Aliases for CRTAC1 Gene
Aliases for CRTAC1 Gene
External Ids for CRTAC1 Gene
- HGNC: 14882
- Entrez Gene: 55118
- Ensembl: ENSG00000095713
- OMIM: 606276
- UniProtKB: Q9NQ79
Previous GeneCards Identifiers for CRTAC1 Gene
- GC10M098518
- GC10M098858
- GC10M099755
- GC10M099289
- GC10M099614
- GC10M093250
Summaries for CRTAC1 Gene
-
This gene encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture. The presence of FG-GAP motifs and an RGD integrin-binding motif suggests that this protein may be involved in cell-cell or cell-matrix interactions. Copy number alterations in this gene have been observed in neurofibromatosis type 1-associated glomus tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
GeneCards Summary for CRTAC1 Gene
CRTAC1 (Cartilage Acidic Protein 1) is a Protein Coding gene. Diseases associated with CRTAC1 include Bone Fracture. Gene Ontology (GO) annotations related to this gene include calcium ion binding.
Additional gene information for CRTAC1 Gene
- Monarch Initiative
- Search for CRTAC1 at DataMed
- Search for CRTAC1 at HumanCyc
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRTAC1 Gene
Genomics for CRTAC1 Gene
GeneHancer (GH) Regulatory Elements for CRTAC1 Gene
Promoters and enhancers for CRTAC1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CRTAC1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CRTAC1 gene promoter:
Regulatory Element Products
Genomic Locations for CRTAC1 Gene
Genomic Locations for CRTAC1 Gene
- chr10:97,854,711-98,030,828
- (GRCh38/hg38)
- Size:
- 176,118 bases
- Orientation:
- Minus strand
- chr10:99,624,757-99,790,585
- (GRCh37/hg19)
Genomic View for CRTAC1 Gene
Genes around CRTAC1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q24.2 by Entrez Gene
- 10q24.2 by HGNC
- 10q24.2 by Ensembl
CRTAC1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CRTAC1 Gene
Proteins for CRTAC1 Gene
-
Protein details for CRTAC1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NQ79-CRAC1_HUMAN
- Recommended name:
- Cartilage acidic protein 1
- Protein Accession:
- Q9NQ79
- B1ALN4
- Q5T4F8
- Q8N4H6
- Q8TE52
- Q9NQ78
- Q9NQ80
- Q9NW46
Protein attributes for CRTAC1 Gene
- Size:
- 661 amino acids
- Molecular mass:
- 71421 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH34245.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91540.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB98268.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB98269.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI12584.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for CRTAC1 Gene
Post-translational modifications for CRTAC1 Gene
- O-glycosylated.
- Glycosylation at posLast=626626, posLast=621621, Thr619, posLast=618618, and Thr608
- Modification sites at PhosphoSitePlus
Other Protein References for CRTAC1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CRTAC1 (CRTAC1)
-
Custom Antibody ServicesOriGene Antibodies for CRTAC1
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- Invitrogen Antibodies for CRTAC1
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-
Boster Bio Antibodies for CRTAC1
- Sino Biological Antibodies for CRTAC1
Protein Products
- R&D Systems Proteins and Enzymes for CRTAC1
-
OriGene Purified Proteins for CRTAC1
- Search Origene for MassSpec and Protein Over-expression Lysates for CRTAC1
- Origene Custom Protein Services for CRTAC1
- antibodies-online: Search results for 4 available CRTAC1 Proteins ranked by validation data
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-
Quality Products:
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Assay Products
- antibodies-online: Search results for 9 available CRTAC1 Elisa Kits ranked by validation data
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-
Quality Products:
No data available for DME Specific Peptides for CRTAC1 Gene
Domains & Families for CRTAC1 Gene
Gene Families for CRTAC1 Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for CRTAC1 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CRTAC1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CRTAC1 Gene
Function for CRTAC1 Gene
Molecular function for CRTAC1 Gene
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by BMP4 (at protein level). Up-regulated in mesenchymal stem cells undergoing chondrogenic differentiation and by BMP4.
