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The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]
CRP (C-Reactive Protein) is a Protein Coding gene. Diseases associated with CRP include Appendicitis and Acute Pyelonephritis. Among its related pathways are Folate Metabolism and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include calcium ion binding and cholesterol binding. An important paralog of this gene is APCS.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH01J159714 | Promoter | 0.7 | EPDnew | 600.7 | 0.0 | -20 | 0.1 | SP1 YY1 ZBTB33 JUND NR2F2 RAD21 HNF4A RXRA FOXA1 TAF1 | CRP lnc-VSIG8-3 piR-47214 HSALNG0007782 DUSP23 | |
GH01J159751 | Enhancer | 0.9 | Ensembl ENCODE | 10.9 | -38.0 | -38012 | 3.2 | ZNF629 SP1 TOE1 CEBPA CEBPB SMARCC1 FOXA2 RAD51 ATF3 RCOR1 | CRP FCRL6 DUSP23 ENSG00000212161 AIM2 RPL27P2 HSALNG0007782 | |
GH01J159755 | Enhancer | 0.6 | Ensembl | 10.9 | -41.7 | -41712 | 1.8 | SP1 FOXA2 ATF3 YY1 ZBTB33 JUND SPI1 HNF4A RXRA MAX | DUSP23 CRP FCRL6 ENSG00000212161 RPL27P2 HSALNG0007782 | |
GH01J159775 | Enhancer | 0.4 | Ensembl | 10.5 | -60.2 | -60212 | 2 | CTCF YY1 SMC3 RAD21 | CRP FCRL6 ENSG00000212161 SNHG28 VSIG8 PIGM lnc-CRP-2 DUSP23 piR-40163-009 | |
GH01J159768 | Enhancer | 0.3 | Ensembl | 10.3 | -53.8 | -53770 | 0.7 | ZNF584 | piR-40163-009 piR-49423-013 FCRL6 CRP ENSG00000212161 OR10J3 PIGM DUSP23 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001849 | complement component C1q binding | IDA | 23544079 |
GO:0005509 | calcium ion binding | IDA | 23544079 |
GO:0005515 | protein binding | IPI | 17293598 |
GO:0030169 | low-density lipoprotein particle binding | IBA,IDA | 18322245 |
GO:0033265 | choline binding | TAS | 2477488 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | NAS | 14718574 |
GO:0005615 | extracellular space | IBA,IDA | 21323571 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
Activation of PKA through GPCR
.71
PKA Signaling
.56
|
2 | Creation of C4 and C2 activators | ||
3 | Folate Metabolism | ||
4 | Innate Immune System |
.61
|
|
5 | IL-6 signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006953 | acute-phase response | TAS | 2477488 |
GO:0006954 | inflammatory response | TAS | 10408362 |
GO:0006958 | complement activation, classical pathway | IBA | 21873635 |
GO:0008228 | opsonization | TAS | 2477488 |
GO:0010628 | positive regulation of gene expression | IDA | 24141169 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Atorvastatin | Approved | Pharma | Inhibitor, Competitive | 893 | ||
Pyridoxine | Approved, Investigational, Vet_approved | Nutra | 229,229 | |||
Vitamin C | Approved | Nutra | 748,748 | |||
Vitamin D3 | Approved | Nutra | Fat-soluble secosteroids | 1095,1095 | ||
Adalimumab | Approved | Pharma | 602 |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||
SP4: | - | - | - | - | - | ||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||
SP7: | - | - | - | - | |||||||||||||||||||||||
SP8: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CRP 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CRP 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Crp 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Crp 30 |
|
||
Dog (Canis familiaris) |
Mammalia | CRP 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CRP 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | CRP 30 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100486739 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.16219 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | CRP 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
709552 | Benign: not provided | 159,714,095(-) | A/C | SYNONYMOUS_VARIANT | |
726464 | Likely Benign: not provided | 159,713,840(-) | G/A | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
752112 | Likely Benign: not provided | 159,713,564(-) | C/A | SYNONYMOUS_VARIANT | |
791614 | Benign: not provided | 159,714,071(-) | C/T | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3578217 | CNV | loss | 25503493 |
nsv1005195 | CNV | gain | 25217958 |
nsv825076 | CNV | loss | 20364138 |
Disorder | Aliases | PubMed IDs |
---|---|---|
appendicitis |
|
|
acute pyelonephritis |
|
|
acute pancreatitis |
|
|
meningitis |
|
|
temporal arteritis |
|