Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CRYGN Gene

Aliases for CRYGN Gene

  • Crystallin Gamma N 2 3 5
  • Gamma-N-Crystallin 3 4
  • Crystallin, Gamma N 2
  • Gamma-Crystallin N 3
  • GammaN-Crystallin 3

External Ids for CRYGN Gene

Previous GeneCards Identifiers for CRYGN Gene

  • GC07M149373
  • GC07M150440
  • GC07M150517
  • GC07M150564
  • GC07M150757
  • GC07M151125
  • GC07M144938

Summaries for CRYGN Gene

Entrez Gene Summary for CRYGN Gene

  • This gene encodes a member of the crystallin family of proteins that are localized to the refractive structure of vertebrate eye lenses. The protein encoded by this gene is unique in that it has both beta and gamma crystallin protein motifs. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]

GeneCards Summary for CRYGN Gene

CRYGN (Crystallin Gamma N) is a Protein Coding gene. An important paralog of this gene is CRYBA2.

Additional gene information for CRYGN Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRYGN Gene

Genomics for CRYGN Gene

GeneHancer (GH) Regulatory Elements for CRYGN Gene

Promoters and enhancers for CRYGN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I151439 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 556.1 +7.6 7577 3.4 PKNOX1 USF1 ZSCAN4 SIN3A CEBPG FEZF1 POLR2A ADNP EGR2 EZH2 CRYGN ENSG00000241456 WDR86 MIR3907
GH07I151448 Enhancer 0.9 Ensembl ENCODE 550.8 -0.3 -283 1.4 CTCF RB1 MAX SIN3A RAD21 CC2D1A CTBP1 MTA3 PHF20 ARID2 CRYGN ENSG00000241456 RHEB SMARCD3 ENSG00000243018 CHPF2 ABCF2 GC07M151465
GH07I152024 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 9.9 -577.4 -577448 1.8 HDGF PKNOX1 CLOCK ARNT SIN3A DMAP1 ZNF2 POLR2B E2F8 FOS PIR42090 GALNT11 ENSG00000276213 CRYGN LINC01003
GH07I151456 Enhancer 1.4 FANTOM5 Ensembl ENCODE 10.2 -10.9 -10921 6.2 SIN3A FEZF1 ZNF2 ZNF766 GLIS2 RXRA PPARG ZNF592 SREBF1 MAFF ENSG00000241456 SMARCD3 CRYGN RHEB GC07M151465
GH07I151365 Enhancer 1.1 Ensembl ENCODE 11.9 +81.3 81253 3.5 HDGF ATF1 ZNF2 ZNF48 YY1 ARID2 ZNF207 ZNF143 FOS ATF7 GC07M151365 WDR86 WDR86-AS1 CRYGN ENSG00000241456 RHEB SMARCD3 ENSG00000243018 NUB1 GC07P151348
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CRYGN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CRYGN gene promoter:

Genomic Locations for CRYGN Gene

Genomic Locations for CRYGN Gene
chr7:151,428,835-151,448,419
(GRCh38/hg38)
Size:
19,585 bases
Orientation:
Minus strand
chr7:151,125,921-151,137,899
(GRCh37/hg19)

Genomic View for CRYGN Gene

Genes around CRYGN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRYGN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRYGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRYGN Gene

Proteins for CRYGN Gene

  • Protein details for CRYGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXF5-CRGN_HUMAN
    Recommended name:
    Gamma-crystallin N
    Protein Accession:
    Q8WXF5
    Secondary Accessions:
    • Q496G6

    Protein attributes for CRYGN Gene

    Size:
    182 amino acids
    Molecular mass:
    20624 Da
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for CRYGN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRYGN Gene

Post-translational modifications for CRYGN Gene

No Post-translational modifications

Other Protein References for CRYGN Gene

No data available for DME Specific Peptides for CRYGN Gene

Domains & Families for CRYGN Gene

Gene Families for CRYGN Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CRYGN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WXF5

UniProtKB/Swiss-Prot:

CRGN_HUMAN :
  • Belongs to the beta/gamma-crystallin family.
Family:
  • Belongs to the beta/gamma-crystallin family.
genes like me logo Genes that share domains with CRYGN: view

Function for CRYGN Gene

Phenotypes From GWAS Catalog for CRYGN Gene

genes like me logo Genes that share phenotypes with CRYGN: view

miRNA for CRYGN Gene

miRTarBase miRNAs that target CRYGN

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CRYGN Gene

Localization for CRYGN Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRYGN gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CRYGN Gene

Pathways & Interactions for CRYGN Gene

SuperPathways for CRYGN Gene

No Data Available

Interacting Proteins for CRYGN Gene

Gene Ontology (GO) - Biological Process for CRYGN Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CRYGN Gene

Drugs & Compounds for CRYGN Gene

No Compound Related Data Available

Transcripts for CRYGN Gene

mRNA/cDNA for CRYGN Gene

Unigene Clusters for CRYGN Gene

Crystallin, gamma N:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRYGN Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: - -
SP2: - -
SP3:

Relevant External Links for CRYGN Gene

GeneLoc Exon Structure for
CRYGN
ECgene alternative splicing isoforms for
CRYGN

Expression for CRYGN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRYGN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRYGN Gene

This gene is overexpressed in Thyroid (x21.9).

NURSA nuclear receptor signaling pathways regulating expression of CRYGN Gene:

CRYGN

SOURCE GeneReport for Unigene cluster for CRYGN Gene:

Hs.647104

mRNA Expression by UniProt/SwissProt for CRYGN Gene:

Q8WXF5-CRGN_HUMAN
Tissue specificity: Not specifically expressed in eye.
genes like me logo Genes that share expression patterns with CRYGN: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRYGN Gene

Orthologs for CRYGN Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRYGN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRYGN 33 34
  • 98.53 (n)
mouse
(Mus musculus)
Mammalia Crygn 33 16 34
  • 89.21 (n)
rat
(Rattus norvegicus)
Mammalia Crygn 33
  • 88.51 (n)
cow
(Bos Taurus)
Mammalia CRYGN 33 34
  • 88.49 (n)
dog
(Canis familiaris)
Mammalia CRYGN 34 33
  • 85.37 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRYGN 34
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRYGN 34
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves CRYGN 33 34
  • 70.74 (n)
lizard
(Anolis carolinensis)
Reptilia CRYGN 34
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crygn 33
  • 76.26 (n)
zebrafish
(Danio rerio)
Actinopterygii crygn1 33 34
  • 72.9 (n)
crygn2 34
  • 50 (a)
OneToMany
CRYGN (2 of 3) 34
  • 26 (a)
OneToMany
Dr.29203 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13121 33
Species where no ortholog for CRYGN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRYGN Gene

ENSEMBL:
Gene Tree for CRYGN (if available)
TreeFam:
Gene Tree for CRYGN (if available)

Paralogs for CRYGN Gene

(9) SIMAP similar genes for CRYGN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CRYGN: view

Variants for CRYGN Gene

Sequence variations from dbSNP and Humsavar for CRYGN Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000044490 -- 151,449,033(-) T/G upstream_transcript_variant
rs1000129970 -- 151,446,067(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000272069 -- 151,431,848(-) A/G coding_sequence_variant, genic_downstream_transcript_variant, intron_variant, missense_variant
rs1000333437 -- 151,448,544(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1000336052 -- 151,442,257(-) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CRYGN Gene

Variant ID Type Subtype PubMed ID
nsv6006 CNV insertion 18451855
nsv1151906 OTHER inversion 26484159
nsv1067934 OTHER inversion 25765185
dgv3695n106 OTHER inversion 24896259

Variation tolerance for CRYGN Gene

Residual Variation Intolerance Score: 81.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.13; 51.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRYGN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRYGN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRYGN Gene

Disorders for CRYGN Gene

Additional Disease Information for CRYGN

No disorders were found for CRYGN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRYGN Gene

Publications for CRYGN Gene

  1. Genetics of crystallins: cataract and beyond. (PMID: 19007775) Graw J (Experimental eye research 2009) 3 22 58
  2. gammaN-crystallin and the evolution of the betagamma-crystallin superfamily in vertebrates. (PMID: 15853812) Wistow G … Vihtelic T (The FEBS journal 2005) 3 4 58
  3. Prenatal tobacco smoke exposure is associated with childhood DNA CpG methylation. (PMID: 24964093) Breton CV … Asthma BRIDGE consortium (PloS one 2014) 3 58
  4. Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human. (PMID: 17452356) Leparc GG … Mitra RD (Nucleic acids research 2007) 3 58
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R … Stanton LW (Nature biotechnology 2004) 3 58

Products for CRYGN Gene

Sources for CRYGN Gene

Content
Loading form....