This gene encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture. The presence of FG-GAP motifs and an RGD integrin-binding motif suggests that this protein may be involved in cell-cell or... See more...

Aliases for CRTAC1 Gene

Aliases for CRTAC1 Gene

  • Cartilage Acidic Protein 1 2 3 4 5
  • ASPIC1 3 4
  • CEP-68 3 4
  • ASPIC 3 4
  • CEP68 3 4
  • Chondrocyte Expressed Protein 68 KDa CEP-68 3
  • Acidic Secreted Protein In Cartilage 3
  • 68 KDa Chondrocyte-Expressed Protein 4
  • LOTUS 3

External Ids for CRTAC1 Gene

Previous GeneCards Identifiers for CRTAC1 Gene

  • GC10M098518
  • GC10M098858
  • GC10M099755
  • GC10M099289
  • GC10M099614
  • GC10M093250

Summaries for CRTAC1 Gene

Entrez Gene Summary for CRTAC1 Gene

  • This gene encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture. The presence of FG-GAP motifs and an RGD integrin-binding motif suggests that this protein may be involved in cell-cell or cell-matrix interactions. Copy number alterations in this gene have been observed in neurofibromatosis type 1-associated glomus tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for CRTAC1 Gene

CRTAC1 (Cartilage Acidic Protein 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding.

Additional gene information for CRTAC1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CRTAC1 Gene

Genomics for CRTAC1 Gene

GeneHancer (GH) Regulatory Elements for CRTAC1 Gene

Promoters and enhancers for CRTAC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J098029 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.2 227 1.6 ZNF423 ZBTB26 ZNF341 EZH2 POLR2A SP2 MXI1 ZNF76 PHF8 KLF8 CRTAC1 ENSG00000230928 RF01045-024
GH10J097771 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 10.1 +258.6 258642 2 PHB2 ZIC2 ZBTB10 GABPA ZBTB26 CTBP1 ZEB1 EZH2 NCOR1 NEUROD1 SFRP5 ZFYVE27 CRTAC1 MARVELD1 piR-43107-046
GH10J097786 Promoter/Enhancer 1.5 EPDnew ENCODE dbSUPER 10.7 +242.5 242528 3.8 CTCF NRF1 PHB2 ZNF10 ZIC2 ZBTB11 ZNF423 TARDBP REST MYC SFRP5 MARVELD1 CRTAC1 ZFYVE27 piR-43107-046 lnc-GOLGA7B-3
GH10J097837 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.6 +191.9 191927 6.2 CTCF TCF12 RBAK JUND FOS ZBTB11 AFF1 REST MYC TOE1 piR-40459 SFRP5 CRTAC1 GOLGA7B piR-39488-046 piR-55281-062 piR-56022-052 piR-56088-003 LINC00866 lnc-GOLGA7B-2
GH10J097914 Enhancer 1 Ensembl ENCODE 13.4 +115.8 115828 0.8 CTCF REST RAD21 TRIM22 SMC3 PCBP1 SIN3A TCF12 RXRA ZBTB17 CRTAC1 RF01045-023 RF01045-024
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CRTAC1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CRTAC1

Top Transcription factor binding sites by QIAGEN in the CRTAC1 gene promoter:
  • CUTL1
  • E2F
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • NF-kappaB1
  • NRSF form 1
  • NRSF form 2
  • Pax-5

Genomic Locations for CRTAC1 Gene

Genomic Locations for CRTAC1 Gene
chr10:97,854,711-98,030,828
(GRCh38/hg38)
Size:
176,118 bases
Orientation:
Minus strand
chr10:99,624,757-99,790,585
(GRCh37/hg19)
Size:
165,829 bases
Orientation:
Minus strand

Genomic View for CRTAC1 Gene

Genes around CRTAC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRTAC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRTAC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRTAC1 Gene

Proteins for CRTAC1 Gene

  • Protein details for CRTAC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQ79-CRAC1_HUMAN
    Recommended name:
    Cartilage acidic protein 1
    Protein Accession:
    Q9NQ79
    Secondary Accessions:
    • B1ALN4
    • Q5T4F8
    • Q8N4H6
    • Q8TE52
    • Q9NQ78
    • Q9NQ80
    • Q9NW46

    Protein attributes for CRTAC1 Gene

    Size:
    661 amino acids
    Molecular mass:
    71421 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 1]: Shares an exon with the neighboring tail-to-tail oriented gene GOLGA7B.
    SequenceCaution:
    • Sequence=AAH34245.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAA91540.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAB98268.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAB98269.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for CRTAC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRTAC1 Gene

Post-translational modifications for CRTAC1 Gene

  • O-glycosylated.
  • Glycosylation at Thr608, Thr618, Thr619, Thr621, and Thr626
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CRTAC1 Gene

Domains & Families for CRTAC1 Gene

Gene Families for CRTAC1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CRTAC1 Gene

Blocks:
  • EGF-like calcium-binding
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CRTAC1 Gene

GenScript: Design optimal peptide antigens:
  • Cartilage acidic protein 1 (B1ALN2_HUMAN)
  • ASPIC (CRAC1_HUMAN)
  • Cartilage acidic protein 1 (Q5T4F6_HUMAN)
genes like me logo Genes that share domains with CRTAC1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CRTAC1 Gene

Function for CRTAC1 Gene

Molecular function for CRTAC1 Gene

UniProtKB/Swiss-Prot Induction:
Up-regulated by BMP4 (at protein level). Up-regulated in mesenchymal stem cells undergoing chondrogenic differentiation and by BMP4.

Phenotypes From GWAS Catalog for CRTAC1 Gene

Gene Ontology (GO) - Molecular Function for CRTAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CRTAC1: view
genes like me logo Genes that share phenotypes with CRTAC1: view

Animal Models for CRTAC1 Gene

MGI Knock Outs for CRTAC1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CRTAC1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRTAC1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRTAC1 Gene

Localization for CRTAC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRTAC1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRTAC1 gene
Compartment Confidence
extracellular 3
plasma membrane 2
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CRTAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0030426 growth cone IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with CRTAC1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CRTAC1 Gene

Pathways & Interactions for CRTAC1 Gene

PathCards logo

SuperPathways for CRTAC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CRTAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007413 axonal fasciculation IEA --
GO:0021772 olfactory bulb development IEA --
GO:1900121 negative regulation of receptor binding IEA --
genes like me logo Genes that share ontologies with CRTAC1: view

No data available for Pathways by source and SIGNOR curated interactions for CRTAC1 Gene

Drugs & Compounds for CRTAC1 Gene

No Compound Related Data Available

Transcripts for CRTAC1 Gene

mRNA/cDNA for CRTAC1 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRTAC1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CRTAC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21
SP1: - - - - - - -
SP2: - - -
SP3: - - -
SP4:
SP5: - - - -
SP6:
SP7: - - -

Relevant External Links for CRTAC1 Gene

GeneLoc Exon Structure for
CRTAC1

Expression for CRTAC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CRTAC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CRTAC1 Gene

This gene is overexpressed in Bladder (x5.5) and Artery - Tibial (x5.4).

Protein differential expression in normal tissues from HIPED for CRTAC1 Gene

This gene is overexpressed in Synovial fluid (40.0), Vitreous humor (10.4), and Cerebrospinal fluid (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CRTAC1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CRTAC1

SOURCE GeneReport for Unigene cluster for CRTAC1 Gene:

Hs.500736

mRNA Expression by UniProt/SwissProt for CRTAC1 Gene:

Q9NQ79-CRAC1_HUMAN
Tissue specificity: Expressed in the interterritorial matrix of articular deep zone cartilage (at protein level). Isoform 1 and isoform 2 are expressed in brain. Isoform 1 is detected in lung and chondrocytes. Detected in cartilage, bone, cultured chondrocytes and lung, and at low levels in heart. Not detected in osteoblasts.

Evidence on tissue expression from TISSUES for CRTAC1 Gene

  • Nervous system(4.7)
  • Eye(2.5)
genes like me logo Genes that share expression patterns with CRTAC1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRTAC1 Gene

Orthologs for CRTAC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRTAC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRTAC1 31 30
  • 98.39 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CRTAC1 31 30
  • 92.2 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CRTAC1 31 30
  • 92.04 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CRTAC1 31
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crtac1 17 31 30
  • 88.68 (n)
rat
(Rattus norvegicus)
Mammalia Crtac1 30
  • 88.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CRTAC1 31
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves CRTAC1 31 30
  • 76.05 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CRTAC1 31
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia crtac1 30
  • 70.01 (n)
zebrafish
(Danio rerio)
Actinopterygii crtac1b 31 30
  • 68.97 (n)
OneToMany
crtac1a 31
  • 67 (a)
OneToMany
Dr.6210 30
Species where no ortholog for CRTAC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CRTAC1 Gene

ENSEMBL:
Gene Tree for CRTAC1 (if available)
TreeFam:
Gene Tree for CRTAC1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CRTAC1: view image

Paralogs for CRTAC1 Gene

No data available for Paralogs for CRTAC1 Gene

Variants for CRTAC1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CRTAC1 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs2297935 - p.Val569Met
rs35853031 - p.Ala253Thr
rs56007204 - p.Glu658Lys

Additional dbSNP identifiers (rs#s) for CRTAC1 Gene

Structural Variations from Database of Genomic Variants (DGV) for CRTAC1 Gene

Variant ID Type Subtype PubMed ID
esv2660852 CNV deletion 23128226
esv3306622 CNV mobile element insertion 20981092
esv3444944 CNV insertion 20981092
esv3546732 CNV deletion 23714750
esv3624328 CNV loss 21293372
esv3624329 OTHER inversion 21293372
nsv1047572 CNV gain 25217958
nsv25263 CNV deletion 16902084
nsv474763 CNV novel sequence insertion 20440878
nsv509364 CNV insertion 20534489
nsv513013 CNV insertion 21212237
nsv7510 CNV insertion 18451855
nsv819567 CNV gain 19587683
nsv831953 CNV gain 17160897

Variation tolerance for CRTAC1 Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.75; 66.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CRTAC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRTAC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRTAC1 Gene

Disorders for CRTAC1 Gene

Additional Disease Information for CRTAC1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CRTAC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CRTAC1 Gene

Publications for CRTAC1 Gene

  1. Chondrocyte secreted CRTAC1: a glycosylated extracellular matrix molecule of human articular cartilage. (PMID: 17074475) Steck E … Richter W (Matrix biology : journal of the International Society for Matrix Biology 2007) 3 4 23 54
  2. Chondrocyte expressed protein-68 (CEP-68), a novel human marker gene for cultured chondrocytes. (PMID: 11139377) Steck E … Richter W (The Biochemical journal 2001) 2 3 4 54
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  4. A genome-wide association study of the metabolic syndrome in Indian Asian men. (PMID: 20694148) Zabaneh D … Balding DJ (PloS one 2010) 3 41 54
  5. Genes up- or down-regulated by high calcium medium in parathyroid tissue explants from patients with primary hyperparathyroidism. (PMID: 19952464) Nakajima K … Sato K (Endocrine journal 2010) 3 23 54

Products for CRTAC1 Gene

Sources for CRTAC1 Gene