Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CRTC3 Gene

Aliases for CRTC3 Gene

  • CREB Regulated Transcription Coactivator 3 2 3 5
  • TORC-3 3 4
  • TORC3 3 4
  • Transducer Of Regulated CAMP Response Element-Binding Protein (CREB) 3 3
  • Transducer Of Regulated CAMP Response Element-Binding Protein 3 4
  • CREB-Regulated Transcription Coactivator 3 3
  • Transducer Of Regulated CREB Protein 3 3
  • Transducer Of CREB Protein 3 4

External Ids for CRTC3 Gene

Previous GeneCards Identifiers for CRTC3 Gene

  • GC15P088875
  • GC15P091073
  • GC15P067184

Summaries for CRTC3 Gene

Entrez Gene Summary for CRTC3 Gene

  • This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for CRTC3 Gene

CRTC3 (CREB Regulated Transcription Coactivator 3) is a Protein Coding gene. Diseases associated with CRTC3 include Human T-Cell Leukemia Virus Type 1 and Mucoepidermoid Carcinoma. Among its related pathways are Organelle biogenesis and maintenance and HTLV-I infection. Gene Ontology (GO) annotations related to this gene include cAMP response element binding protein binding. An important paralog of this gene is CRTC2.

UniProtKB/Swiss-Prot for CRTC3 Gene

  • Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 Ser-133 phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

Gene Wiki entry for CRTC3 Gene

Additional gene information for CRTC3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRTC3 Gene

Genomics for CRTC3 Gene

GeneHancer (GH) Regulatory Elements for CRTC3 Gene

Promoters and enhancers for CRTC3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J090528 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 662.1 +0.4 414 2.9 HDGF ATF1 ARID4B SIN3A ZNF2 GLIS2 ATF7 SP3 SMARCB1 ZNF592 CRTC3 IQGAP1 SEMA4B GC15M090544
GH15J090556 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 21.8 +31.9 31889 11.2 HDGF FOXA2 ARID4B BRCA1 ZNF48 YY1 FOS ATF7 RUNX3 DEK CRTC3 IQGAP1 ENSG00000200677 FES UNC45A ENSG00000228998 ENSG00000259212 CIB1 GDPGP1 GC15M090544
GH15J090591 Enhancer 1.4 Ensembl ENCODE dbSUPER 24.8 +65.2 65242 7.8 HDGF PKNOX1 FOXA2 ARNT BRCA1 YY1 ZNF121 ZNF766 ZNF143 FOS ENSG00000259212 CRTC3 IQGAP1 UNC45A ENSG00000259314 ENSG00000200677 NGRN GC15P090584
GH15J090867 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.1 +341.5 341475 7 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF143 ZNF263 SP3 FURIN UNC45A ENSG00000259314 FES LOC100631255 ENSG00000259212 IQGAP1 VPS33B CRTC3 GC15P090874
GH15J090659 Enhancer 1.4 Ensembl ENCODE dbSUPER 23.5 +131.0 131020 2.6 HDGF PKNOX1 ATF1 SMAD1 ARNT SIN3A IRF4 POLR2B ZNF766 FOS LINC01585 CRTC3 UNC45A ENSG00000259314 BLM ENSG00000200677 GC15P090677 CRTC3-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CRTC3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CRTC3 gene promoter:
  • deltaCREB
  • CREB
  • Nkx6-1
  • Msx-1
  • AML1a
  • CRE-BP1
  • ATF-2
  • CP2
  • Zic3

Genomic Locations for CRTC3 Gene

Genomic Locations for CRTC3 Gene
chr15:90,529,886-90,645,345
(GRCh38/hg38)
Size:
115,460 bases
Orientation:
Plus strand
chr15:91,073,157-91,188,577
(GRCh37/hg19)
Size:
115,421 bases
Orientation:
Plus strand

Genomic View for CRTC3 Gene

Genes around CRTC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRTC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRTC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRTC3 Gene

Proteins for CRTC3 Gene

  • Protein details for CRTC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UUV7-CRTC3_HUMAN
    Recommended name:
    CREB-regulated transcription coactivator 3
    Protein Accession:
    Q6UUV7
    Secondary Accessions:
    • Q6DK61
    • Q6DK62
    • Q8NF38
    • Q9H6U2

    Protein attributes for CRTC3 Gene

    Size:
    619 amino acids
    Molecular mass:
    66959 Da
    Quaternary structure:
    • Binding, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1 enhances recruitment of TAF4 to the promoter (PubMed:14506290). Arg-314 in the bZIP domain of CREB1 is essential for this interaction (By similarity). Interaction with HTLV-1 TAX enhances its transcriptional activity (PubMed:15466468, PubMed:16809310). Interacts, via the N-terminal with the ankyrin repeats of BCL3, to form a complex with CREB1 on CRE and TxRE responsive elements and represses HTLV-1 LTR-mediated transcription (PubMed:17644518).
    SequenceCaution:
    • Sequence=BAC03424.1; Type=Frameshift; Positions=82; Evidence={ECO:0000305};

    Alternative splice isoforms for CRTC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRTC3 Gene

Post-translational modifications for CRTC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for CRTC3
  • Boster Bio Antibodies for CRTC3
  • Santa Cruz Biotechnology (SCBT) Antibodies for CRTC3

No data available for DME Specific Peptides for CRTC3 Gene

Domains & Families for CRTC3 Gene

Gene Families for CRTC3 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for CRTC3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CRTC3 Gene

Graphical View of Domain Structure for InterPro Entry

Q6UUV7

UniProtKB/Swiss-Prot:

CRTC3_HUMAN :
  • Belongs to the TORC family.
Family:
  • Belongs to the TORC family.
genes like me logo Genes that share domains with CRTC3: view

Function for CRTC3 Gene

Molecular function for CRTC3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 Ser-133 phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

Phenotypes From GWAS Catalog for CRTC3 Gene

Gene Ontology (GO) - Molecular Function for CRTC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008140 cAMP response element binding protein binding IBA --
genes like me logo Genes that share ontologies with CRTC3: view
genes like me logo Genes that share phenotypes with CRTC3: view

Animal Models for CRTC3 Gene

MGI Knock Outs for CRTC3:

Animal Model Products

Clone Products

  • Addgene plasmids for CRTC3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRTC3 Gene

Localization for CRTC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRTC3 Gene

Nucleus. Cytoplasm. Note=Appears to be mainly nuclear. {ECO:0000269 PubMed:15454081}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRTC3 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CRTC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA,IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with CRTC3: view

Pathways & Interactions for CRTC3 Gene

genes like me logo Genes that share pathways with CRTC3: view

Pathways by source for CRTC3 Gene

1 Cell Signaling Technology pathway for CRTC3 Gene

SIGNOR curated interactions for CRTC3 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CRTC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016032 viral process IEA --
GO:0032793 positive regulation of CREB transcription factor activity IBA,IEA --
GO:0042116 macrophage activation IMP 23033494
genes like me logo Genes that share ontologies with CRTC3: view

Drugs & Compounds for CRTC3 Gene

(1) Drugs for CRTC3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with CRTC3: view

Transcripts for CRTC3 Gene

Unigene Clusters for CRTC3 Gene

CREB regulated transcription coactivator 3:
Representative Sequences:

Clone Products

  • Addgene plasmids for CRTC3

Alternative Splicing Database (ASD) splice patterns (SP) for CRTC3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a ·
SP1: - - - -
SP2:
SP3:
SP4:
SP5: - -
SP6: - - - -
SP7:
SP8:
SP9:

ExUns: 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for CRTC3 Gene

GeneLoc Exon Structure for
CRTC3
ECgene alternative splicing isoforms for
CRTC3

Expression for CRTC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRTC3 Gene

Protein differential expression in normal tissues from HIPED for CRTC3 Gene

This gene is overexpressed in Testis (24.8), Placenta (11.3), and CD8 Tcells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CRTC3 Gene



Protein tissue co-expression partners for CRTC3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CRTC3 Gene:

CRTC3

SOURCE GeneReport for Unigene cluster for CRTC3 Gene:

Hs.567572

mRNA Expression by UniProt/SwissProt for CRTC3 Gene:

Q6UUV7-CRTC3_HUMAN
Tissue specificity: Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach.

Evidence on tissue expression from TISSUES for CRTC3 Gene

  • Nervous system(4.6)
  • Spleen(4.3)
genes like me logo Genes that share expression patterns with CRTC3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRTC3 Gene

Orthologs for CRTC3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRTC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRTC3 34 33
  • 99.57 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crtc3 33
  • 88.19 (n)
mouse
(Mus musculus)
Mammalia Crtc3 16 34 33
  • 87.24 (n)
cow
(Bos Taurus)
Mammalia CRTC3 34 33
  • 85.13 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CRTC3 34 33
  • 84.22 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRTC3 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRTC3 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crtc3 33
  • 61.32 (n)
zebrafish
(Danio rerio)
Actinopterygii crtc3 34 33
  • 59.46 (n)
OneToOne
Species where no ortholog for CRTC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRTC3 Gene

ENSEMBL:
Gene Tree for CRTC3 (if available)
TreeFam:
Gene Tree for CRTC3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CRTC3: view image

Paralogs for CRTC3 Gene

Paralogs for CRTC3 Gene

(3) SIMAP similar genes for CRTC3 Gene using alignment to 3 proteins:

  • CRTC3_HUMAN
  • H0YK33_HUMAN
  • H0YK64_HUMAN
genes like me logo Genes that share paralogs with CRTC3: view

Variants for CRTC3 Gene

Sequence variations from dbSNP and Humsavar for CRTC3 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs193921108 uncertain-significance, Malignant tumor of prostate 90,638,566(+) C/A/G/T coding_sequence_variant, missense_variant
rs1000027365 -- 90,600,560(+) T/C intron_variant
rs1000038445 -- 90,535,551(+) G/C intron_variant
rs1000042469 -- 90,573,441(+) C/G intron_variant
rs1000076197 -- 90,595,426(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CRTC3 Gene

Variant ID Type Subtype PubMed ID
dgv1259n106 CNV deletion 24896259
esv1007679 CNV deletion 20482838
esv1236283 CNV deletion 17803354
esv2234796 CNV deletion 18987734
esv2512119 CNV deletion 19546169
esv2750011 CNV deletion 23290073
esv3217123 CNV deletion 24192839
esv33061 CNV loss 17666407
esv3552839 CNV deletion 23714750
esv3569875 CNV gain 25503493
esv3955 CNV loss 18987735
esv5649 CNV gain 19470904
esv8010 CNV loss 19470904
nsv1045042 CNV gain 25217958
nsv1069883 CNV deletion 25765185
nsv1078211 CNV insertion 25765185
nsv1127452 CNV deletion 24896259
nsv1142183 CNV tandem duplication 24896259
nsv1148246 CNV deletion 26484159
nsv1662 CNV insertion 18451855
nsv475139 CNV novel sequence insertion 20440878
nsv479235 CNV novel sequence insertion 20440878
nsv509582 CNV insertion 20534489
nsv570396 CNV gain 21841781
nsv833088 CNV loss 17160897
nsv94691 CNV deletion 16902084
nsv957961 CNV deletion 24416366
nsv984108 CNV duplication 23825009

Variation tolerance for CRTC3 Gene

Residual Variation Intolerance Score: 37.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.81; 89.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRTC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRTC3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRTC3 Gene

Disorders for CRTC3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CRTC3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
human t-cell leukemia virus type 1
  • htlv-1
mucoepidermoid carcinoma
  • mec
warthin tumor
  • adenolymphoma
- elite association - COSMIC cancer census association via MalaCards
Search CRTC3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CRTC3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CRTC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRTC3 Gene

Publications for CRTC3 Gene

  1. Enhanced activation of tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3. (PMID: 15466468) Koga H … Shimotohno K (The Journal of biological chemistry 2004) 3 4 22 58
  2. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. (PMID: 14506290) Iourgenko V … Labow MA (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4 58
  3. TORCs: transducers of regulated CREB activity. (PMID: 14536081) Conkright MD … Montminy M (Molecular cell 2003) 2 3 4 58
  4. Whole genome association scan for genetic polymorphisms influencing information processing speed. (PMID: 21130836) Luciano M … Deary IJ (Biological psychology 2011) 3 44 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for CRTC3 Gene

Sources for CRTC3 Gene

Content
Loading form....