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Aliases for CRYAA2 Gene

Aliases for CRYAA2 Gene

  • Crystallin Alpha A2 2 3 5
  • Alpha-Crystallin A Chain 3
  • LOC102724652 12
  • CRYAA 3

External Ids for CRYAA2 Gene

Summaries for CRYAA2 Gene

GeneCards Summary for CRYAA2 Gene

CRYAA2 (Crystallin Alpha A2) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum. An important paralog of this gene is CRYAA.

Additional gene information for CRYAA2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRYAA2 Gene

Genomics for CRYAA2 Gene

GeneHancer (GH) Regulatory Elements for CRYAA2 Gene

Promoters and enhancers for CRYAA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J006564 Enhancer 0.2 Ensembl 0.7 +4.6 4603 2.3 CRYAA2 LOC102724677
GH21J006569 Enhancer 0.2 Ensembl 0.4 +9.7 9744 2.8 CRYAA2 LOC102724677
GH21J006553 Enhancer 0.2 Ensembl 0.4 -6.5 -6455 2 ENSG00000278927 CRYAA2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CRYAA2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CRYAA2 Gene

Genomic Locations for CRYAA2 Gene
chr21:6,560,656-6,564,489
(GRCh38/hg38)
Size:
3,834 bases
Orientation:
Plus strand

Genomic View for CRYAA2 Gene

Genes around CRYAA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRYAA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRYAA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRYAA2 Gene

Proteins for CRYAA2 Gene

  • Protein details for CRYAA2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A140G945-A0A140G945_HUMAN
    Recommended name:
    Alpha crystallin A chain
    Protein Accession:
    A0A140G945

    Protein attributes for CRYAA2 Gene

    Size:
    173 amino acids
    Molecular mass:
    19909 Da
    Quaternary structure:
    No Data Available
  • Protein details for CRYAA2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A096LPJ9-A0A096LPJ9_HUMAN
    Recommended name:
    Uncharacterized protein
    Protein Accession:
    A0A096LPJ9

    Protein attributes for CRYAA2 Gene

    Size:
    127 amino acids
    Molecular mass:
    14267 Da
    Quaternary structure:
    No Data Available
  • Protein details for CRYAA2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    E9PHE4-E9PHE4_HUMAN
    Recommended name:
    Alpha-crystallin A chain
    Protein Accession:
    E9PHE4

    Protein attributes for CRYAA2 Gene

    Size:
    136 amino acids
    Molecular mass:
    15316 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CRYAA2 Gene

Post-translational modifications for CRYAA2 Gene

No Post-translational modifications

Other Protein References for CRYAA2 Gene

No data available for DME Specific Peptides for CRYAA2 Gene

Domains & Families for CRYAA2 Gene

Gene Families for CRYAA2 Gene

Unknown:
  • Belongs to the small heat shock protein (HSP20) family.
  • Belongs to the small heat shock protein (HSP20) family.
  • Belongs to the small heat shock protein (HSP20) family.

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CRYAA2: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CRYAA2 Gene

Function for CRYAA2 Gene

Phenotypes for CRYAA2 Gene

genes like me logo Genes that share phenotypes with CRYAA2: view

Animal Models for CRYAA2 Gene

MGI Knock Outs for CRYAA2:

Animal Model Products

miRNA for CRYAA2 Gene

miRTarBase miRNAs that target CRYAA2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRYAA2 Gene

Localization for CRYAA2 Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CRYAA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with CRYAA2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for CRYAA2 Gene

Pathways & Interactions for CRYAA2 Gene

genes like me logo Genes that share pathways with CRYAA2: view

Pathways by source for CRYAA2 Gene

1 KEGG pathway for CRYAA2 Gene

Interacting Proteins for CRYAA2 Gene

Gene Ontology (GO) - Biological Process for CRYAA2 Gene

None

No data available for SIGNOR curated interactions for CRYAA2 Gene

Drugs & Compounds for CRYAA2 Gene

No Compound Related Data Available

Transcripts for CRYAA2 Gene

mRNA/cDNA for CRYAA2 Gene

(2) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CRYAA2 Gene

No ASD Table

Relevant External Links for CRYAA2 Gene

GeneLoc Exon Structure for
CRYAA2
ECgene alternative splicing isoforms for
CRYAA2

Expression for CRYAA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

genes like me logo Genes that share expression patterns with CRYAA2: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRYAA2 Gene

Orthologs for CRYAA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CRYAA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRYAA 33
  • 99.42 (n)
cow
(Bos Taurus)
Mammalia CRYAA 33
  • 90.94 (n)
dog
(Canis familiaris)
Mammalia CRYAA 33
  • 90.37 (n)
rat
(Rattus norvegicus)
Mammalia Cryaa 33
  • 89.21 (n)
mouse
(Mus musculus)
Mammalia Cryaa 16 33
  • 88.25 (n)
chicken
(Gallus gallus)
Aves CRYAA 33
  • 78.42 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488185 33
  • 75.1 (n)
zebrafish
(Danio rerio)
Actinopterygii cryaa 33
  • 74.31 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005548 33
  • 54 (n)
Species where no ortholog for CRYAA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRYAA2 Gene

ENSEMBL:
Gene Tree for CRYAA2 (if available)
TreeFam:
Gene Tree for CRYAA2 (if available)

Paralogs for CRYAA2 Gene

Paralogs for CRYAA2 Gene

genes like me logo Genes that share paralogs with CRYAA2: view

Variants for CRYAA2 Gene

Additional Variant Information for CRYAA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRYAA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for CRYAA2 Gene

Disorders for CRYAA2 Gene

Additional Disease Information for CRYAA2

No disorders were found for CRYAA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRYAA2 Gene

Publications for CRYAA2 Gene

  1. CRISPR/Cas9-Mediated Mutation of αA-Crystallin Gene Induces Congenital Cataracts in Rabbits. (PMID: 28475701) Yuan L … Lai L (Investigative ophthalmology & visual science 2017) 3 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  3. Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. (PMID: 12107411) Wistow G … Peterson K (Molecular vision 2002) 3 58
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 58

Products for CRYAA2 Gene

Sources for CRYAA2 Gene

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