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Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the... See more...
Aliases for CSE1L Gene
Aliases for CSE1L Gene
External Ids for CSE1L Gene
- HGNC: 2431
- Entrez Gene: 1434
- Ensembl: ENSG00000124207
- OMIM: 601342
- UniProtKB: P55060
Previous GeneCards Identifiers for CSE1L Gene
- GC20P047391
- GC20P048302
- GC20P048348
- GC20P047096
- GC20P047662
- GC20P044412
Summaries for CSE1L Gene
-
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
GeneCards Summary for CSE1L Gene
CSE1L (Chromosome Segregation 1 Like) is a Protein Coding gene. Diseases associated with CSE1L include Speech Disorder and Colorectal Cancer. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Direct p53 effectors. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is IPO7.
UniProtKB/Swiss-Prot Summary for CSE1L Gene
-
Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Additional gene information for CSE1L Gene
- HGNC(2431)
- Entrez Gene(1434)
- Ensembl(ENSG00000124207)
- OMIM(601342)
- UniProtKB(P55060)
- Open Targets Platform(ENSG00000124207)
- Monarch Initiative
- Search for CSE1L at DataMed
- Search for CSE1L at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CSE1L Gene
Genomics for CSE1L Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CSE1L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CSE1L on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CSE1L
- Top Transcription factor binding sites by QIAGEN in the CSE1L gene promoter:
-
- E4BP4
- FOXL1
- Gfi-1
- HFH-1
- HNF-4alpha1
- HNF-4alpha2
- Ik-3
- MRF-2
- Pax-6
- Sp1
Genomic Locations for CSE1L Gene
Genomic Locations for CSE1L Gene
- chr20:49,046,246-49,096,960
- (GRCh38/hg38)
- Size:
- 50,715 bases
- Orientation:
- Plus strand
- chr20:47,662,838-47,713,489
- (GRCh37/hg19)
- Size:
- 50,652 bases
- Orientation:
- Plus strand
Genomic View for CSE1L Gene
Genes around CSE1L on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.13 by HGNC
- 20q13.13 by Entrez Gene
- 20q13.13 by Ensembl
CSE1L Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CSE1L Gene
Proteins for CSE1L Gene
-
Protein details for CSE1L Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P55060-XPO2_HUMAN
- Recommended name:
- Exportin-2
- Protein Accession:
- P55060
- A3RLL6
- B2R5T4
- E1P5Y0
- F8W904
- O75432
- Q32M40
- Q9H5B7
- Q9NTS0
- Q9UP98
- Q9UP99
- Q9UPA0
Protein attributes for CSE1L Gene
- Size:
- 971 amino acids
- Molecular mass:
- 110417 Da
- Quaternary structure:
-
- Found in a complex with CSE1L/XPO2, Ran and KPNA2 (PubMed:9323134, PubMed:9786944). Binds with high affinity to importin-alpha only in the presence of RanGTP. The complex is dissociated by the combined action of RanBP1 and RanGAP1 (PubMed:9323134). Interacts with CFTR (PubMed:20933420).
Protein Expression for CSE1L Gene
Post-translational modifications for CSE1L Gene
Other Protein References for CSE1L Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences CSE1L Monoclonal Antibody and CSE1L Antibody
- G Biosciences Immunotag™ CAS Antibody
- GeneTex Anti-CSE1L antibody [GT5111] and Anti-CSE1L antibody
-
Custom Antibody ServicesOriGene Antibodies for CSE1L
- Novus Biologicals Antibodies for CSE1L
-
Abcam antibodies for CSE1L
- Invitrogen Antibodies for CSE1L (AFLGC-CSE1L)
-
Santa Cruz Biotechnology (SCBT) Antibodies for CSE1L
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CSE1L
- Origene Custom Protein Services for CSE1L
-
Signalway Proteins for CSE1L
-
Abcam proteins for CSE1L
Assay Products
- antibodies-online: Show 3 available XPO2 / Extin-2 Elisa Kits ranked by validation data
- Compare Top XPO2 / Extin-2 Elisa Kits
-
Quality Products:
-
Boster Bio ELISA Kits for CSE1L
No data available for DME Specific Peptides for CSE1L Gene
Domains & Families for CSE1L Gene
Gene Families for CSE1L Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Transporters
Protein Domains for CSE1L Gene
- InterPro:
- Blocks:
-
- Importin-beta, N-terminal
- CAS/CSE protein C-terminal
- ProtoNet:
Suggested Antigen Peptide Sequences for CSE1L Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ59343, highly similar to Exportin-2 (B4DM67_HUMAN)
- cDNA FLJ53202, highly similar to Exportin-2 (B4DUC5_HUMAN)
- Importin-alpha re-exporter (XPO2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P55060- Family:
-
- Belongs to the XPO2/CSE1 family.
Function for CSE1L Gene
Molecular function for CSE1L Gene
- UniProtKB/Swiss-Prot Function:
- Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
- GENATLAS Biochemistry:
- cellular apoptosis susceptibility gene (CAS),human homolog of the yeast chromosome segregation gene 1 (CSE1),highly expressed in proliferating tissues,involved in the cell cycle of mammalian cells and in apoptosis,transport factor necessary for recycling of importin-alpha from the nucleus to the cytoplasm
Phenotypes From GWAS Catalog for CSE1L Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005049 | nuclear export signal receptor activity | TAS,IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 17719542 |
| GO:0008536 | Ran GTPase binding | IEA | -- |
Phenotypes for CSE1L Gene
- MGI mutant phenotypes for CSE1L:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CSE1L:
-
- no effect
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased vaccinia virus (VACV) infection
- Decreased viability ratio
- Decreased viability of wild-type and TP53 knockout cells
- Synthetic lethal with Ras
- Increased IL-8 secretion
- Reduced mammosphere formation
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Strongly decreased NFAT1-GFP nuclear translocation
- Increased shRNA abundance (Z-score > 2)
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased viability
- Increased circadian period length
- Increased viability with MLN4924 (a NAE inhibitor)
- Increased caspase activity
- Downregulation of RLR pathway after Sendai virus (SeV) infection
- Increased cell death in DLD-1 cells
- Increased cell death in HCT116 cells
- Synthetic lethal with gemcitabine
Animal Models for CSE1L Gene
- MGI Knock Outs for CSE1L:
-
- Cse1l Cse1l<tmIpa>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CSE1L - Select products 50% OFF >
- * CSE1L CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CSE1L
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CSE1L
-
Santa Cruz Biotechnology (SCBT) CRISPR for CSE1L
miRNA for CSE1L Gene
- miRTarBase miRNAs that target CSE1L
-
- hsa-miR-137 (MIRT007252)
- hsa-miR-155-5p (MIRT020837)
- hsa-miR-130b-5p (MIRT038321)
- hsa-miR-320a (MIRT044669)
- hsa-miR-34a-5p (MIRT047399)
- hsa-miR-5590-3p (MIRT538336)
- hsa-miR-142-5p (MIRT538337)
- hsa-miR-5692a (MIRT538338)
- hsa-miR-548l (MIRT538339)
- hsa-miR-8054 (MIRT538340)
- hsa-miR-548k (MIRT538341)
- hsa-miR-548av-5p (MIRT538342)
- hsa-miR-559 (MIRT538343)
- hsa-miR-548y (MIRT538344)
- hsa-miR-548w (MIRT538345)
- hsa-miR-548o-5p (MIRT538346)
- hsa-miR-548i (MIRT538347)
- hsa-miR-548j-5p (MIRT538348)
- hsa-miR-548h-5p (MIRT538349)
- hsa-miR-548d-5p (MIRT538350)
- hsa-miR-548c-5p (MIRT538351)
- hsa-miR-548bb-5p (MIRT538352)
- hsa-miR-548b-5p (MIRT538353)
- hsa-miR-548ay-5p (MIRT538354)
- hsa-miR-548au-5p (MIRT538355)
- hsa-miR-548as-5p (MIRT538356)
- hsa-miR-548ar-5p (MIRT538357)
- hsa-miR-548aq-5p (MIRT538358)
- hsa-miR-548ap-5p (MIRT538359)
- hsa-miR-548am-5p (MIRT538360)
- hsa-miR-548ak (MIRT538361)
- hsa-miR-548ae-5p (MIRT538362)
- hsa-miR-548ad-5p (MIRT538363)
- hsa-miR-548ab (MIRT538364)
- hsa-miR-548a-5p (MIRT538365)
- hsa-miR-3671 (MIRT545454)
- hsa-miR-372-5p (MIRT545455)
- hsa-miR-371a-5p (MIRT545456)
- hsa-miR-616-5p (MIRT545457)
- hsa-miR-373-5p (MIRT545458)
- hsa-miR-371b-5p (MIRT545459)
- hsa-miR-6827-3p (MIRT545460)
- hsa-miR-340-3p (MIRT545461)
- hsa-miR-7703 (MIRT626791)
- hsa-miR-6720-5p (MIRT626792)
- hsa-miR-6512-3p (MIRT626793)
- hsa-miR-421 (MIRT626794)
- hsa-miR-1227-3p (MIRT626795)
- hsa-miR-505-3p (MIRT626796)
- hsa-miR-4252 (MIRT626797)
- hsa-miR-4793-3p (MIRT626798)
- hsa-miR-1273g-3p (MIRT626799)
- hsa-miR-4709-5p (MIRT626800)
- hsa-miR-938 (MIRT659337)
- hsa-miR-129-2-3p (MIRT659338)
- hsa-miR-129-1-3p (MIRT659339)
- hsa-miR-1252-3p (MIRT659340)
- hsa-miR-3646 (MIRT659341)
- hsa-miR-3065-5p (MIRT675620)
- hsa-miR-3529-3p (MIRT675621)
- hsa-miR-3165 (MIRT765180)
- hsa-miR-3614-5p (MIRT766034)
- hsa-miR-3665 (MIRT766533)
- hsa-miR-3672 (MIRT766584)
- hsa-miR-4433a-3p (MIRT768993)
- hsa-miR-4459 (MIRT769254)
- hsa-miR-4736 (MIRT771805)
- hsa-miR-6089 (MIRT775735)
- hsa-miR-6500-3p (MIRT776440)
- hsa-miR-6864-3p (MIRT780611)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CSE1L
- Browse OriGene Inhibitory RNA Products For CSE1L
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSE1L
Clone Products
- Applied Biological Materials (abm): Clones for CSE1L - Select products 50% OFF >
- * CSE1L as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CSE1L
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CSE1L
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CSE1L Gene
Localization for CSE1L Gene
Subcellular locations from UniProtKB/Swiss-Prot for CSE1L Gene
- Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000269 PubMed:9323134}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 4 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS | 9323134 |
| GO:0005635 | nuclear envelope | IBA | 21873635 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | TAS | 9323134 |
| GO:0005829 | cytosol | IBA,IDA | -- |
Pathways & Interactions for CSE1L Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Salmonella infection (KEGG) | ||
| 2 | MAPK Erk Pathway |
.32
|
|
| 3 | Cell cycle_Spindle assembly and chromosome separation |
Cell cycle_Spindle assembly and chromosome separation
-
|
|
| 4 | Direct p53 effectors | ||
| 5 | p53 pathway | ||
Pathways by source for CSE1L Gene
1 Sino Biological pathway for CSE1L Gene
2 BioSystems pathways for CSE1L Gene
1 KEGG pathway for CSE1L Gene
1 GeneGo (Thomson Reuters) pathway for CSE1L Gene
- Cell cycle_Spindle assembly and chromosome separation
Interacting Proteins for CSE1L Gene
Selected Interacting proteins:
P55060-XPO2_HUMAN
ENSP00000262982
for CSE1L Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CSE1L
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006606 | protein import into nucleus | IBA | 21873635 |
| GO:0006611 | protein export from nucleus | IBA | 21873635 |
| GO:0006886 | intracellular protein transport | IEA | -- |
| GO:0015031 | protein transport | IEA | -- |
No data available for SIGNOR curated interactions for CSE1L Gene
Drugs & Compounds for CSE1L Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Guanosine triphosphate | Experimental | Pharma | 0 |
Transcripts for CSE1L Gene
mRNA/cDNA for CSE1L Gene
- 4 REFSEQ mRNAs :
- 22 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000262982 3550 nts (view in UCSC)
- ENST00000469700 1401 nts (view in UCSC)
- ENST00000396192 3459 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CSE1L - Select products 50% OFF >
- * CSE1L CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CSE1L
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CSE1L
-
Santa Cruz Biotechnology (SCBT) CRISPR for CSE1L
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CSE1L
- Browse OriGene Inhibitory RNA Products For CSE1L
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSE1L
Clone Products
- Applied Biological Materials (abm): Clones for CSE1L - Select products 50% OFF >
- * CSE1L as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CSE1L
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CSE1L
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
| ExUns: | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | · | 25c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||
| SP2: | |||||||||||||||||
| SP3: | |||||||||||||||||
| SP4: | |||||||||||||||||
| SP5: | |||||||||||||||||
| SP6: |
Relevant External Links for CSE1L Gene
- GeneLoc Exon Structure for
- CSE1L
Expression for CSE1L Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Bone (37.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CSE1L Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CSE1L
SOURCE GeneReport for Unigene cluster for CSE1L Gene:
Hs.90073mRNA Expression by UniProt/SwissProt for CSE1L Gene:
P55060-XPO2_HUMAN
Tissue specificity:
Detected in brain, placenta, ovary, testis and trachea (at protein level) (PubMed:10331944). Widely expressed (PubMed:10331944). Highly expressed in testis and in proliferating cells (PubMed:7479798,PubMed:10331944).
Evidence on tissue expression from TISSUES for CSE1L Gene
- Nervous system(5)
- Liver(4.6)
- Blood(4.5)
- Skin(3.7)
- Stomach(3.5)
- Kidney(3.1)
- Heart(2.9)
- Intestine(2.6)
- Eye(2.5)
- Muscle(2.2)
- Lymph node(2.2)
- Pancreas(2.2)
- Lung(2.1)
Primer Products
-
OriGene qPCR primer pairs for CSE1L
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSE1L Gene
Orthologs for CSE1L Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CSE1L 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CSE1L 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CSE1L 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CSE1L 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CSE1L 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Cse1l 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Cse1l 30 |
|
||
| Chicken (Gallus gallus) |
Aves | CSE1L 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CSE1L 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cse1l 30 |
|
||
| Str.7149 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.11576 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | cse1l 30 30 31 |
|
OneToOne | |
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5928 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010711 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Cas 30 31 32 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | xpo-2 31 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CSE1 30 31 33 |
|
OneToOne | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0A00869g 30 |
|
||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AFR273W 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT2G46520 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os01g0235400 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10467 31 |
|
OneToOne | |
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | kap109 30 |
|
||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU04104 30 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.3837 30 |
|
- Species where no ortholog for CSE1L was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for CSE1L Gene
- ENSEMBL:
- Gene Tree for CSE1L (if available)
- TreeFam:
- Gene Tree for CSE1L (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CSE1L: view image
Paralogs for CSE1L Gene
Variants for CSE1L Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CSE1L Gene
| SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_036558 | A colorectal cancer sample | p.Cys842Phe | |||
| rs2229042 | - | p.Ile754Val | |||
| rs3505 | - | p.Val968Leu |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2762079 | CNV | gain | 21179565 |
| esv3646009 | CNV | gain | 21293372 |
| nsv1066050 | CNV | gain | 25217958 |
| nsv1067146 | CNV | loss | 25217958 |
Residual Variation Intolerance Score:
2.29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.92;
48.90% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CSE1L Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CSE1L
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CSE1L Gene
Disorders for CSE1L Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| speech disorder |
|
|
| colorectal cancer |
|
Search CSE1L in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CSE1L
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CSE1L Gene
Publications for CSE1L Gene
- Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1. (PMID: 7479798) Brinkmann U … Pastan I (Proceedings of the National Academy of Sciences of the United States of America 1995) 2 3 4 23
- Tissue-specific alternative splicing of the CSE1L/CAS (cellular apoptosis susceptibility) gene. (PMID: 10331944) Brinkmann U … Pastan I (Genomics 1999) 3 4 23
- The human CAS (cellular apoptosis susceptibility) gene mapping on chromosome 20q13 is amplified in BT474 breast cancer cells and part of aberrant chromosomes in breast and colon cancer cell lines. (PMID: 8963895) Brinkmann U … Pastan I (Genome research 1996) 2 3 23
- Function of CSE1L/CAS in the secretion of HT-29 human colorectal cells and its expression in human colon. (PMID: 19224336) Tsao TY … Jiang MC (Molecular and cellular biochemistry 2009) 3 23
- Dissection of the molecular mechanisms that control the nuclear accumulation of transport factors importin-alpha and CAS in stressed cells. (PMID: 18425415) Kodiha M … Stochaj U (Cellular and molecular life sciences : CMLS 2008) 3 23
ExternalLinks
Products for CSE1L Gene
- Custom Antibody ServicesOriGene Antibodies for CSE1L
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CSE1L
- Origene Custom Protein Services for CSE1L
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CSE1L
- Browse OriGene Inhibitory RNA Products For CSE1L
- OriGene qPCR primer pairs for CSE1L
- OriGene CRISPR knockouts for CSE1L
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CSE1L
- Sino Biological Human cDNA Clone for CSE1L
- Browse Sino Biological Recombinant Proteins
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CSE1L
- Novus Biologicals proteins and lysates for CSE1L
- Browse Antibodies
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- Abcam proteins for CSE1L
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- Invitrogen Antibodies for CSE1L (AFLGC-CSE1L)
- VectorBuilder Custom and pre-made DNA vectors for CSE1L (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CSE1L (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CSE1L (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CSE1L CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CSE1L
- antibodies-online: Show 95 available XPO2 / Extin-2 Antibodies ranked by validation data
- Compare Top XPO2 / Extin-2 Antibodies
- antibodies-online: Show 3 available XPO2 / Extin-2 Elisa Kits ranked by validation data
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- Quality Products:
- antibodies-online: Show 4 available XPO2 / Extin-2 Proteins ranked by validation data
- Compare Top XPO2 / Extin-2 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CSE1L
- Search Santa Cruz Biotechnology (SCBT) for CSE1L siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CSE1L
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CSE1L
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CSE1L
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CSE1L
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CSE1L
- Signalway Proteins for CSE1L
Sources for CSE1L Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB