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Aliases for CRYL1 Gene

Aliases for CRYL1 Gene

  • Crystallin Lambda 1 2 3 5
  • L-Gulonate 3-Dehydrogenase 2 3 4
  • Lambda-Crystallin Homolog 2 3
  • Crystallin, Lamda 1 2 3
  • Gul3DH 3 4
  • Testicular Tissue Protein Li 44 3
  • Epididymis Luminal Protein 30 3
  • Crystallin, Lambda 1 2
  • EC 4
  • Lambda-CRY 3
  • HEL30 3
  • GDH 3
  • CRY 4

External Ids for CRYL1 Gene

Previous GeneCards Identifiers for CRYL1 Gene

  • GC13M018957
  • GC13M014957
  • GC13M019907
  • GC13M018775
  • GC13M019875
  • GC13M020977
  • GC13M001781

Summaries for CRYL1 Gene

Entrez Gene Summary for CRYL1 Gene

  • The uronate cycle functions as an alternative glucose metabolic pathway, accounting for about 5% of daily glucose catabolism. The product of this gene catalyzes the dehydrogenation of L-gulonate into dehydro-L-gulonate in the uronate cycle. The enzyme requires NAD(H) as a coenzyme, and is inhibited by inorganic phosphate. A similar gene in the rabbit is thought to serve a structural role in the lens of the eye. [provided by RefSeq, Jul 2008]

GeneCards Summary for CRYL1 Gene

CRYL1 (Crystallin Lambda 1) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and NAD+ binding.

Additional gene information for CRYL1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRYL1 Gene

Genomics for CRYL1 Gene

GeneHancer (GH) Regulatory Elements for CRYL1 Gene

Promoters and enhancers for CRYL1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I020517 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 569.5 +3.2 3232 9.4 FOXA2 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS SP3 NFYC ZHX2 CRYL1 MIR4499
GH13I020474 Enhancer 1.3 FANTOM5 Ensembl ENCODE 22.5 +49.9 49866 3.2 INSM2 FEZF1 ZNF2 IRF4 SCRT2 ETV6 BCLAF1 IKZF2 RUNX3 EGR2 CRYL1 IFT88 MIR4499
GH13I020494 Enhancer 1 Ensembl ENCODE 23.3 +30.0 30031 1.9 HDAC1 ELF3 PKNOX1 FOXA2 ARID4B DNMT3B RAD21 ETS1 RFX5 YY1 CRYL1 EEF1AKMT1 MIR4499
GH13I020565 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.3 -41.4 -41419 2.9 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF143 FOS SP3 IFT88 LOC105370103 PIR57097 SLC35E1P1 ZMYM2 XPO4 ZMYM5 CRYL1 IL17D
GH13I020702 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 10.8 -177.5 -177529 2.8 PKNOX1 RB1 ARID4B SIN3A BMI1 ZNF48 RFX5 ZNF335 ZNF121 ELK1 IL17D GC13M020702 ENSG00000278291 IFT88 EEF1AKMT1 CRYL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CRYL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CRYL1 gene promoter:

Genomic Locations for CRYL1 Gene

Genomic Locations for CRYL1 Gene
122,207 bases
Minus strand

Genomic View for CRYL1 Gene

Genes around CRYL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRYL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRYL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRYL1 Gene

Proteins for CRYL1 Gene

  • Protein details for CRYL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lambda-crystallin homolog
    Protein Accession:
    Secondary Accessions:
    • A0PJ43
    • B3KN92
    • Q0VDI1
    • Q7Z4Z9
    • Q9P0G7

    Protein attributes for CRYL1 Gene

    319 amino acids
    Molecular mass:
    35419 Da
    Quaternary structure:
    • Homodimer.
    • Sequence=AAD27782.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAD27782.1; Type=Miscellaneous discrepancy; Note=Unknown reasons.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CRYL1 Gene

    Alternative splice isoforms for CRYL1 Gene


neXtProt entry for CRYL1 Gene

Post-translational modifications for CRYL1 Gene

No Post-translational modifications

Other Protein References for CRYL1 Gene

No data available for DME Specific Peptides for CRYL1 Gene

Domains & Families for CRYL1 Gene

Gene Families for CRYL1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CRYL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
  • Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
genes like me logo Genes that share domains with CRYL1: view

Function for CRYL1 Gene

Molecular function for CRYL1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.01 mM for NAD {ECO:0000269 PubMed:15809331}; KM=0.0008 mM for NADH {ECO:0000269 PubMed:15809331};
UniProtKB/Swiss-Prot CatalyticActivity:
L-gulonate + NAD(+) = 3-dehydro-L-gulonate + NADH.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by malonate.

Enzyme Numbers (IUBMB) for CRYL1 Gene

Phenotypes From GWAS Catalog for CRYL1 Gene

Gene Ontology (GO) - Molecular Function for CRYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0042803 protein homodimerization activity IPI 15809331
GO:0050104 L-gulonate 3-dehydrogenase activity IDA,EXP 15809331
GO:0070403 NAD+ binding IDA 15809331
genes like me logo Genes that share ontologies with CRYL1: view
genes like me logo Genes that share phenotypes with CRYL1: view

miRNA for CRYL1 Gene

miRTarBase miRNAs that target CRYL1

Clone Products

  • Addgene plasmids for CRYL1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CRYL1 Gene

Localization for CRYL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRYL1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRYL1 gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 3
nucleus 3
plasma membrane 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoli (2)
  • Nucleus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CRYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA,IDA 19056867
genes like me logo Genes that share ontologies with CRYL1: view

Pathways & Interactions for CRYL1 Gene

genes like me logo Genes that share pathways with CRYL1: view

Pathways by source for CRYL1 Gene

Gene Ontology (GO) - Biological Process for CRYL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006631 fatty acid metabolic process IEA --
GO:0019640 glucuronate catabolic process to xylulose 5-phosphate TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with CRYL1: view

No data available for SIGNOR curated interactions for CRYL1 Gene

Drugs & Compounds for CRYL1 Gene

(3) Drugs for CRYL1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Approved Nutra 0
Acetoacetyl-CoA Experimental Pharma 0
NAD Pharma Full agonist, Agonist 0

(4) Additional Compounds for CRYL1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (S)-3-hydroxyhexadecanoyl-coenzyme A
  • (S)-3-hydroxypalmitoyl-coenzyme A
  • b-Hydroxypalmitoyl-CoA
  • b-Hydroxypalmitoyl-Coenzyme A
  • beta-Hydroxypalmitoyl-CoA
  • 3-Dehydro-L-gulonic acid
  • L-Xylo-hex-3-ulosonic acid
Gulonic acid
  • D-Gulonate
  • D-Gulonic acid
  • Gulonate
  • L-Gulonate
  • L-Gulonic acid
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with CRYL1: view

Transcripts for CRYL1 Gene

Unigene Clusters for CRYL1 Gene

Crystallin, lambda 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for CRYL1

Alternative Splicing Database (ASD) splice patterns (SP) for CRYL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - - -
SP2: - -

Relevant External Links for CRYL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRYL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRYL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRYL1 Gene

This gene is overexpressed in Kidney - Cortex (x5.3) and Liver (x4.6).

Protein differential expression in normal tissues from HIPED for CRYL1 Gene

This gene is overexpressed in Kidney (11.4), Liver, secretome (8.7), and Liver (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CRYL1 Gene

Protein tissue co-expression partners for CRYL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CRYL1 Gene:


SOURCE GeneReport for Unigene cluster for CRYL1 Gene:


mRNA Expression by UniProt/SwissProt for CRYL1 Gene:

Tissue specificity: Widely expressed, with highest levels in liver and kidney.

Evidence on tissue expression from TISSUES for CRYL1 Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Skin(2.7)
  • Kidney(2.3)
genes like me logo Genes that share expression patterns with CRYL1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CRYL1 Gene

Orthologs for CRYL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRYL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CRYL1 33 34
  • 99.37 (n)
(Canis familiaris)
Mammalia CRYL1 33 34
  • 84.85 (n)
(Rattus norvegicus)
Mammalia Cryl1 33
  • 82.65 (n)
(Mus musculus)
Mammalia Cryl1 33 16 34
  • 82.03 (n)
(Bos Taurus)
Mammalia CRYL1 33 34
  • 77.39 (n)
(Monodelphis domestica)
Mammalia CRYL1 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia CRYL1 34
  • 73 (a)
(Gallus gallus)
Aves CRYL1 33 34
  • 68.61 (n)
(Anolis carolinensis)
Reptilia CRYL1 34
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cryl1 33
  • 65.7 (n)
Str.4182 33
(Danio rerio)
Actinopterygii cryl1 33 34
  • 59.96 (n)
Dr.13038 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1375 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013544 33
  • 56.43 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9914 35 33 34
  • 54.83 (n)
CG10131 35 34
  • 41 (a)
(Caenorhabditis elegans)
Secernentea Y71F9B.9 35 34
  • 36 (a)
Species where no ortholog for CRYL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CRYL1 Gene

Gene Tree for CRYL1 (if available)
Gene Tree for CRYL1 (if available)

Paralogs for CRYL1 Gene

No data available for Paralogs for CRYL1 Gene

Variants for CRYL1 Gene

Sequence variations from dbSNP and Humsavar for CRYL1 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000000490 -- 20,464,166(-) G/A intron_variant
rs1000002395 -- 20,472,713(-) G/A intron_variant
rs1000047251 -- 20,460,715(-) T/C intron_variant
rs1000094978 -- 20,464,397(-) A/C intron_variant
rs1000115126 -- 20,510,686(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CRYL1 Gene

Variant ID Type Subtype PubMed ID
nsv952523 CNV deletion 24416366
nsv818947 CNV loss 17921354
nsv1151909 OTHER inversion 26484159
nsv1151319 CNV insertion 26484159
nsv1140246 OTHER inversion 24896259
nsv1124860 CNV deletion 24896259
nsv1078303 OTHER inversion 25765185
nsv1046946 CNV gain 25217958
esv7898 CNV gain 19470904
esv3892302 CNV loss 25118596
esv3892301 CNV loss 25118596
esv3631431 CNV loss 21293372
esv3631430 CNV loss 21293372
esv34984 CNV loss 17911159
esv2759925 CNV loss 17122850
esv2751132 CNV loss 17911159
esv27122 CNV gain 19812545
esv1659805 CNV insertion 17803354
dgv959e59 CNV duplication 20981092
dgv3075n54 CNV loss 21841781
dgv3072n54 CNV loss 21841781
dgv221n27 CNV loss 19166990
dgv1612n100 CNV loss 25217958

Variation tolerance for CRYL1 Gene

Residual Variation Intolerance Score: 64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRYL1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRYL1 Gene

Disorders for CRYL1 Gene

Additional Disease Information for CRYL1

No disorders were found for CRYL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRYL1 Gene

Publications for CRYL1 Gene

  1. Human CRYL1, a novel enzyme-crystallin overexpressed in liver and kidney and downregulated in 58% of liver cancer tissues from 60 Chinese patients, and four new homologs from other mammalians. (PMID: 12527201) Chen J … Zhao S (Gene 2003) 2 3 4 22 58
  2. Structural and functional characterization of rabbit and human L-gulonate 3-dehydrogenase. (PMID: 15809331) Ishikura S … Hara A (Journal of biochemistry 2005) 3 4 22 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for CRYL1 Gene

Sources for CRYL1 Gene

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