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Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stab... See more...
Aliases for CRYBB2 Gene
Aliases for CRYBB2 Gene
External Ids for CRYBB2 Gene
- HGNC: 2398
- Entrez Gene: 1415
- Ensembl: ENSG00000244752
- OMIM: 123620
- UniProtKB: P43320
Previous HGNC Symbols for CRYBB2 Gene
- CCA2
- CRYB2A
- CRYB2
Previous GeneCards Identifiers for CRYBB2 Gene
- GC22P022313
- GC22P023940
- GC22P023941
- GC22P025615
- GC22P008563
Summaries for CRYBB2 Gene
-
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B3. A chain-terminating mutation was found to cause type 2 cerulean cataracts. [provided by RefSeq, Jul 2008]
GeneCards Summary for CRYBB2 Gene
CRYBB2 (Crystallin Beta B2) is a Protein Coding gene. Diseases associated with CRYBB2 include Cataract 3, Multiple Types and Cerulean Cataract. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and structural molecule activity. An important paralog of this gene is CRYBB3.
UniProtKB/Swiss-Prot Summary for CRYBB2 Gene
-
Crystallins are the dominant structural components of the vertebrate eye lens.
Additional gene information for CRYBB2 Gene
- HGNC(2398)
- Entrez Gene(1415)
- Ensembl(ENSG00000244752)
- OMIM(123620)
- UniProtKB(P43320)
- Open Targets Platform(ENSG00000244752)
- Monarch Initiative
- Search for CRYBB2 at DataMed
- Search for CRYBB2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CRYBB2 Gene
Genomics for CRYBB2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CRYBB2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CRYBB2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CRYBB2
- Top Transcription factor binding sites by QIAGEN in the CRYBB2 gene promoter:
-
- Brachyury
- E47
- Lmo2
- Zic1
- Zic3
Genomic Locations for CRYBB2 Gene
Genomic Locations for CRYBB2 Gene
- chr22:25,211,660-25,231,870
- (GRCh38/hg38)
- Size:
- 20,211 bases
- Orientation:
- Plus strand
- chr22:25,615,489-25,627,836
- (GRCh37/hg19)
- Size:
- 12,348 bases
- Orientation:
- Plus strand
Genomic View for CRYBB2 Gene
Genes around CRYBB2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q11.23 by HGNC
- 22q11.23 by Entrez Gene
- 22q11.23 by Ensembl
CRYBB2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CRYBB2 Gene
Proteins for CRYBB2 Gene
-
Protein details for CRYBB2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P43320-CRBB2_HUMAN
- Recommended name:
- Beta-crystallin B2
- Protein Accession:
- P43320
- Q9UCM8
Protein attributes for CRYBB2 Gene
- Size:
- 205 amino acids
- Molecular mass:
- 23380 Da
- Quaternary structure:
-
- Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms (By similarity).
Protein Expression for CRYBB2 Gene
Post-translational modifications for CRYBB2 Gene
Other Protein References for CRYBB2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ CRYBB2 Antibody
-
Custom Antibody ServicesOriGene Antibodies for CRYBB2
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-
Abcam antibodies for CRYBB2
- Invitrogen Antibodies for CRYBB2 (AFLGC-Crybb2)
-
Santa Cruz Biotechnology (SCBT) Antibodies for CRYBB2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CRYBB2
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-
Abcam proteins for CRYBB2
Assay Products
- antibodies-online: Show 8 available CRYbB2 Elisa Kits ranked by validation data
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-
Quality Products:
No data available for DME Specific Peptides for CRYBB2 Gene
Domains & Families for CRYBB2 Gene
Gene Families for CRYBB2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
Protein Domains for CRYBB2 Gene
- InterPro:
- Blocks:
-
- Beta and gamma crystallin
- Gamma-crystallin related
- ProtoNet:
Suggested Antigen Peptide Sequences for CRYBB2 Gene
- GenScript: Design optimal peptide antigens:
-
- Beta-crystallin Bp (CRBB2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P43320UniProtKB/Swiss-Prot:
CRBB2_HUMAN :- Has a two-domain beta-structure, folded into four very similar Greek key motifs.
- Belongs to the beta/gamma-crystallin family.
- Domain:
-
- Has a two-domain beta-structure, folded into four very similar Greek key motifs.
- Family:
-
- Belongs to the beta/gamma-crystallin family.
Function for CRYBB2 Gene
Molecular function for CRYBB2 Gene
- UniProtKB/Swiss-Prot Function:
- Crystallins are the dominant structural components of the vertebrate eye lens.
- GENATLAS Biochemistry:
- crystallin,beta polypeptide B2
Phenotypes From GWAS Catalog for CRYBB2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005198 | structural molecule activity | NAS | 8224918 |
| GO:0005212 | structural constituent of eye lens | IBA | 21873635 |
| GO:0042802 | identical protein binding | IPI | 16319073 |
Phenotypes for CRYBB2 Gene
- MGI mutant phenotypes for CRYBB2:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for CRYBB2:
Animal Models for CRYBB2 Gene
- MGI Knock Outs for CRYBB2:
-
- Crybb2 Crybb2<tm1Itl>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CRYBB2 - Select products 50% OFF >
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-
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miRNA Products
Inhibitory RNA Products
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Clone Products
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CRYBB2
- Addgene plasmids for CRYBB2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRYBB2
Cell Line Products
-
Horizon Cell Lines for CRYBB2
No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for CRYBB2 Gene
Localization for CRYBB2 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Nucleoplasm (2)
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CRYBB2 Gene
Pathways & Interactions for CRYBB2 Gene
Interacting Proteins for CRYBB2 Gene
Selected Interacting proteins:
P43320-CRBB2_HUMAN
ENSP00000381273
for CRYBB2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CRYBB2
SIGNOR curated interactions for CRYBB2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002088 | lens development in camera-type eye | IBA | 21873635 |
| GO:0007601 | visual perception | IBA | 21873635 |
| GO:0043010 | camera-type eye development | IEA | -- |
| GO:0050896 | response to stimulus | IEA | -- |
No data available for Pathways by source for CRYBB2 Gene
Transcripts for CRYBB2 Gene
mRNA/cDNA for CRYBB2 Gene
- 1 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000651629 1019 nts (view in UCSC)
- ENST00000398215 769 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CRYBB2 - Select products 50% OFF >
- * CRYBB2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for CRYBB2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CRYBB2
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Clone Products
- Applied Biological Materials (abm): Clones for CRYBB2 - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CRYBB2
- Addgene plasmids for CRYBB2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRYBB2
Relevant External Links for CRYBB2 Gene
- GeneLoc Exon Structure for
- CRYBB2
Expression for CRYBB2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Juxtaglomerular Cells Afferent Arteriole
-
Smooth Muscle (Muscoskeletal System)
- Juxtaglomerular Cells Afferent Arteriole
-
Dermis (Integumentary System)
- Dermal Fibroblasts Dorsal Dermis
-
Fibroblasts
- Dermal Fibroblasts Dorsal Dermis
- Eye (Sensory Organs)
mRNA differential expression in normal tissues according to GTEx for CRYBB2 Gene
This gene is overexpressed in Testis (x4.0).
This gene is overexpressed in Vitreous humor (68.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CRYBB2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CRYBB2
SOURCE GeneReport for Unigene cluster for CRYBB2 Gene:
Hs.373074Evidence on tissue expression from TISSUES for CRYBB2 Gene
- Eye(5)
- Nervous system(3.7)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CRYBB2 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- nervous
- skeletal muscle
Regions:
Head and neck:
- brain
- cranial nerve
- eye
- head
General:
- peripheral nervous system
Primer Products
-
OriGene qPCR primer pairs for CRYBB2
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt for CRYBB2 Gene
Orthologs for CRYBB2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CRYBB2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CRYBB2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CRYBB2 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CRYBB2 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Crybb2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Crybb2 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CRYBB2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CRYBB2 30 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | crybb2 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.17581 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | crybb2 30 31 |
|
OneToOne | |
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2640 30 |
|
- Species where no ortholog for CRYBB2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CRYBB2 Gene
- ENSEMBL:
- Gene Tree for CRYBB2 (if available)
- TreeFam:
- Gene Tree for CRYBB2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CRYBB2: view image
Paralogs for CRYBB2 Gene
Paralogs for CRYBB2 Gene
(15) SIMAP similar genes for CRYBB2 Gene using alignment to 2 proteins:
- CRBB2_HUMAN
- R4UMM2_HUMAN
Pseudogenes.org Pseudogenes for CRYBB2 Gene
Variants for CRYBB2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CRYBB2 Gene
| SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 667923 | Benign: Cataract 3, multiple types; not provided | 25,221,469(+) | T/A | MISSENSE_VARIANT | |
| 729477 | Likely Benign: not provided | 25,227,958(+) | C/T | SYNONYMOUS_VARIANT | |
| 849925 | Uncertain Significance: Cataract 3, multiple types | 25,227,860(+) | G/A | MISSENSE_VARIANT | |
| 863971 | Uncertain Significance: Cataract 3, multiple types | 25,224,942(+) | T/G | MISSENSE_VARIANT | |
| rs146763276 | Uncertain Significance: Cataract 3, multiple types | 25,227,921(+) | G/A | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv175e55 | CNV | gain | 17911159 |
| dgv24e196 | CNV | duplication | 17116639 |
| dgv575n27 | CNV | loss | 19166990 |
| dgv576n27 | CNV | gain | 19166990 |
| dgv731e201 | CNV | deletion | 23290073 |
| dgv8071n54 | CNV | gain | 21841781 |
| esv23681 | CNV | gain+loss | 19812545 |
| esv2758829 | CNV | gain+loss | 17122850 |
| esv3575452 | CNV | gain | 25503493 |
| nsv1110863 | OTHER | inversion | 24896259 |
| nsv428388 | CNV | loss | 18775914 |
| nsv469659 | CNV | gain+loss | 16826518 |
| nsv588756 | CNV | gain+loss | 21841781 |
| nsv7350 | OTHER | inversion | 18451855 |
| nsv834162 | CNV | loss | 17160897 |
| nsv834163 | CNV | gain+loss | 17160897 |
| nsv962779 | CNV | duplication | 23825009 |
| nsv9888 | CNV | gain | 18304495 |
Residual Variation Intolerance Score:
62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.13;
51.32% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CRYBB2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRYBB2 Gene
Disorders for CRYBB2 Gene
(18) MalaCards diseases for CRYBB2 Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cataract 3, multiple types |
|
|
| cerulean cataract |
|
|
| early-onset posterior subcapsular cataract |
|
|
| early-onset sutural cataract |
|
|
| cataract 30, multiple types |
|
|
Search CRYBB2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
CRBB2_HUMAN- Cataract 3, multiple types (CTRCT3) [MIM:601547]: An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. CTRCT3 includes congenital cerulean and sutural cataract with punctate and cerulean opacities, among others. Cerulean cataract is characterized by peripheral bluish and white opacifications organized in concentric layers with occasional central lesions arranged radially. The opacities are observed in the superficial layers of the fetal nucleus as well as the adult nucleus of the lens. Involvement is usually bilateral. Visual acuity is only mildly reduced in childhood. In adulthood, the opacifications may progress, making lens extraction necessary. Histologically the lesions are described as fusiform cavities between lens fibers which contain a deeply staining granular material. Although the lesions may take on various colors, a dull blue is the most common appearance and is responsible for the designation cerulean cataract. Sutural cataract with punctate and cerulean opacities is characterized by white opacification around the anterior and posterior Y sutures, and grayish and bluish, spindle shaped, oval punctate and cerulean opacities of various sizes arranged in lamellar form. The spots are more concentrated towards the peripheral layers and do not delineate the embryonal or fetal nucleus. Phenotypic variation with respect to the size and density of the sutural opacities as well as the number and position of punctate and cerulean spots is observed among affected subjects. {ECO:0000269 PubMed:10634616, ECO:0000269 PubMed:9158139}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for CRYBB2
No data available for Genatlas for CRYBB2 Gene
Publications for CRYBB2 Gene
- Sequence of the human lens beta B2-crystallin-encoding cDNA. (PMID: 8224918) Chambers C … Russell P (Gene 1993) 2 3 4 23
- Autosomal dominant cerulean cataract is associated with a chain termination mutation in the human beta-crystallin gene CRYBB2. (PMID: 9158139) Litt M … Maumenee IH (Human molecular genetics 1997) 2 3 4
- Post-translational modifications of water-soluble human lens crystallins from young adults. (PMID: 8175657) Miesbauer LR … Smith JB (The Journal of biological chemistry 1994) 3 4 23
- Autosomal-dominant cerulean cataract in a chinese family associated with gene conversion mutation in beta-B2-crystallin. (PMID: 19321936) Wang L … Qi Y (Ophthalmic research 2009) 3 23
- Gene conversion mutation in crystallin, beta-B2 (CRYBB2) in a Chilean family with autosomal dominant cataract. (PMID: 17234267) Bateman JB … Spence MA (Ophthalmology 2007) 3 23
ExternalLinks
Products for CRYBB2 Gene
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Sources for CRYBB2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB