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Aliases for CRYBG3 Gene

Aliases for CRYBG3 Gene

  • Crystallin Beta-Gamma Domain Containing 3 2 3 5
  • Beta/Gamma Crystallin Domain-Containing Protein 3 3 4
  • Beta-Gamma Crystallin Domain Containing 3 2 3
  • VlAKAP 3 4
  • Very Large A-Kinase Anchor Protein 3
  • DKFZp667G2110 3

External Ids for CRYBG3 Gene

Previous GeneCards Identifiers for CRYBG3 Gene

  • GC03P099078
  • GC03P097595
  • GC03P094910

Summaries for CRYBG3 Gene

GeneCards Summary for CRYBG3 Gene

CRYBG3 (Crystallin Beta-Gamma Domain Containing 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is CRYBG1.

UniProtKB/Swiss-Prot for CRYBG3 Gene

  • Isoform vlAKAP: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA).

Additional gene information for CRYBG3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRYBG3 Gene

Genomics for CRYBG3 Gene

GeneHancer (GH) Regulatory Elements for CRYBG3 Gene

Promoters and enhancers for CRYBG3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J097820 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 650.7 +0.5 543 3.1 RB1 SIN3A STAT5A DMAP1 BMI1 ZNF48 YY1 ZNF335 ZNF366 SCRT2 LOC101929298 CRYBG3 RIOX2 LOC105373994
GH03J098035 Promoter 0.8 EPDnew 15.6 +213.4 213398 0.1 ZNF316 MAFG NFE2 MAFK NFE2L2 GABRR3 CRYBG3 GC03P098051
GH03J098038 Enhancer 1 Ensembl ENCODE 9 +217.5 217509 1 HDGF ATF1 RB1 MLX SIN3A BRCA1 RAD21 ZNF335 ZNF614 SCRT2 OR5K4 CRYBG3 GABRR3 GC03P098051
GH03J097969 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 4.6 +149.5 149548 4 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 ATF7 RUNX3 RIOX2 CRYBG3 LOC105373994
GH03J097910 Enhancer 1 Ensembl ENCODE 4.7 +89.1 89134 1.7 HDAC1 PKNOX1 ATF1 FOXA2 ARNT NFRKB TCF12 ZNF766 GATA2 ETV6 RIOX2 CRYBG3 LOC105373994
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CRYBG3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CRYBG3 gene promoter:
  • HFH-3
  • MZF-1
  • FOXD3
  • SRF
  • SRF (504 AA)
  • FOXI1
  • Meis-1a
  • Meis-1

Genomic Locations for CRYBG3 Gene

Genomic Locations for CRYBG3 Gene
123,050 bases
Plus strand
122,943 bases
Plus strand

Genomic View for CRYBG3 Gene

Genes around CRYBG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRYBG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRYBG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRYBG3 Gene

Proteins for CRYBG3 Gene

  • Protein details for CRYBG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Very large A-kinase anchor protein
    Protein Accession:
    Secondary Accessions:
    • B4DLE8
    • F6VHI2
    • Q4G0V8
    • Q7Z4R9
    • Q86VD0
    • Q8N262
    • Q8N7F1
    • Q8NDQ8

    Protein attributes for CRYBG3 Gene

    2970 amino acids
    Molecular mass:
    330633 Da
    Quaternary structure:
    • Isoform vlAKAP binds to dimeric RII-alpha regulatory subunit of PKA (PRKAR2A/PRKAR2B).
    • Sequence=AAH36247.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP97687.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03608.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH18168.1; Type=Frameshift; Positions=14; Evidence={ECO:0000305};

    Alternative splice isoforms for CRYBG3 Gene


neXtProt entry for CRYBG3 Gene

Post-translational modifications for CRYBG3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CRYBG3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CRYBG3 Gene

Domains & Families for CRYBG3 Gene

Gene Families for CRYBG3 Gene

Suggested Antigen Peptide Sequences for CRYBG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the beta/gamma-crystallin family.
  • Belongs to the beta/gamma-crystallin family.
genes like me logo Genes that share domains with CRYBG3: view

Function for CRYBG3 Gene

Molecular function for CRYBG3 Gene

UniProtKB/Swiss-Prot Function:
Isoform vlAKAP: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA).

Gene Ontology (GO) - Molecular Function for CRYBG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
GO:0051018 protein kinase A binding IPI 25097019
genes like me logo Genes that share ontologies with CRYBG3: view
genes like me logo Genes that share phenotypes with CRYBG3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRYBG3

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CRYBG3 Gene

Localization for CRYBG3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRYBG3 gene
Compartment Confidence
nucleus 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CRYBG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032991 protein-containing complex IDA 25097019
genes like me logo Genes that share ontologies with CRYBG3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CRYBG3 Gene

Pathways & Interactions for CRYBG3 Gene

SuperPathways for CRYBG3 Gene

No Data Available

Interacting Proteins for CRYBG3 Gene

Gene Ontology (GO) - Biological Process for CRYBG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with CRYBG3: view

No data available for Pathways by source and SIGNOR curated interactions for CRYBG3 Gene

Drugs & Compounds for CRYBG3 Gene

No Compound Related Data Available

Transcripts for CRYBG3 Gene

mRNA/cDNA for CRYBG3 Gene

(2) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CRYBG3 Gene

Beta-gamma crystallin domain containing 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRYBG3

Alternative Splicing Database (ASD) splice patterns (SP) for CRYBG3 Gene

No ASD Table

Relevant External Links for CRYBG3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CRYBG3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRYBG3 Gene

Protein differential expression in normal tissues from HIPED for CRYBG3 Gene

This gene is overexpressed in Heart (22.8), Ovary (19.5), and Testis (16.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CRYBG3 Gene

Protein tissue co-expression partners for CRYBG3 Gene

NURSA nuclear receptor signaling pathways regulating expression of CRYBG3 Gene:


SOURCE GeneReport for Unigene cluster for CRYBG3 Gene:


Evidence on tissue expression from TISSUES for CRYBG3 Gene

  • Skin(4.3)
  • Lymph node(4.2)
  • Nervous system(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with CRYBG3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRYBG3 Gene

Orthologs for CRYBG3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRYBG3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CRYBG3 34 33
  • 99.29 (n)
(Bos Taurus)
Mammalia CRYBG3 34
  • 86 (a)
LOC516526 33
  • 80.71 (n)
(Canis familiaris)
Mammalia CRYBG3 33
  • 82.93 (n)
(Mus musculus)
Mammalia Crybg3 16 34 33
  • 79.44 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 76 (a)
-- 34
  • 63 (a)
(Rattus norvegicus)
Mammalia Crybg3 33
  • 75.59 (n)
(Ornithorhynchus anatinus)
Mammalia CRYBG3 34
  • 26 (a)
(Gallus gallus)
Aves CRYBG3 34
  • 65 (a)
(Anolis carolinensis)
Reptilia CRYBG3 34
  • 54 (a)
Species where no ortholog for CRYBG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CRYBG3 Gene

Gene Tree for CRYBG3 (if available)
Gene Tree for CRYBG3 (if available)
Evolutionary constrained regions (ECRs) for CRYBG3: view image

Paralogs for CRYBG3 Gene

Paralogs for CRYBG3 Gene

(11) SIMAP similar genes for CRYBG3 Gene using alignment to 4 proteins:

  • C9J5N2_HUMAN
  • C9J659_HUMAN
genes like me logo Genes that share paralogs with CRYBG3: view

Variants for CRYBG3 Gene

Sequence variations from dbSNP and Humsavar for CRYBG3 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000069027 -- 97,944,780(+) A/T 3_prime_UTR_variant, non_coding_transcript_variant
rs1000086957 -- 97,842,988(+) A/G intron_variant
rs1000128156 -- 97,937,374(+) C/A intron_variant
rs1000136898 -- 97,890,407(+) A/G intron_variant
rs1000148450 -- 97,918,910(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CRYBG3 Gene

Variant ID Type Subtype PubMed ID
esv2725668 CNV deletion 23290073
esv3597104 CNV loss 21293372
nsv1011526 CNV gain 25217958
nsv1012322 CNV gain 25217958
nsv1013060 CNV gain 25217958
nsv520553 CNV gain 19592680

Variation tolerance for CRYBG3 Gene

Gene Damage Index Score: 11.52; 92.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRYBG3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRYBG3 Gene

Disorders for CRYBG3 Gene

Additional Disease Information for CRYBG3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CRYBG3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRYBG3 Gene

Publications for CRYBG3 Gene

  1. A systematic evaluation of protein kinase A-A-kinase anchoring protein interaction motifs. (PMID: 25097019) Burgers PP … Scholten A (Biochemistry 2015) 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. (PMID: 27880917) St-Denis N … Gingras AC (Cell reports 2016) 3 58

Products for CRYBG3 Gene

Sources for CRYBG3 Gene

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