This gene encodes a member of the IL-6 superfamily of cytokines. The encoded cytokine controls the production, differentiation, and function of granulocytes. Granulocytes are a type of white blood cell that are part of the innate immune response. A modified form of this protein is commonly administered to manage chemotherapy-induced neutropenia. Alternatively spliced transcript... See more...

Aliases for CSF3 Gene

Aliases for CSF3 Gene

  • Colony Stimulating Factor 3 2 3 5
  • Pluripoietin 2 3 4
  • Lenograstim 2 3 4
  • Filgrastim 2 3 4
  • Granulocyte Colony-Stimulating Factor 3 4
  • C17orf33 3 4
  • GCSF 3 4
  • Colony Stimulating Factor 3 (Granulocyte) 2
  • Granulocyte Colony Stimulating Factor 2
  • Granulocyte-Colony Stimulating Factor 3
  • Chromosome 17 Open Reading Frame 33 2
  • MGC45931 2
  • CSF3OS 3
  • G-CSF 4
  • CSF3 5

External Ids for CSF3 Gene

Previous HGNC Symbols for CSF3 Gene

  • GCSF
  • G-CSF
  • C17orf33

Previous GeneCards Identifiers for CSF3 Gene

  • GC17M037625
  • GC17P040169
  • GC17P038081
  • GC17P038546
  • GC17P035425
  • GC17P038171
  • GC17P033965

Summaries for CSF3 Gene

Entrez Gene Summary for CSF3 Gene

  • This gene encodes a member of the IL-6 superfamily of cytokines. The encoded cytokine controls the production, differentiation, and function of granulocytes. Granulocytes are a type of white blood cell that are part of the innate immune response. A modified form of this protein is commonly administered to manage chemotherapy-induced neutropenia. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2020]

GeneCards Summary for CSF3 Gene

CSF3 (Colony Stimulating Factor 3) is a Protein Coding gene. Diseases associated with CSF3 include Neutropenia and Mucositis. Among its related pathways are PEDF Induced Signaling and Hematopoietic cell lineage. Gene Ontology (GO) annotations related to this gene include enzyme binding and growth factor activity.

UniProtKB/Swiss-Prot Summary for CSF3 Gene

  • Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.

Gene Wiki entry for CSF3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CSF3 Gene

Genomics for CSF3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CSF3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J040014 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 604.6 +3.8 3799 10.7 HNRNPL GATAD2A CTCF PRDM10 TFE3 KDM1A RCOR2 JUND PRDM1 MTA2 CSF3 MED24 GSDMA MSL1 ENSG00000265799 lnc-MED24-6 lnc-NR1D1-5 THRA
GH17J040053 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 0.3 +38.8 38840 2 SP1 CREB1 GATAD2A PRDM10 ZNF629 SIX5 LEF1 NFKBIZ NFRKB POLR2A MED24 lnc-NR1D1-3 MED1 SMARCE1 CDK12 THRA RF00017-2376 CSF3
GH17J040024 Enhancer 1 ENCODE dbSUPER 0.4 +10.8 10835 3.1 GATAD2A CTCF PRDM10 ZNF143 RBFOX2 RXRB REST SMAD5 RAD21 IRF2 MIR6884 SNORD124 GSDMA MED24 lnc-NR1D1-5 CSF3 THRA
GH17J040038 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.4 +23.6 23640 1.6 GATAD2A CTCF TEAD4 TFE3 RFX1 PRDM1 REST IRF2 SP1 FOXJ2 RF00017-2375 lnc-THRA-1 MED24 GSDMA lnc-NR1D1-3 THRA CSF3
GH17J040031 Enhancer 0.7 ENCODE dbSUPER 0.4 +17.1 17087 2.4 ZSCAN4 SP1 JUND RAD21 HNF4A RXRA REST HNF4G YY1 FOXA1 lnc-NR1D1-33 lnc-NR1D1-4 piR-61945-207 MED24 GSDMA THRA PSMD3 RAPGEFL1 LRRC3C ORMDL3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CSF3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CSF3

Top Transcription factor binding sites by QIAGEN in the CSF3 gene promoter:
  • AML1a

Genomic Locations for CSF3 Gene

Genomic Locations for CSF3 Gene
chr17:40,015,361-40,017,813
(GRCh38/hg38)
Size:
2,453 bases
Orientation:
Plus strand
chr17:38,171,614-38,174,066
(GRCh37/hg19)
Size:
2,453 bases
Orientation:
Plus strand

