Free for academic non-profit institutions. Other users need a Commercial license
The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 [PubMed 18329370]).[supplied by OMIM, Feb 2009] See more...
Aliases for CRTAM Gene
Aliases for CRTAM Gene
External Ids for CRTAM Gene
- HGNC: 24313
- NCBI Entrez Gene: 56253
- Ensembl: ENSG00000109943
- OMIM®: 612597
- UniProtKB/Swiss-Prot: O95727
Previous GeneCards Identifiers for CRTAM Gene
- GC11P124710
- GC11P124222
- GC11P122743
- GC11P122246
- GC11P122214
- GC11P118652
Summaries for CRTAM Gene
-
The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 [PubMed 18329370]).[supplied by OMIM, Feb 2009]
GeneCards Summary for CRTAM Gene
CRTAM (Cytotoxic And Regulatory T Cell Molecule) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An important paralog of this gene is CADM2.
UniProtKB/Swiss-Prot Summary for CRTAM Gene
-
Mediates heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets (By similarity). Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952). Regulates CD8+ T-cell proliferation in response to T-cell receptor (TCR) activation (By similarity). Appears to be dispensable for CD8+ T-cell-mediated cytotoxicity (By similarity). Interaction with SCRIB promotes the late phase of cellular polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG, IL17 and IL22 production (By similarity). By interacting with CADM1 on CD8+ dendritic cells, regulates the retention of activated CD8+ T-cells within the draining lymph node (By similarity). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity). Interaction with CADM1 promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity).
Additional gene information for CRTAM Gene
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CRTAM Gene
Genomics for CRTAM Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CRTAM Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH11J122837 | Promoter/Enhancer | 1.4 | EPDnew Ensembl ENCODE dbSUPER | 250.7 | +0.1 | 90 | 1 | JUND ATF2 JUN CREB1 ATF3 EGR2 ZBTB17 ATF7 CTCF ZFHX2 | CRTAM JHY ENSG00000285909 | |
| GH11J122839 | Enhancer | 0.3 | ENCODE dbSUPER | 250.7 | +1.8 | 1759 | 1.6 | CRTAM JHY ENSG00000285909 | ||
| GH11J122882 | Promoter/Enhancer | 1.5 | Ensembl ENCODE CraniofacialAtlas | 19.2 | +44.9 | 44882 | 2.2 | ZNF207 POLR2A ZIC2 ZNF592 ZNF341 SIN3A ELF1 FOXA2 MAFF SP2 | JHY CRTAM BSX RF00017-958 | |
| GH11J122748 | Enhancer | 1.1 | FANTOM5 ENCODE dbSUPER | 15.7 | -89.3 | -89294 | 1.2 | ZNF316 EBF1 NFE2 MAX BATF MAFK MAFG BACH1 SP1 PKNOX1 | CRTAM ENSG00000239079 UBASH3B HSALNG0087791 | |
| GH11J122812 | Enhancer | 0.7 | Ensembl ENCODE | 22.9 | -25.3 | -25318 | 4.2 | POLR2A SMC3 CTCF RAD21 NANOG USF1 CEBPB EZH2 | CRTAM JHY lnc-BSX-1 HSALNG0087793 HSALNG0087792 ENSG00000285909 UBASH3B |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CRTAM on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CRTAM
- Top Transcription factor binding sites by QIAGEN in the CRTAM gene promoter:
-
- AML1a
- IRF-1
- IRF-2
- NF-kappaB
- NF-kappaB1
- NF-kappaB2
- Nkx2-5
- RORalpha1
Genomic Locations for CRTAM Gene
Latest Assembly
- chr11:122,838,419-122,872,643
- (GRCh38/hg38)
- Size:
- 34,225 bases
- Orientation:
- Plus strand
Previous Assembly
- chr11:122,709,208-122,743,351
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 34,144 bases
- Orientation:
- Plus strand
Genomic View for CRTAM Gene
Genes around CRTAM on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q24.1 by HGNC
- 11q24.1 by Entrez Gene
- 11q24.1 by Ensembl
CRTAM Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CRTAM Gene
Proteins for CRTAM Gene
-
Protein details for CRTAM Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95727-CRTAM_HUMAN
- Recommended name:
- Cytotoxic and regulatory T-cell molecule
- Protein Accession:
- O95727
- Q59EI1
- Q6IRX2
Protein attributes for CRTAM Gene
- Size:
- 393 amino acids
- Molecular mass:
- 44641 Da
- Quaternary structure:
-
- Monomer (PubMed:23583034). May form homodimer (via Ig-like V-type domain) (PubMed:23583034, PubMed:23871486). Interacts (via Ig-like V-type domain) with CADM1 (via Ig-like V-type domain); the interaction competes with CRTAM homodimerization and CADM1 homodimerization (PubMed:15781451, PubMed:15811952, PubMed:23871486). Interacts (via PDZ-binding motif) with SCRIB (via PDZ domain 3); the interaction promotes CRTAM and SCRIB polarization in a subset of CD4+ T-cells (By similarity).
- SequenceCaution:
-
- Sequence=BAD93067.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for CRTAM Gene
Post-translational modifications for CRTAM Gene
Other Protein References for CRTAM Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- Novus Biologicals Antibodies for CRTAM
-
Abcam antibodies for CRTAM
- Invitrogen Antibodies for CRTAM (AFLGC-CRTAM)
- antibodies-online: Show 3 available CRTAM Antibodies ranked by validation data
- Compare Top CRTAM Antibodies
-
Recommended
- 29 WB Antibodies (anti-human)
- 19 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 BCA Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 12 IF (p) Antibodies (anti-mouse)
- 4 WB Antibodies (anti-mouse)
- 3 FACS Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 1 ELISPOT (Detection) Antibody (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 4 WB Antibodies (anti-rat)
-
Boster Bio Antibodies for CRTAM
-
Santa Cruz Biotechnology (SCBT) Antibodies for CRTAM
- Sino Biological Antibodies for CRTAM
Protein products for research
-
OriGene Purified Proteins for CRTAM
- Search Origene for MassSpec and Protein Over-expression Lysates for CRTAM
- Origene Custom Protein Services for CRTAM
- Novus Biologicals lysates for CRTAM
- Sino Biological Recombinant Proteins for CRTAM
- Sino Biological Cell Lysates for CRTAM
- ProSpec Recombinant Proteins for CRTAM
-
Abcam proteins for CRTAM
Assay products for research
- RayBiotech Human CRTAM ELISA
- antibodies-online: Show 8 available CRTAM Elisa Kits ranked by validation data
- Compare Top CRTAM Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for CRTAM Gene
Domains & Families for CRTAM Gene
Gene Families for CRTAM Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- Predicted membrane proteins
Protein Domains for CRTAM Gene
Suggested Antigen Peptide Sequences for CRTAM Gene
- GenScript: Design optimal peptide antigens:
-
- Class-I MHC-restricted T-cell-associated molecule (CRTAM_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O95727UniProtKB/Swiss-Prot:
CRTAM_HUMAN :- The extracellular domain is required for the regulation of IFNG and IL22 production, but is dispensable for late T-cell polarization.
- Belongs to the nectin family.
- Domain:
-
- The extracellular domain is required for the regulation of IFNG and IL22 production, but is dispensable for late T-cell polarization.
- Family:
-
- Belongs to the nectin family.
Function for CRTAM Gene
Molecular function for CRTAM Gene
- UniProtKB/Swiss-Prot Function:
- Mediates heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets (By similarity). Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952). Regulates CD8+ T-cell proliferation in response to T-cell receptor (TCR) activation (By similarity). Appears to be dispensable for CD8+ T-cell-mediated cytotoxicity (By similarity). Interaction with SCRIB promotes the late phase of cellular polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG, IL17 and IL22 production (By similarity). By interacting with CADM1 on CD8+ dendritic cells, regulates the retention of activated CD8+ T-cells within the draining lymph node (By similarity). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity). Interaction with CADM1 promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity).
Phenotypes From GWAS Catalog for CRTAM Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | IPI | 15811952 |
| GO:0005515 | protein binding | IPI | -- |
| GO:0042802 | identical protein binding | IPI | -- |
Phenotypes for CRTAM Gene
- MGI mutant phenotypes for CRTAM:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CRTAM:
Animal Models for research
-
Taconic Biosciences Mouse Models for CRTAM
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CRTAM - Starting at $85 >
- * CRTAM CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CRTAM
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CRTAM
-
Santa Cruz Biotechnology (SCBT) CRISPR for CRTAM
miRNA for CRTAM Gene
- miRTarBase miRNAs that target CRTAM
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CRTAM
- Browse OriGene Inhibitory RNA Products For CRTAM
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRTAM
Clone products for research
- Applied Biological Materials (abm): Clones for CRTAM - Starting at $45 >
- * CRTAM as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CRTAM
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRTAM
Cell Lines for research
-
Horizon Cell Lines for CRTAM
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRTAM Gene
Localization for CRTAM Gene
Subcellular locations from UniProtKB/Swiss-Prot for CRTAM Gene
- Cell membrane. Single-pass type I membrane protein. Note=In a subset of CD4+ T-cells, colocalizes with SCRIB at the immunological synapse during the late phase of T-cell activation. {ECO:0000250 UniProtKB:Q149L7}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001772 | immunological synapse | ISS | -- |
| GO:0005886 | plasma membrane | IDA,TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CRTAM Gene
Pathways & Interactions for CRTAM Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Innate Immune System |
.61
|
|
| 3 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||
Pathways by source for CRTAM Gene
3 Reactome pathways for CRTAM Gene
Interacting Proteins for CRTAM Gene
Selected Interacting proteins:
O95727-CRTAM_HUMAN
ENSP00000227348
for CRTAM Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CRTAM
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001768 | establishment of T cell polarity | ISS | -- |
| GO:0001819 | positive regulation of cytokine production | IDA | 15811952 |
| GO:0001913 | NOT T cell mediated cytotoxicity | IDA | 15811952 |
| GO:0002250 | adaptive immune response | IEA | -- |
| GO:0002355 | detection of tumor cell | IBA,IDA | 15811952 |
No data available for SIGNOR curated interactions for CRTAM Gene
Transcripts for CRTAM Gene
mRNA/cDNA for CRTAM Gene
- 2 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000227348 2473 nts (view in UCSC)
- ENST00000533416 592 nts (view in UCSC)
- ENST00000533709 1929 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for CRTAM - Starting at $85 >
- * CRTAM CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for CRTAM
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CRTAM
-
Santa Cruz Biotechnology (SCBT) CRISPR for CRTAM
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CRTAM
- Browse OriGene Inhibitory RNA Products For CRTAM
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRTAM
Clone products for research
- Applied Biological Materials (abm): Clones for CRTAM - Starting at $45 >
- * CRTAM as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for CRTAM
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRTAM
Relevant External Links for CRTAM Gene
- GeneLoc Exon Structure for
- CRTAM
Expression for CRTAM Gene
mRNA differential expression in normal tissues according to GTEx for CRTAM Gene
This gene is overexpressed in Brain - Cerebellar Hemisphere (x26.3) and Brain - Cerebellum (x22.3).
This gene is overexpressed in CD8 Tcells (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CRTAM Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CRTAM
SOURCE GeneReport for Unigene cluster for CRTAM Gene:
Hs.159523mRNA Expression by UniProt/SwissProt for CRTAM Gene:
O95727-CRTAM_HUMAN
Tissue specificity:
In the immune system, expression is restricted to activated class-I MHC-restricted cells, including NKT and CD8 T-cells (PubMed:10811014, PubMed:15811952, PubMed:16300832). Strongly expressed in spleen, thymus, small intestine, peripheral blood leukocyte, and in Purkinje neurons in cerebellum. Expressed at much lower levels in testis, ovary, colon, lung and lymphoid tissues (PubMed:16300832).
Evidence on tissue expression from TISSUES for CRTAM Gene
- Nervous system(3.2)
- Blood(2.3)
- Lymph node(2)
Primer products for research
-
OriGene qPCR primer pairs for CRTAM
-
OriGene qPCR primer pairs and template standards for CRTAM
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRTAM Gene
Orthologs for CRTAM Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CRTAM 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CRTAM 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CRTAM 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Crtam 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Crtam 29 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | CRTAM 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CRTAM 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CRTAM 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CRTAM 30 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | LOC101884219 29 |
|
||
| BX120005.1 30 |
|
OneToOne |
- Species where no ortholog for CRTAM was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CRTAM Gene
- ENSEMBL:
- Gene Tree for CRTAM (if available)
- TreeFam:
- Gene Tree for CRTAM (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CRTAM: view image
- Alliance of Genome Resources:
- Additional Orthologs for CRTAM
Paralogs for CRTAM Gene
Variants for CRTAM Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CRTAM Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs34397316 | Benign: not provided | 122,851,732(+) |
p.Ala78AspC/A |
MISSENSE | |
| rs35136295 | Benign: not provided | 122,855,722(+) |
p.Asp173GlyA/G |
MISSENSE | |
| rs35411582 | Benign: not provided | 122,850,068(+) |
p.Glu16AlaA/C |
MISSENSE | |
| rs35561350 | Benign: not provided | 122,855,783(+) |
G/A NM_019604.4(CRTAM):c.579G>A (p.Thr193=) |
SYNONYMOUS | |
| rs56388952 | Benign: not provided | 122,854,037(+) |
G/A NM_019604.4(CRTAM):c.441G>A (p.Lys147=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3627947 | CNV | gain | 21293372 |
| nsv1133175 | CNV | tandem duplication | 24896259 |
| nsv1140492 | CNV | tandem duplication | 24896259 |
| nsv480269 | CNV | novel sequence insertion | 20440878 |
| nsv520988 | CNV | gain | 19592680 |
| nsv556481 | CNV | loss | 21841781 |
| nsv556482 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.36;
76.90% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CRTAM Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRTAM Gene
Disorders for CRTAM Gene
Additional Disease Information for CRTAM
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No disorders were found for CRTAM Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRTAM Gene
Publications for CRTAM Gene
- Human class-I restricted T cell associated molecule is highly expressed in the cerebellum and is a marker for activated NKT and CD8+ T lymphocytes. (PMID: 16300832) Patiño-Lopez G … Zlotnik A (Journal of neuroimmunology 2006) 2 3 4
- A molecular analysis of NKT cells: identification of a class-I restricted T cell-associated molecule (CRTAM). (PMID: 10811014) Kennedy J … Zlotnik A (Journal of leukocyte biology 2000) 2 3 4
- Competition of cell adhesion and immune recognition: insights into the interaction between CRTAM and nectin-like 2. (PMID: 23871486) Zhang S … Gao GF (Structure (London, England : 1993) 2013) 3 4
- Characterization of CRTAM gene promoter: AP-1 transcription factor control its expression in human T CD8 lymphocytes. (PMID: 19695707) Valle-Rios R … Ortiz-Navarrete V (Molecular immunology 2009) 3 22
- The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM. (PMID: 15811952) Boles KS … Colonna M (Blood 2005) 3 4
ExternalLinks
Products for CRTAM Gene
- View all 16 R&D Systems CRTAM (CRTAM) Products
- View all R&D Systems CRTAM (CRTAM) Proteins and Enzymes
- View all 13 R&D Systems CRTAM (CRTAM) Primary Antibodies
- View all R&D Systems CRTAM (CRTAM) ELISAs
- View all R&D Systems CRTAM (CRTAM) cDNA Clones
- Learn more about R&D Systems custom CRTAM antibody, protein, and immunoassay development services
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CRTAM
- Search Origene for MassSpec and Protein Over-expression Lysates for CRTAM
- Origene Custom Protein Services for CRTAM
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CRTAM
- Browse OriGene Inhibitory RNA Products For CRTAM
- OriGene qPCR primer pairs for CRTAM
- OriGene qPCR primer pairs and template standards for CRTAM
- OriGene CRISPR knockouts for CRTAM
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CRTAM
- Sino Biological Human cDNA Clone for CRTAM
- Sino Biological Recombinant Proteins for CRTAM
- Sino Biological Cell Lysates for CRTAM
- Sino Biological Antibodies for CRTAM
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CRTAM
- Novus Biologicals lysates for CRTAM
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CRTAM
- Abcam proteins for CRTAM
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for CRTAM
- Taconic Biosciences Mouse Models for CRTAM
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CRTAM (AFLGC-CRTAM)
- VectorBuilder Custom and pre-made DNA vectors for CRTAM (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CRTAM (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CRTAM (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CRTAM CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CRTAM
- antibodies-online: Show 3 available CRTAM Antibodies ranked by validation data
- Compare Top CRTAM Antibodies
- Recommended
- 29 WB Antibodies (anti-human)
- 19 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 BCA Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 12 IF (p) Antibodies (anti-mouse)
- 4 WB Antibodies (anti-mouse)
- 3 FACS Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 1 ELISPOT (Detection) Antibody (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 4 WB Antibodies (anti-rat)
- antibodies-online: Show 8 available CRTAM Elisa Kits ranked by validation data
- Compare Top CRTAM Elisa Kits
- Quality Products:
- antibodies-online: Show 14 available CRTAM Proteins ranked by validation data
- Compare Top CRTAM Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CRTAM
- Search Santa Cruz Biotechnology (SCBT) for CRTAM siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CRTAM
- Horizon Cell Lines for CRTAM
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CRTAM
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRTAM
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CRTAM
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRTAM
- Boster Bio Antibodies for CRTAM
- Browse Boster Bio ELISA Kits
Sources for CRTAM Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources