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The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 [PubMed 18329370]).[supplied by OMIM, Feb 2009]
CRTAM (Cytotoxic And Regulatory T Cell Molecule) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An important paralog of this gene is CADM2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | IPI | 15811952 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001772 | immunological synapse | ISS | -- |
GO:0005886 | plasma membrane | IDA,TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Class I MHC mediated antigen processing and presentation | ||
2 | Innate Immune System |
.61
|
|
3 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001768 | establishment of T cell polarity | ISS | -- |
GO:0001913 | NOT T cell mediated cytotoxicity | IDA | 15811952 |
GO:0002250 | adaptive immune response | IEA | -- |
GO:0002355 | detection of tumor cell | IDA | 15811952 |
GO:0002376 | immune system process | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CRTAM 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CRTAM 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CRTAM 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Crtam 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Crtam 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | CRTAM 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CRTAM 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CRTAM 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CRTAM 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | LOC101884219 30 |
|
||
BX120005.1 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
776673 | Benign: not provided | 122,851,732(+) | C/A | MISSENSE_VARIANT | |
776674 | Benign: not provided | 122,854,037(+) | G/A | SYNONYMOUS_VARIANT | |
776675 | Benign: not provided | 122,855,783(+) | G/A | SYNONYMOUS_VARIANT | |
778566 | Benign: not provided | 122,855,722(+) | A/G | MISSENSE_VARIANT | |
781238 | Benign: not provided | 122,850,068(+) | A/C | MISSENSE_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3627947 | CNV | gain | 21293372 |
nsv1133175 | CNV | tandem duplication | 24896259 |
nsv1140492 | CNV | tandem duplication | 24896259 |
nsv480269 | CNV | novel sequence insertion | 20440878 |
nsv520988 | CNV | gain | 19592680 |
nsv556481 | CNV | loss | 21841781 |
nsv556482 | CNV | loss | 21841781 |
No disorders were found for CRTAM Gene.