Aliases for CRTC1 Gene

Aliases for CRTC1 Gene

  • CREB Regulated Transcription Coactivator 1 2 3 5
  • Mucoepidermoid Carcinoma Translocated Protein 1 3 4
  • CREB-Regulated Transcription Coactivator 1 3 4
  • TORC-1 3 4
  • WAMTP1 3 4
  • MECT1 3 4
  • TORC1 3 4
  • Transducer Of Regulated CAMP Response Element-Binding Protein (CREB) 1 3
  • Transducer Of Regulated CAMP Response Element-Binding Protein 1 4
  • Transducer Of Regulated CAMP Response Element-Binding Protein 2
  • Mucoepidermoid Carcinoma Translocated 1 2
  • Transducer Of CREB Protein 1 4
  • Mastermind-Like Protein 2 3
  • KIAA0616 4
  • MAML2 3
  • Mam-2 3

External Ids for CRTC1 Gene

Previous HGNC Symbols for CRTC1 Gene

  • MECT1

Previous GeneCards Identifiers for CRTC1 Gene

  • GC19P018656
  • GC19P018794
  • GC19P018417
  • GC19P020502
  • GC19P020645
  • GC19P018811
  • GC19P018813
  • GC19P019037
  • GC19P019352
  • GC19P019683
  • GC19P020053
  • GC19P020363

Summaries for CRTC1 Gene

GeneCards Summary for CRTC1 Gene

CRTC1 (CREB Regulated Transcription Coactivator 1) is a Protein Coding gene. Diseases associated with CRTC1 include Mucoepidermoid Carcinoma and Cutaneous Mucoepidermoid Carcinoma. Among its related pathways are BMAL1-CLOCK,NPAS2 activates circadian gene expression and Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include cAMP response element binding protein binding. An important paralog of this gene is CRTC2.

UniProtKB/Swiss-Prot Summary for CRTC1 Gene

  • Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.
  • (Microbial infection) Plays a role of coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

Gene Wiki entry for CRTC1 Gene

Additional gene information for CRTC1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CRTC1 Gene

Genomics for CRTC1 Gene

GeneHancer (GH) Regulatory Elements for CRTC1 Gene

Promoters and enhancers for CRTC1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CRTC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CRTC1 gene promoter:
  • CREB
  • deltaCREB
  • GCNF
  • GCNF-1
  • GCNF-2
  • Max1
  • SRF
  • SRF (504 AA)

Genomic Locations for CRTC1 Gene

Genomic Locations for CRTC1 Gene
chr19:18,683,615-18,782,333
(GRCh38/hg38)
Size:
98,719 bases
Orientation:
Plus strand
chr19:18,794,425-18,893,143
(GRCh37/hg19)
Size:
98,719 bases
Orientation:
Plus strand

Genomic View for CRTC1 Gene

Genes around CRTC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRTC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRTC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRTC1 Gene

Proteins for CRTC1 Gene

  • Protein details for CRTC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UUV9-CRTC1_HUMAN
    Recommended name:
    CREB-regulated transcription coactivator 1
    Protein Accession:
    Q6UUV9
    Secondary Accessions:
    • A6NMG5
    • O75114
    • Q6Y3A3
    • Q7LDZ2
    • Q8IUL3
    • Q8IZ34
    • Q8IZL1
    • Q8N6W3
    • Q96AI8
    • Q9H801

    Protein attributes for CRTC1 Gene

    Size:
    634 amino acids
    Molecular mass:
    67300 Da
    Quaternary structure:
    • Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1 (PubMed:14536081). 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction (PubMed:14536081). Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1 (PubMed:14536081). Interacts with 14-3-3 proteins, including YWHAE/14-3-3 epsilon (PubMed:30611118). Interacts with calmodulin-dependent catalytic subunit PPP3CA/calcineurin A (PubMed:30611118).
    • (Microbial infection) Interacts with HTLV1 Tax.
    SequenceCaution:
    • Sequence=AAH17075.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH23614.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP12463.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CRTC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRTC1 Gene

Post-translational modifications for CRTC1 Gene

  • Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation is mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1 (By similarity).
  • Ubiquitination at Lys47
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for CRTC1
  • Boster Bio Antibodies for CRTC1

No data available for DME Specific Peptides for CRTC1 Gene

Domains & Families for CRTC1 Gene

Gene Families for CRTC1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for CRTC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CRTC1 Gene

GenScript: Design optimal peptide antigens:
  • Transducer of regulated cAMP response element-binding protein 1 (CRTC1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6UUV9

UniProtKB/Swiss-Prot:

CRTC1_HUMAN :
  • Belongs to the TORC family.
Family:
  • Belongs to the TORC family.
genes like me logo Genes that share domains with CRTC1: view

Function for CRTC1 Gene

Molecular function for CRTC1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Plays a role of coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).

Phenotypes From GWAS Catalog for CRTC1 Gene

Gene Ontology (GO) - Molecular Function for CRTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14506290
GO:0008140 cAMP response element binding protein binding IDA,IBA 14536081
genes like me logo Genes that share ontologies with CRTC1: view
genes like me logo Genes that share phenotypes with CRTC1: view

Animal Models for CRTC1 Gene

MGI Knock Outs for CRTC1:
  • Crtc1 Crtc1<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for CRTC1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRTC1 Gene

Localization for CRTC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRTC1 Gene

Cytoplasm. Nucleus. Note=Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins (PubMed:16817901). Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels (PubMed:15589160). Light stimulation triggers a nuclear accumulation in the suprachiasmatic nucleus (SCN) of the brain (By similarity). {ECO:0000250 UniProtKB:Q68ED7, ECO:0000269 PubMed:15589160, ECO:0000269 PubMed:16817901}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRTC1 gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CRTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 14506290
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IBA 21873635
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with CRTC1: view

Pathways & Interactions for CRTC1 Gene

genes like me logo Genes that share pathways with CRTC1: view

SIGNOR curated interactions for CRTC1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CRTC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007613 memory IEA --
GO:0016032 viral process IEA --
GO:0032793 positive regulation of CREB transcription factor activity IEA,ISS --
GO:0043153 entrainment of circadian clock by photoperiod IEA,ISS --
GO:0045944 positive regulation of transcription by RNA polymerase II IDA,IEA 14536081
genes like me logo Genes that share ontologies with CRTC1: view

Drugs & Compounds for CRTC1 Gene

(10) Drugs for CRTC1 Gene - From: ApexBio, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Approved Nutra 7773
cyclic amp Experimental Pharma 0
QL-IX-55 Pharma TORC1/TORC2 inhibitor 0
BEZ235 Pharma Inhibition, inhibitor PI3K/mTOR inhibitor, Kinase Inhibitors, Phosphatidylinositol-3- kinase (PI-3K) inhibitors, PI3K/mTOR Inhibitors 0
DS-3078a Pharma Inhibition, inhibitor TORC1/2 kinase inhibitor 0

(1) ApexBio Compounds for CRTC1 Gene

Compound Action Cas Number
QL-IX-55 TORC1/TORC2 inhibitor 1223002-54-7
genes like me logo Genes that share compounds with CRTC1: view

Transcripts for CRTC1 Gene

mRNA/cDNA for CRTC1 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for CRTC1

Alternative Splicing Database (ASD) splice patterns (SP) for CRTC1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b
SP1:
SP2:
SP3: - - - -
SP4: -
SP5: - - -
SP6:

Relevant External Links for CRTC1 Gene

GeneLoc Exon Structure for
CRTC1
ECgene alternative splicing isoforms for
CRTC1

Expression for CRTC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRTC1 Gene

mRNA differential expression in normal tissues according to GTEx for CRTC1 Gene

This gene is overexpressed in Brain - Cerebellum (x5.2) and Brain - Cerebellar Hemisphere (x4.0).

Protein differential expression in normal tissues from HIPED for CRTC1 Gene

This gene is overexpressed in Frontal cortex (13.0), Placenta (11.9), CD8 Tcells (7.1), CD4 Tcells (6.6), and Testis (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CRTC1 Gene



Protein tissue co-expression partners for CRTC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CRTC1 Gene:

CRTC1

SOURCE GeneReport for Unigene cluster for CRTC1 Gene:

Hs.371096

mRNA Expression by UniProt/SwissProt for CRTC1 Gene:

Q6UUV9-CRTC1_HUMAN
Tissue specificity: Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney.

Evidence on tissue expression from TISSUES for CRTC1 Gene

  • Nervous system(4.7)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with CRTC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRTC1 Gene

Orthologs for CRTC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRTC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRTC1 33 32
  • 99.37 (n)
OneToOne
dog
(Canis familiaris)
Mammalia -- 33
  • 92 (a)
OneToMany
CRTC1 32
  • 90.02 (n)
-- 33
  • 81 (a)
OneToMany
-- 33
  • 65 (a)
OneToMany
cow
(Bos Taurus)
Mammalia CRTC1 33 32
  • 91.46 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Crtc1 17 33 32
  • 85.27 (n)
rat
(Rattus norvegicus)
Mammalia Crtc1 32
  • 84.8 (n)
oppossum
(Monodelphis domestica)
Mammalia CRTC1 33
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRTC1 33
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves CRTC1 33 32
  • 78.11 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crtc1 32
  • 72.19 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12669 32
zebrafish
(Danio rerio)
Actinopterygii LOC101886240 32
  • 68.18 (n)
crtc1a 33
  • 68 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4116 33
  • 39 (a)
OneToOne
Species where no ortholog for CRTC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRTC1 Gene

ENSEMBL:
Gene Tree for CRTC1 (if available)
TreeFam:
Gene Tree for CRTC1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CRTC1: view image

Paralogs for CRTC1 Gene

Paralogs for CRTC1 Gene

(2) SIMAP similar genes for CRTC1 Gene using alignment to 3 proteins:

  • CRTC1_HUMAN
  • M0QX46_HUMAN
  • M0QXN6_HUMAN

Pseudogenes.org Pseudogenes for CRTC1 Gene

genes like me logo Genes that share paralogs with CRTC1: view

Variants for CRTC1 Gene

Sequence variations from dbSNP and Humsavar for CRTC1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs537572167 likely-benign, Multiple Epiphyseal Dysplasia, Dominant, Pseudoachondroplastic spondyloepiphyseal dysplasia syndrome 18,782,760(+) C/G downstream_transcript_variant
rs886054301 uncertain-significance, Pseudoachondroplastic spondyloepiphyseal dysplasia syndrome, Multiple Epiphyseal Dysplasia, Dominant 18,782,804(+) T/C downstream_transcript_variant
rs9407 likely-benign, Pseudoachondroplastic spondyloepiphyseal dysplasia syndrome, Multiple Epiphyseal Dysplasia, Dominant 18,782,823(+) C/T downstream_transcript_variant
rs1000072022 -- 18,721,318(+) C/T intron_variant
rs1000077770 -- 18,716,061(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CRTC1 Gene

Variant ID Type Subtype PubMed ID
dgv1728n106 CNV duplication 24896259
esv2610416 CNV insertion 19546169
esv2674391 CNV deletion 23128226
esv3343198 CNV insertion 20981092
esv3366303 CNV duplication 20981092
esv3643842 CNV loss 21293372
esv3643844 CNV loss 21293372
esv999375 CNV insertion 20482838
nsv1113983 CNV deletion 24896259
nsv1123231 CNV deletion 24896259
nsv1151217 CNV deletion 26484159
nsv2431 CNV insertion 18451855
nsv2433 CNV insertion 18451855
nsv833777 CNV loss 17160897
nsv952422 CNV deletion 24416366

Variation tolerance for CRTC1 Gene

Residual Variation Intolerance Score: 6.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.53; 77.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRTC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRTC1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRTC1 Gene

Disorders for CRTC1 Gene

MalaCards: The human disease database

(16) MalaCards diseases for CRTC1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mucoepidermoid carcinoma
  • mec
cutaneous mucoepidermoid carcinoma
  • mucoepidermoid carcinoma of skin
clear cell hidradenoma
  • eccrine acrospiroma
salivary gland carcinoma
  • salivary gland cancer
lacrimal gland mucoepidermoid carcinoma
  • mucoepidermoid carcinoma of the lacrimal gland
- elite association - COSMIC cancer census association via MalaCards
Search CRTC1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CRTC1_HUMAN
  • Note=A chromosomal aberration involving CRTC1 is found in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. Translocation t(11;19)(q21;p13) with MAML2. The fusion protein consists of the N-terminus of CRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of CRTC1 has been detected in a small number of mucoepidermoid carcinomas.

Additional Disease Information for CRTC1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CRTC1: view

No data available for Genatlas for CRTC1 Gene

Publications for CRTC1 Gene

  1. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. (PMID: 14506290) Iourgenko V … Labow MA (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4 23 56
  2. Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins. (PMID: 15589160) Bittinger MA … Labow M (Current biology : CB 2004) 3 4 23 56
  3. TORCs: transducers of regulated CREB activity. (PMID: 14536081) Conkright MD … Montminy M (Molecular cell 2003) 2 3 4 56
  4. t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. (PMID: 12539049) Tonon G … Kaye FJ (Nature genetics 2003) 2 3 4 56
  5. Clock and light regulation of the CREB coactivator CRTC1 in the suprachiasmatic circadian clock. (PMID: 23699513) Sakamoto K … Obrietan K (The Journal of neuroscience : the official journal of the Society for Neuroscience 2013) 3 4 56

Products for CRTC1 Gene

Sources for CRTC1 Gene