This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated... See more...

Aliases for CRY1 Gene

Aliases for CRY1 Gene

  • Cryptochrome Circadian Regulator 1 2 3 5
  • Cryptochrome 1 (Photolyase-Like) 2 3
  • Cryptochrome Circadian Clock 1 2 3
  • Cryptochrome-1 3 4
  • PHLL1 3 4
  • DSPD 3
  • CRY1 5

External Ids for CRY1 Gene

Previous HGNC Symbols for CRY1 Gene

  • PHLL1

Previous GeneCards Identifiers for CRY1 Gene

  • GC12M106495
  • GC12M107265
  • GC12M105887
  • GC12M107385
  • GC12M104445

Summaries for CRY1 Gene

Entrez Gene Summary for CRY1 Gene

  • This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Jan 2014]

GeneCards Summary for CRY1 Gene

CRY1 (Cryptochrome Circadian Regulator 1) is a Protein Coding gene. Diseases associated with CRY1 include Delayed Sleep Phase Disorder and Sleep Disorder. Among its related pathways are Circadian rhythm and Melatonin metabolism and effects. Gene Ontology (GO) annotations related to this gene include nucleotide binding and transcription factor binding. An important paralog of this gene is CRY2.

UniProtKB/Swiss-Prot Summary for CRY1 Gene

  • Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. More potent transcriptional repressor in cerebellum and liver than CRY2, though more effective in lengthening the period of the SCN oscillator. On its side, CRY2 seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY2, is dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. Interacts with CLOCK-ARNTL/BMAL1 independently of PER proteins and is found at CLOCK-ARNTL/BMAL1-bound sites, suggesting that CRY may act as a molecular gatekeeper to maintain CLOCK-ARNTL/BMAL1 in a poised and repressed state until the proper time for transcriptional activation. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1. Represses the CLOCK-ARNTL/BMAL1 induced transcription of ATF4, MTA1, KLF10 and NAMPT (By similarity). May repress circadian target genes expression in collaboration with HDAC1 and HDAC2 through histone deacetylation. Mediates the clock-control activation of ATR and modulates ATR-mediated DNA damage checkpoint. In liver, mediates circadian regulation of cAMP signaling and gluconeogenesis by binding to membrane-coupled G proteins and blocking glucagon-mediated increases in intracellular cAMP concentrations and CREB1 phosphorylation. Inhibits hepatic gluconeogenesis by decreasing nuclear FOXO1 levels that downregulates gluconeogenic gene expression (By similarity). Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4 (By similarity). Represses PPARD and its target genes in the skeletal muscle and limits exercise capacity (By similarity). Plays an essential role in the generation of circadian rhythms in the retina (By similarity). Represses the transcriptional activity of NR1I2 (By similarity).

Gene Wiki entry for CRY1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CRY1 Gene

Genomics for CRY1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CRY1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CRY1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CRY1

Top Transcription factor binding sites by QIAGEN in the CRY1 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • FOXO1
  • FOXO1a
  • Sp1
  • Tal-1

Genomic Locations for CRY1 Gene

Genomic Locations for CRY1 Gene
chr12:106,991,364-107,093,872
(GRCh38/hg38)
Size:
102,509 bases
Orientation:
Minus strand
chr12:107,385,142-107,487,607
(GRCh37/hg19)
Size:
102,466 bases
Orientation:
Minus strand

Genomic View for CRY1 Gene

Genes around CRY1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRY1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRY1 Gene

Proteins for CRY1 Gene

  • Protein details for CRY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16526-CRY1_HUMAN
    Recommended name:
    Cryptochrome-1
    Protein Accession:
    Q16526

    Protein attributes for CRY1 Gene

    Size:
    586 amino acids
    Molecular mass:
    66395 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Cofactor:
    Name=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate; Xref=ChEBI:CHEBI:15636;
    Quaternary structure:
    • Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARNTL/BMAL1 or ARNTL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins (By similarity). Interacts directly with TIMELESS (By similarity). Interacts directly with PER1 and PER3 (By similarity). Interacts directly with PER2; interaction with PER2 inhibits its ubiquitination and vice versa (PubMed:21613214). Interacts with FBXL21 (By similarity). Interacts with FBXL3 (PubMed:17463251). Interacts with PPP5C (via TPR repeats) (PubMed:16790549). Interacts with CLOCK-ARNTL/BMAL1 independently of PER2 and DNA (PubMed:28388406). Interacts with HDAC1, HDAC2 and SIN3B. Interacts with nuclear receptors AR, NR1D1, NR3C1/GR, RORA and RORC; the interaction with at least NR3C1/GR is ligand dependent (PubMed:22170608). Interacts with PRKDC (By similarity). Interacts with the G protein subunit alpha GNAS; the interaction may block GPCR-mediated regulation of cAMP concentrations (PubMed:20852621). Interacts with PRMT5 (PubMed:23133559). Interacts with EZH2 (By similarity). Interacts with MYBBP1A, DOCK7, HNRNPU, RPL7A, RPL8 and RPS3 (By similarity). Interacts with MAP1LC3B (By similarity). Interacts with CLOCK (By similarity). Interacts with ARNTL/BMAL1 (By similarity). Interacts weakly with HDAC3; this interaction is enhanced in the presence of FBXL3 (By similarity). Interacts with TRIM28, KCTD5 and DDB1 (By similarity). Interacts with FOXO1 (By similarity). Interacts with DTL and DDB1-CUL4A complex (PubMed:26431207). Interacts with HNF4A (PubMed:30530698). Interacts with PSMD2 in a KDM8-dependent manner (By similarity). Interacts with KDM8 in a FBXL3-dependent manner (By similarity). Interacts with PPARG in a ligand-dependent manner (By similarity). Interacts with PPARD (via domain NR LBD) and NR1I2 (via domain NR LBD) in a ligand-dependent manner (By similarity). Interacts with PPARA, NR1I3 and VDR (By similarity).

neXtProt entry for CRY1 Gene

Post-translational modifications for CRY1 Gene

  • Phosphorylation on Ser-247 by MAPK is important for the inhibition of CLOCK-ARNTL/BMAL1-mediated transcriptional activity. Phosphorylation by CSNK1E requires interaction with PER1 or PER2. Phosphorylation at Ser-71 and Ser-280 by AMPK decreases protein stability. Phosphorylation at Ser-568 exhibits a robust circadian rhythm with a peak at CT8, increases protein stability, prevents SCF(FBXL3)-mediated degradation and is antagonized by interaction with PRKDC.
  • Ubiquitinated by the SCF(FBXL3) and SCF(FBXL21) complexes, regulating the balance between degradation and stabilization. The SCF(FBXL3) complex is mainly nuclear and mediates ubiquitination and subsequent degradation of CRY1. In contrast, cytoplasmic SCF(FBXL21) complex-mediated ubiquitination leads to stabilize CRY1 and counteract the activity of the SCF(FBXL3) complex. The SCF(FBXL3) and SCF(FBXL21) complexes probably mediate ubiquitination at different Lys residues. Ubiquitination at Lys-11 and Lys-107 are specifically ubiquitinated by the SCF(FBXL21) complex but not by the SCF(FBXL3) complex. Ubiquitination may be inhibited by PER2 (PubMed:17463251, PubMed:22798407, PubMed:27565346). Deubiquitinated by USP7 (By similarity).
  • Undergoes autophagy-mediated degradation in the liver in a time-dependent manner. Autophagic degradation of CRY1 (an inhibitor of gluconeogenesis) occurs during periods of reduced feeding allowing induction of gluconeogenesis and maintenance of blood glucose levels.
  • Ubiquitination at Lys11, Lys107, Lys159, Lys329, Lys442, Lys485, and Lys565
  • Modification sites at PhosphoSitePlus

Other Protein References for CRY1 Gene

No data available for DME Specific Peptides for CRY1 Gene

Domains & Families for CRY1 Gene

Gene Families for CRY1 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CRY1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ76110, highly similar to Homo sapiens cryptochrome 1 (CRY1), mRNA (A2I2P0_HUMAN)
  • Cryptochrome-1 (CRY1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16526

UniProtKB/Swiss-Prot:

CRY1_HUMAN :
  • The LIR motifs (LC3-interacting region) 3 and 5 are required for its interaction with MAP1LC3B and for its autophagy-mediated degradation.
  • Belongs to the DNA photolyase class-1 family.
Domain:
  • The LIR motifs (LC3-interacting region) 3 and 5 are required for its interaction with MAP1LC3B and for its autophagy-mediated degradation.
Family:
  • Belongs to the DNA photolyase class-1 family.
genes like me logo Genes that share domains with CRY1: view

Function for CRY1 Gene

Molecular function for CRY1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. More potent transcriptional repressor in cerebellum and liver than CRY2, though more effective in lengthening the period of the SCN oscillator. On its side, CRY2 seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY2, is dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. Interacts with CLOCK-ARNTL/BMAL1 independently of PER proteins and is found at CLOCK-ARNTL/BMAL1-bound sites, suggesting that CRY may act as a molecular gatekeeper to maintain CLOCK-ARNTL/BMAL1 in a poised and repressed state until the proper time for transcriptional activation. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1. Represses the CLOCK-ARNTL/BMAL1 induced transcription of ATF4, MTA1, KLF10 and NAMPT (By similarity). May repress circadian target genes expression in collaboration with HDAC1 and HDAC2 through histone deacetylation. Mediates the clock-control activation of ATR and modulates ATR-mediated DNA damage checkpoint. In liver, mediates circadian regulation of cAMP signaling and gluconeogenesis by binding to membrane-coupled G proteins and blocking glucagon-mediated increases in intracellular cAMP concentrations and CREB1 phosphorylation. Inhibits hepatic gluconeogenesis by decreasing nuclear FOXO1 levels that downregulates gluconeogenic gene expression (By similarity). Besides its role in the maintenance of the circadian clock, is also involved in the regulation of other processes. Represses glucocorticoid receptor NR3C1/GR-induced transcriptional activity by binding to glucocorticoid response elements (GREs). Plays a key role in glucose and lipid metabolism modulation, in part, through the transcriptional regulation of genes involved in these pathways, such as LEP or ACSL4 (By similarity). Represses PPARD and its target genes in the skeletal muscle and limits exercise capacity (By similarity). Plays an essential role in the generation of circadian rhythms in the retina (By similarity). Represses the transcriptional activity of NR1I2 (By similarity).
UniProtKB/Swiss-Prot Induction:
Expression is regulated by light and circadian rhythms and osicllates diurnally. Peak expression in the suprachiasma nucleus (SCN) and eye at the day/night transition (CT12). Levels decrease with ARNTL/BMAL1-CLOCK inhibition as part of the autoregulatory feedback loop.
UniProtKB/Swiss-Prot EnzymeRegulation:
KL001 (N-[3-(9H-carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)-methanesulfonamide) binds to CRY1 and stabilizes it by inhibiting FBXL3- and ubiquitin-dependent degradation of CRY1 resulting in lengthening of the circadian periods.
GENATLAS Biochemistry:
cryptochrome 1,photolyase-like,66kDa,putatively involved in photoreactivation,i.e DNA repair by excision of UV induced DNA damage

Phenotypes From GWAS Catalog for CRY1 Gene

Gene Ontology (GO) - Molecular Function for CRY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003677 DNA binding TAS 9801304
GO:0003690 double-stranded DNA binding IDA 9801304
GO:0003904 NOT deoxyribodipyrimidine photo-lyase activity IDA 8909283
GO:0003914 NOT DNA (6-4) photolyase activity IDA 8909283
genes like me logo Genes that share ontologies with CRY1: view
genes like me logo Genes that share phenotypes with CRY1: view

Human Phenotype Ontology for CRY1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CRY1 Gene

MGI Knock Outs for CRY1:

Animal Model Products

CRISPR Products

miRNA for CRY1 Gene

miRTarBase miRNAs that target CRY1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRY1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CRY1 Gene

Localization for CRY1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRY1 Gene

Cytoplasm. Nucleus. Note=Translocated to the nucleus through interaction with other clock proteins such as PER2 or ARNTL/BMAL1. {ECO:0000250 UniProtKB:P97784}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRY1 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
mitochondrion 3
cytosol 3
plasma membrane 2
extracellular 2
peroxisome 2
endoplasmic reticulum 2
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Microtubules (2)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CRY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with CRY1: view

Pathways & Interactions for CRY1 Gene

genes like me logo Genes that share pathways with CRY1: view

Pathways by source for CRY1 Gene

1 KEGG pathway for CRY1 Gene
2 Qiagen pathways for CRY1 Gene
  • Circadian Clock in Mammals
  • Metabolic States and Circadian Oscillators

SIGNOR curated interactions for CRY1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CRY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 12397359
GO:0006094 gluconeogenesis IEA,ISS --
GO:0006975 DNA damage induced protein phosphorylation ISS --
GO:0007623 circadian rhythm IEA,ISS --
GO:0009416 response to light stimulus ISS --
genes like me logo Genes that share ontologies with CRY1: view

Drugs & Compounds for CRY1 Gene

(2) Drugs for CRY1 Gene - From: PharmGKB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
lithium Experimental Pharma 0

(1) Additional Compounds for CRY1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CRY1: view

Transcripts for CRY1 Gene

mRNA/cDNA for CRY1 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRY1

Alternative Splicing Database (ASD) splice patterns (SP) for CRY1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b
SP1: - -
SP2: -
SP3:
SP4:

Relevant External Links for CRY1 Gene

GeneLoc Exon Structure for
CRY1

Expression for CRY1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CRY1 Gene

Protein differential expression in normal tissues from HIPED for CRY1 Gene

This gene is overexpressed in Urine (19.4), Rectum (16.5), Urinary Bladder (9.3), and Bone (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CRY1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CRY1

SOURCE GeneReport for Unigene cluster for CRY1 Gene:

Hs.151573

Evidence on tissue expression from TISSUES for CRY1 Gene

  • Nervous system(4.7)
  • Liver(3)
  • Eye(2.8)
  • Skin(2.8)
  • Adrenal gland(2.8)
  • Muscle(2.7)
  • Kidney(2.7)
  • Heart(2.6)
  • Intestine(2.6)
  • Blood(2.5)
  • Pancreas(2.5)
  • Thyroid gland(2.3)
  • Stomach(2.1)
  • Lung(2.1)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with CRY1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRY1 Gene

Orthologs for CRY1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CRY1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CRY1 30 31
  • 99.77 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CRY1 30 31
  • 95.79 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CRY1 30 31
  • 94.71 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CRY1 31
  • 92 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Cry1 30 17 31
  • 89.08 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CRY1 31
  • 89 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cry1 30
  • 88.4 (n)
Chicken
(Gallus gallus)
Aves CRY1 30 31
  • 83.11 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CRY1 31
  • 87 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cry1 30
  • 77.15 (n)
Str.16341 30
African clawed frog
(Xenopus laevis)
Amphibia cry1-A 30
Zebrafish
(Danio rerio)
Actinopterygii cry1a 31
  • 78 (a)
OneToMany
cry1b 30 31
  • 74.71 (n)
OneToMany
cry2a 31
  • 71 (a)
OneToMany
cry2b 31
  • 66 (a)
OneToMany
-- 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004261 30
  • 64.36 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta phr6-4 31 32
  • 49 (a)
ManyToMany
cry 32
  • 40 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHR1 31
  • 18 (a)
OneToMany
Barley
(Hordeum vulgare)
Liliopsida Hv.2572 30
Species where no ortholog for CRY1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CRY1 Gene

ENSEMBL:
Gene Tree for CRY1 (if available)
TreeFam:
Gene Tree for CRY1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CRY1: view image

Paralogs for CRY1 Gene

Paralogs for CRY1 Gene

(1) SIMAP similar genes for CRY1 Gene using alignment to 3 proteins:

  • CRY1_HUMAN
  • A2I2P0_HUMAN
  • H0YHT0_HUMAN
genes like me logo Genes that share paralogs with CRY1: view

Variants for CRY1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CRY1 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
729183 Benign: not provided 106,999,695(-) C/T SYNONYMOUS_VARIANT
781261 Benign: not provided 106,997,376(-) T/A SYNONYMOUS_VARIANT
rs184039278 Risk Factor: Sleep-wake schedule disorder, delayed phase type 106,992,962(-) T/G INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for CRY1 Gene

Structural Variations from Database of Genomic Variants (DGV) for CRY1 Gene

Variant ID Type Subtype PubMed ID
esv1001965 CNV insertion 20482838
esv1520737 CNV insertion 17803354
esv2485513 CNV deletion 19546169

Variation tolerance for CRY1 Gene

Residual Variation Intolerance Score: 7.36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRY1 Gene

Human Gene Mutation Database (HGMD)
CRY1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRY1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRY1 Gene

Disorders for CRY1 Gene

MalaCards: The human disease database

(9) MalaCards diseases for CRY1 Gene - From: ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
delayed sleep phase disorder
  • delayed sleep phase disorder, susceptibility to
sleep disorder
  • non-organic sleep disorder
major depressive disorder
  • mdd
retinitis pigmentosa 59
  • rp59
advanced sleep phase syndrome
  • familial advanced sleep-phase syndrome
- elite association - COSMIC cancer census association via MalaCards
Search CRY1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CRY1_HUMAN
  • Delayed sleep phase syndrome (DSPS) [MIM:614163]: A circadian rhythm sleep disorder characterized by sleep-onset insomnia and difficulty in awakening at the desired time. Patients with DSPS have chronic difficulty in adjusting their sleep-onset and wake-up times to occupational, school, and social activities. {ECO:0000269 PubMed:28388406}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. An adenine-to-cytosine transversion within the 5'splice site following exon 11 has been found in multiple members of a DSPD family and segregates with the disorder with autosomal dominant inheritance pattern. This variant is predicted to cause exon 11 skipping and in-frame deletion of 24 residues in the C-terminal region of CRY1. Functional studies show that the mutated protein acts as a more potent transcriptional repressor than wild-type, causes reduced expression of key transcriptional targets and lengthens the period of circadian molecular rhythms. {ECO:0000269 PubMed:28388406}.

Additional Disease Information for CRY1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CRY1: view

No data available for Genatlas for CRY1 Gene

Publications for CRY1 Gene

  1. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. (PMID: 20072116) Soria V … Urretavizcaya M (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010) 3 23 41
  2. Testing the circadian gene hypothesis in prostate cancer: a population-based case-control study. (PMID: 19934327) Zhu Y … Stanford JL (Cancer research 2009) 3 23 41
  3. Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm. (PMID: 18228528) Shi J … Liu C (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 23 41
  4. Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins. (PMID: 8909283) Hsu DS … Sancar A (Biochemistry 1996) 3 4 23
  5. Cloning, tissue expression, and mapping of a human photolyase homolog with similarity to plant blue-light receptors. (PMID: 8921389) van der Spek PJ … Yasui A (Genomics 1996) 2 3 4

Products for CRY1 Gene

  • Signalway ELISA kits for CRY1

Sources for CRY1 Gene