Aliases for CRTC1 Gene
Aliases for CRTC1 Gene
External Ids for CRTC1 Gene
- HGNC: 16062
- Entrez Gene: 23373
- Ensembl: ENSG00000105662
- OMIM: 607536
- UniProtKB: Q6UUV9
Previous HGNC Symbols for CRTC1 Gene
- MECT1
Previous GeneCards Identifiers for CRTC1 Gene
- GC19P018656
- GC19P018794
- GC19P018417
- GC19P018811
- GC19P018813
- GC19P019037
- GC19P019352
- GC19P019683
Summaries for CRTC1 Gene
GeneCards Summary for CRTC1 Gene
CRTC1 (CREB Regulated Transcription Coactivator 1) is a Protein Coding gene. Diseases associated with CRTC1 include Mucoepidermoid Carcinoma and Cutaneous Mucoepidermoid Carcinoma. Among its related pathways are Organelle biogenesis and maintenance and BMAL1-CLOCK,NPAS2 activates circadian gene expression. Gene Ontology (GO) annotations related to this gene include cAMP response element binding protein binding. An important paralog of this gene is CRTC2.
UniProtKB/Swiss-Prot for CRTC1 Gene
-
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 Ser-133 phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.
Additional gene information for CRTC1 Gene
- Monarch Initiative
- Search for CRTC1 at DataMed
- Search for CRTC1 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRTC1 Gene
Genomics for CRTC1 Gene
GeneHancer (GH) Regulatory Elements for CRTC1 Gene
Promoters and enhancers for CRTC1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around CRTC1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CRTC1 gene promoter:
-
- deltaCREB
- CREB
- SRF
- SRF (504 AA)
- GCNF-2
- GCNF-1
- GCNF
- Max1
Regulatory Element Products
Genomic Locations for CRTC1 Gene
Genomic Locations for CRTC1 Gene
- chr19:18,683,615-18,782,333
- (GRCh38/hg38)
- Size:
- 98,719 bases
- Orientation:
- Plus strand
- chr19:18,794,425-18,893,143
- (GRCh37/hg19)
- Size:
- 98,719 bases
- Orientation:
- Plus strand
Genomic View for CRTC1 Gene
Genes around CRTC1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.11 by Entrez Gene
- 19p13.11 by HGNC
- 19p13.11 by Ensembl
CRTC1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CRTC1 Gene
Proteins for CRTC1 Gene
-
Protein details for CRTC1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6UUV9-CRTC1_HUMAN
- Recommended name:
- CREB-regulated transcription coactivator 1
- Protein Accession:
- Q6UUV9
- A6NMG5
- O75114
- Q6Y3A3
- Q7LDZ2
- Q8IUL3
- Q8IZ34
- Q8IZL1
- Q8N6W3
- Q96AI8
- Q9H801
Protein attributes for CRTC1 Gene
- Size:
- 634 amino acids
- Molecular mass:
- 67300 Da
- Quaternary structure:
-
- Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1 (PubMed:14536081). Arg-314 in the bZIP domain of CREB1 is essential for this interaction (PubMed:14536081). Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1 (PubMed:14536081). Binds HTLV1 Tax. Interacts with 14-3-3 proteins (By similarity).
- SequenceCaution:
-
- Sequence=AAH17075.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH23614.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP12463.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for CRTC1 Gene
Post-translational modifications for CRTC1 Gene
- Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation is mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1 (By similarity).
- Ubiquitination at Lys47
- Modification sites at PhosphoSitePlus
Other Protein References for CRTC1 Gene
Antibody Products
- R&D Systems Antibodies for CRTC1 (TORC1)
-
Custom Antibody ServicesOriGene Antibodies for CRTC1
- Novus Biologicals Antibodies for CRTC1
-
Abcam antibodies for CRTC1
- Invitrogen Antibodies for CRTC1
- GeneTex CRTC1 Antibody for CRTC1
-
Santa Cruz Biotechnology (SCBT) Antibodies for CRTC1
Protein Products
-
OriGene Purified Proteins for CRTC1
- Search Origene for MassSpec and Protein Over-expression Lysates for CRTC1
- Origene Custom Protein Services for CRTC1
- antibodies-online: Search results for 7 available CRTC1 Proteins ranked by validation data
- Compare Top CRTC1 Proteins
-
Quality Products:
- Search GeneTex for Proteins for CRTC1
-
Abcam proteins for CRTC1
Assay Products
No data available for DME Specific Peptides for CRTC1 Gene
Domains & Families for CRTC1 Gene
Gene Families for CRTC1 Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for CRTC1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q6UUV9- Family:
-
- Belongs to the TORC family.
Function for CRTC1 Gene
Molecular function for CRTC1 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 Ser-133 phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.
Phenotypes From GWAS Catalog for CRTC1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 14506290 |
| GO:0008140 | cAMP response element binding protein binding | IDA | 14536081 |
Phenotypes for CRTC1 Gene
- MGI mutant phenotypes for CRTC1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CRTC1:
Animal Models for CRTC1 Gene
- MGI Knock Outs for CRTC1:
-
- Crtc1 Crtc1<tm1a(EUCOMM)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CRTC1
-
CRISPR Products
-
OriGene CRISPR knockouts for CRTC1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CRTC1
- genomics-online: gRNA clones - Search results for 94 available CRTC1 gene related products
- Overview of 94 available CRTC1 gene related products
- Applied Biological Materials CRISPR for CRTC1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CRTC1
- GenScript: Design CRISPR guide RNA sequences for CRTC1
miRNA for CRTC1 Gene
- miRTarBase miRNAs that target CRTC1
-
- hsa-mir-125b-5p (MIRT045900)
- hsa-mir-4638-3p (MIRT507621)
- hsa-mir-4787-3p (MIRT507622)
- hsa-mir-132-3p (MIRT507623)
- hsa-mir-212-3p (MIRT507624)
- hsa-mir-4696 (MIRT540388)
- hsa-mir-520f-5p (MIRT540389)
- hsa-mir-3675-3p (MIRT540390)
- hsa-mir-451b (MIRT540391)
- hsa-mir-3667-5p (MIRT540392)
- hsa-mir-3120-3p (MIRT540393)
- hsa-mir-7111-3p (MIRT718101)
- hsa-mir-654-5p (MIRT718102)
- hsa-mir-541-3p (MIRT718103)
- hsa-mir-6862-5p (MIRT718104)
- hsa-mir-4253 (MIRT718105)
- hsa-mir-3945 (MIRT718106)
- hsa-mir-324-5p (MIRT718107)
- hsa-mir-6134 (MIRT718108)
- hsa-mir-6845-3p (MIRT718109)
- hsa-mir-6769b-3p (MIRT718110)
- hsa-mir-3183 (MIRT718111)
- hsa-mir-4723-3p (MIRT718112)
- hsa-mir-5193 (MIRT718113)
- hsa-mir-4667-3p (MIRT718114)
- hsa-mir-1470 (MIRT718115)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CRTC1
- Browse OriGene Inhibitory RNA Products For CRTC1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRTC1
- genomics-online: shRNA clones - Search results for 94 available CRTC1 gene related products
- Overview of 94 available CRTC1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CRTC1
- VectorBuilder custom plasmid, inducible vectors for CRTC1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CRTC1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CRTC1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRTC1
- Applied Biological Materials Clones for CRTC1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CRTC1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRTC1 Gene
Localization for CRTC1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CRTC1 Gene
- Cytoplasm. Nucleus. Note=Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins (PubMed:16817901). Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels (PubMed:15589160). Light stimulation triggers a nuclear accumulation in the suprachiasmatic nucleus (SCN) of the brain (By similarity). {ECO:0000250 UniProtKB:Q68ED7, ECO:0000269 PubMed:15589160, ECO:0000269 PubMed:16817901}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| cytosol | 5 |
- Cytosol (3)
- Nuclear bodies (3)
- Nucleoplasm (3)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 14506290 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA,IBA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0005886 | plasma membrane | IDA | -- |
Pathways & Interactions for CRTC1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | BMAL1-CLOCK,NPAS2 activates circadian gene expression |
.68
|
|
| 2 | Mitochondrial Gene Expression | ||
| 3 | Mesodermal Commitment Pathway | ||
| 4 | HTLV-I infection | ||
| 5 | Glucose / Energy Metabolism | ||
Pathways by source for CRTC1 Gene
4 BioSystems pathways for CRTC1 Gene
1 KEGG pathway for CRTC1 Gene
1 Cell Signaling Technology pathway for CRTC1 Gene
Interacting Proteins for CRTC1 Gene
Selected Interacting proteins:
Q6UUV9-CRTC1_HUMAN
ENSP00000345001
for CRTC1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CRTC1
SIGNOR curated interactions for CRTC1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007613 | memory | IEA | -- |
| GO:0016032 | viral process | IEA | -- |
| GO:0032793 | positive regulation of CREB transcription factor activity | IEA,ISS | -- |
Drugs & Compounds for CRTC1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| calcium | Approved | Nutra | 0 | |||
| cyclic amp | Experimental | Pharma | 0 | |||
| QL-IX-55 | Pharma | TORC1/TORC2 inhibitor | 0 | |||
| BEZ235 | Pharma | Inhibition, inhibitor | PI3K/mTOR inhibitor, Kinase Inhibitors, Phosphatidylinositol-3- kinase (PI-3K) inhibitors, PI3K/mTOR Inhibitors | 0 | ||
| DS-3078a | Pharma | Inhibition, inhibitor | TORC1/2 kinase inhibitor | 0 |
Drug Products
Transcripts for CRTC1 Gene
mRNA/cDNA for CRTC1 Gene
- (13) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (173) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000321949 2501 bps (uc002nkb.5)
- ENST00000338797 6929 bps (uc010ebv.4)
- ENST00000594658 2384 bps (uc060vtw.1)
- ENST00000601916 1834 bps (uc060vtx.1)
Unigene Clusters for CRTC1 Gene
- CREB regulated transcription coactivator 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for CRTC1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CRTC1
- genomics-online: gRNA clones - Search results for 94 available CRTC1 gene related products
- Overview of 94 available CRTC1 gene related products
- Applied Biological Materials CRISPR for CRTC1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CRTC1
- GenScript: Design CRISPR guide RNA sequences for CRTC1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CRTC1
- Browse OriGene Inhibitory RNA Products For CRTC1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRTC1
- genomics-online: shRNA clones - Search results for 94 available CRTC1 gene related products
- Overview of 94 available CRTC1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CRTC1
- VectorBuilder custom plasmid, inducible vectors for CRTC1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CRTC1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CRTC1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRTC1
- Applied Biological Materials Clones for CRTC1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||
| SP6: |
Expression for CRTC1 Gene
mRNA differential expression in normal tissues according to GTEx for CRTC1 Gene
This gene is overexpressed in Brain - Cerebellum (x5.2) and Brain - Cerebellar Hemisphere (x4.0).
This gene is overexpressed in Frontal cortex (13.0), Placenta (11.9), CD8 Tcells (7.1), CD4 Tcells (6.6), and Testis (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CRTC1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CRTC1 Gene:
CRTC1SOURCE GeneReport for Unigene cluster for CRTC1 Gene:
Hs.371096mRNA Expression by UniProt/SwissProt for CRTC1 Gene:
Q6UUV9-CRTC1_HUMAN
Tissue specificity:
Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney.
Evidence on tissue expression from TISSUES for CRTC1 Gene
- Nervous system(4.7)
- Liver(4.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for CRTC1
-
OriGene qPCR primer pairs for CRTC1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRTC1 Gene
Orthologs for CRTC1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CRTC1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | -- 34 |
|
OneToMany | |
| CRTC1 33 |
|
||||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | CRTC1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Crtc1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Crtc1 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CRTC1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CRTC1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CRTC1 34 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | crtc1 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.12669 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC101886240 33 |
|
||
| crtc1a 34 |
|
OneToOne | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4116 34 |
|
OneToOne |
- Species where no ortholog for CRTC1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for CRTC1 Gene
- ENSEMBL:
- Gene Tree for CRTC1 (if available)
- TreeFam:
- Gene Tree for CRTC1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CRTC1: view image
Paralogs for CRTC1 Gene
(2) SIMAP similar genes for CRTC1 Gene using alignment to 3 proteins:
- CRTC1_HUMAN
- M0QX46_HUMAN
- M0QXN6_HUMAN
Pseudogenes.org Pseudogenes for CRTC1 Gene
Variants for CRTC1 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs537572167 | likely-benign, Multiple Epiphyseal Dysplasia, Dominant, Pseudoachondroplastic spondyloepiphyseal dysplasia syndrome | 18,782,760(+) | C/G | downstream_transcript_variant | |
| rs886054301 | uncertain-significance, Pseudoachondroplastic spondyloepiphyseal dysplasia syndrome, Multiple Epiphyseal Dysplasia, Dominant | 18,782,804(+) | T/C | downstream_transcript_variant | |
| rs9407 | likely-benign, Pseudoachondroplastic spondyloepiphyseal dysplasia syndrome, Multiple Epiphyseal Dysplasia, Dominant | 18,782,823(+) | C/T | downstream_transcript_variant | |
| rs1000072022 | -- | 18,721,318(+) | C/T | intron_variant | |
| rs1000077770 | -- | 18,716,061(+) | A/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1728n106 | CNV | duplication | 24896259 |
| esv2610416 | CNV | insertion | 19546169 |
| esv2674391 | CNV | deletion | 23128226 |
| esv3343198 | CNV | insertion | 20981092 |
| esv3366303 | CNV | duplication | 20981092 |
| esv3643842 | CNV | loss | 21293372 |
| esv3643844 | CNV | loss | 21293372 |
| esv999375 | CNV | insertion | 20482838 |
| nsv1113983 | CNV | deletion | 24896259 |
| nsv1123231 | CNV | deletion | 24896259 |
| nsv1151217 | CNV | deletion | 26484159 |
| nsv2431 | CNV | insertion | 18451855 |
| nsv2433 | CNV | insertion | 18451855 |
| nsv833777 | CNV | loss | 17160897 |
| nsv952422 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
6.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.53;
77.78% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CRTC1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CRTC1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRTC1 Gene
Disorders for CRTC1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mucoepidermoid carcinoma |
|
|
| cutaneous mucoepidermoid carcinoma |
|
|
| clear cell hidradenoma |
|
|
| lacrimal gland mucoepidermoid carcinoma |
|
|
| human t-cell leukemia virus type 1 |
|
|
Search CRTC1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
CRTC1_HUMAN- Note=A chromosomal aberration involving CRTC1 is found in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. Translocation t(11;19)(q21;p13) with MAML2. The fusion protein consists of the N-terminus of CRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of CRTC1 has been detected in a small number of mucoepidermoid carcinomas.
Additional Disease Information for CRTC1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for CRTC1 Gene
Publications for CRTC1 Gene
- Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. (PMID: 14506290) Iourgenko V … Labow MA (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4 22 58
- Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins. (PMID: 15589160) Bittinger MA … Labow M (Current biology : CB 2004) 3 4 22 58
- TORCs: transducers of regulated CREB activity. (PMID: 14536081) Conkright MD … Montminy M (Molecular cell 2003) 2 3 4 58
- t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. (PMID: 12539049) Tonon G … Kaye FJ (Nature genetics 2003) 2 3 4 58
- Clock and light regulation of the CREB coactivator CRTC1 in the suprachiasmatic circadian clock. (PMID: 23699513) Sakamoto K … Obrietan K (The Journal of neuroscience : the official journal of the Society for Neuroscience 2013) 3 4 58
Products for CRTC1 Gene
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- VectorBuilder custom plasmid, inducible vectors for CRTC1
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- Yeast expression
- Addgene plasmids for CRTC1
- antibodies-online: Search results for 79 available CRTC1 Antibodies ranked by validation data
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- antibodies-online: Search results for available CRTC1 related products ranked by validation data
- antibodies-online: Search results for 7 available CRTC1 Proteins ranked by validation data
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- Quality Products:
- GeneTex CRTC1 Antibody for CRTC1
- Search GeneTex for Proteins for CRTC1
- Santa Cruz Biotechnology (SCBT) Antibodies for CRTC1
- Search Santa Cruz Biotechnology (SCBT) for CRTC1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CRTC1
- Horizon Cell Lines for CRTC1
- genomics-online: cdna clones - Search results for 94 available CRTC1 gene related products
- Overview of 94 available CRTC1 gene related products
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- Overview of 94 available CRTC1 gene related products
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- Overview of 94 available CRTC1 gene related products
- genomics-online: shRNA clones - Search results for 94 available CRTC1 gene related products
- Overview of 94 available CRTC1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CRTC1
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- GeneCopoeia miRNA 3'UTR Target clone products for CRTC1
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Sources for CRTC1 Gene
- (1) GeneCards
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- (68) Cloud-Clone Corp.
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- (72) neXtProt
- (73) Reactome
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