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The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splici... See more...
Aliases for CSF1 Gene
Aliases for CSF1 Gene
External Ids for CSF1 Gene
- HGNC: 2432
- Entrez Gene: 1435
- Ensembl: ENSG00000184371
- OMIM: 120420
- UniProtKB: P09603
Previous GeneCards Identifiers for CSF1 Gene
- GC01U990031
- GC01P109555
- GC01P109752
- GC01P110165
- GC01P110254
- GC01P110453
- GC01P108322
Summaries for CSF1 Gene
-
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
GeneCards Summary for CSF1 Gene
CSF1 (Colony Stimulating Factor 1) is a Protein Coding gene. Diseases associated with CSF1 include Pigmented Villonodular Synovitis and Tenosynovial Giant Cell Tumor. Among its related pathways are Ras signaling pathway and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and growth factor activity.
UniProtKB/Swiss-Prot Summary for CSF1 Gene
-
Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
Additional gene information for CSF1 Gene
- HGNC(2432)
- Entrez Gene(1435)
- Ensembl(ENSG00000184371)
- OMIM(120420)
- UniProtKB(P09603)
- Open Targets Platform(ENSG00000184371)
- Monarch Initiative
- Search for CSF1 at DataMed
- Search for CSF1 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CSF1 Gene
Genomics for CSF1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CSF1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CSF1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CSF1
- Top Transcription factor binding sites by QIAGEN in the CSF1 gene promoter:
-
- AP-1
- STAT3
Genomic Locations for CSF1 Gene
Genomic Locations for CSF1 Gene
- chr1:109,910,242-109,930,992
- (GRCh38/hg38)
- Size:
- 20,751 bases
- Orientation:
- Plus strand
- chr1:110,452,864-110,473,614
- (GRCh37/hg19)
- Size:
- 20,751 bases
- Orientation:
- Plus strand
Genomic View for CSF1 Gene
Genes around CSF1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p13.3 by HGNC
- 1p13.3 by Entrez Gene
- 1p13.3 by Ensembl
CSF1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CSF1 Gene
Proteins for CSF1 Gene
-
Protein details for CSF1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P09603-CSF1_HUMAN
- Recommended name:
- Macrophage colony-stimulating factor 1
- Protein Accession:
- P09603
- A8K6J5
- Q13130
- Q14086
- Q14806
- Q5VVF3
- Q5VVF4
- Q9UQR8
Protein attributes for CSF1 Gene
- Size:
- 554 amino acids
- Molecular mass:
- 60179 Da
- Quaternary structure:
-
- Homodimer or heterodimer; disulfide-linked. Interacts with CSF1R.
Three dimensional structures from OCA and Proteopedia for CSF1 Gene
Protein Expression for CSF1 Gene
Post-translational modifications for CSF1 Gene
- N- and O-glycosylated. Glycosylation and proteolytic cleavage yield different soluble forms. One high molecular weight soluble form is a proteoglycan containing chondroitin sulfate. O-glycosylated with core 1 or possibly core 8 glycans. Isoform 1 is N- and O-glycosylated. Isoform 3 is only N-glycosylated.
-
Glycosylation at Asn154, Asn172, Ser256, Thr257, Thr266, Thr363, Thr365, Thr376, Thr383, Thr387, Ser391, Ser428, Ser430, Ser431, Ser433, Ser451, Ser461, Ser473, and Thr477
- NX_P09603 (NX_P09603-1)
- Modification sites at PhosphoSitePlus
Other Protein References for CSF1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences CSF1 / MCSF Monoclonal Antibody
- GeneTex Anti-M-CSF antibody [21] and Anti-M-CSF antibody
-
Custom Antibody ServicesOriGene Antibodies for CSF1
- Novus Biologicals Antibodies for CSF1
-
Abcam antibodies for CSF1
- Invitrogen Antibodies for CSF1 (AFLGC-Csf1)
- antibodies-online: Show 210 available CSF1 Antibodies ranked by validation data
- Compare Top CSF1 Antibodies
-
Recommended
- 136 WB Antibodies (anti-human)
- 14 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 3 EIA Antibodies (anti-human)
- 1 RIA Antibody (anti-human)
- 14 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 42 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
-
Santa Cruz Biotechnology (SCBT) Antibodies for CSF1
- Sino Biological Antibodies for CSF1
Protein Products
- RayBiotech Recombinant Human CSF-1
-
OriGene Purified Proteins for CSF1
- Search Origene for MassSpec and Protein Over-expression Lysates for CSF1
- Origene Custom Protein Services for CSF1
- Sino Biological Recombinant Proteins for CSF1
- Sino Biological Cell Lysates for CSF1
- ProSpec Recombinant Proteins for CSF1
-
ProSci Proteins for CSF1
- colony stimulating factor 1 (macrophage) [40-606]
- colony stimulating factor 1 (macrophage) [40-620]
- colony stimulating factor 1 (macrophage) [40-479]
- colony stimulating factor 1 [91-375]
- Colony stimulating factor 1 (macrophage) [96-923]
- colony stimulating factor 1 [91-425]
- colony stimulating factor 1 (macrophage) [91-598]
- colony stimulating factor 1 (macrophage) [40-288]
- colony stimulating factor 1 (macrophage) [40-447]
-
Abcam proteins for CSF1
Assay Products
- RayBiotech Human M-CSF ELISA
- Novus Biologicals ELISA Kits for CSF1
- antibodies-online: Show 114 available CSF1 Elisa Kits ranked by validation data
- Compare Top CSF1 Elisa Kits
-
Quality Products:
- ABIN625043
- ABIN1115841
- ABIN414905
- ABIN365391
- ABIN411321
- ABIN1029180
- ABIN3032957
- ABIN5564632
- ABIN1379980
- ABIN3198595
- ABIN365463
- ABIN625417
- ABIN415526
- ABIN1029181
- ABIN3032826
- ABIN3198466
- ABIN1379958
- ABIN1884550
- ABIN5523394
- ABIN2708571
- ABIN1115844
- ABIN416355
- ABIN365617
- ABIN1571175
- ABIN5523395
- ABIN5671018
- ABIN627277
- ABIN5593816
- ABIN771576
- ABIN5653166
- ABIN628788
- ABIN776365
- ABIN1563826
- ABIN6218356
- ABIN364914
-
Abcam assays for CSF1
- Sino Biological Assays for CSF1
No data available for DME Specific Peptides for CSF1 Gene
Domains & Families for CSF1 Gene
Gene Families for CSF1 Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for CSF1 Gene
- InterPro:
- Blocks:
-
- Macrophage colony stimulating factor-1
- ProtoNet:
Suggested Antigen Peptide Sequences for CSF1 Gene
- GenScript: Design optimal peptide antigens:
-
- Lanimostim (CSF1_HUMAN)
- Colony stimulating factor 1 (Macrophage) (Q5VVF2_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CSF1 Gene
Function for CSF1 Gene
Molecular function for CSF1 Gene
- UniProtKB/Swiss-Prot Function:
- Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
- GENATLAS Biochemistry:
- colony-stimulating factor 1,60kDa,(macrophage),expressed in fibroblast,endothelium,epithelium with two alternatively spliced isoforms,homodimerizing
LifeMap Function Summary for CSF1 Gene
During embryonic development, CSF1 as signaling molecule is secreted from the following cells
- Bone
It affects the following cells:
- Blood
CSF1 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
- Blood
Phenotypes From GWAS Catalog for CSF1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005125 | cytokine activity | IDA | 2460758 |
| GO:0005157 | macrophage colony-stimulating factor receptor binding | TAS | 2460758 |
| GO:0005515 | protein binding | IPI | 22153499 |
| GO:0008083 | growth factor activity | IDA | 2460758 |
| GO:0042802 | identical protein binding | IPI | 22153499 |
Phenotypes for CSF1 Gene
- MGI mutant phenotypes for CSF1:
-
inferred from 4 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- craniofacial phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for CSF1:
Animal Models for CSF1 Gene
- MGI Knock Outs for CSF1:
-
- Csf1 Csf1<tm1.2Sabw>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CSF1 - Select products 50% OFF >
- * CSF1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CSF1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CSF1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CSF1
miRNA for CSF1 Gene
- miRTarBase miRNAs that target CSF1
-
- hsa-miR-130a-3p (MIRT004575)
- hsa-miR-130b-3p (MIRT006200)
- hsa-miR-148b-3p (MIRT007318)
- hsa-miR-335-5p (MIRT016979)
- hsa-miR-505-3p (MIRT041071)
- hsa-miR-30b-5p (MIRT046121)
- hsa-miR-30c-5p (MIRT047860)
- hsa-miR-128-3p (MIRT052998)
- hsa-miR-152-3p (MIRT053188)
- hsa-miR-7847-3p (MIRT569785)
- hsa-miR-6894-5p (MIRT569786)
- hsa-miR-765 (MIRT569787)
- hsa-miR-7154-3p (MIRT569788)
- hsa-miR-766-5p (MIRT569789)
- hsa-miR-5192 (MIRT569790)
- hsa-miR-4306 (MIRT569791)
- hsa-miR-4644 (MIRT569792)
- hsa-miR-185-5p (MIRT569793)
- hsa-miR-184 (MIRT569794)
- hsa-miR-5580-5p (MIRT569795)
- hsa-miR-3135b (MIRT569796)
- hsa-miR-4693-3p (MIRT569797)
- mmu-miR-30c-5p (MIRT599307)
- mmu-miR-30a-5p (MIRT599308)
- mmu-miR-30e-5p (MIRT599309)
- mmu-miR-30b-5p (MIRT599310)
- mmu-miR-384-5p (MIRT599311)
- mmu-miR-30d-5p (MIRT599312)
- mmu-miR-129-5p (MIRT599313)
- mmu-miR-3108-5p (MIRT599314)
- mmu-miR-504-5p (MIRT599315)
- hsa-miR-1207-5p (MIRT732200)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CSF1
- Browse OriGene Inhibitory RNA Products For CSF1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSF1
Clone Products
- Applied Biological Materials (abm): Clones for CSF1 - Select products 50% OFF >
- * CSF1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG208764
- MG226827
- MG227487
- MR208764
- MR208764L3
- MR208764L4
- MR226827
- MR226827L3
- MR226827L4
- MR227487
- MR227487L3
- MR227487L4
- RC205855
- RC205855L3
- RC205855L4
- RC213103
- RC213103L1
- RC213103L2
- RC213103L3
- RC213103L4
- RC217104
- RC217104L3
- RC217104L4
- RC217172
- RC217172L1
- RC217172L2
- RC217172L3
- RC217172L4
- RG205855
- RG213103
- RG217104
- RG217172
- RR212926
- RR212926L3
- RR212926L4
- MR208764L3V
- MR208764L4V
- MR226827L3V
- MR226827L4V
- MR227487L3V
- MR227487L4V
- RC205855L3V
- RC205855L4V
- RC213103L1V
- RC213103L2V
- RC213103L3V
- RC213103L4V
- RC217104L3V
- RC217104L4V
- RC217172L1V
- RC217172L2V
- RC217172L3V
- RC217172L4V
- RR212926L3V
- RR212926L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CSF1
- Addgene plasmids for CSF1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CSF1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSF1 Gene
Localization for CSF1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CSF1 Gene
- Cell membrane. Single-pass type I membrane protein.
- [Processed macrophage colony-stimulating factor 1]: Secreted, extracellular space.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 5 |
| endoplasmic reticulum | 4 |
| cytoskeleton | 3 |
| cytosol | 3 |
| lysosome | 3 |
| mitochondrion | 2 |
| endosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
- Plasma membrane (3)
- Nuclear bodies (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IBA,IDA | 2460758 |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | NAS | 2460758 |
Pathways & Interactions for CSF1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
|
IL-6 Pathway
.61
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
|
| 2 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
|
Molecular Mechanisms of Cancer
.51
|
| 3 | Ras signaling pathway | ||
| 4 | Akt Signaling |
Akt Signaling
.60
|
p38 Signaling
.60
|
| 5 | PAK Pathway |
Antioxidant Action of Vitamin-C
.56
|
PAK Pathway
.56
|
Pathways by source for CSF1 Gene
8 BioSystems pathways for CSF1 Gene
4 Reactome pathways for CSF1 Gene
11 KEGG pathways for CSF1 Gene
2 R&D Systems pathways for CSF1 Gene
18 Qiagen pathways for CSF1 Gene
- Akt Signaling
- all-trans-Retinoic Acid Signaling in Brain
- Antioxidant Action of Vitamin-C
- Endothelin-1 Signaling Pathway
- ERK Signaling
Interacting Proteins for CSF1 Gene
Selected Interacting proteins:
P09603-CSF1_HUMAN
ENSP00000327513
for CSF1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CSF1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001954 | positive regulation of cell-matrix adhesion | ISS | 18566389 |
| GO:0002158 | osteoclast proliferation | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002931 | response to ischemia | IDA | 8922060 |
| GO:0003006 | developmental process involved in reproduction | ISS | 19017797 |
Drugs & Compounds for CSF1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for CSF1 Gene
mRNA/cDNA for CSF1 Gene
- 4 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000527192 577 nts (view in UCSC)
- ENST00000525659 551 nts (view in UCSC)
- ENST00000357302 597 nts (view in UCSC)
- ENST00000329608 3994 nts (view in UCSC)
- ENST00000488198 1009 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CSF1 - Select products 50% OFF >
- * CSF1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CSF1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CSF1
-
Santa Cruz Biotechnology (SCBT) CRISPR for CSF1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CSF1
- Browse OriGene Inhibitory RNA Products For CSF1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSF1
Clone Products
- Applied Biological Materials (abm): Clones for CSF1 - Select products 50% OFF >
- * CSF1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG208764
- MG226827
- MG227487
- MR208764
- MR208764L3
- MR208764L4
- MR226827
- MR226827L3
- MR226827L4
- MR227487
- MR227487L3
- MR227487L4
- RC205855
- RC205855L3
- RC205855L4
- RC213103
- RC213103L1
- RC213103L2
- RC213103L3
- RC213103L4
- RC217104
- RC217104L3
- RC217104L4
- RC217172
- RC217172L1
- RC217172L2
- RC217172L3
- RC217172L4
- RG205855
- RG213103
- RG217104
- RG217172
- RR212926
- RR212926L3
- RR212926L4
- MR208764L3V
- MR208764L4V
- MR226827L3V
- MR226827L4V
- MR227487L3V
- MR227487L4V
- RC205855L3V
- RC205855L4V
- RC213103L1V
- RC213103L2V
- RC213103L3V
- RC213103L4V
- RC217104L3V
- RC217104L4V
- RC217172L1V
- RC217172L2V
- RC217172L3V
- RC217172L4V
- RR212926L3V
- RR212926L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CSF1
- Addgene plasmids for CSF1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CSF1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP11: |
Relevant External Links for CSF1 Gene
- GeneLoc Exon Structure for
- CSF1
Expression for CSF1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Zygote (Early Embryonic Tissues)
- Zygote Zygote
- 8-Cell Embryo Morula
-
Inner Cell Mass (Early Embryo)
- Zygote Zygote
- 8-Cell Embryo Morula
-
Trophoblast (Extraembryonic Tissues)
- Zygote Zygote
- 8-Cell Embryo Morula
-
Heart (Cardiovascular System)
- Mature Cardiac Fibroblasts Myocardium
- Cardiac Fibroblasts Myocardium
-
Fibroblasts
- Mature Cardiac Fibroblasts Myocardium
- Cardiac Fibroblasts Myocardium
-
Bone (Muscoskeletal System)
- Endochondral Osteoblasts Vertebrae
- Endochondral Osteoblasts Rib
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Limb (Muscoskeletal System)
- Limb Muscle Progenitor Cells Forelimb Myotome
-
Skeletal Muscle (Muscoskeletal System)
- Limb Muscle Progenitor Cells Forelimb Myotome
- Glial Cells (Uncategorized)
- Brain (Nervous System)
- Spinal Cord (Nervous System)
This gene is overexpressed in Urine (53.7) and Cerebrospinal fluid (7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CSF1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CSF1
SOURCE GeneReport for Unigene cluster for CSF1 Gene:
Hs.173894Evidence on tissue expression from TISSUES for CSF1 Gene
- Blood(4.7)
- Kidney(4.6)
- Urine(4.3)
- Nervous system(4)
- Bone marrow(3.6)
- Spleen(3.6)
- Lymph node(3.4)
- Bone(3.3)
- Lung(3.1)
- Heart(3)
- Skin(3)
- Intestine(3)
- Liver(2.9)
- Muscle(2.8)
- Pancreas(2.6)
- Adrenal gland(2.3)
- Stomach(2.3)
- Thyroid gland(2.1)
Primer Products
-
OriGene qPCR primer pairs for CSF1
-
OriGene qPCR primer pairs and template standards for CSF1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSF1 Gene
Orthologs for CSF1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CSF1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CSF1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CSF1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Csf1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Csf1 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | CSF1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CSF1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CSF1 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CSF1 31 |
|
OneToOne |
- Species where no ortholog for CSF1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for CSF1 Gene
- ENSEMBL:
- Gene Tree for CSF1 (if available)
- TreeFam:
- Gene Tree for CSF1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CSF1: view image
Paralogs for CSF1 Gene
Pseudogenes.org Pseudogenes for CSF1 Gene
No data available for Paralogs for CSF1 Gene
Variants for CSF1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CSF1 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 720256 | Benign: not provided | 109,924,154(+) | C/T | SYNONYMOUS_VARIANT | |
| 736032 | Benign: not provided | 109,923,833(+) | G/A | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
| 745764 | Likely Benign: not provided | 109,924,798(+) | C/T | MISSENSE_VARIANT | |
| 775573 | Benign: not provided | 109,923,497(+) | G/A | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
| rs1058885 | - | p.Leu408Pro |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2658285 | CNV | deletion | 23128226 |
| esv3567414 | CNV | deletion | 23714750 |
| esv3587160 | CNV | loss | 21293372 |
Residual Variation Intolerance Score:
72.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.08;
50.83% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CSF1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSF1 Gene
Disorders for CSF1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pigmented villonodular synovitis |
|
|
| tenosynovial giant cell tumor |
|
|
| benign giant cell tumor |
|
|
| pulmonary alveolar proteinosis |
|
|
| rheumatoid arthritis |
|
Search CSF1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
CSF1_HUMAN- Note=Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation, invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast, ovarian, prostate, and endometrial cancers.
- Note=Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection.
Additional Disease Information for CSF1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for CSF1 Gene
Publications for CSF1 Gene
- Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor. (PMID: 1455231) Pandit J … Kim SH (Science (New York, N.Y.) 1992) 3 4 23
- Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells. (PMID: 20504948) Wei S … Stanley ER (Journal of leukocyte biology 2010) 3 4
- Elevated levels of macrophage colony-stimulating factor in human fracture healing. (PMID: 19950360) Sarahrudi K … Aharinejad S (Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2010) 3 23
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
- Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PMID: 20452482) Romero R … Menon R (American journal of obstetrics and gynecology 2010) 3 41
ExternalLinks
Products for CSF1 Gene
- View all 33 R&D Systems CSF1 (M-CSF) Products
- View all 5 R&D Systems CSF1 (M-CSF) Proteins and Enzymes
- View all 21 R&D Systems CSF1 (M-CSF) Primary Antibodies
- View all 2 R&D Systems CSF1 (M-CSF) ELISAs
- View all R&D Systems CSF1 (M-CSF) Simple Plex Assays
- View all R&D Systems CSF1 (M-CSF) Luminex Assays
- View all 3 R&D Systems CSF1 (M-CSF) Proteome Profiler Antibody Arrays
- Learn more about R&D Systems custom CSF1 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for CSF1
- Custom Assay Services
- OriGene Purified Proteins for CSF1
- Search Origene for MassSpec and Protein Over-expression Lysates for CSF1
- Origene Custom Protein Services for CSF1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CSF1
- Browse OriGene Inhibitory RNA Products For CSF1
- OriGene qPCR primer pairs for CSF1
- OriGene qPCR primer pairs and template standards for CSF1
- OriGene CRISPR knockouts for CSF1
- MG208764
- MG226827
- MG227487
- MR208764
- MR208764L3
- MR208764L4
- MR226827
- MR226827L3
- MR226827L4
- MR227487
- MR227487L3
- MR227487L4
- RC205855
- RC205855L3
- RC205855L4
- RC213103
- RC213103L1
- RC213103L2
- RC213103L3
- RC213103L4
- RC217104
- RC217104L3
- RC217104L4
- RC217172
- RC217172L1
- RC217172L2
- RC217172L3
- RC217172L4
- RG205855
- RG213103
- RG217104
- RG217172
- RR212926
- RR212926L3
- RR212926L4
- MR208764L3V
- MR208764L4V
- MR226827L3V
- MR226827L4V
- MR227487L3V
- MR227487L4V
- RC205855L3V
- RC205855L4V
- RC213103L1V
- RC213103L2V
- RC213103L3V
- RC213103L4V
- RC217104L3V
- RC217104L4V
- RC217172L1V
- RC217172L2V
- RC217172L3V
- RC217172L4V
- RR212926L3V
- RR212926L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CSF1
- Sino Biological Human cDNA Clone for CSF1
- Sino Biological Recombinant Proteins for CSF1
- Sino Biological Cell Lysates for CSF1
- Sino Biological Antibodies for CSF1
- Sino Biological Assays for CSF1
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CSF1
- Novus Biologicals proteins and lysates for CSF1
- Novus Biologicals ELISA Kits for CSF1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CSF1
- Abcam proteins for CSF1
- Abcam assays for CSF1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for CSF1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CSF1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CSF1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CSF1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CSF1
- Addgene plasmids for CSF1
- antibodies-online: Show 210 available CSF1 Antibodies ranked by validation data
- Compare Top CSF1 Antibodies
- Recommended
- 136 WB Antibodies (anti-human)
- 14 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 3 EIA Antibodies (anti-human)
- 1 RIA Antibody (anti-human)
- 14 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 42 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- antibodies-online: Show 114 available CSF1 Elisa Kits ranked by validation data
- Compare Top CSF1 Elisa Kits
- Quality Products:
- ABIN625043
- ABIN1115841
- ABIN414905
- ABIN365391
- ABIN411321
- ABIN1029180
- ABIN3032957
- ABIN5564632
- ABIN1379980
- ABIN3198595
- ABIN365463
- ABIN625417
- ABIN415526
- ABIN1029181
- ABIN3032826
- ABIN3198466
- ABIN1379958
- ABIN1884550
- ABIN5523394
- ABIN2708571
- ABIN1115844
- ABIN416355
- ABIN365617
- ABIN1571175
- ABIN5523395
- ABIN5671018
- ABIN627277
- ABIN5593816
- ABIN771576
- ABIN5653166
- ABIN628788
- ABIN776365
- ABIN1563826
- ABIN6218356
- ABIN364914
- antibodies-online: Show 126 available CSF1 Proteins ranked by validation data
- Compare Top CSF1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CSF1
- Search Santa Cruz Biotechnology (SCBT) for CSF1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CSF1
- Search for CSF1 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for CSF1
- colony stimulating factor 1 (macrophage) [40-606]
- colony stimulating factor 1 (macrophage) [40-620]
- colony stimulating factor 1 (macrophage) [40-479]
- colony stimulating factor 1 [91-375]
- Colony stimulating factor 1 (macrophage) [96-923]
- colony stimulating factor 1 [91-425]
- colony stimulating factor 1 (macrophage) [91-598]
- colony stimulating factor 1 (macrophage) [40-288]
- colony stimulating factor 1 (macrophage) [40-447]
- Horizon Cell Lines for CSF1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CSF1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CSF1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CSF1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSF1
Sources for CSF1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt