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The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly du... See more...
Aliases for CRP Gene
Aliases for CRP Gene
External Ids for CRP Gene
- HGNC: 2367
- Entrez Gene: 1401
- Ensembl: ENSG00000132693
- OMIM: 123260
- UniProtKB: P02741
Previous GeneCards Identifiers for CRP Gene
- GC01M157474
- GC01M155414
- GC01M156459
- GC01M156899
- GC01M156495
- GC01M157948
- GC01M159682
- GC01M131038
- GC01M159714
- GC01M159715
Summaries for CRP Gene
-
The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]
GeneCards Summary for CRP Gene
CRP (C-Reactive Protein) is a Protein Coding gene. Diseases associated with CRP include Appendicitis and Acute Pyelonephritis. Among its related pathways are Folate Metabolism and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include calcium ion binding and cholesterol binding. An important paralog of this gene is APCS.
UniProtKB/Swiss-Prot Summary for CRP Gene
-
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
Additional gene information for CRP Gene
- HGNC(2367)
- Entrez Gene(1401)
- Ensembl(ENSG00000132693)
- OMIM(123260)
- UniProtKB(P02741)
- Open Targets Platform(ENSG00000132693)
- Monarch Initiative
- Search for CRP at DataMed
- Search for CRP at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CRP Gene
Genomics for CRP Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CRP Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH01J159714 | Promoter | 0.7 | EPDnew | 600.7 | 0.0 | -20 | 0.1 | SP1 YY1 ZBTB33 JUND NR2F2 RAD21 HNF4A RXRA FOXA1 TAF1 | CRP lnc-VSIG8-3 piR-47214 HSALNG0007782 DUSP23 | |
| GH01J159751 | Enhancer | 0.9 | Ensembl ENCODE | 10.9 | -38.0 | -38012 | 3.2 | ZNF629 SP1 TOE1 CEBPA CEBPB SMARCC1 FOXA2 RAD51 ATF3 RCOR1 | CRP FCRL6 DUSP23 ENSG00000212161 AIM2 RPL27P2 HSALNG0007782 | |
| GH01J159755 | Enhancer | 0.6 | Ensembl | 10.9 | -41.7 | -41712 | 1.8 | SP1 FOXA2 ATF3 YY1 ZBTB33 JUND SPI1 HNF4A RXRA MAX | DUSP23 CRP FCRL6 ENSG00000212161 RPL27P2 HSALNG0007782 | |
| GH01J159775 | Enhancer | 0.4 | Ensembl | 10.5 | -60.2 | -60212 | 2 | CTCF YY1 SMC3 RAD21 | CRP FCRL6 ENSG00000212161 SNHG28 VSIG8 PIGM lnc-CRP-2 DUSP23 piR-40163-009 | |
| GH01J159768 | Enhancer | 0.3 | Ensembl | 10.3 | -53.8 | -53770 | 0.7 | ZNF584 | piR-40163-009 piR-49423-013 FCRL6 CRP ENSG00000212161 OR10J3 PIGM DUSP23 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CRP on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CRP
- Top Transcription factor binding sites by QIAGEN in the CRP gene promoter:
-
- AREB6
- c-Myc
- CUTL1
- FOXO3
- FOXO3a
- FOXO3b
- Max1
- Nkx2-5
- TBP
Genomic Locations for CRP Gene
Genomic Locations for CRP Gene
- chr1:159,712,289-159,714,589
- (GRCh38/hg38)
- Size:
- 2,301 bases
- Orientation:
- Minus strand
- chr1:159,682,079-159,684,379
- (GRCh37/hg19)
- Size:
- 2,301 bases
- Orientation:
- Minus strand
Genomic View for CRP Gene
Genes around CRP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q23.2 by HGNC
- 1q23.2 by Entrez Gene
- 1q23.2 by Ensembl
CRP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CRP Gene
Proteins for CRP Gene
-
Protein details for CRP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P02741-CRP_HUMAN
- Recommended name:
- C-reactive protein
- Protein Accession:
- P02741
- A8K078
- D3DVD9
- D3DVE0
- Q08AK3
- Q8WW75
Protein attributes for CRP Gene
- Size:
- 224 amino acids
- Molecular mass:
- 25039 Da
- Cofactor:
- Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Quaternary structure:
-
- Homopentamer. Pentraxin (or pentaxin) have a discoid arrangement of 5 non-covalently bound subunits. Interacts with FCN1; may regulate monocyte activation by FCN1.
- Miscellaneous:
-
- This protein owes its name to its ability precipitate pneumococcal C-polysaccharide in the presence of calcium.
Three dimensional structures from OCA and Proteopedia for CRP Gene
Protein Expression for CRP Gene
Post-translational modifications for CRP Gene
Other Protein References for CRP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences CRP / C-Reactive Protein Antibody and CRP / C-Reactive Protein Monoclonal Antibody
- G Biosciences Immunotag™ CRP Antibody
- NSJ Bioreagents CRP Antibody / C-Reactive Protein
- Creative Diagnostics Anti-C Reactive Protein monoclonal antibody, clone C893M
-
Creative Biolabs
- Recombinant Mouse Anti-Human CRP Antibody Fab Fragment
- Mouse Anti-CRP Recombinant Antibody (CBFYC-2220)
- Mouse Anti-CRP Recombinant Antibody (1-BB-100)
- Mouse Anti-CRP Recombinant Antibody (CBFYC-2228)
- Mouse Anti-CRP Recombinant Antibody (10K175)
- Mouse Anti-CRP Recombinant Antibody (3H109)
- Mouse Anti-CRP Recombinant Antibody (8G1)
-
Custom Antibody ServicesOriGene Antibodies for CRP
- 4C28-C1
- 4C28-C2
- 4C28-C3
- 4C28-C4
- 4C28-C5
- 4C28-C6
- 4C28-C7
- 4C28cc-C6cc
- 4C28-CRP11
- 4C28-CRP135
- 4C28-CRP169
- 4C28-CRP30
- 4C28-CRP36
- AM03133BT-N
- AM03133PU-N
- AM06764SU-N
- AM09005PU-N
- AM09005PU-S
- AM09267PU-N
- AM09268PU-N
- AM20202PU-N
- AM20203PU-N
- AM20788PU-L
- AM20788PU-N
- AM20788PU-S
- AM21031PU-N
- AM26061PU-N
- AP08116PU-N
- AP08116PU-S
- AP08403PU-N
- AP23303PU-N
- AP54805SU-N
- CF807716
- CF807723
- CF807727
- CF807731
- CF807732
- CF807733
- CF809641
- DM1008
- DM1009
- R1597
- TA323623
- TA323624
- TA326781
- TA346207
- TA354557
- TA354559
- TA354576
- TA807716
- TA807716S
- TA807723
- TA807723S
- TA807727
- TA807727S
- TA807731
- TA807731S
- TA807732
- TA807732S
- TA807733
- TA807733S
- TA809641
- TA809641S
- Novus Biologicals Antibodies for CRP
-
Abcam antibodies for CRP
- Invitrogen Antibodies for CRP (AFLGC-Crp)
- antibodies-online: Show 303 available Crp Antibodies ranked by validation data
- Compare Top Crp Antibodies
-
Recommended
- 219 WB Antibodies (anti-human)
- 15 IHC (p) Antibodies (anti-human)
- 6 EIA Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 5 TB Antibodies (anti-human)
- 4 IF Antibodies (anti-human)
- 3 IP Antibodies (anti-human)
- 3 IT Antibodies (anti-human)
- 2 IHC (fro) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IA Antibody (anti-human)
- 1 ID Antibody (anti-human)
- 1 IEP Antibody (anti-human)
- 1 RID Antibody (anti-human)
- 35 WB Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 2 RIA Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 42 WB Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 2 IP Antibodies (anti-rat)
- 2 RIA Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for CRP
- Sino Biological Antibodies for CRP
Protein Products
- G Biosciences Human C-Reactive Protein/CRP, Lyophilized
- RayBiotech Recombinant Human C-reactive Protein
- Search Origene for MassSpec and Protein Over-expression Lysates for CRP
- Origene Custom Protein Services for CRP
- Novus Biologicals proteins for CRP
- Sino Biological Recombinant Proteins for CRP
- Sino Biological Cell Lysates for CRP
- ProSpec Recombinant Proteins for CRP
- antibodies-online: Show 52 available Crp Proteins ranked by validation data
- Compare Top Crp Proteins
-
ProSci Proteins for CRP
-
Abcam proteins for CRP
Assay Products
- RayBiotech Human CRP ELISA
-
Creative Diagnostics
- FELINE C-REACTIVE PROTEIN ELISA Kit
- Human C-Reactive Protein (CRP) ELISA Kit
- C-reactive Protein (1-point-calibration) ELISA Kit
- hsCRP ELISA Kit
- RABBIT C-REACTIVE PROTEIN ELISA Kit
- C Reactive Protein Human ELISA Kit (DEIA1407)
- Porcine CRP ELISA Kit
- Human C-Reactive Protein, Pentraxin-Related, CRP ELISA Kit
- C Reactive Protein Human ELISA Kit (DEIA1408)
- C-reactive Protein ELISA Kit (DEIA012J)
- Pig CRP (C-Reactive Protein) ELISA Kit
- C-reactive Protein ELISA Kit (DEIA031J)
- Canine CRP ELISA Kit
- Mouse CRP ELISA Kit
-
Aviva Systems Biology
- High sensitivity c-reactive protein ELISA Kit (Human) : 96 Wells (OKBA00016)
- CRP ELISA Kit (Human) : 96 Wells (OKAG00214)
- CRP ELISA Kit (Human) : 96 Wells (OKEH02700)
- CRP High Sensitivity ELISA Kit (Human) (OKCD01339)
- CRP Chemi-Luminescent ELISA Kit (Human) (OKCD03397)
- CRP ELISA Kit (Human) (OKCD06860)
- Novus Biologicals ELISA Kits for CRP
- antibodies-online: Show 151 available Crp Elisa Kits ranked by validation data
- Compare Top Crp Elisa Kits
-
Quality Products:
- ABIN6574220
- ABIN1113846
- ABIN1874314
- ABIN5067610
- ABIN612674
- ABIN1873256
- ABIN1028279
- ABIN492135
- ABIN2472067
- ABIN2708177
- ABIN367781
- ABIN1113849
- ABIN3198402
- ABIN2708487
- ABIN2010767
- ABIN5670042
- ABIN1569188
- ABIN772888
- ABIN5652371
- ABIN5564598
- ABIN6574109
- ABIN6720465
- ABIN368062
- ABIN1113847
- ABIN1874230
- ABIN1305241
- ABIN492136
- ABIN2708634
- ABIN612803
- ABIN5670711
- ABIN989578
- ABIN4967605
- ABIN5074274
-
Abcam assays for CRP
- Sino Biological Assays for CRP
No data available for DME Specific Peptides for CRP Gene
Domains & Families for CRP Gene
Gene Families for CRP Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for CRP Gene
- InterPro:
- Blocks:
-
- Pentaxin
- ProtoNet:
Suggested Antigen Peptide Sequences for CRP Gene
- GenScript: Design optimal peptide antigens:
-
- C-reactive protein (CRP_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P02741- Family:
-
- Belongs to the pentraxin family.
Function for CRP Gene
Molecular function for CRP Gene
- UniProtKB/Swiss-Prot Function:
- Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
- UniProtKB/Swiss-Prot Induction:
- The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli. It is induced by IL1/interleukin-1 and IL6/interleukin-6.
- GENATLAS Biochemistry:
- C-reactive protein,acute phase reactant,pentaxin (pentraxin) family,bacterial catabolite activator protein
Phenotypes From GWAS Catalog for CRP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001849 | complement component C1q binding | IDA | 23544079 |
| GO:0005509 | calcium ion binding | IDA | 23544079 |
| GO:0005515 | protein binding | IPI | 17293598 |
| GO:0030169 | low-density lipoprotein particle binding | IBA,IDA | 18322245 |
| GO:0033265 | choline binding | TAS | 2477488 |
Phenotypes for CRP Gene
- MGI mutant phenotypes for CRP:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CRP:
Animal Models for CRP Gene
- MGI Knock Outs for CRP:
-
- Crp Crp<tm1Hjf>
Animal Model Products
-
Taconic Biosciences Mouse Models for CRP
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CRP - Select products 50% OFF >
- * CRP CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CRP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CRP
-
Santa Cruz Biotechnology (SCBT) CRISPR for CRP
miRNA for CRP Gene
- miRTarBase miRNAs that target CRP
-
- mmu-miR-5098 (MIRT579045)
- mmu-miR-466c-3p (MIRT579046)
- mmu-miR-466b-3p (MIRT579047)
- mmu-miR-466p-3p (MIRT579048)
- mmu-miR-410-3p (MIRT579049)
- mmu-miR-344e-3p (MIRT579050)
- mmu-miR-344d-3p (MIRT579051)
- hsa-miR-1184 (MIRT735890)
- hsa-miR-1273g-3p (MIRT736816)
- hsa-miR-4252 (MIRT743326)
- hsa-miR-4418 (MIRT744150)
- hsa-miR-509-3-5p (MIRT749667)
- hsa-miR-509-5p (MIRT749703)
- hsa-miR-7156-3p (MIRT759268)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CRP
- Browse OriGene Inhibitory RNA Products For CRP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRP
Clone Products
- Applied Biological Materials (abm): Clones for CRP - Select products 50% OFF >
- * CRP as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CRP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRP
Cell Line Products
-
Horizon Cell Lines for CRP
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRP Gene
Localization for CRP Gene
Subcellular locations from UniProtKB/Swiss-Prot for CRP Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 4 |
| plasma membrane | 3 |
| cytoskeleton | 3 |
| mitochondrion | 3 |
| nucleus | 3 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 1 |
- Vesicles (3)
- Intermediate filaments (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | NAS | 14718574 |
| GO:0005615 | extracellular space | IBA,IDA | 21323571 |
Pathways & Interactions for CRP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
Activation of PKA through GPCR
.71
PKA Signaling
.56
|
| 2 | Creation of C4 and C2 activators | ||
| 3 | Folate Metabolism | ||
| 4 | Innate Immune System |
.61
|
|
| 5 | IL-6 signaling pathway | ||
Pathways by source for CRP Gene
6 BioSystems pathways for CRP Gene
6 Reactome pathways for CRP Gene
3 GeneGo (Thomson Reuters) pathways for CRP Gene
- Development_Leptin signaling via JAK/STAT and MAPK cascades
- Development_Thrombopoetin signaling via JAK-STAT pathway
- Immune response Classical complement pathway
4 Qiagen pathways for CRP Gene
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- cAMP Pathway
- PKA Signaling
Interacting Proteins for CRP Gene
Selected Interacting proteins:
P02741-CRP_HUMAN
ENSP00000255030
for CRP Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for CRP
SIGNOR curated interactions for CRP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006953 | acute-phase response | TAS | 2477488 |
| GO:0006954 | inflammatory response | TAS | 10408362 |
| GO:0006958 | complement activation, classical pathway | IBA | 21873635 |
| GO:0008228 | opsonization | TAS | 2477488 |
| GO:0010628 | positive regulation of gene expression | IDA | 24141169 |
Drugs & Compounds for CRP Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Atorvastatin | Approved | Pharma | Inhibitor, Competitive | 893 | ||
| Pyridoxine | Approved, Investigational, Vet_approved | Nutra | 229,229 | |||
| Vitamin C | Approved | Nutra | 748,748 | |||
| Vitamin D3 | Approved | Nutra | Fat-soluble secosteroids | 1095,1095 | ||
| Adalimumab | Approved | Pharma | 602 |
Drug Products
- G Biosciences Human C-Reactive Protein/CRP, Lyophilized
- RayBiotech Recombinant Human C-reactive Protein
Transcripts for CRP Gene
mRNA/cDNA for CRP Gene
- 4 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000255030 2015 nts (view in UCSC)
- ENST00000368110 667 nts (view in UCSC)
- ENST00000368111 512 nts (view in UCSC)
- ENST00000368112 787 nts (view in UCSC)
- ENST00000437342 1063 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CRP - Select products 50% OFF >
- * CRP CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CRP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CRP
-
Santa Cruz Biotechnology (SCBT) CRISPR for CRP
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CRP
- Browse OriGene Inhibitory RNA Products For CRP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRP
Clone Products
- Applied Biological Materials (abm): Clones for CRP - Select products 50% OFF >
- * CRP as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CRP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRP
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||
| SP7: | - | - | - | - | |||||||||||||||||||||||
| SP8: | - |
Relevant External Links for CRP Gene
- GeneLoc Exon Structure for
- CRP
Expression for CRP Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
-
Gall Bladder (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for CRP Gene
This gene is overexpressed in Liver (x52.1).
This gene is overexpressed in Synovial fluid (11.2), Serum (7.9), and Stomach (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CRP Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CRP
SOURCE GeneReport for Unigene cluster for CRP Gene:
Hs.76452mRNA Expression by UniProt/SwissProt for CRP Gene:
P02741-CRP_HUMAN
Tissue specificity:
Found in plasma.
Evidence on tissue expression from TISSUES for CRP Gene
- Liver(5)
- Heart(4.1)
- Blood(4)
- Muscle(3.9)
- Intestine(3.8)
- Nervous system(3.6)
- Urine(3.6)
- Kidney(3.6)
- Gall bladder(3.6)
- Skin(3.5)
- Spleen(3.5)
- Lung(3.3)
- Bone(3.2)
- Pancreas(3.1)
- Adrenal gland(3.1)
- Thyroid gland(3)
- Bone marrow(3)
- Lymph node(3)
- Eye(2.7)
- Stomach(2.7)
- Saliva(2.6)
Primer Products
-
OriGene qPCR primer pairs for CRP
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRP Gene
Orthologs for CRP Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CRP 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CRP 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Crp 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Crp 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | CRP 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CRP 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | CRP 30 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| -- 31 |
|
ManyToMany | |||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100486739 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.16219 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | CRP 31 |
|
OneToMany |
- Species where no ortholog for CRP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for CRP Gene
- ENSEMBL:
- Gene Tree for CRP (if available)
- TreeFam:
- Gene Tree for CRP (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CRP: view image
Paralogs for CRP Gene
Variants for CRP Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CRP Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 709552 | Benign: not provided | 159,714,095(-) | A/C | SYNONYMOUS_VARIANT | |
| 726464 | Likely Benign: not provided | 159,713,840(-) | G/A | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
| 752112 | Likely Benign: not provided | 159,713,564(-) | C/A | SYNONYMOUS_VARIANT | |
| 791614 | Benign: not provided | 159,714,071(-) | C/T | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3578217 | CNV | loss | 25503493 |
| nsv1005195 | CNV | gain | 25217958 |
| nsv825076 | CNV | loss | 20364138 |
Residual Variation Intolerance Score:
54.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.10;
22.35% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CRP Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRP Gene
Disorders for CRP Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| appendicitis |
|
|
| acute pyelonephritis |
|
|
| acute pancreatitis |
|
|
| meningitis |
|
|
| temporal arteritis |
|
Search CRP in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CRP
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CRP Gene
Publications for CRP Gene
- Polymorphisms in the CRP gene moderate an association between depressive symptoms and circulating levels of C-reactive protein. (PMID: 19796676) Halder I … Manuck SB (Brain, behavior, and immunity 2010) 3 23 41
- CRP gene variation and risk of community-acquired pneumonia. (PMID: 19947988) Mukamal KJ … Rimm EB (Respirology (Carlton, Vic.) 2010) 3 23 41
- Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach. (PMID: 19906786) Welsh P … Sattar N (The Journal of clinical endocrinology and metabolism 2010) 3 23 41
- The interaction of adiposity with the CRP gene affects CRP levels: age, gene/environment susceptibilty-Reykjavik study. (PMID: 19139754) Eiriksdottir G … Gudnason V (International journal of obesity (2005) 2009) 3 23 41
- Pleiotropy of C-reactive protein gene polymorphisms with C-reactive protein levels and heart rate variability in healthy male twins. (PMID: 19962488) Su S … Vaccarino V (The American journal of cardiology 2009) 3 23 41
ExternalLinks
Products for CRP Gene
- View all 28 R&D Systems CRP (C-Reactive Protein/CRP) Products
- View all R&D Systems CRP (C-Reactive Protein/CRP) Proteins and Enzymes
- View all 17 R&D Systems CRP (C-Reactive Protein/CRP) Primary Antibodies
- View all 4 R&D Systems CRP (C-Reactive Protein/CRP) ELISAs
- View all R&D Systems CRP (C-Reactive Protein/CRP) Simple Plex Assays
- View all 2 R&D Systems CRP (C-Reactive Protein/CRP) Luminex Assays
- View all 3 R&D Systems CRP (C-Reactive Protein/CRP) Proteome Profiler Antibody Arrays
- Learn more about R&D Systems custom CRP antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for CRP
- 4C28-C1
- 4C28-C2
- 4C28-C3
- 4C28-C4
- 4C28-C5
- 4C28-C6
- 4C28-C7
- 4C28cc-C6cc
- 4C28-CRP11
- 4C28-CRP135
- 4C28-CRP169
- 4C28-CRP30
- 4C28-CRP36
- AM03133BT-N
- AM03133PU-N
- AM06764SU-N
- AM09005PU-N
- AM09005PU-S
- AM09267PU-N
- AM09268PU-N
- AM20202PU-N
- AM20203PU-N
- AM20788PU-L
- AM20788PU-N
- AM20788PU-S
- AM21031PU-N
- AM26061PU-N
- AP08116PU-N
- AP08116PU-S
- AP08403PU-N
- AP23303PU-N
- AP54805SU-N
- CF807716
- CF807723
- CF807727
- CF807731
- CF807732
- CF807733
- CF809641
- DM1008
- DM1009
- R1597
- TA323623
- TA323624
- TA326781
- TA346207
- TA354557
- TA354559
- TA354576
- TA807716
- TA807716S
- TA807723
- TA807723S
- TA807727
- TA807727S
- TA807731
- TA807731S
- TA807732
- TA807732S
- TA807733
- TA807733S
- TA809641
- TA809641S
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CRP
- Origene Custom Protein Services for CRP
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CRP
- Browse OriGene Inhibitory RNA Products For CRP
- OriGene qPCR primer pairs for CRP
- OriGene CRISPR knockouts for CRP
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CRP
- Sino Biological Human cDNA Clone for CRP
- Sino Biological Recombinant Proteins for CRP
- Sino Biological Cell Lysates for CRP
- Sino Biological Antibodies for CRP
- Sino Biological Assays for CRP
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CRP
- Novus Biologicals proteins for CRP
- Novus Biologicals ELISA Kits for CRP
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CRP
- Abcam proteins for CRP
- Abcam assays for CRP
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for CRP
- Taconic Biosciences Mouse Models for CRP
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for CRP (AFLGC-Crp)
- VectorBuilder Custom and pre-made DNA vectors for CRP (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CRP (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CRP (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CRP CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CRP
- antibodies-online: Show 303 available Crp Antibodies ranked by validation data
- Compare Top Crp Antibodies
- Recommended
- 219 WB Antibodies (anti-human)
- 15 IHC (p) Antibodies (anti-human)
- 6 EIA Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 5 TB Antibodies (anti-human)
- 4 IF Antibodies (anti-human)
- 3 IP Antibodies (anti-human)
- 3 IT Antibodies (anti-human)
- 2 IHC (fro) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 1 IA Antibody (anti-human)
- 1 ID Antibody (anti-human)
- 1 IEP Antibody (anti-human)
- 1 RID Antibody (anti-human)
- 35 WB Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 2 RIA Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 42 WB Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- 2 IP Antibodies (anti-rat)
- 2 RIA Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- antibodies-online: Show 151 available Crp Elisa Kits ranked by validation data
- Compare Top Crp Elisa Kits
- Quality Products:
- ABIN6574220
- ABIN1113846
- ABIN1874314
- ABIN5067610
- ABIN612674
- ABIN1873256
- ABIN1028279
- ABIN492135
- ABIN2472067
- ABIN2708177
- ABIN367781
- ABIN1113849
- ABIN3198402
- ABIN2708487
- ABIN2010767
- ABIN5670042
- ABIN1569188
- ABIN772888
- ABIN5652371
- ABIN5564598
- ABIN6574109
- ABIN6720465
- ABIN368062
- ABIN1113847
- ABIN1874230
- ABIN1305241
- ABIN492136
- ABIN2708634
- ABIN612803
- ABIN5670711
- ABIN989578
- ABIN4967605
- ABIN5074274
- antibodies-online: Show 52 available Crp Proteins ranked by validation data
- Compare Top Crp Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CRP
- Search Santa Cruz Biotechnology (SCBT) for CRP siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CRP
- Horizon Cell Lines for CRP
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CRP
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CRP
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CRP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CRP
Sources for CRP Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB