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CRTC1 (CREB Regulated Transcription Coactivator 1) is a Protein Coding gene. Diseases associated with CRTC1 include Mucoepidermoid Carcinoma and Cutaneous Mucoepidermoid Carcinoma. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial Gene Expression. Gene Ontology (GO) annotations related to this gene include cAMP response element binding protein binding. An important paralog of this gene is CRTC2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 14506290 |
GO:0008140 | cAMP response element binding protein binding | IBA,IDA | 14536081 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 14506290 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IEA,IBA | 21873635 |
GO:0005829 | cytosol | IDA | -- |
GO:0005886 | plasma membrane | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | BMAL1-CLOCK,NPAS2 activates circadian gene expression |
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2 | Mitochondrial Gene Expression | ||
3 | Mesodermal Commitment Pathway | ||
4 | Glucose / Energy Metabolism | ||
5 | Human T-cell leukemia virus 1 infection |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007613 | memory | IEA | -- |
GO:0016032 | viral process | IEA | -- |
GO:0032793 | positive regulation of CREB transcription factor activity | IEA,ISS | -- |
GO:0043153 | entrainment of circadian clock by photoperiod | IEA,ISS | -- |
GO:0045944 | positive regulation of transcription by RNA polymerase II | IEA,IDA | 14536081 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
cyclic amp | Experimental | Pharma | 0 | |||
BEZ235 | Pharma | Inhibition, inhibitor | PI3K/mTOR inhibitor, Kinase Inhibitors, Phosphatidylinositol-3- kinase (PI-3K) inhibitors, PI3K/mTOR Inhibitors | 0 | ||
DS-3078a | Pharma | Inhibition, inhibitor | TORC1/2 kinase inhibitor | 0 | ||
DS-7423 | Pharma | inhibitor, Biomarker | PI3K/mTOR inhibitor, PI3K/mTOR Inhibitors | 0 | ||
INK128 | Pharma | inhibitor | 0 |
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||||
SP6: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CRTC1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
CRTC1 30 |
|
||||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | CRTC1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Crtc1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Crtc1 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | CRTC1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CRTC1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CRTC1 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | crtc1 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.12669 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC101886240 30 |
|
||
crtc1a 31 |
|
OneToOne | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4116 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
708132 | Likely Benign: not provided | 18,777,217(+) | T/G | SYNONYMOUS_VARIANT | |
748565 | Likely Benign: not provided | 18,760,017(+) | G/A | SYNONYMOUS_VARIANT | |
751822 | Likely Benign: not provided | 18,742,927(+) | C/T | SYNONYMOUS_VARIANT | |
753883 | Likely Benign: not provided | 18,747,094(+) | C/T | SYNONYMOUS_VARIANT | |
788467 | Benign: not provided | 18,760,188(+) | G/A | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1728n106 | CNV | duplication | 24896259 |
esv2610416 | CNV | insertion | 19546169 |
esv2674391 | CNV | deletion | 23128226 |
esv3343198 | CNV | insertion | 20981092 |
esv3366303 | CNV | duplication | 20981092 |
esv3643842 | CNV | loss | 21293372 |
esv3643844 | CNV | loss | 21293372 |
esv999375 | CNV | insertion | 20482838 |
nsv1113983 | CNV | deletion | 24896259 |
nsv1123231 | CNV | deletion | 24896259 |
nsv1151217 | CNV | deletion | 26484159 |
nsv2431 | CNV | insertion | 18451855 |
nsv2433 | CNV | insertion | 18451855 |
nsv833777 | CNV | loss | 17160897 |
nsv952422 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
mucoepidermoid carcinoma |
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cutaneous mucoepidermoid carcinoma |
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clear cell hidradenoma |
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hidradenoma |
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human t-cell leukemia virus type 1 |
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