csgalnact1 34 |
|
||
| cow (Bos Taurus) |
Mammalia | CSGALNACT1 35 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CSGALNACT1 35 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CSGALNACT1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | csgalnact1 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC793671 34 |
|
||
| CSGALNACT1 (1 of 2) 35 |
|
OneToMany | |||
| CSGALNACT1 (2 of 2) 35 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG12913 35 34 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007720 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.6775 35 |
|
OneToMany |
- Species where no ortholog for CSGALNACT1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for CSGALNACT1 Gene
- ENSEMBL:
- Gene Tree for CSGALNACT1 (if available)
- TreeFam:
- Gene Tree for CSGALNACT1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CSGALNACT1: view image
Paralogs for CSGALNACT1 Gene
Variants for CSGALNACT1 Gene
| SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000003229 | -- | 19,572,581(-) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000005334 | -- | 19,595,766(-) | A/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000014054 | -- | 19,458,588(-) | C/G/T | 5_prime_UTR_variant, coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs1000025838 | -- | 19,656,543(-) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000036800 | -- | 19,458,770(-) | C/T | intron_variant |
Residual Variation Intolerance Score:
68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.24;
62.30% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CSGALNACT1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CSGALNACT1
- Human Gene Mutation Database (HGMD)
- CSGALNACT1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSGALNACT1 Gene
Disorders for CSGALNACT1 Gene
Additional Disease Information for CSGALNACT1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for CSGALNACT1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CSGALNACT1 Gene
Publications for CSGALNACT1 Gene
- Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage. (PMID: 17145758) Sakai K … Watanabe H (The Journal of biological chemistry 2007) 2 3 4 58
- Differential roles of two N-acetylgalactosaminyltransferases, CSGalNAcT-1, and a novel enzyme, CSGalNAcT-2. Initiation and elongation in synthesis of chondroitin sulfate. (PMID: 12446672) Sato T … Narimatsu H (The Journal of biological chemistry 2003) 2 3 4 58
- Chondroitin Sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT-1) Deficiency Results in a Mild Skeletal Dysplasia and Joint Laxity. (PMID: 27599773) Vodopiutz J … Janecke AR (Human mutation 2017) 3 4 58
- Chondroitin beta-1,4-N-acetylgalactosaminyltransferase-1 missense mutations are associated with neuropathies. (PMID: 21160489) Saigoh K … Kusunoki S (Journal of human genetics 2011) 3 4 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 58
Products for CSGALNACT1 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CSGALNACT1
- Origene Custom Protein Services for CSGALNACT1
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CSGALNACT1
- Browse OriGene Inhibitory RNA Products For CSGALNACT1
- OriGene qPCR primer pairs for CSGALNACT1
- OriGene CRISPR knockouts for CSGALNACT1
- MG208499
- MR208499
- MR208499L1
- MR208499L1V
- MR208499L2
- MR208499L2V
- MR208499L3
- MR208499L3V
- MR208499L4
- MR208499L4V
- MR230401
- RC219296
- RC219296L1
- RC219296L1V
- RC219296L2
- RC219296L2V
- RC219296L3
- RC219296L3V
- RC219296L4
- RC219296L4V
- RC225915
- RC225915L1
- RC225915L1V
- RC225915L2
- RC225915L2V
- RC225915L3
- RC225915L3V
- RC225915L4
- RC225915L4V
- RG219296
- RG225915
- RR205692
- RR205692L1
- RR205692L1V
- RR205692L2
- RR205692L2V
- RR205692L3
- RR205692L3V
- RR205692L4
- RR205692L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CSGALNACT1
- Sino Biological Human cDNA Clone for CSGALNACT1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CSGALNACT1
- Novus Biologicals proteins and lysates for CSGALNACT1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CSGALNACT1
- Abcam proteins for CSGALNACT1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for CSGALNACT1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CSGALNACT1 (AFLGC-CSGALNACT1)
- antibodies-online: Search results for 67 available CSGALNACT1 Antibodies ranked by validation data
- Compare Top CSGALNACT1 Antibodies
- Recommended
- 44 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IHC (p) Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 18 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 5 WB Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- antibodies-online: Search results for available CSGALNACT1 related products ranked by validation data
- antibodies-online: Search results for 5 available CSGALNACT1 Proteins ranked by validation data
- Compare Top CSGALNACT1 Proteins
- Browse Santa Cruz Biotechnology (SCBT) Antibodies
- Search Santa Cruz Biotechnology (SCBT) for CSGALNACT1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CSGALNACT1
- Horizon Cell Lines for CSGALNACT1
- genomics-online: cdna clones - Search results for 98 available CSGALNACT1 gene related products
- Overview of 98 available CSGALNACT1 gene related products
- orf clones - Search results for 98 available CSGALNACT1 gene related products
- Overview of 98 available CSGALNACT1 gene related products
- genomics-online: gRNA clones - Search results for 98 available CSGALNACT1 gene related products
- Overview of 98 available CSGALNACT1 gene related products
- genomics-online: primer clones - Search results for 98 available CSGALNACT1 gene related products
- Overview of 98 available CSGALNACT1 gene related products
- genomics-online: shRNA clones - Search results for 98 available CSGALNACT1 gene related products
- Overview of 98 available CSGALNACT1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CSGALNACT1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CSGALNACT1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CSGALNACT1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSGALNACT1
Sources for CSGALNACT1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) HGMD
- (45) GAD
- (46) BGMUT
- (47) HuGE
- (48) Atlas
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) OCA
- (69) Proteopedia
- (70) MOPED
- (71) neXtProt
- (72) Reactome
- (73) GeneGo (Thomson Reuters)
- (74) fRNAdb
- (75) DISEASES
- (76) SIMAP
- (77) GenomeRNAi
- (78) LifeMap
- (79) miRTarBase
- (80) MalaCards
- (81) Invitrogen
- (82) BitterDB
- (83) ESI-BIO
- (84) RefSeq
- (85) BioSystems
- (86) MaxQB
- (87) IUPHAR
- (88) BioGPS
- (89) Illumina
- (90) COMPARTMENTS
- (91) HOMER
- (92) PaxDb
- (93) ApexBio
- (94) Addgene
- (95) antibodies-online
- (96) CYP
- (97) NONCODE
- (98) SwitchGear Genomics
- (99) TreeFam
- (100) PathCards
- (101) GeneReviews
- (102) GeneTex
- (103) Taconic Biosciences
- (104) GTEx
- (105) ProteomicsDB
- (106) SCBT
- (107) DGIdb
- (108) ClinicalTrials
- (109) FDA Approved Drugs
- (110) RVIS
- (111) SIGNOR
- (112) diseasecard
- (113) NIH Rare Diseases
- (114) Orphanet
- (115) UMLS
- (116) GTR
- (117) Disease Ontology
- (118) Genetics Home Reference
- (119) MeSH
- (120) MedlinePlus
- (121) CDC
- (122) NINDS
- (123) NCBI Bookshelf
- (124) ClinVar
- (125) Gene Damage Index
- (126) ViGene Biosciences
- (127) HPO
- (128) UDN
- (129) VISTA
- (130) FANTOM5
- (131) ENCODE
- (132) ProSci
- (133) Horizon
- (134) NURSA
- (135) IID
- (136) Cyagen
- (137) VectorBuilder
- (138) SNPedia
- (139) BRCA Exchange
- (140) St John's Lab
- (141) CIViC
- (142) ProteoGenix
- (143) dbSUPER
- (144) TISSUES
- (145) Gene ORGANizer
- (146) abm
- (147) CrownBio
- (148) Human Protein Atlas
- (149) GWAS Catalog
- (150) Monarch Initiative
- (151) DataMed
- (152) HumanCyc
- (153) genomics-online
- (154) UCNEbase
- (155) EPDnew
- (156) Applied Biosystems
- (157) GlyConnect
- (158) Aminode
- (159) GeneCopoeia
- (160) GPS-Prot
- (161) RNACentral
- (162) LncRNADisease
- (163) LOVD
- (164) miR2Disease
- (165) DiseaseEnhancer
- (166) Boster Bio
- (167) Biorbyt
- (168) Biocompare
- (169) Mastermind