Aliases for CROCC2 Gene

Aliases for CROCC2 Gene

  • Ciliary Rootlet Coiled-Coil, Rootletin Family Member 2 2 3 5
  • Putative Ciliary Rootlet Coiled-Coil Protein 2 3 4
  • Putative Ciliary Rootlet Coiled-Coil Protein-Like 3 Protein 3
  • Rootletin-Like 3
  • CROCC2 5

External Ids for CROCC2 Gene

Summaries for CROCC2 Gene

GeneCards Summary for CROCC2 Gene

CROCC2 (Ciliary Rootlet Coiled-Coil, Rootletin Family Member 2) is a Protein Coding gene. An important paralog of this gene is CROCC.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CROCC2 Gene

Genomics for CROCC2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CROCC2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J240905 Enhancer 0.5 Ensembl 250.7 -0.7 -659 1 ZIC2 GLIS1 ZFP69B HNRNPL ZNF692 RAD21 GLIS2 EP300 CROCC2 HSALNG0023623 MAB21L4 AGXT
GH02J240906 Enhancer 0.5 Ensembl 250.7 +0.4 441 0.8 SAP130 BHLHE40 RFX1 HNRNPL RAD21 RFX3 CROCC2 HSALNG0023623 MAB21L4 HSALNG0023624 SNED1
GH02J240946 Enhancer 0.5 Ensembl 11.3 +40.7 40741 1.8 EBF1 CTBP1 MAZ RFX5 RFX1 ZFHX2 KLF9 KLF4 ENSG00000223991 UICLM ENSG00000229996 CROCC2 AGXT KIF1A HSALNG0023628 HSALNG0023627 SNED1
GH02J240912 Enhancer 1.5 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 +9.0 9006 6.7 MXD4 ZNF217 CTCF ZIC2 THAP11 TRIM22 MIER3 SMC3 GABPB1 RAD21 MAB21L4 AGXT ENSG00000223991 SNED1 GPC1 RNPEPL1 CROCC2 HSALNG0023624
GH02J240895 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 0.4 -8.6 -8624 3.5 ZEB1 ELF1 ZIC2 SMAD4 SAP130 RXRA GABPB1 CTBP1 RARA TEAD3 MAB21L4 AGXT CROCC2 HSALNG0023623
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CROCC2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CROCC2

Genomic Locations for CROCC2 Gene

Latest Assembly
chr2:240,906,160-240,993,311
(GRCh38/hg38)
Size:
87,152 bases
Orientation:
Plus strand

Previous Assembly
chr2:241,845,753-241,932,728
(GRCh37/hg19 by Entrez Gene)
Size:
86,976 bases
Orientation:
Plus strand

chr2:241,858,202-241,932,728
(GRCh37/hg19 by Ensembl)
Size:
74,527 bases
Orientation:
Plus strand

Genomic View for CROCC2 Gene

Genes around CROCC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CROCC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CROCC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CROCC2 Gene

Proteins for CROCC2 Gene

  • Protein details for CROCC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    H7BZ55-CRCC2_HUMAN
    Recommended name:
    Putative ciliary rootlet coiled-coil protein 2
    Protein Accession:
    H7BZ55

    Protein attributes for CROCC2 Gene

    Size:
    1653 amino acids
    Molecular mass:
    185641 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CROCC2 Gene

Post-translational modifications for CROCC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CROCC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CROCC2 Gene

Domains & Families for CROCC2 Gene

Gene Families for CROCC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CROCC2 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

H7BZ55

UniProtKB/Swiss-Prot:

CRCC2_HUMAN :
  • Belongs to the rootletin family.
Family:
  • Belongs to the rootletin family.
genes like me logo Genes that share domains with CROCC2: view

No data available for Suggested Antigen Peptide Sequences for CROCC2 Gene

Function for CROCC2 Gene

Phenotypes From GWAS Catalog for CROCC2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CROCC2 Gene

Localization for CROCC2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CROCC2 gene
Compartment Confidence
nucleus 2
cytosol 1
peroxisome 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CROCC2 Gene

Pathways & Interactions for CROCC2 Gene

PathCards logo

SuperPathways for CROCC2 Gene

No Data Available

Interacting Proteins for CROCC2 Gene

Gene Ontology (GO) - Biological Process for CROCC2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CROCC2 Gene

Drugs & Compounds for CROCC2 Gene

No Compound Related Data Available

Transcripts for CROCC2 Gene

mRNA/cDNA for CROCC2 Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CROCC2 Gene

No ASD Table

Relevant External Links for CROCC2 Gene

GeneLoc Exon Structure for
CROCC2

Expression for CROCC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CROCC2

genes like me logo Genes that share expression patterns with CROCC2: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CROCC2 Gene

Orthologs for CROCC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CROCC2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 95 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC102551034 30
  • 74.27 (n)
Mouse
(Mus musculus)
Mammalia E030010N08Rik 30
  • 70.45 (n)
Crocc2 17
Cow
(Bos Taurus)
Mammalia -- 31
  • 43 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 39 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 26 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 24 (a)
OneToOne
Chicken
(Gallus gallus)
Aves -- 31
  • 10 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 24 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii si:ch211-95g8.1 31
  • 17 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Rootletin 31
  • 9 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 15 (a)
OneToOne
Species where no ortholog for CROCC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CROCC2 Gene

ENSEMBL:
Gene Tree for CROCC2 (if available)
TreeFam:
Gene Tree for CROCC2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CROCC2: view image

Paralogs for CROCC2 Gene

Paralogs for CROCC2 Gene

genes like me logo Genes that share paralogs with CROCC2: view

Variants for CROCC2 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CROCC2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Additional Variant Information for CROCC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CROCC2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for CROCC2 Gene

Disorders for CROCC2 Gene

Additional Disease Information for CROCC2

No disorders were found for CROCC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CROCC2 Gene

Publications for CROCC2 Gene

  1. Pinstripe: a suite of programs for integrating transcriptomic and proteomic datasets identifies novel proteins and improves differentiation of protein-coding and non-coding genes. (PMID: 23044541) Gascoigne DK … Mattick JS (Bioinformatics (Oxford, England) 2012) 2 3
  2. Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development. (PMID: 31343991) Wang P … Xiong Y (The Journal of clinical investigation 2019) 3
  3. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
  4. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N … Gygi SP (Proceedings of the National Academy of Sciences of the United States of America 2008) 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4

Products for CROCC2 Gene

Sources for CROCC2 Gene