Aliases for CRTC3 Gene
- CREB Regulated Transcription Coactivator 3 2 3 5
- TORC-3 3 4
- TORC3 3 4
- Transducer Of Regulated CAMP Response Element-Binding Protein (CREB) 3 3
- Transducer Of Regulated CAMP Response Element-Binding Protein 3 4
- CREB-Regulated Transcription Coactivator 3 3
- Transducer Of Regulated CREB Protein 3 3
- Transducer Of CREB Protein 3 4
External Ids for CRTC3 Gene
Previous GeneCards Identifiers for CRTC3 Gene
This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
GeneCards Summary for CRTC3 Gene
CRTC3 (CREB Regulated Transcription Coactivator 3) is a Protein Coding gene. Diseases associated with CRTC3 include Human T-Cell Leukemia Virus Type 1 and Mucoepidermoid Carcinoma. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial Gene Expression. Gene Ontology (GO) annotations related to this gene include cAMP response element binding protein binding. An important paralog of this gene is CRTC2.
UniProtKB/Swiss-Prot for CRTC3 Gene
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 Ser-133 phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).