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This locus represents naturally occurring read-through transcription between the neighboring CRYZL2P (crystallin zeta like 2 pseudogene) and SEC16B (SEC16 homolog B, endoplasmic reticulum export factor) genes on chromosome 1. The readthrough transcript encodes a protein that shares sequence identity with the downstream gene product. [provided by RefSeq, Oct 2017] See more...
Aliases for CRYZL2P-SEC16B Gene
Aliases for CRYZL2P-SEC16B Gene
External Ids for CRYZL2P-SEC16B Gene
- HGNC: 53757
- Entrez Gene: 111240474
- Ensembl: ENSG00000254154
Summaries for CRYZL2P-SEC16B Gene
-
This locus represents naturally occurring read-through transcription between the neighboring CRYZL2P (crystallin zeta like 2 pseudogene) and SEC16B (SEC16 homolog B, endoplasmic reticulum export factor) genes on chromosome 1. The readthrough transcript encodes a protein that shares sequence identity with the downstream gene product. [provided by RefSeq, Oct 2017]
GeneCards Summary for CRYZL2P-SEC16B Gene
CRYZL2P-SEC16B (CRYZL2P-SEC16B Readthrough) is a Protein Coding gene.
Additional gene information for CRYZL2P-SEC16B Gene
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CRYZL2P-SEC16B Gene
Genomics for CRYZL2P-SEC16B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CRYZL2P-SEC16B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CRYZL2P-SEC16B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CRYZL2P-SEC16B
Genomic Locations for CRYZL2P-SEC16B Gene
Genomic Locations for CRYZL2P-SEC16B Gene
- chr1:177,928,788-178,038,007
- (GRCh38/hg38)
- Size:
- 109,220 bases
- Orientation:
- Minus strand
- chr1:177,897,923-178,007,142
- (GRCh37/hg19)
- Size:
- 109,220 bases
- Orientation:
- Minus strand
Genomic View for CRYZL2P-SEC16B Gene
Genes around CRYZL2P-SEC16B on UCSC Golden Path with GeneCards custom track
CRYZL2P-SEC16B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CRYZL2P-SEC16B Gene
Proteins for CRYZL2P-SEC16B Gene
Post-translational modifications for CRYZL2P-SEC16B Gene
No Post-translational modifications
Other Protein References for CRYZL2P-SEC16B Gene
- REFSEQ proteins:
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CRYZL2P-SEC16B
- Origene Custom Protein Services for CRYZL2P-SEC16B
No data available for DME Specific Peptides for CRYZL2P-SEC16B Gene
Domains & Families for CRYZL2P-SEC16B Gene
No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CRYZL2P-SEC16B Gene
Function for CRYZL2P-SEC16B Gene
Phenotypes From GWAS Catalog for CRYZL2P-SEC16B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 21478858 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
miRNA Products
Inhibitory RNA Products
Clone Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CRYZL2P-SEC16B Gene
Localization for CRYZL2P-SEC16B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0005789 | endoplasmic reticulum membrane | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0012507 | ER to Golgi transport vesicle membrane | IBA | 21873635 |
| GO:0043231 | intracellular membrane-bounded organelle | IDA | 21768384 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for CRYZL2P-SEC16B Gene
Pathways & Interactions for CRYZL2P-SEC16B Gene
Interacting Proteins for CRYZL2P-SEC16B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006888 | ER to Golgi vesicle-mediated transport | IMP, TAS | 22355596 |
| GO:0007029 | endoplasmic reticulum organization | IDA, IBA | 21768384 |
| GO:0007030 | Golgi organization | IBA | 21873635 |
| GO:0007031 | peroxisome organization | IDA | 21768384 |
| GO:0010628 | positive regulation of gene expression | IMP | 21768384 |
No data available for Pathways by source and SIGNOR curated interactions for CRYZL2P-SEC16B Gene
Transcripts for CRYZL2P-SEC16B Gene
mRNA/cDNA for CRYZL2P-SEC16B Gene
- 2 REFSEQ mRNAs :
- 4 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000354921 4998 nts (view in UCSC)
- ENST00000466953 6212 nts (view in UCSC)
- ENST00000464428 5890 nts (view in UCSC)
- 19 RNACentral transcripts :
- 19 LNCipedia transcripts :
- 12 NONCODE transcripts :
- 6 LncBook transcripts :
miRNA Products
Inhibitory RNA Products
Clone Products
Relevant External Links for CRYZL2P-SEC16B Gene
- GeneLoc Exon Structure for
- CRYZL2P-SEC16B
Expression for CRYZL2P-SEC16B Gene
No Expression Related Data Available
Primer Products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRYZL2P-SEC16B Gene
Orthologs for CRYZL2P-SEC16B Gene
No data available for Orthologs for CRYZL2P-SEC16B Gene
Paralogs for CRYZL2P-SEC16B Gene
No data available for Paralogs for CRYZL2P-SEC16B Gene
Variants for CRYZL2P-SEC16B Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CRYZL2P-SEC16B Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 720900 | Benign: not provided | 177,933,233(-) | G/A | MISSENSE_VARIANT | |
| 732165 | Likely Benign: not provided | 177,936,319(-) | T/G | MISSENSE_VARIANT | |
| 732634 | Benign: not provided | 177,967,930(-) | C/T | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT | |
| 746400 | Likely Benign: not provided | 177,960,356(-) | T/C | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT,INTRON_VARIANT | |
| 773416 | Likely Benign: not provided | 177,947,920(-) | C/T | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT |
Additional Variant Information for CRYZL2P-SEC16B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CRYZL2P-SEC16B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for CRYZL2P-SEC16B Gene
Disorders for CRYZL2P-SEC16B Gene
Additional Disease Information for CRYZL2P-SEC16B
No disorders were found for CRYZL2P-SEC16B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRYZL2P-SEC16B Gene
Publications for CRYZL2P-SEC16B Gene
- An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 3
- Characterization of human Sec16B: indications of specialized, non-redundant functions. (PMID: 22355596) Budnik A … Stephens DJ (Scientific reports 2011) 3
- Sec16B is involved in the endoplasmic reticulum export of the peroxisomal membrane biogenesis factor peroxin 16 (Pex16) in mammalian cells. (PMID: 21768384) Yonekawa S … Tani K (Proceedings of the National Academy of Sciences of the United States of America 2011) 3
- TFG-1 function in protein secretion and oncogenesis. (PMID: 21478858) Witte K … Audhya A (Nature cell biology 2011) 3
- Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
Products for CRYZL2P-SEC16B Gene
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Sources for CRYZL2P-SEC16B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
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- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB