This locus represents naturally occurring read-through transcription between the neighboring CRYZL2P (crystallin zeta like 2 pseudogene) and SEC16B (SEC16 homolog B, endoplasmic reticulum export factor) genes on chromosome 1. The readthrough transcript encodes a protein that shares sequence identity with the downstream gene product. [provided by RefSeq, Oct 2017] See more...

Aliases for CRYZL2P-SEC16B Gene

Aliases for CRYZL2P-SEC16B Gene

  • CRYZL2P-SEC16B Readthrough 2 3 5
  • Regucalcin Gene Promoter Region-Related Protein P117 3
  • Leucine Zipper Transcription Regulator 2 3
  • Protein Transport Protein Sec16B 3
  • SEC16 Homolog B 3
  • NONHSAG003561.2 91
  • CRYZL2P-SEC16B 5
  • HSALNG0008675 164
  • Lnc-SEC16B-2 165

External Ids for CRYZL2P-SEC16B Gene

Summaries for CRYZL2P-SEC16B Gene

Entrez Gene Summary for CRYZL2P-SEC16B Gene

  • This locus represents naturally occurring read-through transcription between the neighboring CRYZL2P (crystallin zeta like 2 pseudogene) and SEC16B (SEC16 homolog B, endoplasmic reticulum export factor) genes on chromosome 1. The readthrough transcript encodes a protein that shares sequence identity with the downstream gene product. [provided by RefSeq, Oct 2017]

GeneCards Summary for CRYZL2P-SEC16B Gene

CRYZL2P-SEC16B (CRYZL2P-SEC16B Readthrough) is a Protein Coding gene.

Additional gene information for CRYZL2P-SEC16B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CRYZL2P-SEC16B Gene

Genomics for CRYZL2P-SEC16B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CRYZL2P-SEC16B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J178037 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 0.0 -29 1.9 HNRNPL GATAD2A CTCF ZNF512 NFKBIZ KDM1A RBFOX2 RXRB REST IRF2 CRYZL2P CRYZL2P-SEC16B SEC16B piR-30188-011 RASAL2
GH01J177983 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 11.2 +54.0 53969 1.8 CREB1 PRDM10 SIX5 ZNF692 ZNF174 ZIC2 POLR2A ZNF501 GABPA ZNF600 SEC16B CRYZL2P-SEC16B lnc-SEC16B-2 BRINP2
GH01J178188 Enhancer 0.9 FANTOM5 Ensembl 11.5 -151.0 -150994 3.2 GATAD2A CTCF TEAD4 FOXA1 RAD21 TRIM22 FOXA2 SMC3 TEAD1 JUNB RASAL2-AS1 RASAL2 CRYZL2P-SEC16B SEC16B ENSG00000270575 lnc-SEC16B-7 lnc-SEC16B-4 CLEC20A
GH01J177986 Enhancer 0.6 Ensembl 11.5 +51.6 51606 0.8 FOXA2 SAP130 FOXA1 DRAP1 HOMEZ MNT EGR2 RBPJ ELF3 FOXA3 piR-48222-026 CRYZL2P-SEC16B SEC16B
GH01J178072 Enhancer 0.3 FANTOM5 Ensembl 11.4 -34.5 -34494 1.8 RASAL2 RASAL2-AS1 CRYZL2P-SEC16B SEC16B CRYZL2P HSALNG0008680 piR-53338-012
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CRYZL2P-SEC16B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CRYZL2P-SEC16B

Genomic Locations for CRYZL2P-SEC16B Gene

Genomic Locations for CRYZL2P-SEC16B Gene
chr1:177,928,788-178,038,007
(GRCh38/hg38)
Size:
109,220 bases
Orientation:
Minus strand
chr1:177,897,923-178,007,142
(GRCh37/hg19)
Size:
109,220 bases
Orientation:
Minus strand

Genomic View for CRYZL2P-SEC16B Gene

Genes around CRYZL2P-SEC16B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRYZL2P-SEC16B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRYZL2P-SEC16B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRYZL2P-SEC16B Gene

Proteins for CRYZL2P-SEC16B Gene

Post-translational modifications for CRYZL2P-SEC16B Gene

No Post-translational modifications

Other Protein References for CRYZL2P-SEC16B Gene

REFSEQ proteins:

No data available for DME Specific Peptides for CRYZL2P-SEC16B Gene

Domains & Families for CRYZL2P-SEC16B Gene

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CRYZL2P-SEC16B Gene

Function for CRYZL2P-SEC16B Gene

Phenotypes From GWAS Catalog for CRYZL2P-SEC16B Gene

Gene Ontology (GO) - Molecular Function for CRYZL2P-SEC16B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21478858
genes like me logo Genes that share ontologies with CRYZL2P-SEC16B: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CRYZL2P-SEC16B Gene

Localization for CRYZL2P-SEC16B Gene

Gene Ontology (GO) - Cellular Components for CRYZL2P-SEC16B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005829 cytosol TAS --
GO:0012507 ER to Golgi transport vesicle membrane IBA 21873635
GO:0043231 intracellular membrane-bounded organelle IDA 21768384
genes like me logo Genes that share ontologies with CRYZL2P-SEC16B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for CRYZL2P-SEC16B Gene

Pathways & Interactions for CRYZL2P-SEC16B Gene

PathCards logo

SuperPathways for CRYZL2P-SEC16B Gene

No Data Available

Interacting Proteins for CRYZL2P-SEC16B Gene

Gene Ontology (GO) - Biological Process for CRYZL2P-SEC16B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport IMP, TAS 22355596
GO:0007029 endoplasmic reticulum organization IDA, IBA 21768384
GO:0007030 Golgi organization IBA 21873635
GO:0007031 peroxisome organization IDA 21768384
GO:0010628 positive regulation of gene expression IMP 21768384
genes like me logo Genes that share ontologies with CRYZL2P-SEC16B: view

No data available for Pathways by source and SIGNOR curated interactions for CRYZL2P-SEC16B Gene

Drugs & Compounds for CRYZL2P-SEC16B Gene

No Compound Related Data Available

Transcripts for CRYZL2P-SEC16B Gene

mRNA/cDNA for CRYZL2P-SEC16B Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
19 RNACentral transcripts :
19 LNCipedia transcripts :
12 NONCODE transcripts :
6 LncBook transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for CRYZL2P-SEC16B Gene

No ASD Table

Relevant External Links for CRYZL2P-SEC16B Gene

GeneLoc Exon Structure for
CRYZL2P-SEC16B

Expression for CRYZL2P-SEC16B Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRYZL2P-SEC16B Gene

Orthologs for CRYZL2P-SEC16B Gene

Evolution for CRYZL2P-SEC16B Gene

ENSEMBL:
Gene Tree for CRYZL2P-SEC16B (if available)
TreeFam:
Gene Tree for CRYZL2P-SEC16B (if available)

No data available for Orthologs for CRYZL2P-SEC16B Gene

Paralogs for CRYZL2P-SEC16B Gene

No data available for Paralogs for CRYZL2P-SEC16B Gene

Variants for CRYZL2P-SEC16B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CRYZL2P-SEC16B Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
720900 Benign: not provided 177,933,233(-) G/A MISSENSE_VARIANT
732165 Likely Benign: not provided 177,936,319(-) T/G MISSENSE_VARIANT
732634 Benign: not provided 177,967,930(-) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT
746400 Likely Benign: not provided 177,960,356(-) T/C NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON_VARIANT
773416 Likely Benign: not provided 177,947,920(-) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for CRYZL2P-SEC16B Gene

Additional Variant Information for CRYZL2P-SEC16B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRYZL2P-SEC16B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for CRYZL2P-SEC16B Gene

Disorders for CRYZL2P-SEC16B Gene

No disorders were found for CRYZL2P-SEC16B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRYZL2P-SEC16B Gene

Publications for CRYZL2P-SEC16B Gene

  1. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 3
  2. Characterization of human Sec16B: indications of specialized, non-redundant functions. (PMID: 22355596) Budnik A … Stephens DJ (Scientific reports 2011) 3
  3. Sec16B is involved in the endoplasmic reticulum export of the peroxisomal membrane biogenesis factor peroxin 16 (Pex16) in mammalian cells. (PMID: 21768384) Yonekawa S … Tani K (Proceedings of the National Academy of Sciences of the United States of America 2011) 3
  4. TFG-1 function in protein secretion and oncogenesis. (PMID: 21478858) Witte K … Audhya A (Nature cell biology 2011) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for CRYZL2P-SEC16B Gene

Sources for CRYZL2P-SEC16B Gene