Genomic View for CSF3 Gene

Genes around CSF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSF3 Gene

Proteins for CSF3 Gene

  • Protein details for CSF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09919-CSF3_HUMAN
    Recommended name:
    Granulocyte colony-stimulating factor
    Protein Accession:
    P09919
    Secondary Accessions:
    • A8MXR7

    Protein attributes for CSF3 Gene

    Size:
    207 amino acids
    Molecular mass:
    22293 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CSF3 Gene

    Alternative splice isoforms for CSF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSF3 Gene

Post-translational modifications for CSF3 Gene

  • O-glycan consists of Gal-GalNAc disaccharide which can be modified with up to two sialic acid residues (done in recombinantly expressed G-CSF from CHO cells).
  • Glycosylation at Thr166
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for CSF3

No data available for DME Specific Peptides for CSF3 Gene

Domains & Families for CSF3 Gene

Gene Families for CSF3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for CSF3 Gene

InterPro:
Blocks:
  • Granulocyte colony-stimulating/myelomonocytic growth factor
ProtoNet:

Suggested Antigen Peptide Sequences for CSF3 Gene

GenScript: Design optimal peptide antigens:
  • Colony stimulating factor 3 (Granulocyte) (C3VB11_HUMAN)
  • Pluripoietin (CSF3_HUMAN)
  • Granulocyte colony-stimulating factor (D7RVA3_HUMAN)
  • Colony stimulating factor 3 nirs variant 1 (Q5FBY7_HUMAN)
  • cDNA, FLJ94067, Homo sapiens colony stimulating factor 3 (granulocyte) (CSF3),transcript variant 2, mRNA (Q6FH65_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P09919

UniProtKB/Swiss-Prot:

CSF3_HUMAN :
  • Belongs to the IL-6 superfamily.
Family:
  • Belongs to the IL-6 superfamily.
genes like me logo Genes that share domains with CSF3: view

Function for CSF3 Gene

Molecular function for CSF3 Gene

UniProtKB/Swiss-Prot Function:
Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.
GENATLAS Biochemistry:
colony-stimulating factor 3,22.3kDa,(granulocyte),playing a pivotal role in growth control of granulocytic progenitors,regulated by SPI1,MYB,others and inducing PRTN3 (see symbols),inducingJUNB and/or TOP in the proliferative response of human myeloidleukemia,putatively involved in severe congenital neutropenia

LifeMap Function Summary for CSF3 Gene

CSF3 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Phenotypes From GWAS Catalog for CSF3 Gene

Gene Ontology (GO) - Molecular Function for CSF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA,NAS 15664994
GO:0005130 granulocyte colony-stimulating factor receptor binding TAS,IBA 21873635
GO:0008083 growth factor activity IBA 21873635
GO:0019899 enzyme binding IPI 12393522
genes like me logo Genes that share ontologies with CSF3: view
genes like me logo Genes that share phenotypes with CSF3: view

Animal Models for CSF3 Gene

MGI Knock Outs for CSF3:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSF3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CSF3 Gene

Localization for CSF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CSF3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CSF3 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 3
nucleus 3
cytosol 3
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CSF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space TAS,IBA 21873635
genes like me logo Genes that share ontologies with CSF3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CSF3 Gene

Pathways & Interactions for CSF3 Gene

PathCards logo

SuperPathways for CSF3 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.47
.46
2 ERK Signaling
.61
.61
.51
3 Akt Signaling
.60
.60
4 PAK Pathway
.56
.56
5 Cytokine Signaling in Immune system
genes like me logo Genes that share pathways with CSF3: view

Pathways by source for CSF3 Gene

2 GeneGo (Thomson Reuters) pathways for CSF3 Gene
  • Cytokine production by Th17 cells in CF
  • Cytokine production by Th17 cells in CF (Mouse model)
1 R&D Systems pathway for CSF3 Gene
15 Qiagen pathways for CSF3 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Endothelin-1 Signaling Pathway
  • ERK Signaling

SIGNOR curated interactions for CSF3 Gene

Activates:

Gene Ontology (GO) - Biological Process for CSF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IEA --
GO:0007165 signal transduction IEA --
GO:0007275 multicellular organism development TAS 2420009
GO:0008284 positive regulation of cell proliferation TAS,IBA 21873635
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IDA 23001182
genes like me logo Genes that share ontologies with CSF3: view

Drugs & Compounds for CSF3 Gene

(78) Drugs for CSF3 Gene - From: ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Talabostat Investigational Pharma 0
Dexamethasone (DHAP) Pharma Glucocorticoidan;ti-inflammatory 0

(47) Additional Compounds for CSF3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for CSF3 Gene

Compound Action Cas Number
Dexamethasone (DHAP) Glucocorticoidan;ti-inflammatory 1950-02-2
genes like me logo Genes that share compounds with CSF3: view

Transcripts for CSF3 Gene

mRNA/cDNA for CSF3 Gene

4 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSF3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CSF3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - - -
SP2: - -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: - - - -
SP7:
SP8:
SP9: - - -

Relevant External Links for CSF3 Gene

GeneLoc Exon Structure for
CSF3

Expression for CSF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CSF3 Gene

mRNA differential expression in normal tissues according to GTEx for CSF3 Gene

This gene is overexpressed in Lung (x8.2), Heart - Atrial Appendage (x8.2), Adipose - Visceral (Omentum) (x4.3), and Muscle - Skeletal (x4.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CSF3

SOURCE GeneReport for Unigene cluster for CSF3 Gene:

Hs.2233

Evidence on tissue expression from TISSUES for CSF3 Gene

  • Bone marrow(3.8)
  • Blood(3.8)
  • Pancreas(3.3)
  • Nervous system(3.3)
  • Liver(3.2)
  • Spleen(3.2)
  • Lymph node(3.1)
  • Lung(3.1)
  • Kidney(3.1)
  • Intestine(3.1)
  • Heart(3)
  • Muscle(3)
  • Skin(2.8)
  • Bone(2.7)
  • Stomach(2.6)
  • Urine(2.3)
  • Adrenal gland(2.3)
genes like me logo Genes that share expression patterns with CSF3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSF3 Gene

Orthologs for CSF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CSF3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CSF3 30 31
  • 97.1 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CSF3 30 31
  • 87.18 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CSF3 30 31
  • 85.98 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Csf3 30
  • 79.49 (n)
Mouse
(Mus musculus)
Mammalia Csf3 30 17 31
  • 78.71 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CSF3 31
  • 59 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CSF3 31
  • 57 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CSF3 30 31
  • 56.49 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CSF3 31
  • 27 (a)
OneToOne
Species where no ortholog for CSF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for CSF3 Gene

ENSEMBL:
Gene Tree for CSF3 (if available)
TreeFam:
Gene Tree for CSF3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CSF3: view image

Paralogs for CSF3 Gene

No data available for Paralogs for CSF3 Gene

Variants for CSF3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CSF3 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
712649 Benign: not provided 40,016,804(+) C/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
712650 Benign: not provided 40,016,854(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
720537 Benign: not provided 40,016,855(+) G/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
728891 Benign: not provided 40,016,787(+) C/G INTRON_VARIANT
741620 Benign: not provided 40,015,818(+) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for CSF3 Gene

Structural Variations from Database of Genomic Variants (DGV) for CSF3 Gene

Variant ID Type Subtype PubMed ID
esv3573064 CNV gain 25503493
nsv1146669 OTHER inversion 26484159

Variation tolerance for CSF3 Gene

Residual Variation Intolerance Score: 79.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CSF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSF3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSF3 Gene

Disorders for CSF3 Gene

MalaCards: The human disease database

(158) MalaCards diseases for CSF3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
neutropenia
  • leukopenia
mucositis
  • inflammatory disease of mucous membrane
felty syndrome
  • felty's syndrome
granulocytopenia
  • agranulocytosis
cyclic neutropenia
  • cyclic hematopoiesis
- elite association - COSMIC cancer census association via MalaCards
Search CSF3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CSF3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CSF3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CSF3 Gene

Publications for CSF3 Gene

  1. Association of genetic variations in the CSF2 and CSF3 genes with lung function in smoking-induced COPD. (PMID: 18353856) He JQ … Sandford AJ (The European respiratory journal 2008) 3 23 41
  2. Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex. (PMID: 16492764) Tamada T … Kuroki R (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 23
  3. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 41
  4. Complete sequencing of the recombinant granulocyte-colony stimulating factor (filgrastim) and detection of biotinylation by mass spectrometry. (PMID: 19526310) Ahmed KE … Lubec G (Amino acids 2010) 3 23
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41

Products for CSF3 Gene

Sources for CSF3 Gene