Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CRNDE Gene

Aliases for CRNDE Gene

  • Colorectal Neoplasia Differentially Expressed 2 3 5
  • Colorectal Neoplasia Differentially Expressed (Non-Protein Coding) 2 3
  • Long Intergenic Non-Protein Coding RNA 180 2 3
  • Colorectal Neoplasia Differentially Expressed Peptide 3
  • NCRNA00180 3
  • LINC00180 3
  • PNAS-108 3
  • LincIRX5 3
  • CRNDEP 3

External Ids for CRNDE Gene

Previous GeneCards Identifiers for CRNDE Gene

  • GC16M053512
  • GC16M054953
  • GC16M040838

Summaries for CRNDE Gene

Entrez Gene Summary for CRNDE Gene

  • This gene is transcribed into multiple transcript variants, some of which may function as non-coding RNAs. One of the transcript variants encodes a putative short protein that is localized to the nucleus (PMID:25978564). Expression of this locus is increased in proliferating tissues, including certain tumors such as colorectal adenomas and adenocarcinomas. Transcription from this gene is negatively regulated by insulin and insulin-like growth factors, and may regulate the expression of genes involved in metabolism. [provided by RefSeq, May 2015]

GeneCards Summary for CRNDE Gene

CRNDE (Colorectal Neoplasia Differentially Expressed) is a Protein Coding gene. Diseases associated with CRNDE include Childhood Medulloblastoma and Hepatoblastoma.

Additional gene information for CRNDE Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRNDE Gene

Genomics for CRNDE Gene

GeneHancer (GH) Regulatory Elements for CRNDE Gene

Promoters and enhancers for CRNDE Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J054926 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 8 -3.4 -3363 12.9 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 POLR2B ZNF143 KLF13 ZNF263 IRX5 IRX3 CRNDE ENSG00000259711 ENSG00000259725
GH16J054922 Enhancer 0.5 dbSUPER 7.6 +6.0 5958 0.9 OSR2 PKNOX1 PRDM10 SP7 CRNDE GC16M054907
GH16J054921 Enhancer 1.1 UCNEbase dbSUPER 0.4 +7.8 7822 0.3 PKNOX1 INSM2 FEZF1 ZNF664 POLR2A ZNF366 PRDM10 KLF8 OVOL3 ZEB2 GC16M054907 CRNDE
GH16J054846 Enhancer 0.7 ENCODE 0.2 +81.9 81949 1.9 FOXA2 ZBTB21 FEZF1 ZNF664 ZNF366 PRDM10 NR2F6 FOS ZNF362 NR2F1 LOC101927480 LOC105371276 CRNDE
GH16J054890 Enhancer 0.4 UCNEbase 0.3 +38.4 38441 0.3 GC16M054885 LOC105371275 CRNDE
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CRNDE on UCSC Golden Path with GeneCards custom track

Genomic Locations for CRNDE Gene

Genomic Locations for CRNDE Gene
chr16:54,845,189-54,929,189
(GRCh38/hg38)
Size:
84,001 bases
Orientation:
Minus strand
chr16:54,952,775-54,963,101
(GRCh37/hg19)
Size:
10,327 bases
Orientation:
Minus strand

Genomic View for CRNDE Gene

Genes around CRNDE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CRNDE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CRNDE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRNDE Gene

Proteins for CRNDE Gene

Post-translational modifications for CRNDE Gene

No Post-translational modifications

Other Protein References for CRNDE Gene

No data available for DME Specific Peptides for CRNDE Gene

Domains & Families for CRNDE Gene

Gene Families for CRNDE Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CRNDE: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CRNDE Gene

Function for CRNDE Gene

Phenotypes for CRNDE Gene

genes like me logo Genes that share phenotypes with CRNDE: view

Animal Model Products

miRNA for CRNDE Gene

miRTarBase miRNAs that target CRNDE

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CRNDE Gene

Localization for CRNDE Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CRNDE gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CRNDE Gene

Pathways & Interactions for CRNDE Gene

SuperPathways for CRNDE Gene

No Data Available

Interacting Proteins for CRNDE Gene

Gene Ontology (GO) - Biological Process for CRNDE Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CRNDE Gene

Drugs & Compounds for CRNDE Gene

No Compound Related Data Available

Transcripts for CRNDE Gene

mRNA/cDNA for CRNDE Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(14) RNA Central transcripts :

Unigene Clusters for CRNDE Gene

Colorectal neoplasia differentially expressed (non-protein coding):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CRNDE Gene

No ASD Table

Relevant External Links for CRNDE Gene

GeneLoc Exon Structure for
CRNDE
ECgene alternative splicing isoforms for
CRNDE

Expression for CRNDE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CRNDE Gene

mRNA differential expression in normal tissues according to GTEx for CRNDE Gene

This gene is overexpressed in Testis (x10.7).

NURSA nuclear receptor signaling pathways regulating expression of CRNDE Gene:

CRNDE

SOURCE GeneReport for Unigene cluster for CRNDE Gene:

Hs.237396
genes like me logo Genes that share expression patterns with CRNDE: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRNDE Gene

Orthologs for CRNDE Gene

Evolution for CRNDE Gene

ENSEMBL:
Gene Tree for CRNDE (if available)
TreeFam:
Gene Tree for CRNDE (if available)

No data available for Orthologs for CRNDE Gene

Paralogs for CRNDE Gene

No data available for Paralogs for CRNDE Gene

Variants for CRNDE Gene

Sequence variations from dbSNP and Humsavar for CRNDE Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000217083 -- 54,928,325(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000520352 -- 54,926,720(-) A/G intron_variant
rs1000588505 -- 54,928,074(-) C/G 5_prime_UTR_variant, intron_variant
rs1001195200 -- 54,929,479(-) A/C upstream_transcript_variant
rs1001625127 -- 54,929,694(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CRNDE Gene

Variant ID Type Subtype PubMed ID
nsv827657 CNV gain 20364138

Additional Variant Information for CRNDE Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CRNDE

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CRNDE Gene

Disorders for CRNDE Gene

MalaCards: The human disease database

(16) MalaCards diseases for CRNDE Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
childhood medulloblastoma
  • pediatric medulloblastoma
hepatoblastoma
  • hbl
gallbladder cancer
  • gallbladder ca
malignant glioma
bladder urothelial carcinoma
  • bladder transitional cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search CRNDE in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CRNDE

genes like me logo Genes that share disorders with CRNDE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CRNDE Gene

Publications for CRNDE Gene

  1. The Novel Gene CRNDE Encodes a Nuclear Peptide (CRNDEP) Which Is Overexpressed in Highly Proliferating Tissues. (PMID: 25978564) Szafron LM … Kupryjanczyk J (PloS one 2015) 2 3 58
  2. Multiple knockout mouse models reveal lincRNAs are required for life and brain development. (PMID: 24381249) Sauvageau M … Rinn JL (eLife 2013) 2 3 58
  3. CRNDE: A Long Non-Coding RNA Involved in CanceR, Neurobiology, and DEvelopment. (PMID: 23226159) Ellis BC … Graham LD (Frontiers in genetics 2012) 2 3 58
  4. The lncRNA CRNDE promotes colorectal cancer cell proliferation and chemoresistance via miR-181a-5p-mediated regulation of Wnt/β-catenin signaling. (PMID: 28086904) Han P … Cui BB (Molecular cancer 2017) 3 58
  5. Long non-coding RNA-CRNDE: a novel regulator of tumor growth and angiogenesis in hepatoblastoma. (PMID: 28178668) Dong R … Dong KR (Oncotarget 2017) 3 58

Products for CRNDE Gene

Sources for CRNDE Gene

Content
Loading form....