Aliases for CRTC1 Gene
External Ids for CRTC1 Gene
Previous HGNC Symbols for CRTC1 Gene
Previous GeneCards Identifiers for CRTC1 Gene
GeneCards Summary for CRTC1 Gene
CRTC1 (CREB Regulated Transcription Coactivator 1) is a Protein Coding gene. Diseases associated with CRTC1 include Mucoepidermoid Carcinoma and Cutaneous Mucoepidermoid Carcinoma. Among its related pathways are BMAL1-CLOCK,NPAS2 activates circadian gene expression and Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include cAMP response element binding protein binding. An important paralog of this gene is CRTC2.
UniProtKB/Swiss-Prot Summary for CRTC1 Gene
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.
(Microbial infection) Plays a role of coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).