Phenotypes From GWAS Catalog for CRTAC1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005509 | calcium ion binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for CRTAC1 Gene
- MGI mutant phenotypes for CRTAC1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CRTAC1:
Animal Models for CRTAC1 Gene
- MGI Knock Outs for CRTAC1:
-
- Crtac1 Crtac1<tm1Kota>
Animal Model Products
-
Taconic Biosciences Mouse Models for CRTAC1
- Cyagen custom Knockout/knockin (KOKI) mouse models for CRTAC1
-
CRISPR Products
-
OriGene CRISPR knockouts for CRTAC1
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- genomics-online: gRNA clones - Search results for available CRTAC1 gene related products
- Applied Biological Materials CRISPR for CRTAC1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CRTAC1
- GenScript: Design CRISPR guide RNA sequences for CRTAC1
miRNA for CRTAC1 Gene
- miRTarBase miRNAs that target CRTAC1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CRTAC1
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Clone Products
- Sino Biological Human cDNA Clone for CRTAC1
- VectorBuilder custom plasmid, inducible vectors for CRTAC1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CRTAC1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRTAC1
- genomics-online: cdna clones - Search results for available CRTAC1 gene related products
- orf clones - Search results for available CRTAC1 gene related products
- Applied Biological Materials Clones for CRTAC1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CRTAC1
Cell Line Products
-
Horizon Cell Lines for CRTAC1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRTAC1 Gene
Localization for CRTAC1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CRTAC1 Gene
- Secreted, extracellular space, extracellular matrix.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 2 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0030426 | growth cone | IEA | -- |
| GO:0070062 | extracellular exosome | HDA | 23533145 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CRTAC1 Gene
Pathways & Interactions for CRTAC1 Gene
No Data Available
Interacting Proteins for CRTAC1 Gene
Selected Interacting proteins:
Q9NQ79-CRAC1_HUMAN
ENSP00000359629
for CRTAC1 Gene via
IID
UniProtKB
STRING
GPS-Prot Interaction Network for CRTAC1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007413 | axonal fasciculation | IEA | -- |
| GO:0021772 | olfactory bulb development | IEA | -- |
| GO:1900121 | negative regulation of receptor binding | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for CRTAC1 Gene
Transcripts for CRTAC1 Gene
mRNA/cDNA for CRTAC1 Gene
- (102) Selected AceView cDNA sequences:
- (7) Additional mRNA sequences :
- (6) REFSEQ mRNAs :
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000309155 1946 bps (uc057vgs.1)
- ENST00000370591 2348 bps (uc001kov.4)
- ENST00000370597 2890 bps (uc001kou.2)
- ENST00000413387 2179 bps (uc057vgo.1)
- ENST00000436034 474 bps (uc057vgr.1)
Unigene Clusters for CRTAC1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CRTAC1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CRTAC1
- genomics-online: gRNA clones - Search results for available CRTAC1 gene related products
- Applied Biological Materials CRISPR for CRTAC1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CRTAC1
- GenScript: Design CRISPR guide RNA sequences for CRTAC1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for CRTAC1
- Browse OriGene Inhibitory RNA Products For CRTAC1
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Clone Products
- Sino Biological Human cDNA Clone for CRTAC1
- VectorBuilder custom plasmid, inducible vectors for CRTAC1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CRTAC1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRTAC1
- genomics-online: cdna clones - Search results for available CRTAC1 gene related products
- orf clones - Search results for available CRTAC1 gene related products
- Applied Biological Materials Clones for CRTAC1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CRTAC1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ | 21 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - |
Expression for CRTAC1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- nGnG Amacrine Cells Inner Nuclear Layer
- Corneal Epithelium
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Neurons
- nGnG Amacrine Cells Inner Nuclear Layer
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
-
Gonad
- Primordial Germ Cells Allantois
- Brain (Nervous System)
- Head Mesenchyme (Muscoskeletal System)
- Neural Tube (Nervous System)
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
-
Lung (Respiratory System)
mRNA differential expression in normal tissues according to GTEx for CRTAC1 Gene
This gene is overexpressed in Bladder (x5.5) and Artery - Tibial (x5.4).
This gene is overexpressed in Synovial fluid (40.0), Vitreous humor (10.4), and Cerebrospinal fluid (8.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CRTAC1 Gene
NURSA nuclear receptor signaling pathways regulating expression of CRTAC1 Gene:
CRTAC1SOURCE GeneReport for Unigene cluster for CRTAC1 Gene:
Hs.500736mRNA Expression by UniProt/SwissProt for CRTAC1 Gene:
Q9NQ79-CRAC1_HUMAN
Tissue specificity:
Expressed in the interterritorial matrix of articular deep zone cartilage (at protein level). Isoform 1 and isoform 2 are expressed in brain. Isoform 1 is detected in lung and chondrocytes. Detected in cartilage, bone, cultured chondrocytes and lung, and at low levels in heart. Not detected in osteoblasts.
Evidence on tissue expression from TISSUES for CRTAC1 Gene
- Nervous system(4.7)
- Eye(2.5)
Primer Products
-
OriGene qPCR primer pairs for CRTAC1
- genomics-online: primer clones - Search results for available CRTAC1 gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRTAC1 Gene
Orthologs for CRTAC1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CRTAC1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CRTAC1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CRTAC1 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | CRTAC1 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Crtac1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Crtac1 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CRTAC1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CRTAC1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CRTAC1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | crtac1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | crtac1b 34 33 |
|
OneToMany | |
| crtac1a 34 |
|
OneToMany | |||
| Dr.6210 33 |
|
- Species where no ortholog for CRTAC1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for CRTAC1 Gene
- ENSEMBL:
- Gene Tree for CRTAC1 (if available)
- TreeFam:
- Gene Tree for CRTAC1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CRTAC1: view image
Paralogs for CRTAC1 Gene
No data available for Paralogs for CRTAC1 Gene
Variants for CRTAC1 Gene
| SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000009290 | -- | 97,877,505(-) | C/A | genic_downstream_transcript_variant, intron_variant | |
| rs1000011797 | -- | 97,955,392(-) | C/G | intron_variant | |
| rs1000075711 | -- | 97,904,225(-) | C/T | intron_variant | |
| rs1000083887 | -- | 97,984,739(-) | C/T | intron_variant | |
| rs1000083894 | -- | 97,877,071(-) | G/A | genic_downstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2660852 | CNV | deletion | 23128226 |
| esv3306622 | CNV | mobile element insertion | 20981092 |
| esv3444944 | CNV | insertion | 20981092 |
| esv3546732 | CNV | deletion | 23714750 |
| esv3624328 | CNV | loss | 21293372 |
| esv3624329 | OTHER | inversion | 21293372 |
| nsv1047572 | CNV | gain | 25217958 |
| nsv25263 | CNV | deletion | 16902084 |
| nsv474763 | CNV | novel sequence insertion | 20440878 |
| nsv509364 | CNV | insertion | 20534489 |
| nsv513013 | CNV | insertion | 21212237 |
| nsv7510 | CNV | insertion | 18451855 |
| nsv819567 | CNV | gain | 19587683 |
| nsv831953 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.75;
66.51% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CRTAC1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CRTAC1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRTAC1 Gene
Disorders for CRTAC1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| bone fracture |
|
|
Search CRTAC1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CRTAC1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CRTAC1 Gene
Publications for CRTAC1 Gene
- Chondrocyte secreted CRTAC1: a glycosylated extracellular matrix molecule of human articular cartilage. (PMID: 17074475) Steck E … Richter W (Matrix biology : journal of the International Society for Matrix Biology 2007) 3 4 22 58
- Chondrocyte expressed protein-68 (CEP-68), a novel human marker gene for cultured chondrocytes. (PMID: 11139377) Steck E … Richter W (The Biochemical journal 2001) 2 3 4 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Genes up- or down-regulated by high calcium medium in parathyroid tissue explants from patients with primary hyperparathyroidism. (PMID: 19952464) Nakajima K … Sato K (Endocrine journal 2010) 3 22 58
- CRTAC1 homolog proteins are conserved from cyanobacteria to man and secreted by the teleost fish pituitary gland. (PMID: 20171266) Redruello B … Power DM (Gene 2010) 3 22 58
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 51 available CRTAC1 Antibodies ranked by validation data
- Compare Top CRTAC1 Antibodies
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRTAC1
- Boster Bio Antibodies for CRTAC1
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Sources for CRTAC1 Gene
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