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Aliases for CSAG2 Gene

Aliases for CSAG2 Gene

  • CSAG Family Member 2 2 3 5
  • Taxol-Resistant-Associated Gene 3 Protein 3 4
  • Cancer/Testis Antigen Family 24, Member 2 2 3
  • Cancer/Testis Antigen 24.2 3 4
  • CSAG Family, Member 3B 2 3
  • CT24.2 3 4
  • TRAG-3 3 4
  • TRAG3 3 4
  • Chondrosarcoma-Associated Gene 2/3 Protein-Like 3
  • Chondrosarcoma-Associated Gene 2/3 Protein 3
  • Taxol Resistance Associated Gene 3 3
  • CSAG Family, Member 2 2
  • CSAG3B 3
  • CSAG3A 4
  • CSAG3 3

External Ids for CSAG2 Gene

Previous HGNC Symbols for CSAG2 Gene

  • CSAG3B

Previous GeneCards Identifiers for CSAG2 Gene

  • GC0XM151547
  • GC0XP151680
  • GC0XP151922

Summaries for CSAG2 Gene

GeneCards Summary for CSAG2 Gene

CSAG2 (CSAG Family Member 2) is a Protein Coding gene. Diseases associated with CSAG2 include Chondrosarcoma. An important paralog of this gene is CSAG3.

UniProtKB/Swiss-Prot for CSAG2 Gene

  • Drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplastic phenotype. May also be linked to the malignant phenotype.

Additional gene information for CSAG2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CSAG2 Gene

Genomics for CSAG2 Gene

GeneHancer (GH) Regulatory Elements for CSAG2 Gene

Promoters and enhancers for CSAG2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ152714 Promoter 0.5 EPDnew 650.7 -0.1 -54 0.1 CSAG2 MAGEA2B MAGEA12 CSAG1 GC0XM152591
GH0XJ152716 Promoter 0.5 EPDnew 0.7 -2.3 -2304 0.1 MAGEA2B CSAG2 CSAG1 GC0XM152591
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CSAG2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CSAG2 gene promoter:

Genomic Locations for CSAG2 Gene

Genomic Locations for CSAG2 Gene
chrX:152,708,261-152,714,549
(GRCh38/hg38)
Size:
6,289 bases
Orientation:
Minus strand
chrX:151,922,445-151,928,738
(GRCh37/hg19)

Genomic View for CSAG2 Gene

Genes around CSAG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CSAG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CSAG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CSAG2 Gene

Proteins for CSAG2 Gene

  • Protein details for CSAG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5P2-CSAG2_HUMAN
    Recommended name:
    Chondrosarcoma-associated gene 2/3 protein
    Protein Accession:
    Q9Y5P2
    Secondary Accessions:
    • O75605
    • Q0VDC3
    • Q96IU8
    • O75605
    • Q0VDC3
    • Q96IU8

    Protein attributes for CSAG2 Gene

    Size:
    127 amino acids
    Molecular mass:
    14430 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CSAG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CSAG2 Gene

Post-translational modifications for CSAG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CSAG2 Gene

No data available for DME Specific Peptides for CSAG2 Gene

Domains & Families for CSAG2 Gene

Gene Families for CSAG2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CSAG2 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CSAG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CSAG2: view

No data available for UniProtKB/Swiss-Prot for CSAG2 Gene

Function for CSAG2 Gene

Molecular function for CSAG2 Gene

UniProtKB/Swiss-Prot Function:
Drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplastic phenotype. May also be linked to the malignant phenotype.
genes like me logo Genes that share phenotypes with CSAG2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CSAG2 Gene

Localization for CSAG2 Gene

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CSAG2 Gene

Pathways & Interactions for CSAG2 Gene

SuperPathways for CSAG2 Gene

No Data Available

Interacting Proteins for CSAG2 Gene

Gene Ontology (GO) - Biological Process for CSAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042493 response to drug TAS 10095106
genes like me logo Genes that share ontologies with CSAG2: view

No data available for Pathways by source and SIGNOR curated interactions for CSAG2 Gene

Drugs & Compounds for CSAG2 Gene

No Compound Related Data Available

Transcripts for CSAG2 Gene

mRNA/cDNA for CSAG2 Gene

(2) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CSAG2 Gene

No ASD Table

Relevant External Links for CSAG2 Gene

GeneLoc Exon Structure for
CSAG2
ECgene alternative splicing isoforms for
CSAG2

Expression for CSAG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CSAG2 Gene

mRNA differential expression in normal tissues according to GTEx for CSAG2 Gene

This gene is overexpressed in Testis (x22.6), Brain - Putamen (basal ganglia) (x6.5), Brain - Caudate (basal ganglia) (x5.4), Spleen (x5.2), Brain - Frontal Cortex (BA9) (x5.0), and Prostate (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of CSAG2 Gene:

CSAG2

mRNA Expression by UniProt/SwissProt for CSAG2 Gene:

Q9Y5P2-CSAG2_HUMAN
Tissue specificity: Weakly expressed in kidney. Expressed in various tumor cell lines including carcinomas, myeloid and lymphoid malignancies, melanomas and prostate cancer. Overexpressed in taxol-resistant breast cancer line MDA 435TR and the doxorubicin-resistant multiple myelanoma lines RPMI-8226/Dox40 and RPMI-8226/MDR10V.
genes like me logo Genes that share expression patterns with CSAG2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CSAG2 Gene

Orthologs for CSAG2 Gene

Evolution for CSAG2 Gene

ENSEMBL:
Gene Tree for CSAG2 (if available)
TreeFam:
Gene Tree for CSAG2 (if available)

No data available for Orthologs for CSAG2 Gene

Paralogs for CSAG2 Gene

Paralogs for CSAG2 Gene

(1) SIMAP similar genes for CSAG2 Gene using alignment to 2 proteins:

  • CSAG2_HUMAN
  • Q5ZEY7_HUMAN
genes like me logo Genes that share paralogs with CSAG2: view

Variants for CSAG2 Gene

Sequence variations from dbSNP and Humsavar for CSAG2 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs375460525 -- 152,714,800(-) G/C upstream_transcript_variant
rs5742340 -- 152,709,629(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs5925213 -- 152,715,704(-) C/T upstream_transcript_variant
rs5925223 -- 152,710,863(-) T/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs5970369 -- 152,714,316(-) A/G upstream_transcript_variant

Additional Variant Information for CSAG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CSAG2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for CSAG2 Gene

Disorders for CSAG2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CSAG2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
chondrosarcoma
  • chondrosarcoma of bone
- elite association - COSMIC cancer census association via MalaCards
Search CSAG2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CSAG2

genes like me logo Genes that share disorders with CSAG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CSAG2 Gene

Publications for CSAG2 Gene

  1. TRAG-3, a novel gene, isolated from a taxol-resistant ovarian carcinoma cell line. (PMID: 10095106) Duan Z … Seiden MV (Gene 1999) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Upregulation of TRAG3 gene in urothelial carcinoma of the bladder. (PMID: 20734393) Karam JA … Hsieh JT (International journal of cancer 2011) 3 58
  4. Human tumor antigen-specific helper and regulatory T cells share common epitope specificity but exhibit distinct T cell repertoire. (PMID: 20483736) Fourcade J … Zarour HM (Journal of immunology (Baltimore, Md. : 1950) 2010) 3 58
  5. A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family. (PMID: 17342728) Hansen MA … Leffers H (Molecular reproduction and development 2008) 3 58

Products for CSAG2 Gene

Sources for CSAG2 Gene

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